• polymorphism
  • Investigations of the relation between the AR polymorphism and breast cancer ( Table 1 ) have been conflicting, variably reporting that short repeats are associated with a decreased risk ( 14 - 18 ) or are not associated with risk ( 19 - 21 ) or are associated with decreased breast cancer survival ( 16 , 22 , 23 ). (aacrjournals.org)
  • genetic
  • News Release, Weizmann Institute of Science, "Scientists at the Weizmann Institute, using computer simulations, have provided an explanation as to why certain genetic diseases caused by repeats in the code are "genetic time-bombs" whose onset and progression can be accurately predicted," November 21, 2007, at http://80.70.129.162/site/en/weizman.asp?pi=371&doc_id=5042. (wikipedia.org)
  • genetic analyis of trinucleotide repeat expansions. (monash.edu)
  • Humans
  • Some types of satellite DNA in humans are: A repeated pattern can be between 1 base pair long (a mononucleotide repeat) to several thousand base pairs long[citation needed], and the total size of a satellite DNA block can be several megabases without interruption. (wikipedia.org)
  • This elongation is variable in length, with as few as 6 and as many as 81 repeats reported in humans. (wikipedia.org)
  • polymerase
  • We describe conditions for producing uninterrupted expanded CTG repeats consisting of up to 2000 repeats using 29 DNA polymerase. (nih.gov)
  • DNA polymerase reassembles its position on the template strand and resumes normal replication, but during the course of reassembling, the polymerase complex backtracks and repeats the insertion of deoxyribonucleotides that were previously added. (wikipedia.org)
  • replication
  • Recombination induced by double‐strand breaks (DSBs) in yeast leads to a higher proportion of expansions to contractions than does replication‐associated tract length changes. (embopress.org)
  • This repeat is prone to errors in DNA replication and can vary widely in length between individuals. (wikipedia.org)
  • genes
  • The degree of disease aggressiveness depends on the number of repeats and resultant alteration in the expression of several genes. (omicsonline.org)
  • Category II expansions tend to be more phenotypically diverse with heterogeneous expansions that are generally small in magnitude, but also found in the exons of genes. (wikipedia.org)
  • FECD
  • The purpose of this present study was to evaluate the TNR expansion in a larger cohort of Caucasian FECD patients. (arvojournals.org)
  • 50 is highly specific for the disease This association suggests that trinucleotide expansion may play a pathogenic role in the majority of FECD cases and is a predictor of disease risk. (jove.com)
  • tract
  • Correctly ligated products generating a dimerized repeat tract formed substrates for rolling circle amplification (RCA). (nih.gov)
  • Acc65I and BsrGI cleave on either side of the repeat tract. (nih.gov)
  • locus
  • Overexpression of Mre11p or Rad50p suppresses the inhibition of DSB repair by CAG 98 and significantly increases the average size of expansions found at the recipient locus. (embopress.org)
  • strand
  • However, if the loop out structure is formed on the parent strand, a decrease in the number of repeats occurs. (wikipedia.org)
  • In the presence of two non-complementary primers, hybridizing to either strand of DNA, ligations can be amplified to generate microgram quantities of repeat containing DNA. (nih.gov)
  • The newly synthesized strand then detaches from the template strand and pairs with another direct repeat upstream. (wikipedia.org)
  • This results in some repeats found in the template strand being replicated twice into the daughter strand. (wikipedia.org)
  • onset
  • Repeats of 39 or more uninterrupted CAG triplets cause disease, and longer repeat tracts are correlated with earlier age of onset and faster progression. (wikipedia.org)
  • alleles
  • We did not find any associations between AR or VDR microsatellite lengths and breast cancer when we used a priori determined cutoffs (≤21 or ≥22 repeats for AR and ≤18 or ≥19 for VDR ) to define long and short alleles. (aacrjournals.org)
  • 20 AR CAG n repeats had an increased risk for breast cancer, odds ratio of 1.67 (95% confidence interval, 1.17-2.38), compared with those with two alleles with ≥20 repeats. (aacrjournals.org)
  • specifically, the length differences observed between microsatellite alleles are generally multiples of the repeat unit length. (wikipedia.org)
  • MBNL1
  • The human homolog of mbl, MBNL1, which was originally identified as binding CUG repeats in RNA, has since been shown to bind CAG (and CCG) repeats as well. (wikipedia.org)
  • corneal
  • Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. (nih.gov)