• Trifluoroethanol is used as a specialized solvent in organic chemistry. (wikipedia.org)
  • Here we studied the effect of co-solvent 2,2,2-trifluoroethanol (TFE) on the ability of anti-ovalbumin monoclonal antibodies to interact with its specific antigen. (ukrbiochemjournal.org)
  • Use of trifluoroethanol as a solvent allowed for significant improvements in substrate compatibilities. (organic-chemistry.org)
  • The reactions were performed under microwave irradiation using 2,2,2-trifluoroethanol (TFE) as the solvent. (chemistryviews.org)
  • Chaubey B, Chandrakumar N, Pal S. ( 2021 ) Preferential solvation of carbohydrates in water-trifluoroethanol mixtures: a solvent detected heteronuclear NMR approach. (academictree.org)
  • For 500 μm diameter PLA fibers, the optimized treatment involves soaking the fibers for 24 h in a solvent mixture containing 60% trifluoroethanol (TFE) and 40% H 2 O dispersed with 10 wt % tin(II) oxalate and subsequent air-drying of the fibers. (illinois.edu)
  • Beta-hairpin formation in aqueous solution and in the presence of trifluoroethanol: a (1)H and (13)C nuclear magnetic resonance conformational study of designed peptides. (ukrbiochemjournal.org)
  • In addition, CD and NMR data show that IA3 undergoes a coil to helix transition in the presence of trifluoroethanol (TFE). (usda.gov)
  • Mechanism of helix induction by trifluoroethanol: a framework for extrapolating the helix-forming properties of peptides from trifluoroethanol/water mixtures back to water. (ukrbiochemjournal.org)
  • Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. (uchicago.edu)
  • Carre B, Devynck J. The acidity functions of trifluoroethanol and hexafluoroisopropanol, and their mixtures with water. (ukrbiochemjournal.org)
  • Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: a molecular dynamics study. (ukrbiochemjournal.org)
  • Anderson VL, Ramlall TF, Rospigliosi CC, Webb WW, Eliezer D. Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation. (ukrbiochemjournal.org)
  • Role of electrostatic interactions in 2,2,2-trifluoroethanol-induced structural changes and aggregation of alpha-chymotrypsin. (protabank.org)
  • It has been recently demonstrated that alpha-chymotrypsin (CT) can be driven toward amyloid aggregation by addition of 2,2,2-trifluoroethanol (TFE), at intermediate concentrations. (protabank.org)
  • Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide. (ukrbiochemjournal.org)
  • To probe the two-stage model, the structures of peptides representing individual transmembrane helices of the disulfide bond forming protein B have been studied in trifluoroethanol solution as well as in detergent micelles using nuclear magnetic resonance (NMR) and circular dichroism spectroscopy. (rcsb.org)
  • Pirkle's alcohol, an anthracene derivative of trifluoroethanol, is perhaps one of the most famous chiral shift reagent in nuclear magnetic resonance spectroscopy, and can be used to determine the absolute configuration and the enantiomeric purity of chiral molecules. (illinois.edu)
  • This species was prepared by the reaction of trifluoroethanol with acetylene. (wikipedia.org)
  • Upon induction of an α-helical structure by the addition of trifluoroethanol, the thiol click reaction occurs preferentially with the i,i+4 spacing. (beilstein-journals.org)
  • The 1 H-NMR spectrum of deuterated trifluoroethanol is a singlet at 11.5 ppm (vs. TMSP). (bruker.com)
  • By signing up to our promotional enews, you agree to our Privacy Policy under https://www.bruker.com/en/legal/privacy-policy.html . (bruker.com)
  • Thermodynamic characteristics of interest include the number of moles of hydrating water molecules per mole of DNA, the number of moles of associated counterions, B-to-A form DNA transition propensity (measured in relative humidity upon addition of trifluoroethanol), and DNA duplex melting temperature. (hhs.gov)
  • This single-tube protocol builds upon trifluoroethanol digestion and further minimizes sample losses by tube pretreatment and the addition of carrier proteins. (nih.gov)
  • Cambridge Isotope Laboratories (CIL) is pleased to offer highly enriched and pure deuterated trifluoroethanol acid for use with high-field, NMR spectroscopy These products are carefully manufactured and packaged so that the introduction of any impurity, including paramagnetic impurities, such as dissolved O 2 (g), into the product is minimized. (bruker.com)
  • This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research 2,2,2-Trifluoroethanol Compiled by Hartmut Schwertfeger Hartmut Schwertfeger was born in 1979 in Lahn-Gießen, Germany. (archive.org)
  • Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride. (wikipedia.org)
  • Oxidation of trifluoroethanol yields trifluoroacetic acid. (wikipedia.org)
  • Trifluoroacetic acid-2,2,2-trifluoroethanol (TFA-TFE) is as an effective combination for achieving SNAr reactions between anilines and heterocycles (e.g., purines and pyrimidines) substituted with a leaving group (fluoro-, chloro-, bromo- or alkylsulfonyl). (ncl.ac.uk)
  • The decapeptides adopt helical conformations in methanol and trifluoroethanol, with characteristic negative CD bands at 222 and 205 nm. (iisc.ac.in)
  • Circular dichroism spectral data suggested a consecutive beta turn or 3(10) helical conformation for the peptide in trifluoroethanol. (mcmaster.ca)
  • The molecular basis for antibacterial activity is presumed to be due to their predicted amphipathic α-helical structures which is supported by circular dichroism measurements that found significant helical content (63-69% α-helix) in 40% trifluoroethanol. (elsevierpure.com)
  • The team reports a novel approach for the synthesis of trifluoroethanol-substituted isoquinolines, employing N-alkoxyphthalimide as a coupling partner. (know-todays-news.com)
  • Novel photocatalytic system for synthesis of trifluoroethanol-substituted isoquinolines. (know-todays-news.com)
  • AcSIR Researchers have now reported a novel approach for the synthesis of trifluoroethanol-substituted isoquinolines by employing N-alkoxyphthalimide as a coupling partner. (know-todays-news.com)
  • This research is an important breakthrough in the synthesis of trifluoroethanol. (know-todays-news.com)
  • Researchers from AcSIR have developed a novel photocatalytic system for the synthesis of trifluoroethanol-substituted isoquinolines. (know-todays-news.com)
  • In order to determine the stereochemistry of solvolytic displacement and intramolecular nucleophilic substitution by a remote double bond at a vinyl center, the synthesis and solvolysis in trifluoroethanol of (Z)- and (E)-3-methyl-2,6-heptadien-2-yl trifluoro-methanesulfonate were undertaken. (caltech.edu)
  • Ethanol and 2,2,2-trifluoroethanol (TFE) were used to induce changes in the secondary structure of the immobilized polypeptides and the protein respectively. (uea.ac.uk)
  • The results of our study showed that blend preparation directly affected the features of the resulting fibers, and when the parameters of the blend are precisely controlled, fibers with a regular diameter could be produced fairly easily when 2,2,2-trifluoroethanol was used as a solvent instead of tetrahydrofuran. (ibecbarcelona.eu)
  • A series of three-dimensional structures of the 1-29 fragment of human growth hormone releasing factor in trifluoroethanol have been determined by molecular dynamics and distance geometry methods. (nih.gov)
  • Futhermore, a novel radical approach was disclosed by Shen's group for the direct transfer of the di-/trifluoroethanol motif using fluoroalkylsilicon reagents via a SiC bond activation strategy. (know-todays-news.com)
  • This single-tube protocol builds upon trifluoroethanol digestion and further minimizes sample losses by tube pretreatment and the addition of carrier proteins. (nih.gov)
  • Tosoh Finechem's unique hydrolysis process for the conversion of 1-Chloro-2,2,2-trifluoroethane (HCFC-133a) has enabled the company to become the world's largest and most competitive supplier of 2,2,2-Trifluoroethanol (TFEA). (tosohusa.com)
  • [ 38 ] Although the role of many of these additional additives remains unclear, one such additive, trifluoroethanol, does appear to improve the recovery of membrane proteins. (medscape.com)