Troponin c. Medical search. Frequent questions

Since the initial 1st-generation assays, 5th-generation high-sensitivity cardiac troponin (hs-cTn) assays have been developed, and are now widely used. (nih.gov)
Singulex has received the CE mark for its Sgx Clarity cTnI assay, an ultra-sensitive test that measures cardiac troponin at lower levels than most existing assays. (aacc.org)
The very recent commercialization of methods with further improved analytical sensitivity (i.e., "ultra-sensitive" assays), which allow to measure cardiac troponin values in the vast majority of healthy subjects, is now challenging the diagnostic paradigm based on early rule-out of subjects with cardiac troponin values comprised between the 99th percentile and LoD. (srce.hr)
Scheitz JF, Nolte CH, Laufs U, Endres M. Application and interpretation of high-sensitivity cardiac troponin assays in patients with acute ischemic stroke. (eso-stroke.org)
Recent approvals of high sensitivity cardiac troponin (hs-cTn) assays by the U.S. Food and Drug Administration (FDA) and international regulatory bodies have enabled clinical labs to develop more sophisticated diagnostic protocols based on utilization of low cTn measurements at or near the assays' limit of detection (LoD) to expediate and improve the accuracy of acute myocardial infarction diagnosis. (clpmag.com)
Non-high sensitivity cardiac troponin assays lack the analytical sensitivity to reliably measure small cTn concentrations and their subsequent changes below the 99th percentile upper reference limit (URL). (clpmag.com)
Assays for hs-cTnI and hs-cTnT have allowed clinical labs to shift emphasis from using cardiac troponin as binary tests (in which the 99th percentile URL of a healthy reference population was used as a cut-off for defining normal vs increased cTn values) to more complex diagnostic protocols utilizing cTn values below the 99th percentiles' URLs. (clpmag.com)
Siemens Healthineers offers proven, true high-sensitivity troponin I assays that provide fast, actionable, and reliable results you can count on. (siemens-healthineers.com)
High-sensitivity assays for cardiac troponin have been available for years in multiple countries to help in diagnosing patients with suspected MI. (tctmd.com)
We report analytical data from a fully automated digital immunoassay for cardiac troponin I (cTnI) based on Single Molecule Array (Simoa) technology with a limit of detection 2 logs lower than contemporary high sensitivity troponin assays. (quanterix.com)
It is important to keep in mind that it is commonly acknowledged among experts that both conventional and high sensitive troponin assays can lead to abnormally non-repeatable overestimated values especially in the lower part of the measuring range. (canada.ca)
Ninety-Minute vs 3-h Performance of High-Sensitivity Cardiac Troponin Assays for Predicting Hospitalization for Acute Coronary Syndrome. (lifelabs.com)
These changes were instituted following the introduction of increasingly sensitive and precise troponin assays. (medscape.com)
Two different reference ranges are used in troponin assays. (medscape.com)
Troponins are generally undetectable in healthy patients, although this may eventually change as more sensitive assays become available. (medscape.com)
The 99th percentile of a reference decision limit (medical decision cutoff) for cardiac troponin (cTn) assays should be determined in each local laboratory with internal studies using the specific assay that is used in clinical practice or validating a reference interval that is based on findings in the literature. (medscape.com)
Table 1 shows the calculated 99th upper reference limit values for some of the available troponin assays. (medscape.com)
When measured with older generation assays, elevated troponin levels can be detected 6-12 hours after onset of myocardial injury, peaking at about 24 hours, followed by a gradual decline over several days (up to 2 weeks). (medscape.com)

Most patients who have had a heart attack have increased troponin levels within 6 hours. (medlineplus.gov)

Slow skeletal troponin T1, TNNT1 (19q13.4, 191041) Cardiac troponin T2, TNNT2 (1q32, 191045) Fast skeletal troponin T3, TNNT3 (11p15.5, 600692) The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL. (wikipedia.org)
Cardiac troponins (cTn), cardiac troponin I (cTnI) and cardiac troponin T (cTnT), are important analytes for acute myocardial infarction diagnosis and are used to guide treatment and patient management decisions. (clpmag.com)
The primary aim of this study was to determine optimal thresholds of preoperative and perioperative changes in high-sensitivity cardiac troponin T (hs-cTnT) to predict MACCE and mortality. (lu.se)
The use of troponin T (cTnT) and N-terminal Pro-BNP (NTpBNP) in combination with echocardiography assessment may facilitate the development of a superior predictive model. (bmj.com)
The 99th percentile cutoff point for cardiac troponin T (cTnT) is well-known at 0.01 ng/mL (with 10% coefficient of variance value at the 99th percentile of 0.03 ng/mL), as only one cTnT assay exists. (medscape.com)
We aimed to determine whether serum cardiac troponin T (cTnT) levels measured with a highly sensitive assay [high sensitivity cTnT (HS-cTnT)] may predict cardiovascular events (CVEs) in SLE. (bvsalud.org)

The reference range for the high sensitivity troponin T is a normal 52 ng/L. The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. (wikipedia.org)
Some labs use different measurements (for example, "high sensitivity troponin test") or test different samples. (medlineplus.gov)
The US Food and Drug Administration (FDA) has approved the Architect Stat (Abbott Laboratories) high-sensitivity troponin-I assay, which can detect myocardial infarction (MI) faster and more accurately than other troponin tests, according to the company. (medscape.com)
The addition of Abbott's high sensitivity troponin-I assay to the laboratory's diagnostic testing menu is a great step forward to help laboratory scientists and clinicians better evaluate patients suspected of having a heart attack," Fred Apple, PhD, professor of laboratory medicine and pathology at the University of Minnesota in Minneapolis, said in the release. (medscape.com)
Cite this: FDA Clears Architect Stat High-Sensitivity Troponin Test for MI - Medscape - Oct 02, 2019. (medscape.com)
Hs-cTnI levels were measured using the ARCHITECT STAT High-Sensitivity Troponin-I assay in blood samples collected pre-angiogram. (acc.org)
A laboratory's strategy to reduce the time from "order to result" of high-sensitivity troponin, defined as an imprecision level (%CV) of ?10% at the 99th percentile of normal by the joint ESC/ACC committee, is discussed. (clpmag.com)
2 However, high-sensitivity troponin is elevated in 20-55% of acute stroke patients, 3 many of whom without thrombotic acute coronary syndrome (ACS). (eso-stroke.org)
Hear the results of their studies, how transitioning to a high-sensitivity troponin I assay impacted their labs, and the realized benefits to patients and hospitals. (siemens-healthineers.com)
Discover how a study in Italy has validated the high-sensitivity troponin I assay as an essential tool for one diagnostic laboratory. (siemens-healthineers.com)
By employing a high-sensitivity Troponin I test, laboratory scientists led by Dr. Katell Peoc'h from Paris Diderot University Hospital have been able to more rapidly and accurately diagnose those suffering from acute cardiac events. (siemens-healthineers.com)
Dr. Antonio Buno, La Paz University Hospital, has been working to transform the delivery of cardiac care by implementing a high-sensitivity Troponin I assay. (siemens-healthineers.com)
These videos are part of a series of educational videos focusing on the clinical utility of high-sensitivity troponin I. Hear other leaders in the area of cardiovascular disease and laboratory diagnostics discuss implementing a high-sensitivity troponin I assay into their facility. (siemens-healthineers.com)
The aim of this study is to investigate myocardial damage in recovering coronavirus disease 2019 (COVID-19) patients with high-sensitivity troponin levels (hsTnT) and echocardiography. (go.jp)
All presented to an emergency department for possible ACS and had available data for ECG and high-sensitivity troponin measurement. (tctmd.com)
It is unclear if a high-sensitivity troponin assay will have enough discriminative power to become a decision support in primary care. (altmetric.com)
The aim of this study was to evaluate a high-sensitivity troponin T assay performed in three primary health care centres in southeast Sweden and to compare the outcome with a point-of-care troponin T test. (altmetric.com)
High-Sensitivity Troponin at the point of care or lab? (siemens-healthineers.com)
The value of high-sensitivity troponin I in the assessment of patients with suspected acute coronary syndrome (ACS) has been well established in clinical practice guidelines. (siemens-healthineers.com)

The purpose of this study was to evaluate whether high-sensitivity cardiac troponin I (hs-cTnI) in patients with undergoing angiography for suspected CAD is associated with MI or CV death. (acc.org)
Patients with hs-cTnI levels above the 99% URL were four times more likely to experience MI or CV death compared to those with troponin concentrations below 5 ng/L, and improved risk discrimination. (acc.org)
In patients undergoing coronary angiography for suspected coronary artery disease (CAD), do high-sensitivity cardiac troponin I (hs-cTnI) levels improve risk stratification for the primary outcome of myocardial infarction (MI) or cardiovascular (CV) death at follow-up? (acc.org)
Evaluation with serum cardiac troponin I (CTnI), a specific indicator of myocardial injury, could improve the comprehensive evaluation of patients with suspected NAT. (qxmd.com)
Under 2020 och 21 införs inom Region Skåne en ny högkänslig blodprovsanalys för troponin I (hs-cTnI) som kan avslöja hjärtskada eller hjärtinfarkt. (lu.se)
Phosphorylation levels of cardiac troponin I (cTnI) were determined by Western blot. (cdc.gov)

A recent publication has shown that cardiac troponin T (TnT) concentrations measured with a highly sensitive assay were significantly associated with the incidence of cardiovascular death and heart failure in stable coronary artery disease after adjustment for other independent prognostic indicators [ 13 ]. (hindawi.com)
With the increased clinical utility of sub-99th percentile hs-cTn measurements, quality controls with lower cardiac troponin concentrations are needed to monitor and validate hs-cTn assay performance. (clpmag.com)
Serum cardiac troponin I and cardiac troponin T concentrations in dogs with gastric dilatation-volvulus. (vin.com)
Very low concentrations of hs-troponin are associated with greater variability and are not routinely reported for clinical use. (cdc.gov)

Cardiac troponins are components of the contractile apparatus of cardiomyocytes and are released during myocardial necrosis in patients with ACS [ 7 ]. (hindawi.com)
Serum troponin (Tn) elevation is a specific and well-established necrosis biomarker in ACS, being the only biomarker currently used for risk stratification and guided invasive management decision in non-STEACS [ 8 , 9 ]. (hindawi.com)
For PCI in patients with normal baseline troponin values, elevations of cardiac biomarkers above the 99th percentile upper reference limit indicate periprocedural myocardial necrosis. (medscape.com)
If the injury persists and necrosis progresses, further troponins are released from the muscular pool. (medscape.com)

In the HiSTORIC study, for example, of more than 30,000 consecutive patients, a single cardiac troponin measurement using the test safely and effectively ruled out MI at presentation. (medscape.com)
The measurement of cardiac troponins, either cardiac troponin I or T, has become the culprit of clinical decision making in patients with suspected acute coronary syndrome (ACS), especially in those with non-ST elevation myocardial infarction (NSTEMI). (srce.hr)
With respect to high prognostic relevance, 1 international guidelines recommend the measurement of troponin in all patients presenting with acute ischemic stroke. (eso-stroke.org)
With questions swirling on how best to use a new high-sensitivity cardiac troponin T assay soon to be released in the United States, a new study suggests t hat a single blood draw and measurement in conjunction with ECG may be sufficient to rapidly rule out acute MI in up to 30% of patients and provide for earlier decision-making. (tctmd.com)
Ultra-sensitive cardiac troponin measurement offers a promising new tool for early detection and monitoring of cardiovascular disease. (quanterix.com)

Highly sensitive serum cardiac troponin T and cardiovascular events in patients with systemic lupus erythematosus (TROPOPLUS study). (bvsalud.org)

The level of troponin is measured in the bloodstream and it is used to differentiate between unstable angina (no elevation of troponin, the myocardium is not irreversibly damaged) versus either non ST elevation MI or ST elevation MI (heart attack) in patients with chest pain . (wikidoc.org)
however, elevation of troponin levels can occur in myriad conditions other than ischemic damage. (medscape.com)

Troponin T binds to tropomyosin and helps position it on actin, and together with the rest of the troponin complex, modulates contraction of striated muscle. (wikipedia.org)
A TROPONIN complex subunit that binds calcium and help regulate calcium-dependent muscle contraction. (nih.gov)
Troponin is a component of thin filaments (along with actin and tropomyosin ), and is the protein to which calcium binds to accomplish this regulation. (wikidoc.org)
Three types of troponins exist-troponin I, troponin T, and troponin C. Each subunit has a unique function: Troponin T binds the troponin components to tropomyosin, troponin I inhibits the interaction of myosin with actin, and troponin C contains the binding sites for Ca 2+ that helps initiate contraction. (medscape.com)

Increased troponin T levels after an episode of chest pain indicates myocardial infarction. (wikipedia.org)
A troponin test measures the levels of troponin T or troponin I proteins in the blood. (medlineplus.gov)
Cardiac troponin levels are normally so low they cannot be detected with most blood tests. (medlineplus.gov)
Having normal troponin levels 12 hours after chest pain has started means a heart attack is unlikely. (medlineplus.gov)
Very high levels of troponin are a sign that a heart attack has occurred. (medlineplus.gov)
Troponin levels may remain high for 1 to 2 weeks after a heart attack. (medlineplus.gov)
The Architect Stat test detects very low levels of troponin, allowing clinicians to assess patients with suspected MI within 2 to 4 hours of admission, the company said. (medscape.com)
Women may particularly benefit from this technology as they often have lower levels of troponin than men, which could lead to an undiagnosed heart attack with contemporary troponin tests," they add in a news release . (medscape.com)
Based on a meta-analysis that was inclusive for clinically and geographically diverse patients, Pickering and colleagues found that those who had no or very low levels of detectable cardiac troponin T on the high-sensitivity assay plus a nonischemic ECG had very low risk for acute MI or MACE within 30 days. (tctmd.com)
We then assessed whether the magnitude of troponin elevation was related to in-hospital mortality by calculating mortality rates according to tertiles of peak troponin levels. (duke.edu)
RESULTS: Of 1,145 ischemic stroke patients, 199 (17%) had elevated troponin levels. (duke.edu)
Any troponin elevation was associated with higher mortality, even at very low peak troponin levels (mortality rates 24-29% across tertiles of troponin). (duke.edu)
Patients with persistently rising troponin levels had fewer anticoagulant and antiatherosclerotic therapies, with markedly worse outcomes. (duke.edu)
CONCLUSIONS: Ischemic stroke patients with abnormal troponin levels are at higher risk of in-hospital death, even after accounting for demographic and clinical characteristics, and any degree of troponin elevation identifies this higher level of risk. (duke.edu)
Cardiac troponin I level was elevated in 7 (70%) of 10 patients with levels between 2 and 50 times the upper limit of normal. (qxmd.com)
In this podcast, Michael Blaha, MD, MPH, discusses his team's study on whether troponin levels and coronary artery calcium score can predict future atherosclerotic cardiovascular disease risk, the use of aspirin and statins in patients aged 50 to 79 years, and his team's future work in this area. (consultant360.com)
Your analysis found that detectable CAC and detectable high-sensitivity cardiac troponin was associated with higher rates of ASCVD, compared to undetectable levels. (consultant360.com)
I don't think it would surprise anyone that higher levels of troponin and higher levels of calcium scores predict risk. (consultant360.com)
What was also notable is that undetectable levels of troponin or calcium scores of zero also predicted extremely low-risk states. (consultant360.com)
Violin plots show distribution of expression levels for Troponin I (SMED30021982) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Violin plots show distribution of expression levels for Troponin I (SMED30021982) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
For example, patients with elevated troponin levels but negative CK-MB values who were formerly diagnosed with unstable angina or minor myocardial injury are now reclassified as non-ST-segment elevation MI (NSTEMI), even in the absence of diagnostic electrocardiographic (ECG) changes. (medscape.com)

The aim of this study was to evaluate the potential utility of genetic diagnosis in clinical management of families with hypertrophic cardiomyopathy (HCM) caused by mutations in the gene for cardiac troponin I (TNNI3). (nih.gov)
Univariate and multivariate logistic regression was carried out to examine possible connections between troponin T ≥ 15 ng/L, clinical variables and laboratory findings at baseline. (altmetric.com)
METHODS: Using data collected in the American Heart Association's 'Get With The Guidelines' stroke registry between 2008 and 2012 at a tertiary care US hospital, we used logistic regression to evaluate the independent relationship between troponin elevation and mortality after adjusting for demographic and clinical characteristics. (duke.edu)
Electrocardiography and cardiac troponin (cTn) now form the diagnostic cornerstones of clinical assessment. (radcliffecardiology.com)
The cardiac troponins, in particular, have become the cardiac markers of choice for patients with ACS, eclipsing CK-MB and myoglobin in terms of clinical value. (medscape.com)
N-terminal B-type natriuretic peptide or troponin elevations, or the Background use of inotropes during admission, are much more powerful and Risk stratification and prediction is an integral part of clinical accurate predictors than admission to hospital alone. (who.int)

The main difference is that the TnC subunit of troponin in skeletal muscle has four calcium ion binding sites, whereas in cardiac muscle there are only three. (wikidoc.org)

Elevated troponin in acute ischemic stroke - a matter of debate? (eso-stroke.org)
This question was addressed by the Troponin Elevation in Acute Ischemic Stroke (TRELAS) study, which included 2123 consecutive patients presenting with acute ischemic stroke, who did not have ST-segment-elevation myocardial infarction (STEMI). (eso-stroke.org)
The recently launched Prediction of Acute Coronary Syndrome in Acute Ischemic Stroke (PRAISE) study aims to develop a diagnostic algorithm that allows the prediction of acute coronary syndrome in stroke patients with elevated troponin. (eso-stroke.org)
So, elevated troponin in acute ischemic stroke remains a matter of debate! (eso-stroke.org)
Jensen JK, Atar D, Mickley H. Mechanism of troponin elevations in patients with acute ischemic stroke. (eso-stroke.org)
Coronary Angiographic Findings in Acute Ischemic Stroke Patients With Elevated Cardiac Troponin: The Troponin Elevation in Acute Ischemic Stroke (TRELAS) Study. (eso-stroke.org)
Scholars@Duke publication: Ischemic Stroke with Troponin Elevation: Patient Characteristics, Resource Utilization, and In-Hospital Outcomes. (duke.edu)
BACKGROUND: Among patients hospitalized for acute ischemic stroke, abnormal serum troponins are associated with higher risk of short-term mortality. (duke.edu)
If a patient is troponin positive, and has signs and symptoms of ischemic heart disease (substernal chest pain or pressure, electrocardiographic EKG changes), then an early invasive strategy is warranted. (wikidoc.org)

Troponin T (shortened TnT or TropT) is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. (wikipedia.org)
Troponin is a complex of three proteins that is integral to muscle contraction in skeletal and cardiac muscle , but not smooth muscle . (wikidoc.org)
Determining the level of cardiac troponins (cTn), structural proteins unique to the heart, is a cornerstone of AMI diagnosis. (radcliffecardiology.com)
The troponins are regulatory proteins found in skeletal and cardiac muscle. (medscape.com)

Troponin is attached to the protein tropomyosin and lies within the groove between actin filaments in muscle tissue. (wikidoc.org)
Some of this calcium attaches to troponin, causing a conformational change that moves tropomyosin out of the way so that the cross bridges can attach to actin and produce muscle contraction. (wikidoc.org)

The role of cardiac troponins as diagnostic biomarkers of myocardial injury in the context of acute coronary syndrome (ACS) is well established. (nih.gov)

Troponin T was analysed by a point-of-care test and a high-sensitivity method together with N-terminal pro-B-type natriuretic peptide (NT-proBNP) and creatinine. (altmetric.com)

See also Acute coronary syndromes Two subtypes of troponin (cardiac troponin I and T) are very sensitive and specific indicators of damage to the heart muscle ( myocardium ). (wikidoc.org)

Atherosclerotic cardiovascular disease risk stratification based on measurements of troponin and coronary artery calcium. (consultant360.com)
Troponin is a simple yet potent tool for risk stratification. (wikidoc.org)

Troponin C Troponin I Calcium-binding protein Sliding filament model Jin, Jian-Ping (2016-01-01), Jeon, Kwang W. (ed. (wikipedia.org)
Low values of high-sensitivity cardiac troponin and coronary artery calcium scores of zero are associated with a low risk for atherosclerotic cardiovascular disease (or ASCVD). (consultant360.com)
And really thinking here was to figure out how each marker performed-the troponin and the calcium score-for risk prediction and how they perform together, with a distinct emphasis on low values of each marker-undetectable troponin values and calcium scores of zero-and to what degree those can discriminate patients that are actually low-risk patients. (consultant360.com)
On the converse, while the troponin and the calcium score both predicted risk well. (consultant360.com)
Calcium score and undetectable troponins were associated event rates that were lower than the usual threshold considered for a statin benefit or aspirin benefit in primary prevention. (consultant360.com)
So, the study would suggest that the event rates in patients with undetectable troponin or calcium scores of zero are below which we'd expect there to be a net benefit of preventive pharmacotherapy. (consultant360.com)
But what's notable also is that when you do a 2 × 2 cross tab of these markers, patients who had both undetectable troponin and a calcium score of zero had the lowest event rates on the order of 2% or 3% over 10 years, which is very low. (consultant360.com)

Cite this: Cardiac Troponin Predicts Mortality Post Surgery - Medscape - Sep 27, 2023. (medscape.com)

The gene for the sarcomeric thin-filament protein, slow skeletal muscle troponin T (TNNT1), maps to this interval and was sequenced. (clinicforspecialchildren.org)

We have researched a possibility to apply the Enzyme Multiplied Immunoassay Technique (EMIT-test) for Troponin T to diagnose death resulting from the acute myocardial ischemia in the biological laboratory of the Leningrad Regional Bureau of Forensic Medical Examination. (medline.ru)

It has been shown that even very small elevation in the troponin concentration is associated with increased risk of adverse outcomes in patients with ACS [ 12 ]. (hindawi.com)
An initial small elevation occurs when troponins are released from the cytosolic pool, when troponin molecules in the cytosol of cardiac muscle diffuse across the sarcolemma into the surrounding lymphatics and blood vessels, becoming detectable in blood. (medscape.com)

In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack). (wikipedia.org)
High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. (acc.org)

They note that the current diagnostic criteria for perioperative myocardial infarction /injury "need to be updated with these high-sensitivity cardiac troponin data. (medscape.com)
The aim of this article is to provide an update on commercially available HS and "ultra"-sensitive techniques for measuring cardiac troponins, along with possible implications of increasingly enhanced analytical sensitivity on diagnostic algorithms for evaluating patients with suspected ACS. (srce.hr)
5 Of all included patients, a subset of 29 of 291 patients with elevated troponin underwent diagnostic coronary angiography. (eso-stroke.org)
The total level and the dynamic of the troponin increase may help to predict myocardial infarction, 6 but eventually, the diagnostic work up and treatment of individual patients remains a matter of debate between neurologists and cardiologists. (eso-stroke.org)
The EMIT-test for Troponin T - a protein of the myocardial troponin complex - is nowadays of the great diagnostic value. (medline.ru)
Studies were identified by searching Medline to December 1999 with terms and phrases related to troponin, diagnosis, and diagnostic use. (bmj.com)
Discussions of troponin often pertain to its functional characteristics and/or to its usefulness as a diagnostic marker for various heart disorders. (wikidoc.org)

Fourteen of the 21 patients, without signs of AMI or UA at baseline, still had increased troponin T at follow-up after 2-3 years. (altmetric.com)
To better understand the relationship between these measurements and future ASCVD risk, a group of researchers evaluated baseline high-sensitivity cardiac troponin and CAC measurements taken from 6749 participants in the MESA study. (consultant360.com)

Up to 80% of patients with acute MI will have an elevated troponin level within 2-3 hours of emergency department (ED) arrival, versus 6-9 hours or more with CK-MB and other cardiac markers. (medscape.com)

4 Further conditions frequently associated with elevated troponin include atrial fibrillation, heart failure, pulmonary embolism, sepsis, and renal insufficiency. (eso-stroke.org)

The purpose of this study was to examine whether the combination of two simple tests, electrocardiography (ECG) and serum troponin I (TnI) level, may serve as reliable predictors of BCI or the absence of it. (unboundmedicine.com)

One of the more common uses of troponin is to determine if a patient with chest pain has sustained death of the myocytes (heart muscle cells) as a result of thrombotic (blood clot related) occlusion of a coronary artery which would warrant urgent medical or interventional therapy. (wikidoc.org)

Recognizing that cardiac troponin measurements may be elevated in disease states not primarily related to myocardial ischemia, a fourth universal definition of acute MI was developed by the American College of Cardiology (ACC), European Society of Cardiology (ESC), American Hospital Association (AHA), and World Health Federation (WHF) in 2018. (medscape.com)

Perioperative myocardial injury, reflected by release of high-sensitivity cardiac troponin T, is associated with 30-day mortality after various cardiac surgeries at postoperative prognostic cutoffs higher than proposed in current definitions, new research suggests. (medscape.com)

Even a slight increase in the troponin level will often mean there has been some damage to the heart. (medlineplus.gov)
Troponin T appears in blood a little earlier that CK-MB, two and a half hours after the onset of the heart attack, reaches its maximum in 8-10 hours (the first peak) and in 3-4 days (the second peak), and its level becomes standard in 10-14 days. (medline.ru)
The standard level of Troponin T must be close to zero because it should not get into the blood flow with healthy people. (medline.ru)
Of the 11 level-I studies (3736 patients), 7 increased troponin T, and 4 increased troponin I. Of the 8 level-II studies (1998 patients), 6 increased troponin T, 1 increased troponin I, and 1 increased both. (bmj.com)
Overall, 30.6% of the cohort-ranging from 3.8% to 73.5% across studies-had a troponin level less than 0.005 µg/L and were classified as being at low risk for acute MI. (tctmd.com)
Elevated cardiac troponin I level in cases of thoracic nonaccidental trauma. (qxmd.com)

Troponins are protein molecules that are part of cardiac and skeletal muscle. (medscape.com)

This review discusses troponin as a marker of cardiac injury, its testing, utility, appropriateness use criteria, and interpretation of abnormal values. (medscape.com)

The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs. (wikipedia.org)
This webinar will cover the utilization of high-sensitivity cardiac troponin (cTn) in the emergency department (ED) and its impact when delivered via a rapid point of care device or core laboratory. (siemens-healthineers.com)

Troponin T - contemporary approach towards diagnosing acute myocardial ischemia. (medline.ru)
It means that Troponin T lends itself most widely for a diagnosis uniting the advantages of the quick and slow markers with the acute myocardial ischemia. (medline.ru)

Three subunits have been identified: troponin I (TnI), troponin T (TnT), and troponin C (TnC). (medscape.com)

Canine Cardiac Troponin I Significantly Complements Established Prognostic Composite Score In Dogs With Systemic Inflammation. (ku.dk)

Anatomy10

Organisms6

Diseases3

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes9

Information Science2

Assays18

Increased troponin levels1

CTnT6

Sensitivity troponin19

CTnI6

Concentrations4

Necrosis4

Measurement5

Serum cardiac troponin1

Elevation of troponin2

Binds4

Levels22

Clinical6

Subunit1

Ischemic9

Proteins4

Tropomyosin2

Acute Coronary1

Natriuretic peptide1

Myocardium1

Risk stratification2

Calcium7

Medscape1

TNNT11

Immunoassay1

Small elevation2

Coronary Artery2

Diagnostic7

Baseline2

Patients with acute1

Pulmonary Embolism1

Electrocardiography1

Chest pain1

Measurements1

Perioperative1

Level6

Protein1

Abnormal1

Laboratory2

Ischemia2

Subunits1

Prognostic1