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  • lung
  • There was an increase in leukocyte numbers in tumor compared with distant lung in adenocarcinoma. (uio.no)
  • When expressed as percent of total leukocytes, we found an increase in B cells in tumor compared with distant lung in both adenocarcinoma and squamous cell carcinoma. (uio.no)
  • Squamous cell carcinoma tumors had a decrease of CD141+ mDCs compared with distant lung. (uio.no)
  • association
  • This study compares the association of uPAR expression in both colorectal tumor-associated stromal cells and neoplastic cells with clinico-pathological characteristics and patient survival using tissue micro arrays TMA. (duhnnae.com)
  • malignant tumors
  • Taking their findings one step further, Gilmour and her team in 2017 demonstrated that a polyamine blockade therapy (PBT) they developed inhibited the growth of malignant tumors in mice and activated an immune response to those tumors. (wikipedia.org)
  • hypoxic
  • While it may seem that an increase in blood vessel quantity would provide sufficient oxygen to tumors, the abnormal vessels deliver less oxygen leading to a hypoxic tumor environment [ 13 ]. (hindawi.com)
  • angiogenesis
  • This will further stimulate tumor growth and aberrant angiogenesis [ 22 , 23 ]. (hindawi.com)
  • Collective tumor cell invasion (CTCI) is reflected by a protrusion of tumor cells or cell debris visible by R3050/2PAF/3PAF, angiogenesis (An) by a protrusion of 3PAF-visible vesicles, tumor-associated collagen structure-3 (TACS-3) by a protrusion of collagen fibers, and lymphangiogenesis (LA) by a protrusion of elastin fibers. (uiuc.edu)
  • survival
  • The patient's response is then tracked as closely as possible, often using surrogate measures such as tumor load (v. true outcomes, such as 5 year survival rate), and the treatment finely adapted to the patient's response. (wikipedia.org)
  • AXL has been implicated as a cancer driver and correlated with poor survival in numeorus aggressive tumors including triple-negative breast cancer (TNBC), acute myeloid leukemia (AML), non-small-cell lung cancer (NSCLC), pancreatic cancer and ovarian cancer, among others. (wikipedia.org)
  • cancerous
  • The National Toxicology Program (NTP) concluded there is clear evidence that male rats exposed to high levels of radio frequency radiation (RFR) like that used in 2G and 3G cell phones developed cancerous heart tumors, according to final reports released today. (blogspot.com)
  • tissue
  • Traditional fluorescence microscope imaging techniques, while highlighting specific features of tumor tissue by labeling, like nucleus, lose many other molecular information that can indicate some biological structures found in tumor microenvironments. (uiuc.edu)
  • Our label-free multi-modal multi-photon imaging system, aiming for the intrinsic optical response of tumor tissue, manage to visualize various kinds of biological features in tumor microenvironments, which are either absent or covered in traditional labeled fluorescent imaging. (uiuc.edu)
  • Gilmour continued her research at The Wistar Institute in Philadelphia, Pennsylvania, first as postdoctoral fellow (1984 to 1987) and then as research associate (1988 to 1990 While at Wistar, she began her work in characterizing the regulation and expression of ornithine decarboxylase (ODC) in both normal and tumor tissue. (wikipedia.org)
  • Inter-personal difference of molecular pathology is diverse, so as inter-personal difference in the exposome, which influence disease processes through the interactome within the tissue microenvironment, differentially from person to person. (wikipedia.org)
  • metastatic
  • This adds to Taconic's current platform offering bioluminescent human tumor cell lines and tumor xenograft studies, including the use of orthotopic and metastatic models. (andhranews.net)
  • Abnormalities in tumor vessel shape and structure not only impair drug delivery, but also can facilitate metastatic spread [ 20 , 21 ]. (hindawi.com)
  • Thus, we can conclude that insufficiency of immunological defense mechanisms leading to disruption of maligned cell elimination process is the primary pathogenic factor for metastatic tumor development. (ssmj.ru)
  • abnormal
  • You S, Tu H, Zhao Y, Liu Y, Chaney EJ, Marjanovic M, Boppart SA, Raman spectroscopic analysis reveals abnormal fatty acid composition in tumor micro- and macroenvironments in human breast and rat mammary cancer. (uiuc.edu)
  • cell
  • In contrast to healthy vessels, tumor vessels are immature, often mal-shaped, irregular, and have a tortuous structure with a leaky endothelial cell lining [ 13 , 14 ]. (hindawi.com)
  • To determine the probable mechanism, they established a naive T cell-macrophage-endometrial stromal cell co-culture system to mimic the peritoneal cavity microenvironment. (humanimmunologynews.com)
  • It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. (biomedcentral.com)
  • She discovered that overexpression of ODC and c-Raf activation is sufficient to convert a normal primary keratinocyte into a malignant, invasive tumor cell. (wikipedia.org)
  • Primary effusion lymphoma (PEL) is a B-cell lymphoma, presenting with a malignant effusion without a tumor mass. (wikipedia.org)
  • molecular
  • Scientific discoveries: Gilmour's study of polyamines has broadened the scope of medical knowledge about tumor function at the cellular and molecular levels. (wikipedia.org)
  • These include uncovering the barriers to the delivery and efficacy of molecular and nano-medicines in tumors, developing new strategies to overcome these barriers, and then translating these strategies from bench to bedside. (wikipedia.org)
  • novel
  • Taconic will employ the DuPont OncoMouse® technology to expand its translational oncology research services by performing efficacy and compound profiling studies on behalf of clients and making novel spontaneous tumor mouse models available to investigators for in-house research programs. (andhranews.net)
  • role
  • Using skin-targeted transgenic mice, she demonstrated that elevated levels of ODC play a causal role in the development of tumors. (wikipedia.org)
  • found
  • Historically, the term gatekeeper gene was first coined in association with the APC gene, a tumor suppressor that is consistently found to be mutated in colorectal tumors. (wikipedia.org)
  • patients
  • Use of some antiplatelet agents appears safe in patients undergoing transurethral resection of bladder tumor. (wisc.edu)
  • response
  • Tumors induce the proliferative vascular response of host blood vessels by influencing the local balance of angiogenic regulators, a rate-limiting step termed the angiogenic switch [ 9 , 10 ]. (hindawi.com)
  • study
  • Tumor microenvironment study is of huge significance in terms of cancer invasiveness observation and characterization. (uiuc.edu)
  • She recently developed an animal model to study arsenic-induced skin cancer and to demonstrate that in utero exposure to trace levels of arsenic in drinking water leads to skin tumor formation when the animals mature to young adults. (wikipedia.org)
  • local
  • Large-area of co-localized single-modality multiphoton images revealing vital signatures of local tumor invasion in a week 8 tumor. (uiuc.edu)
  • Local symptoms may occur due to the mass of the tumor or its ulceration. (wikipedia.org)
  • promote
  • T-lymphocyte turnover is promoted by the production of interleukin-6, interleukin-1, interleukin-2, and tumor necrosis factor (TNF)- α , all of which promote HIV replication [ 1 ]. (hindawi.com)