Trypanosoma cruzi. Medical search. Frequent questions

Reptiles have been described as natural hosts of We assessed 4 lizard species in Chile for Trypanosoma some Trypanosomatid species transmitted by fly spe- cruzi , the causative agent of Chagas disease, and 1 spe- cies ( 7 ). (cdc.gov)
Trypanosoma cruzi , the etiological agent of Chagas disease, presents high variability in both chromosomes size and copy number among strains, though the underlying mechanisms are unknown. (biomedcentral.com)
Members of the subfamily Triatominae (Hemiptera: Reduviidae) are vectors of Trypanosoma cruzi , the causal agent of Chagas disease. (biomedcentral.com)
The TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease, is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2α, and in turn, inhibits translation initiation. (qxmd.com)
The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. (ox.ac.uk)

Subcellular findings in murine studies with induced T. cruzi infection revealed that the chronic state is associated with the persistent elevation of phosphorylated (activated) extracellular-signal-regulated kinase (ERK), AP-1, and NF-κB. (wikipedia.org)
The etiologic agent is Trypanosoma cruzi , a (i.e., naturally infected species) or indirectly (i.e., vec- zoonotic protozoan maintained in the Americas by wild tor blood meal sources) involved and evaluate their and domestic mammals and transmitted by hematoph- contribution to kissing bug infection. (cdc.gov)
We examined T. cruzi infection in 4 lizard species of mammals occurs by contamination of broken skin from the Pacific coast of Chile coexisting with kissing or mucous membranes with the protozoan in kissing bug species. (cdc.gov)
Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation. (harvard.edu)
mTOR signaling inhibition decreases lysosome migration and impairs the success of Trypanosoma cruzi infection and replication in cardiomyocytes. (harvard.edu)
Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease. (harvard.edu)
Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy. (harvard.edu)
The inflammatory response that follows the infection by T. cruzi is essential to the host resistance, but it is also responsible for the damage observed in Chagas disease [ 4 ]. (hindawi.com)
The diagnosis of Chagas infection was based on positivity of at least two of the three reactions in the blood and/or pericardial fluid: ELISA, passive hemagglutination and indirect immunofluorescence for T. cruzi . (hindawi.com)
Also,we describe hematological alterations and clinical signs that were positively correlated with the parasitemia during the experimental infection with the three strains of T.cruzi, and demonstrate that experimental infection of Beagle is a trustworthy model for Chagas disease. (scielo.br)
We previously proposed that extracellular ATP is involved in thymus atrophy induced by Trypanosoma cruzi infection through the induction of CD4+/CD8+ double-positive cell death and that P2X7 could be involved in this process. (fiocruz.br)
Possibly the fact that T. cruzi infection bears a fitness cost for triatomines is what narrows the niche breadth of the insects. (biomedcentral.com)
During Trypanosoma cruzi infection, oxidative stress is considered a contributing factor for dilated cardiomyopathy development. (parasite-journal.org)
In vivo , ASTX did not have any therapeutic value against acute Trypanosoma cruzi infection, used either alone or in combination with NFMX. (parasite-journal.org)
In this study, we investigated the effect of a high-fat diet on liver morphology and physiology, lipid metabolism, immune signaling, energy homeostasis, and stress responses in the murine model of acute T. cruzi infection. (elsevierpure.com)
Early wasting and subsequent mortality may occur in mice of some inbred strains following infection with Trypanosoma cruzi. (pasteur.fr)
Thus, sera collected from mice of strains differing in their susceptibility or resistance to Trypanosoma cruzi infection were checked for the presence and level of TNF alpha, a cytokine able to exert acute toxic effects. (pasteur.fr)
C3H/HeJ or C3H/HePas (susceptible), BALB/c (intermediate) and C57BL/6 (resistant) mice were infected with the CL or Colombian strain of Trypanosoma cruzi, and TNF activity was measured in the sera during the acute phase of the infection. (pasteur.fr)
The TNF alpha/cachectin release in the sera of C3H mice may play a role in the early wasting and death of these mice after Trypanosoma cruzi infection. (pasteur.fr)
Ceballos, L.A. Long-term reduction of Trypanosoma cruzi infection in sylvatic mammals following deforestation and sustained vector surveillance in northwestern Argentina. (uba.ar)
Murine models susceptibility to distinct Trypanosoma cruzi i genotypes infection por: León C.M., et al. (ccb.org.co)
Trypanosoma cruzi infection was detected using PCR primers specific for the minicircle variable region of the parasite's kinetoplast DNA (kDNA). (cwu.edu)
García-Jordán N, Berrizbeitia M, Rodríguez J, Concepción JL, Cáceres A, Quiñones W. Seroprevalence of Trypanosoma cruzi infection in the rural population of Sucre State, Venezuela. (healthdata.org)
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection. (bvsalud.org)
When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests , over 21% in Honduras , and an alarming 72% in Mexico . (bvsalud.org)
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
The organism T cruzi and infection in humans were first described in 1909 by the Brazilian physician Carlos RJ Chagas. (medscape.com)
T cruzi infection in humans occurs in a spotty distribution throughout the range of the sylvatic cycle. (medscape.com)
New cases of vector-borne T cruzi infection usually occur in persons who live in primitive houses in areas where the sylvatic cycle is active. (medscape.com)
T cruzi infection is life-long. (medscape.com)
A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
Chagas disease is infection with Trypanosoma cruzi , transmitted by Triatominae bug bites or, less commonly, via ingestion of sugar cane juice or foods contaminated with infected Triatominae bugs or their feces, via blood transfusion or an organ transplant from an infected donor, or via maternal-fetal transmission. (msdmanuals.com)
The incidence of T. cruzi infection has been decreasing in Latin America because of improved housing, screening of blood and organ donors, and other control measures. (msdmanuals.com)
Acute T. cruzi infection in endemic areas usually occurs in childhood and can be asymptomatic. (msdmanuals.com)

Chagas disease is one of the most neglected vec- tebrates involved in persistence and transmission of torborne diseases, infecting 6-7 million persons T. cruzi protozoa. (cdc.gov)
Household distribution of seroreactivity to Trypanosoma cruzi in inhabitants was analyzed in relation to house construction and the distribution of Panstrongylus megistus, the principal domestic vector of Chagas' disease in a rural area in northeast Brazil. (nih.gov)
High Triatoma brasiliensis Densities and Trypanosoma cruzi Prevalence in Domestic and Peridomestic Habitats in the State of Rio Grande do Norte, Brazil: The Source for Chagas Disease Outbreaks? (ajtmh.org)
To confirm that Beagle dogs are a good experimental model for Chagas disease, we evaluated hematological alterations during the acute and chronic phases in Beagle dogs infected with the Y, Berenice-78 (Be-78) and ABC strains of Trypanosomacruzi, correlating clinical signs with the parasitemia curve. (scielo.br)
Here, we examined the niche use of seven triatomine species that occur in Mexico, based on whether they are infected or not with Trypanosoma cruzi , the vectors and causative parasites of Chagas disease, respectively. (biomedcentral.com)
An image from a peripheral blood smear showing Trypanosoma cruzi (center) in a patient with Chagas disease (100X oil immersion). (ualberta.ca)
Chagas disease is cased by the parastie Trypanosoma Cruzi and is spread by infected triatomine bugs. (cdc.gov)
Chagas disease is a tropical parasitic disease caused by the protozoan Trypanosoma cruzi, which affects about ten million people in its endemic regions of Latin America. (elsevierpure.com)
Our results indicate that in T. cruzi-infected mice, diet differentially regulates several liver processes, including autophagy, a stress response mechanism, with corresponding implications for human Chagas disease patients. (elsevierpure.com)
Introduction: The biological diversity of circulating Trypanosoma cruzi stocks in the Amazon region most likely plays an important role in the peculiar clinic-epidemiological features of Chagas disease in this area. (unl.pt)
Chagas disease is a complex zoonosis caused by the kinetoplastid parasite Trypanosoma cruzi. (ccb.org.co)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi , which is transmitted to domestic and sylvatic mammals via the feces of hematophagous hemiptera of the subfamily Triatominae (Reduviidae). (cwu.edu)
The results have important implications for understanding the geographical distribution of T. cruzi DTUs and epidemiology of Chagas disease in Mexico. (cwu.edu)
Trypanosoma species (American trypanosomiasis, Chagas' disease): biology of trypanosomes. (medlineplus.gov)
Triatomine bugs are a type of reduviid bug that can carry Trypanosoma cruzi , the parasite that causes Chagas disease. (cdc.gov)
Can I get Trypanosoma cruzi , the parasite that causes Chagas disease, from a triatomine bug? (cdc.gov)
Background Trypanosoma cruzi the protozoan responsible for Chagas disease belongs to a group of organisms that branched very early in eukaryotic development. (healthandwellnesssource.org)
Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a debilitating condition that affects over 10 million humans in the American continents. (uga.edu)
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites . (bvsalud.org)
The natural products pulchrol and pulchral, isolated from the roots of the Mexican plant Bourreria pulchra, have previously been shown to possess an antiparasitic activity toward Trypanosoma cruzi, Leishmania braziliensis and L. amazonensis, protozoa responsible for the Chagas disease and leishmaniasis. (lu.se)

Infectious T. cruzi are called metacyclic trypomastigotes. (wikipedia.org)
In the present work, we have annotated the 5′UTRs of the Trypanosoma cruzi genome both in epimastigotes and metacyclic trypomastigotes and, using a stringent classification approach, we identified putative regulatory uORFs in about 9% of the analyzed 5′UTRs. (figshare.com)
Background Trypomastigotes of Trypanosoma cruzi have the ability to invade various kinds non-phagocytic cells through a lysosomal reliant mechanism. (healthanddietblog.info)
Trypanosoma cruzi trypomastigotes in a mouse blood smear (Giemsa, x625). (medscape.com)

The complexes exhibited antiparasitic activity against Trypanosoma cruzi, while the metal-free thioureas did not. (unesp.br)
Previous work showed that propolis extracts exhibited in vitro activity against Trypanosoma cruzi (Higashi and de Castro, 1994). (propolisscience.org)

In the present work we identified Tcp12CKS1 a member of the CKS family in the parasite Trypanosoma cruzi. (lancs.ac.uk)

Amastinas são glicoproteínas de superfície inicialmente descritas como específicas de formas amastigotas de T. cruzi e Leishmania donovani. (ufpr.br)
Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. (ox.ac.uk)

Presence data for seven species of triatomines ( Triatoma barberi , T. dimidiata , T. longipennis , T. mazzottii , T. pallidipennis , T. phyllosoma and T. picturata ) were used and divided into populations infected and not infected by T. cruzi . (biomedcentral.com)
This study focused on the molecular identification of T. cruzi DTUs circulating in Triatoma near the Estación de Biología Chamela, on the southwest coast of Jalisco, Mexico. (cwu.edu)
My observations indicate a much higher diversity of T. cruzi DTUs in Triatoma than previously reported in Jalisco. (cwu.edu)

Caracterizacao de cepas do Trypanosoma cruzi isoladas no Reconcavo Baiano (contribuicao ao estudo geral da doenca de Chagas em nosso meio). (degruyter.com)
Para confirmar que cães Beagle são um bom modelo para doença de Chagas, foram avaliadas as alterações hematológicas durante as fases aguda e crônica em cães Beagle infectados com as cepas Y, Berenice-78 (Be-78) e ABC de Trypanosomacruzi, correlacionando os sinais clínicos com a curva de parasitemia. (scielo.br)
Ainda, foram descritas alterações hematológicas e sinais clínicos positivamente correlacionados com a parasitemia durante a infecção experimental com as três cepas de T.cruzi estudadas, demonstrando que a infecção em cães Beagle constitui um modelo fidedigno para a doença de Chagas. (scielo.br)
Estudo imunopatológico de camundongos de seis diferentes linhagens isogênicas ¿a infecção por três tipos de cepas do Trypanosoma cruzi / Virginia Andrade. (who.int)

Trypanosoma cruzi and Trypanosoma brucei , which are responsible for more than 50,000 deaths annually [ 17 ]. (biomedcentral.com)
This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which a nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)

The Trypanosoma cruzi life cycle starts in an animal reservoir, usually mammals, wild or domestic, including humans. (wikipedia.org)
Although the role of al and Livestock Service of Chile (permits 805/2018, mammals in T. cruzi transmission has been studied, 334/2019, and 4944/2019), and the National Forestry less is known about the relevance of nonmammalian Corporation of Chile (permit 66/2018). (cdc.gov)
Methods: Seven stocks of T. cruzi were recently isolated in the State of Amazonas, Brazil, from humans, wild mammals, and triatomines. (unl.pt)
[ 1 ] T cruzi mostly is found in blood-sucking triatomine insects (kissing bugs) and small mammals in a sylvatic cycle that is enzootic from the southern and southwestern United States to central Argentina and Chile. (medscape.com)

In Swiss mice the T. cruzi Mogi isolate showed a prepatent period of about 22 days, intermittent parasitemia in some animals, and tropism for cardiac and colonic muscles. (degruyter.com)
Different formulations of propolis were administered to experimentally Trypanosoma cruzi-infected mice and the parasitemia kinetics and survival rate were monitored. (propolisscience.org)

Trypanosoma cruzi, the causative agent of Chagas heart disease, is a relevant model to explore this possibility because these intracellular parasites rely on their major lysosomal cysteine protease (cruzipain) to invade and multiply in mammalian host cells. (lu.se)

Reviewing the literature, we came across few studies of direct microscopic examination of Trypanosoma cruzi in chronically infected human tissues and we did not find studies evaluating both research on T. cruzi and inflammatory infiltration simultaneously in histological sections of esophagus and colon from chagasic patients with and without mega. (hindawi.com)
Worldwide, an estimated 8 million people are chronically infected with T. cruzi . (msdmanuals.com)

All lizard species were infected, and the could become experimentally infected by T. cruzi pro- tested species was capable of transmitting the protozo- tozoa ( 8 , 9 ) and one showed an association between an, highlighting their role as T. cruzi reservoirs. (cdc.gov)
Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi. (degruyter.com)

Mexican Ninoa and Queretaro (Qro) TcI strains of Trypanosoma cruzi have shown different degrees of virulence, and the two strains produce heterogeneous immune responses in the hearts of infected mice. (ijbs.com)
Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. (bvsalud.org)

Here we have mapped sites of DNA replication initiation across the T. cruzi genome using Marker Frequency Analysis, which has previously only been deployed in two related trypanosomatids. (biomedcentral.com)
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. (ox.ac.uk)

abstract = "Protein kinase A (PKA) is an important mediator of many signal transduction pathways that occur in eukaryotic cells, and it has been implicated as a regulator of stage differentiation in Trypanosoma cruzi. (elsevierpure.com)

Genetic control of resistance to Trypanosoma cruzi in inbred mice / by Ruth Anna Wrightsman. (who.int)
Existencias: Trypanosoma cruzi I: Towards the need of genetic subdivision? (ccb.org.co)
Multilocus PCR-RFLP profiling in Trypanosoma cruzi I highlights an intraspecific genetic variation pattern por: Ramírez, Juan David, et al. (ccb.org.co)
A systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic cardiomyopathy por: Jiménez P., et al. (ccb.org.co)
Trypanosoma cruzi is found only in the Americas and displays remarkable genetic diversity. (cwu.edu)
There was high genetic diversity of T. cruzi in my samples, with the DTUs TcI, TcII, TcIV, TcVI, and Tcbat being identified. (cwu.edu)

The infective forms of T cruzi are contained in the feces of the insect vectors and gain entry into its mammalian hosts through contamination. (medscape.com)

Prevalence of Trypanosoma cruzi's Discrete Typing Units in a cohort of Latin American migrants in Spain por: Martinez-Perez, Angela, et al. (ccb.org.co)

Less commonly, T. cruzi is transmitted via ingestion of sugar cane juice or food contaminated with infected Triatominae bugs or their feces, transplacentally from an infected mother to her fetus, or via blood transfusion or an organ transplant from an infected donor. (msdmanuals.com)

To evaluate the importance of the PKA catalytic subunit of T. cruzi (TcPKAc), a gene encoding a PKA inhibitor (PKI) containing a specific PKA pseudosubstrate, R-R-N-A, was subcloned into a pTREX vector and introduced into epimastigotes by electroporation. (elsevierpure.com)
The molecules were assayed in vitro to-ward T. cruzi epimastigotes, L. braziliensis promastigotes and L. amazonensis promastigotes. (lu.se)

Trypanosoma cruzi is a species of parasitic euglenoids. (wikipedia.org)
We also evaluated the competence of the bug feces, by congenital transmission, and orally when most abundant lizard species to transmit T. cruzi pro- feeding on infected kissing bugs (or their feces) or other tozoa to kissing bugs. (cdc.gov)

Towards an understanding of the interactions of Trypanosoma cruzi and Trypanosoma rangeli within the reduviid insect host Rhodnius prolixus. (degruyter.com)

Mud-brick houses had the lowest infestation rates of P. megistus and the lowest household rates of seroreactivity to T. cruzi. (nih.gov)
A systematic, house-based serological survey for Trypanosoma cruzi seroreactivity was conducted in three contiguous communities in Olopa municipality, Chiquimula Department, Guatemala. (paho.org)

Here we report the isolation, biochemical characterization, developmental stage distribution and subcellular localization of chagasin, an endogenous cysteine protease inhibitor in T. cruzi. (lu.se)

Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model por: Cruz, Lissa, et al. (ccb.org.co)

Is TNF alpha involved in early susceptibility of Trypanosoma cruzi-infected C3H/He mice? (pasteur.fr)

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L. (ualg.pt)
The results demonstrated that the compounds described here can be considered as promising anti-Mycobacterium tuberculosis and anti-T. cruzi agents, since in both cases their in vitro activity were better than reference drugs available for the treatment of both diseases. (unesp.br)
L'ASTX a été testée in vitro sur des parasites cultivés axéniquement et en co-culture avec des cellules Vero. (parasite-journal.org)

Conclusions: Biological and histopathological characterization allowed us to demonstrate the low infectivity and virulence of T. cruzi stocks isolated from the State of Amazonas. (unl.pt)

Phylogenetic analysis performed with the trypanosomatid barcode confirmed that the isolate belongs to the TcI group, with high homology to the 3014 c1 T.cruzi strain. (degruyter.com)
Brisse, S., Barnabé, C., Tibayrenc, M., Identification of six Trypanosoma cruzi phylogenetic lineages by random amplified polymorphic DNA and multilocus enzyme electrophoresis (2000) Int. J. Parasitol. (uba.ar)

Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases. (bvsalud.org)

Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood / plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR . (bvsalud.org)

As with other parasites that infect both mammalian and insect hosts, the life cycle of T cruzi is complex (see image below). (medscape.com)
The epimastigote form of Trypanosoma cruzi is the multiplying stage of the parasite that grows in the gut of the insect vector and also in cell-free culture medium as shown here. (medscape.com)

The PCR assays were performed in triplicate by three independent reactions for each T. cruzi population (CL Brener clone, Col1.7G2 clone or JG strain), as indicated in the figure. (biomedcentral.com)
Para T. cruzi (clone CL Brener), foi estimado um total de 14 cópias de genes de amastinas, dos quais duas seriam ßamastinas e 12 d-amastinas. (ufpr.br)

Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi. (harvard.edu)
Identification of inhibitors for the trans-membrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation. (qxmd.com)

To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). (hindawi.com)

The functional complementation between the CKS proteins of two evolutionary distant organisms supports the role of Tcp12CKS1 as a key regulator in T. cruzi cell cycle. (lancs.ac.uk)

Trypanosoma cruzi may have selected for a restricted niche amplitude in triatomines, although we are unaware of the underlying reasons. (biomedcentral.com)

Although there was no increase in any isoform of ERK, there was an increased concentration of phosphorylated ERK in mice infected with T. cruzi. (wikipedia.org)
Effect of different formulations of propolis on mice infected with Trypanosoma cruzi. (propolisscience.org)

To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay ( ELISA ). (bvsalud.org)

Despite the inherent difficulty of identifying correlations amongst the molecular and biological characteristics of different T. cruzi groups, the tropism for colonic muscle demonstrated by T. cruzi Mogi represented a peculiarity of this isolate within the TcI group. (degruyter.com)

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