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  • Intravenous
  • Intravenous injection of a large dose of rTNF-alpha resulted in a decrease in the number of bacteria in the liver and spleen, but an injection of rIFN-gamma and rTNF-alpha did not result in enhanced inhibition of the proliferation of L. monocytogenes. (mysciencework.com)
  • Both intravenous drug abuse (IDU) and HIV infection can increase TNF-alpha activity, but little information is available on the effects of a combination of these factors on TNF-alpha. (nova.edu)
  • These findings show that the effects of HIV infection and intravenous drug use may be additive in increasing TNF-alpha levels. (nova.edu)
  • cytokine
  • TNF-alpha is a highly pleiotropic cytokine and plays an important role in regulating HIV-1 replication. (nova.edu)
  • Methods We measured plasma levels of interleukin (IL)-6, monocyte chemotractant protein 1, IL-10, and soluble tumor necrosis factor receptor type 1 (sTNFR1) during longitudinal testing over a period of two years in 234 patients with HF following AMI recruited for participation in the OPTIMAAL trial, focusing on the possible prognostic value of circulating cytokine levels in these patients. (onlinejacc.org)
  • Although several studies have focused on the possible role of TNF-alpha, the individual cytokine exists as part of a cytokine network, and the effect of various inflammatory cytokines is influenced by other inflammatory as well as anti-inflammatory mediators, illustrating the complexity of this network ( 3 ). (onlinejacc.org)
  • role
  • Given the multiple effects of TNF-alpha in HIV infection, additional investigation of its role is needed. (nova.edu)
  • expression
  • Together, the results of the present study are the first to demonstrate that endogenous TNF-alpha is required in vivo for the expression of macrophage activation with respect to the release of reactive nitrogen intermediates and toxoplasmastatic activity and for enhanced listericidal activity in the livers and spleens of mice stimulated with rIFN-gamma. (mysciencework.com)
  • TNF-alpha mRNA expression in peripheral monocytes was significantly increased in both HIV-1-positive and negative IDUs compared to controls. (nova.edu)
  • proinflammatory
  • However, it has been clearly known that one of the important factors, activating pancreatic stellate cells during pancreatic injury, is proinflammatory cytokines known to be upregulated early in the course of acute pancreatic inflammation [ 3 , 4 ]. (hindawi.com)
  • The clinical use of the potent anti-tumor activity of TNF-alpha has been limited by the proinflammatory side effects including fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. (creativebiomart.net)
  • Identical
  • NO produced by eNOS has been shown to be a vasodilator identical to the endothelium-derived relaxing factor produced in response to shear from increased blood flow in arteries. (wikipedia.org)
  • Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. (wikipedia.org)
  • mRNA
  • In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese premenopausal women by Northern blot analysis. (jci.org)
  • Furthermore, the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA were also analyzed in nine premenopausal obese women, before and after a controlled weight-reduction program. (jci.org)
  • For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. (wikipedia.org)
  • cleaves
  • Functionally, ADAMTS can be divided into three groups: procollagen aminopepidase, aggrecanase, and ADAMTS13 which cleaves von Willebrand factor. (wikipedia.org)
  • Human
  • Detection of human serum tumor necrosis factor-alpha in healthy donors, using a highly sensitive immuno-PCR assay. (springer.com)
  • A highly sensitive immunosensor based on ITO thin films covered by a new semi-conductive conjugated polymer for the determination of TNF alpha in human saliva and serum samples. (springer.com)
  • Human TNF-a, which binds to the murine TNF-R55 but not to the mouse TNF-R75, exhibits retained anti-tumor activity and reduced systemic toxicity in mice compared with murine TNF-a, which binds to both murine TNF receptors. (creativebiomart.net)
  • Recombinant Human TNF-alpha Variant/Mutant compared with the wild-type, has an amino acid sequence deletion from a.a. 1-7, and the following a.a. substitutes Arg8, Lys9, Arg10 and Phe157 which is proven to have more activity and with less inflammatory side effect in vivo. (creativebiomart.net)
  • platelet-activa
  • This TNF-dependent EO cytotoxicity is strongly inhibited by heparin and methyprednisolone but unaffected by the platelet-activating factor antagonist BN52012 or scavengers of superoxide anion and H2O2, superoxide dismutase and catalase. (rupress.org)
  • cytokines
  • Genetic factors, especially related to cytokines, may play important roles in susceptibility to pancreatic injury, as well as in the severity and evolution of the inflammatory process [ 5 ]. (hindawi.com)
  • potent
  • These results demonstrate that low concentration BV possess a potent suppressive effect on anti-apoptotic responses of TNF-alpha/Act D-treated hepatocytes and suggest that these compounds may contribute substantial therapeutic potential for the treatment of liver diseases. (unboundmedicine.com)
  • activation
  • BV suppressed TNF-alpha/Act Dtreated activation of bcl-2 family and caspase family, which resulted in inhibition of cytochrome c release and PARP cleavage. (unboundmedicine.com)
  • mice
  • Between days 7 and 10 post-HL surgery 100% of old p75KOs experienced auto-amputation of the operated limbs, whereas none of the age-matched WT mice exhibited HL necrosis. (ahajournals.org)
  • tissue
  • Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. (jci.org)
  • In animals, Y. pseudotuberculosis can cause tuberculosis-like symptoms, including localized tissue necrosis and granulomas in the spleen, liver, and lymph nodes. (wikipedia.org)
  • Species
  • The 70-kb pYV is critical to Yersinia's pathogenicity, since it contains many genes known to encode virulence factors and its loss gives avirulence of all Yersinia species. (wikipedia.org)
  • severity
  • Although fatigue and sleep disturbance are prevalent symptoms in oncology patients and their family caregivers, little is known about the factors that contribute to interindividual variability in symptom severity ratings as well as in their underlying biological mechanisms. (nih.gov)
  • immune
  • It includes an investigation of the effects of infection, inflammation and immune factors on testicular function. (wikipedia.org)
  • Patients
  • The hypothesis is that a subset of patients with chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME), including also patients with no clinical response after B-cell depletion therapy using the anti-CD20 antibody Rituximab, may benefit from tumor necrosis factor-alpha inhibition using Etanercept as weekly subcutaneous injections. (clinicaltrials.gov)
  • Tumor Necrosis Factor-alpha Inhibition Using Etanercept in Moderate and Serious Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME), Including in Patients With no Clinical Response After B-lymphocyte Depletion Using the Anti-CD20 Antibody Rituximab. (clinicaltrials.gov)
  • There was a significant increase in PAI-1 and TNF-alpha in patients as compared to controls (p less than 0.0001), whereas no differences for PAI-2 were observed. (cun.es)
  • PAI-1 and TNF-alpha were significantly higher in 18 patients with gram-negative bacteremia as compared to all other patients (p less than 0.0001). (cun.es)
  • beta
  • Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices. (wikipedia.org)
  • Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. (wikipedia.org)
  • The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. (wikipedia.org)
  • cell
  • ADAMs participate in a wide variety of cell surface remodeling processes, including ectodomain shedding, regulation of growth factor availability and mediating cell-matrix interactions. (wikipedia.org)
  • inflammation
  • and, (2) some factors which normally lead to inflammation are present at high levels in the testis, where they regulate the development of sperm instead of promoting inflammation. (wikipedia.org)
  • results
  • Our results showed statistically significant inhibition in DNA damage caused by BV treatment compared to corresponding TNF-alpha/Act D-treated hepatocytes. (unboundmedicine.com)
  • Intravenous
  • Intravenous injection of a large dose of rTNF-alpha resulted in a decrease in the number of bacteria in the liver and spleen, but an injection of rIFN-gamma and rTNF-alpha did not result in enhanced inhibition of the proliferation of L. monocytogenes. (mysciencework.com)
  • Both intravenous drug abuse (IDU) and HIV infection can increase TNF-alpha activity, but little information is available on the effects of a combination of these factors on TNF-alpha. (nova.edu)
  • These findings show that the effects of HIV infection and intravenous drug use may be additive in increasing TNF-alpha levels. (nova.edu)
  • cytokine
  • TNF-alpha is a highly pleiotropic cytokine and plays an important role in regulating HIV-1 replication. (nova.edu)
  • Methods We measured plasma levels of interleukin (IL)-6, monocyte chemotractant protein 1, IL-10, and soluble tumor necrosis factor receptor type 1 (sTNFR1) during longitudinal testing over a period of two years in 234 patients with HF following AMI recruited for participation in the OPTIMAAL trial, focusing on the possible prognostic value of circulating cytokine levels in these patients. (onlinejacc.org)
  • Although several studies have focused on the possible role of TNF-alpha, the individual cytokine exists as part of a cytokine network, and the effect of various inflammatory cytokines is influenced by other inflammatory as well as anti-inflammatory mediators, illustrating the complexity of this network ( 3 ). (onlinejacc.org)
  • role
  • Given the multiple effects of TNF-alpha in HIV infection, additional investigation of its role is needed. (nova.edu)
  • expression
  • Together, the results of the present study are the first to demonstrate that endogenous TNF-alpha is required in vivo for the expression of macrophage activation with respect to the release of reactive nitrogen intermediates and toxoplasmastatic activity and for enhanced listericidal activity in the livers and spleens of mice stimulated with rIFN-gamma. (mysciencework.com)
  • TNF-alpha mRNA expression in peripheral monocytes was significantly increased in both HIV-1-positive and negative IDUs compared to controls. (nova.edu)
  • mediators
  • indicated that the exposure of retinal neurosensory and glial cells to HIV Tat resulted in increased activation and release of proinflammatory mediators, predominantly the chemokine and neurotoxic factor CXCL10 and the cytokine TNF- α [ 5 ]. (hindawi.com)
  • activation
  • AGE-albumin) and in particular carboxymethyllysine (CML) are known to play a central role in diabetic nephropathy, we studied the activation of nuclear factor κB (NF-κB) in tubular epithelial cells in vivo and in vitro by AGE-albumin and CML. (diabetesjournals.org)
  • Type
  • Administration of Type I IFN has been shown experimentally to inhibit tumor growth in animals, but the beneficial action in human tumors has not been widely documented. (wikipedia.org)
  • cells
  • F-18 16 alpha-fluoroestradiol is actively taken up in tumor cells expressing the estrogen receptor (ER), allowing visualization of ER-positive tumor cells with positron emiision tomography (PET). (newyorkoncology.com)
  • Reflecting the increased amino acid transport capacity of tumor cells, F-18 fluroethyltyrosine (F-18 FET) is actively taken up in tumor cells via amino acid transport system L, but is neither incorporated into proteins nor readily degraded, resulting in high intracellular concentrations of this imaging agent. (newyorkoncology.com)
  • In addition, this agent is able to sensitize FACT-positive tumor cells to the cytotoxic effects of other chemotherapeutic agents. (newyorkoncology.com)
  • proteins
  • Promoters contain specific DNA sequences such as response elements that provide a secure initial binding site for RNA polymerase and for proteins called transcription factors that recruit RNA polymerase. (wikipedia.org)
  • response
  • Anti-tumor necrosis factor (anti-TNF) therapies are highly effective in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but a significant number of patients exhibit only a partial or no therapeutic response. (ox.ac.uk)
  • agents
  • Radiolableled amino acid-based agents are useful in PET brain tumor imaging because F-18 fluoro-deoxyglucose (F-18 FDG), commonly used in PET tumor imaging, is relatively insensitive for detecting tumors in the brain due the high levels of glycolytic metabolism in the normal cortex and to a lesser extent in white matter. (newyorkoncology.com)
  • domain
  • This bundle acts as the GAP domain, because arginine from an alpha helix is inserted into a GTP-ase which catalyses GTP hydrolysis through stabilisation of the transition state. (wikipedia.org)
  • high
  • Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. (bosterbio.com)
  • several
  • Due to several virus- and patient-related factors, treatment is even less successful in certain populations, especially in HCV genotype 1 infection. (clinicaltrials.gov)