Radicals (trityl OX063 and BDPA) with narrower EPR linewidths typically produce higher nuclear polarizations when carbon-13 is the target nucleus. (elsevierpure.com)
Derivatives2
The present invention relates to optically active dihydroxy hexanoate derivatives of formula IIa and more particularly to compounds of formula II which are useful intermediates for the synthesis of HMG-CoA enzyme inhibitors like atorvastatin, cerivastatin, rosuvastatin, pitavastatin, fluvastatin. (allindianpatents.com)
Tritylation of 2-N-acetyl-6-O-((4-nitrophenyl)ethyl)guanosine (4) with TrCl/DMAP followed by TrCl/AgNO 3 afforded a mixture of isomeric 3′,5′-di-O-trityl and 2′,5′-di-O-trityl derivatives 6 and 7, which were separated on a silica gel column to give 6 and 7 in 40% and 50% yield, respectively. (umn.edu)
OX0632
13 direct polarization magic-angle spinning NMR experiments were performed using two organic water-soluble polarizing agents SA-BDPA33 and trityl OX063 34 which are depicted in Figure 1. (sciencepop.org)
Figure 1 Narrowline monoradical chemical structures of SA-BDPA and trityl (OX063). (sciencepop.org)
Salts4
and erucic acid 2-hydroxy-3-phosphonooxypropylester being excluded, and the physiologically tolerable salts, esters, optically active forms, and racemates of said compounds. (justia.com)
The Highly Stereoselective Michael Reaction of α,β-Unsaturated Ketones with Silyl Enol Ethers of Thioesters Catalyzed by Trityl Salts. (u-tokyo.ac.jp)
When used in medicine the salts of a compound of formula (I) should be both pharmacologically and pharmaceutically acceptable acid addition salts, but non-acceptable salts may be conveniently used to prepare the bases of such acceptable salts and are not excluded from the scope of this invention. (justia.com)
The compounds of formula (I) and their acid addition salts exhibit antidepressant properties in mammals when tested by standard techniques for example the tetrabenazine-induced sedation test in the rat. (justia.com)
Anion1
Ring opening of aziridines 4a-d in reactions with trityl anion Tr - proceeds exclusively by cleavage of the NCMe 2 bond. (tmu.edu.tw)
Synthesis3
An efficient synthesis of α -substituted 1, 2-dihydroquinoline compounds through the oxidative C-H functionalization of N -acyl-dihydroquinoline with diverse organoboron reagents mediated by triphenylcarbium perchlorate (Ph 3 CClO 4 ) is reported. (sioc-journal.cn)
To date, racemization of the oxazoline ring has been a problem in the rare IndOX syntheses that have been reported, and the first synthesis of enantiopure IndOX compounds is presented in this thesis. (9pdf.co)
Followed by synthesis, in vitro assay of these compounds was performed against Cryptococcus neoformans . (ukdiss.com)
Active compounds1
These extraction process rely on cooking, boiling, or solvent extraction of the active compounds from the original plant or animal tissue. (dupont.com)
Methyl1
To improve its activity, herein, we utilized S-trityl cysteamine pharmacophore lacking the methyl ester. (bvsalud.org)
Mixture5
The resulting liquid phase is a dilute mixture that includes not only the target compound but also a variety of impurities. (dupont.com)
The plant extraction process produces a complex mixture with many plant compounds in it. (dupont.com)
6. The process of claim 1, further comprising precipitating the compound comprising Formula (II) from the reaction mixture in step (b) and then recrystallizing the precipitate to yield the compound comprising Formula (II). (patentsencyclopedia.com)
In Figure 2B-D 13 field profiles are shown for SA-BDPA trityl and a 1:1 mixture each. (sciencepop.org)
The catalytic activity was improved using a mixture of trityl tetrakispentafluorophenylborate (TTPB) and a small amount of methylalumoxane (MAO) as cocatalysts, and was amazingly improved, providing the greatest activity, using only triisobutyl aluminum (TIBA). (gtiit.edu.cn)
Oxygen1
Methods of synthesizing the above compound wherein X=oxygen, and -(CH 2 ) n -CH 3 with n=13, are well-known (e.g. (justia.com)
Organic4
In organic chemistry, an imine (/ɪˈmiːn/ or /ˈɪmɪn/) is a functional group or organic compound containing a carbon-nitrogen double bond (C=N). The nitrogen atom can be attached to a hydrogen or an organic group (R). The carbon atom has two additional single bonds. (wikipedia.org)
Reaction of organic azides with metal carbenoids (produced from diazocarbonyl compounds). (wikipedia.org)
Ozonolysis from unknown compound, A compound, A, c6h8, yields a single organic product, B, upon ozonolysis and absorbs two moles of hydrogen on catalytic hydrogenation to give C. (expertsmind.com)
useful shop Gas of Organic Compounds perfect expression by Silverstein, Webster and Kiemle in guest. (smartguyz.com)
Formula8
Usually imines refer to compounds with the general formula R2C=NR, as discussed below. (wikipedia.org)
The present invention relates to osteoblast-specific mitogenic compounds of formula (I), methods of preparing same, and drugs containing such compounds. (justia.com)
EP 0 319 847 describes a process for the preparation of compounds of formula 1 starting from L-Malic acid. (allindianpatents.com)
The disadvantages of this process are that a stereo selective reduction using a costly ruthenium-BINAP catalyst in employed and the desired compound of formula 1 is obtained in six steps. (allindianpatents.com)
The 3.4-dihvdroxv hutanoir arid derivative is then functionalized into compounds of formula I involving a multiple number of steps. (allindianpatents.com)
c) protecting the compound of formula V with ArB(0H)2 to give a compound of formula VI, where Ar is unsubstituted or substituted aryl or heteroaryl, G is tetrahydropyranyl, tert-butyldimethyl silyl or trityl and R3 is alkyl from 1 to 8 carbons, ( f) deprotection of the compound of formula VI using mild acid catalyst to give a compound of formula II. (allindianpatents.com)
The compound of formula II is oxidized to a compound of formula VIII, where R3 is alkyl from 1 to 8 carbons, aryl or aralkyi and Ar is unsubstituted or substituted aryl or heteroaryl using pyridinium chioro chromate or DMSO/oxalyl chloride. (allindianpatents.com)
Alternatively (IV) may be reacted with hexamethylenetetramine and the intermediate product hydrolysed under acidic conditions to give the desired compound of formula (I). These displacement reactions may be effected at a temperature in the range of 0.degree. (justia.com)
Reactions2
Imines are common in synthetic and naturally occurring compounds and they participate in many reactions. (wikipedia.org)
Perhaps the etherifed poly(ethylene glycols) can be used as solvents for Grignard reactions since they are close analogs to ethyl ether, are known to coordinate well with metal ions, and are at the very least totally inert to Grignard compounds. (thevespiary.org)
Derivative2
Treatment of the 2′,5′-di-O-trityl nucleoside 7 with CF 3 SO 2 Cl/DMAP in CH 2 Cl 2 , followed by PhCO 2 K/HMPA, afforded the corresponding xylofuranosyl derivative 16 along with 6-O-deprotected nucleoside 19. (umn.edu)
This compound was hydrolyzed with Et 3 N/MeOH/H 2 O to give the 2-N-acetyl derivative 18, which was smoothly converted into the desired 3'-α-fluoro-substituted nucleoside 24 in 76% yield. (umn.edu)
Paramagnetic1
In a DNP experiment the large thermal electron spin polarization of a paramagnetic compound is transferred to surrounding nuclei a process that is driven by irradiating the sample with microwaves.1 2 Immense gains in sensitivity have been reported for various low- nuclei (e.g. 13 15 17 27 and 29Si) using indirect DNP polarization.3-6 Typically a nitroxide-based biradical (e.g. (sciencepop.org)
The equilibrium in this reaction usually favors the carbonyl compound and amine, so that azeotropic distillation or use of a dehydrating agent, such as molecular sieves or magnesium sulfate, is required to favor of imine formation. (wikipedia.org)
tosylimines react with α,β-unsaturated carbonyl compound to give allylic amines in the Aza-Baylis-Hillman reaction. (wikipedia.org)
For compound 4d (acyl = cinnamoyl), the SET reaction is of the innersphere type and proceeds via Michael addition, at least in part. (tmu.edu.tw)
Trityl Perchlorate Catalyzed Tandem Michael-aldol Reaction. (u-tokyo.ac.jp)
Acids1
Condensation of carbon acids with nitroso compounds. (wikipedia.org)
Electron3
If the two electrons have the same and the second electron has a shorter of trityl is shorter33 giving improved CE performance when irradiating near the SA-BDPA resonance. (sciencepop.org)
Earlier results have demonstrated an incongruence between DNP experiments with trityl and BDPA, where the optimal concentrations for polarization transfer are disparate despite similar electron spin resonance linewidths. (elsevierpure.com)
Simplified analysis of increased polarization as a function of decreased electron T 1e used to explain results in trityl are insufficient to describe DNP with BDPA. (elsevierpure.com)
Yields1
Higher yields of para-substituted compounds 11 are obtained from aziridines 4c (acyl = 4-phenylbenzoyl) and 4d. (tmu.edu.tw)
Catalyst1
This graph shows the total number of publications written about "Biphenyl Compounds" by people in Harvard Catalyst Profiles by year, and whether "Biphenyl Compounds" was a major or minor topic of these publication. (harvard.edu)
Pyridine2
A molecular docking study was executed to shed light on the supposed binding mode of the lead compound, STCY1, into the selective pocket of SIRT2 by interaction of the nitrogen of pyridine ring of the compound and Ala135 of the protein. (bvsalud.org)
Compound 24 was deprotected with DBU/pyridine followed by CF 3 COOH/CHCl 3 to give 3′-fluoro-3′-deoxyguanosine in good yield (3b). (umn.edu)
MeSH1
Biphenyl Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Drugs1
Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. (justia.com)
Group2
If this group is not a hydrogen atom, then the compound can sometimes be referred to as a Schiff base. (wikipedia.org)
The leaving group Tr - is eliminated from this partial structure when carbanions 16 attack the marked carbon converting it finally into the substituted ortho carbon of compounds 12. (tmu.edu.tw)
Product1
The Grignard reacts with the most availible substance, which is usually the starting compound, and not wit the end product. (thevespiary.org)
Profiles1
Below are the most recent publications written about "Biphenyl Compounds" by people in Profiles. (harvard.edu)
Effects1
An top cancer of accessible transfer graduate gradients for sample in cancer effects with video healthy compounds. (smartguyz.com)
Method1
A few years after Brunner's discovery54, the first attempt to construct a chiral IndOX compound was made.55 The strategy was to cyclize the corresponding amido alcohol using the DAST method (Scheme 11). (9pdf.co)
Natural1
The natural world is a rich source of medicinal compounds. (dupont.com)
Treatment1
Compounds having a stimulating effect on bone formation and contributing to increase an already diminished bone mass are therefore of particular importance in the treatment of bone metabolic disorders. (justia.com)
Nine compounds were synthesized and assayed affording three biopertinent SIRT2 inhibitors, and two of them, STCY1 and STCY6 showed higher inhibitory activity than STC4. (bvsalud.org)
Source1
The intercalation compound cobalt-phosphide is (CO2P), which forms when a source of phosphorus enters the transition metal, cobalt. (tatayoung.com)
Primary1
When R = H, the compound is a primary imine, when R is hydrocarbyl, the compound is a secondary imine. (wikipedia.org)
Cancer1
These compounds have pronounced anti-proliferative activities against different cancer cell lines. (bvsalud.org)