Tristetraprolin (TTP), the prototype of a class of CCCH zinc finger proteins, is a phosphoprotein that is rapidly and transiently induced by growth factors and serum in fibroblasts. (embl.de)
Tristetraprolin (TTP) is an ARE-binding protein that recruits decapping and deadenylating proteins upon binding to its target mRNAs thereby causing degradation by 5' to 3' exonucleolytic decay or 3' to 5' degradation via the exosome complex. (univie.ac.at)
Whereas ARE-binding proteins such as tristetraprolin and a stem-loop recognizing protein, Roquin, downregulate cytokine mRNA abundance by recruiting a CCR4-NOT deadenylase complex, another stem-loop RBP, Regnase-1, acts as an endoribonuclease, directly degrading target cytokine mRNAs. (go.jp)
The need for RBPs like AUF1, tristetraprolin (TTP), or KSRP (KH-type splicing regulatory proteins, also called KHSRP or significantly upstream sequence-binding proteins 2 (FuBP2)) for immune system regulatory processes continues to be confirmed in knockout pets [5C7]. (iassist2012.org)
ZFP361
On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. (icr.ac.uk)
MRNA7
The zinc finger protein tristetraprolin (TTP) is expressed in response to LPS and regulates the stability of TNF-alpha mRNA. (ed.ac.uk)
The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and recruits complexes of nucleases to promote rapid mRNA turnover. (ox.ac.uk)
mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function. (northwestern.edu)
Ribonucleoprotein complex immunoprecipitation and biotinylated RNA pull-down assays demonstrated that PARP-14 forms a complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3′ untranslated region. (imperial.ac.uk)
Expression of tristetraprolin (G0S24) mRNA, a regulator of tumor necrosis factor-alpha production, in synovial tissues of patients with rheumatoid arthritis. (jrheum.org)
Tristetraprolin (TTP) ist ein solches ARE-bindendes Protein und rekrutiert Enzyme, die das Cap und den Poly-A Schwanz von mRNAs degradieren, gefolgt von exonukleolytischem Abbau der gebundenen mRNA durch Degradation in 5' zu 3' oder 3' zu 5' Richtung. (univie.ac.at)
These protein either stabilize (HuR) or destabilize (AUF1, tristetraprolin, and KSRP) cytokine mRNAs by binding to particular sequence elements, frequently AU-rich components (ARE) situated in the 3 untranslated area (3-UTR) from the mRNA. (iassist2012.org)
Zinc Finger1
commonly referred to as tristetraprolin (TTP)), Zinc Finger Protein 36 like 1 (ZFP36L1), and Zinc Finger Protein 36 like 2 (ZFP36L2), play key roles in the post-transcriptional regulation of gene expression. (nih.gov)
Protein1
Here, we show that the RNA-binding protein tristetraprolin (TTP) is reduced in the livers of diabetic mice and humans and is transcriptionally induced in response to insulin treatment in murine livers in vitro and in vivo. (jci.org)
Macrophages1
Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo. (ox.ac.uk)
Posttranscriptional1
PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression. (bvsalud.org)
Inflammatory responses1
Interferons limit inflammatory responses by induction of tristetraprolin. (jak-stat.at)
Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo. (ox.ac.uk)
Objectives Tristetraprolin (TTP), a negative regulator of many pro-inflammatory genes, is strongly expressed in rheumatoid synovial cells. (aston.ac.uk)
Transcription1
tristetraprolin expression operates through CREB and NF-B transcription factors, which in turn, regulates the stability of chemokines. (edrc2013.org)
TtpA1
A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum. (nih.gov)
Regulates1
Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. (nih.gov)
Regulator1
We found that ZIKV infection of primary hBMECs induces the expression of the ARE-BP tristetraprolin (TTP) and that TTP is a novel regulator of endothelial IFN secretion . (bvsalud.org)
Roles1
During her PhD she examined the roles of neutrophil-FcγRIIIb and tristetraprolin (TTP) expression in rheumatoid arthritis under the direction of Nicolas Goulding and Paul Wallace (Dartmouth, NH). (a-star.edu.sg)
Researchers1
National Institutes of Health researchers have developed knockout mice that do not express Tristetraprolin (TTP). (nih.gov)
Expression1
ZIKV induction of tristetraprolin in endothelial and Sertoli cells post-transcriptionally inhibits IFNß/λ expression and promotes ZIKV persistence. (bvsalud.org)
Science1
His discovery of Tristetraprolin generated widely cited coverage in Science magazine. (nih.gov)