- In particular, B-cell activating factor belonging to the TNF family receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) play critical roles in promoting B-cell survival at distinct stages of development by engaging a proliferation-inducing ligand (APRIL) and/or BAFF. (nih.gov)
- In molecular biology, TACI-CRD2 represents the second cysteine-rich protein domain found in the TACI family of proteins. (wikipedia.org)
- TACI-CRD2 stands for Transmembrane Activator and CAML Interactor- Cysteine Rich Domain 2. (wikipedia.org)
- Recombinant Human TACI is a soluble 159 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous, cysteine-rich extracellular domain of the TACI protein. (peprotech.com)
- that is, transmembrane activator and CAML interactor (TACI) or B-cell maturation (BCMA). (healthcarecoremeasures.com)
- APRIL binds to BCMA and TACI (transmembrane activator and CAML-interactor) and competes with BAFF for receptor binding. (abbiosciences.com)
- Based upon an engineered TACI (transmembrane activator and CAML interactor) domain, povetacicept has exhibited greater potency in preclinical studies versus wild-type TACI-based comparators, as well as other inhibitors of BAFF and/or APRIL alone and B cell depletion. (alpineimmunesciences.com)
- It is closely associated with B cell-activating factor of the TNF family (BAFF) receptor, transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) [ 14 ]. (biomedcentral.com)
- IκBNS-deficient B cells also displayed impaired upregulation of the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), which is essential for TI responses, and decreased sensitivity to TACI ligands upon stimulation. (bvsalud.org)
- BCMA binds to the tumor necrosis factor (ligand) superfamily, BAFF and APRIL and its cytoplasmic tail associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3, TRAF5, TRAF6 and activates NF-κB, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. (abbiosciences.com)
- Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. (lookformedical.com)
- Miembro de la superfamilia de receptores de factores de necrosis tumoral que se encuentra en la mayoría de los LINFOCITOS-T. La activación del receptor por el ANTÍGENO CD79 da lugar a una proliferación de LINFOCITOS-T CD4 POSITIVOS y LINFOCITOS-T CD8 POSITIVOS. (bvsalud.org)
- Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor). (lu.se)
- Chimeric antigen receptor (CAR) T cell therapy has emerged as a novel immunotherapy which modifies T cells with CAR, an artificial fusion protein that incorporates an extracellular antigen recognition domain, a transmembrane domain, and an intracellular domain including costimulation and signaling components [ 4 , 5 ]. (biomedcentral.com)
- In children who have completed immunizations with diphtheria, pertussis, and tetanus (DPT) or Hib-conjugated vaccines, the antibody response to protein antigens can be tested in adults and older children by measuring IgG antibodies to tetanus or diphtheria toxoid and H influenzae type b (Hib) polysaccharide antigen. (medscape.com)
- A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. (wakehealth.edu)
- 3. Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. (abbiosciences.com)
- BCMA is an integral membrane type I protein that is preferentially expressed in mature B lymphocytes , but not in T-cells or monocytes. (abbiosciences.com)
- The ligands are type II transmembrane protein cytokines that have various effects on immune cells, including acting as a: costimulatory molecules, apoptotic agents, growth factors APRIL (also known as TNSF13A, TALL-2, and TRDL-1) is a TNF ligand that is overexpressed by some tumours. (wikipedia.org)
- Atacicept is a fusion protein that blocks B-lymphocyte stimulator and a proliferation-inducing ligand, which are increased in patients with SLE. (bmj.com)
- Die Interleukin-1-Rezeptor-assoziierten Kinase 4 (IRAK-4) ist ein zentrales Protein des sogenannten „Myeloid differentiation primary response 88"-Signalwegs (MyD88-Signalwegs) (Suzuki et al. (springermedizin.de)
- for example, protein kinase activation is part of the platelet activation signal pathway. (lookformedical.com)
- A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. (lookformedical.com)
- It contains an intrinsic protein-tyrosine kinase activity. (rush.edu)
- All these complex signaling events are believed to secure survival by improved manifestation of anti-apoptotic B-cell lymphoma 2 (Bcl2) family members protein in developing and mature B cells. (healthcarecoremeasures.com)
- Depending upon its light chain composition a diverse array of functions can be found for this protein. (wakehealth.edu)
- This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
- Assessment of responses to polysaccharide antigens is important in patients older than 18-24 months because these responses may be deficient in some patients who can respond normally to protein antigens. (medscape.com)
- Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
- Therefore, antibody responses should be measured to polysaccharide antigens that are not present in the protein-conjugated pneumococcal vaccine. (medscape.com)
- We investigated the potential reasons for defective TI responses in mice lacking the atypical inhibitory kappa B (IκB) protein of the NF-κB pathway, IκBNS. (bvsalud.org)
- Both the mature protein and a partially processed form of the hormone are secreted after cleavage of the propeptide. (wikipedia.org)
- Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. (drugbank.com)
- Über Zwischenschritte führt dies zu einer Induktion der Transkriptionsfaktoren „nuclear factor-kappa of B cells" (NF-κB) und „activator protein-1" (AP-1) und einer konsekutiven Expression pro-inflammatorischer Zytokine (Abb. (springermedizin.de)
- The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine. (wikipedia.org)
- With world-class research and development capabilities, a highly productive scientific platform, and a proven management team, Alpine is seeking to create first- or best-in-class multifunctional immunotherapies via unique protein engineering technologies to improve patients' lives. (alpineimmunesciences.com)
- Signaling by the TNFRSF is mediated primarily, albeit not exclusively, via the TNFR-associated factor (TRAF) proteins and activation of the canonical and/or non-canonical nuclear factor-κB (NF-κB) pathways. (nih.gov)
- Telitacicept (Taiai), also known as RC18 or RCT18, is a fully human soluble fusion protein. (biomedcentral.com)
- TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development. (cdc.gov)
- therapeutic_agents C1909 therapeutic_agents C C177537 GDC Value Terminology C128288 Luvixasertib An orally bioavailable, selective inhibitor of the dual specificity protein kinase TTK (monopolar spindle 1 kinase, Mps1), with potential antineoplastic activity. (nih.gov)
- tumor_purity tumor purity C C177536 GDC Property Terminology C13202 Chromosome A structure found in cells that is comprised of a strand of linearized double-stranded DNA plus proteins that package the DNA in a condensed coil form and regulate chromosomal function. (nih.gov)
- Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor B (RANK) Signaling Complex Enhances Osteoclastogenesis. (idrblab.net)
- The effects of BLyS-receptor interaction in humoral immunity were tested by treating mice immunized with nitrophenyl-conjugated chicken gamma globulin (CGG) with the receptor-Fc fusion protein, and following the serum antibody response and splenic histology. (biomedcentral.com)
- CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120. (uams.edu)
- TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. (idrblab.net)
- When B cells mature, they produce special proteins called antibodies (also known as immunoglobulins). (medlineplus.gov)
- TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism. (uchicago.edu)
- Protein conjugated pneumococcal vaccine elicit antibody responses that are T-cell dependent. (medscape.com)
- Protein Cell. (idrblab.net)
- A sialic acid-rich protein and an integral cell membrane mucin. (uams.edu)
- Miembro de la superfamilia de receptores del factor de necrosis tumoral, que se expresa en los LINFOCITOS-B periféricos. (bvsalud.org)
- This assessment can also be done by measuring antibody responses following active immunization with protein or polysaccharide antigens. (medscape.com)
- HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. (idrblab.net)