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TransferrinReceptors, TransferrinIronTransferrinsFerritinsIron RadioisotopesConalbuminTransferrin-Binding ProteinsEndocytosisLactoferrinHemochromatosisIron-Binding ProteinsEndosomesTransferrin-Binding Protein BApoproteinsFerric CompoundsTransferrin-Binding Protein AGalliumAnemia, Iron-DeficiencyBacterial Transferrin Receptor ComplexIron-Regulatory ProteinsIron Chelating AgentsIron OverloadReceptors, Cell SurfaceReticulocytesHepcidinsCoated Pits, Cell-MembraneDeferoxamineAnemia, HypochromicHemoglobinsKineticsClathrinCell LineBiological TransportLactoglobulinsIron Regulatory Protein 1SiderophoresCell MembraneCell CompartmentationCeruloplasminGallium RadioisotopesSerum AlbuminHeptanoatesMembrane ProteinsMolecular Sequence DataProtein Bindingrab4 GTP-Binding ProteinsIron, Dietaryrab GTP-Binding ProteinsNephelometry and TurbidimetryErythrocyte IndicesClathrin-Coated VesiclesAntimicrobial Cationic PeptidesIron IsotopesAmino Acid SequenceSertoli CellsBlood ProteinsErythropoiesisAnemiaIsoelectric FocusingHistocompatibility Antigens Class IAsialoglycoproteinsLiver
SolubleReceptorsFerritinProteinsGlycoproteinProteinTIBCConjugateSerum ironBinds ironRole of transferrinUptakeProduced in CHO cellsHemochromatosisEndocytosisLigandSaturation valueGeneReversiblyConcentrationsTotal iron binPrealbuminReceptor complexELISAGenesVitroTfR1FerricConjugationGlycoproteinsMoleculeApotransferrinPlasmaSynthesisBovinePolypeptide chainClinicalIonsAssayAbsorptionReagentsRecombinantPathwayMolecular weightIron-boundHumanC282YCells
Soluble6
  • The method for measurement of soluble transferrin receptor (sTfR) is immuno-turbidimetry using Roche kits on the Hitachi 912 clinical analyzer. (cdc.gov)
  • Soluble transferrin receptor-1 (sTfR1) concentrations are increased in the plasma under two conditions that are associated with increased iron absorption, i.e. iron deficiency and increased erythropoiesis. (karger.com)
  • In areas with a limited infection pressure, soluble transferrin receptor (sTfR) has been shown to be a promising new tool for the diagnosis of deficiency of iron stores. (bmj.com)
  • High levels of transferrin may be a sign of iron deficiency anemia, and doctors can use a soluble transferrin receptor (sTfR) test to check for these levels. (medicalnewstoday.com)
  • Limiting dilutions of soluble H5 trimers complexed with horseradish peroxidase−conjugated antibodies were used in a fetuin- or transferrin-binding assay. (cdc.gov)
  • Plasma soluble interleukin-2 and transferrin receptor in schizophrenia and major depression. (bvsalud.org)
Receptors8
  • Two main transferrin receptors found in humans denoted as transferrin receptor 1 (TfR1) and transferrin receptor 2 (TfR2). (wikipedia.org)
  • On the basis that iron can effectively reach the brain by using transferrin receptors for crossing the blood-brain barrier, we propose to investigate if a transferrin-bearing generation 3-polypropylenimine dendrimer would allow the transport of plasmid DNA to the brain after intravenous administration. (nih.gov)
  • In vitro, the conjugation of transferrin to the polypropylenimine dendrimer increased the DNA uptake by bEnd.3 murine brain endothelioma cells overexpressing transferrin receptors, by about 1.4-fold and 2.3-fold compared to that observed with the non-targeted dendriplex and naked DNA. (nih.gov)
  • In vitro and in vivo experiments will be conducted to investigate how recombinant transferrin interacts with cellular receptors, regulates iron uptake, and influences cellular proliferation. (prospecbio.com)
  • Receptors, Transferrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Receptors, Transferrin" by people in this website by year, and whether "Receptors, Transferrin" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Receptors, Transferrin" by people in Profiles. (umassmed.edu)
  • M catarrhalis also expresses specific proteins for iron uptake that act as receptors for transferrin and lactoferrin. (medscape.com)
Ferritin7
  • transferrin A plasma protein (a β- globulin ) that can bind to iron and transport it to the liver for storage (see ferritin ) or to the cells of bone marrow , where it is used for the formation of haemoglobin. (encyclopedia.com)
  • These are widely used in clinics and include ferritin, serum iron, serum transferrin, total iron binding capacity (TIBC) and mean cell volume (MCV). (bmj.com)
  • Iron tests (including ferritin, iron, transferrin, and IBC) are ideally drawn early in the morning, after a 12-hour fast, when serum iron values are highest. (medscape.com)
  • Iron tests frequently performed together to diagnose iron deficiency or overload include serum iron, ferritin, IBC, and transferrin levels. (medscape.com)
  • The IBC value and transferrin saturation are best interpreted in the context of additional iron studies (typically, serum iron, ferritin, transferrin) and in the clinical context of the patient's baseline health state. (medscape.com)
  • Serum ferritin and transferrin saturation levels in ß° and ß(+) thalassemia patients. (bvsalud.org)
  • Ferritin levels and transferrin saturation were similar in beta-thalassemics with and without mutations in the HFE gene . (bvsalud.org)
Proteins2
  • Some invertebrates have proteins that act like transferrin found in the hemolymph. (wikipedia.org)
  • Transferrins (TFs) belong to a family of iron-binding proteins that play a crucial role in regulation of the iron levels. (lu.se)
Glycoprotein6
  • Human transferrin is encoded by the TF gene and produced as a 76 kDa glycoprotein. (wikipedia.org)
  • transferrin ( siderophilin ) (trans- fer -in) n. a glycoprotein, found in the blood plasma, that acts as a carrier for iron in the bloodstream. (encyclopedia.com)
  • Human recombinant transferrin, a glycoprotein responsible for iron transport in the body, has gained increasing attention in the fields of biomedicine and health sciences. (prospecbio.com)
  • Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. (creative-biolabs.com)
  • Transferrin is a glycoprotein with a molecular weight of 79570 daltons. (biorexdiagnostics.com)
  • Human transferrin is encoded by the TF gene and is an iron-binding blood plasma glycoprotein that controls the level of free iron in biological fluids. (rockland.com)
Protein13
  • When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, e.g., erythroid precursors in the bone marrow, it binds to it and is transported into the cell in a vesicle by receptor-mediated endocytosis. (wikipedia.org)
  • An increased plasma transferrin level is often seen in patients with iron deficiency anemia, during pregnancy, and with the use of oral contraceptives, reflecting an increase in transferrin protein expression. (wikipedia.org)
  • Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery. (umassmed.edu)
  • Transferrin is a glycosylated metal-carrying serum protein. (rpeptide.com)
  • Transferrin, the transport protein of iron, has been implicated as playing a role in AD and PD by regulating the iron concentrations in the brain. (rpeptide.com)
  • In Chinese hamster ovary (CHO) fibroblast cells the protein kinase C activating phorbol ester, phorbol myristate acetate (PMA), stimulates an increase in cell surface transferrin receptor (TR) expression by increasing the exocytic rate of the recycling pathway. (rupress.org)
  • Transferrin is a visceral protein which serves as the transport protein for iron in the plasma. (rxkinetics.com)
  • Transferrin has an intermediate half-life, 8 to 10 days, and therefore changes in nutrient intake or requirements, especially protein, are reflected in the transferrin level within a week. (rxkinetics.com)
  • Iron gets into the cells by binding to a protein called transferrin. (medicalnewstoday.com)
  • Transferrin levels increase during pregnancy and oestrogen administration and are also associated with a range of conditions including anaemia, iron deficiency, inflammation or malignancy, liver disease, malnutrition and protein loss. (randox.com)
  • Transferrin is the iron transport protein in serum. (biorexdiagnostics.com)
  • [ 4 ] This IBC value is therefore an indirect measure of protein transferrin, which binds iron in serum. (medscape.com)
  • Background: Because iron and cadmium share common transport mechanisms, iron-processing protein variants such as HFE C282Y, HFE H63D, and Transferrin P570S may influence cadmium metabolism. (cdc.gov)
TIBC3
  • Refer to the text below the calculator for more information about the interpretation of transferrin saturation and TIBC. (mdapp.co)
  • The percentage saturation of transferrin with iron is calculated by dividing the serum iron concentration by the total iron binding capacity (TIBC) and multiplying by 100. (mdapp.co)
  • The total iron binding capacity (TIBC) of serum is a measure of total serum transferrin (the three types: apotransferrin, monotransferrin and diferric transferrin) concentration. (mdapp.co)
Conjugate1
  • Mass spectrometry-guided optimization and characterization of a biologically active transferrin-lysozyme model drug conjugate. (umassmed.edu)
Serum iron2
  • Transferrin saturation calculation requires the serum iron and IBC values. (medscape.com)
  • We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). (who.int)
Binds iron2
Role of transferrin2
  • The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all tissues. (wikipedia.org)
  • The primary objective of this research is to elucidate the essential role of transferrin in iron homeostasis and its significance for human health. (prospecbio.com)
Uptake2
  • The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready for another round of iron uptake. (wikipedia.org)
  • Transferrin gold conjugates are suitable for use in cell uptake studies and can be detected using light microscopy (requires silver enhancement), darkfield microscopy, and electron microscopy. (cytodiagnostics-us.com)
Produced in CHO cells1
  • Recombinant Human Transferrin produced in CHO cells is a glycosylated, polypeptide chain containing having a molecular mass of 76 kDa. (prospecbio.com)
Hemochromatosis2
Endocytosis3
  • Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR). (rcsb.org)
  • Serum transferrin binds ferric ions in the bloodstream and transports them to cells, where they are released in a process involving receptor-mediated endocytosis. (rcsb.org)
  • Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. (reactome.org)
Ligand3
  • It enables ligand bonding to the transferrin, as each monomer can bind to one or two atoms of iron. (wikipedia.org)
  • They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (umassmed.edu)
  • The advantages of using TR as a reporter molecule include the ability to monitor trafficking, in both biochemical and microscopy experiments, using the natural ligand transferrin. (rupress.org)
Saturation value2
  • A transferrin saturation value of 30 percent means that 30% of iron-binding sites of transferrin are being occupied by iron. (mdapp.co)
  • A normal transferrin saturation value is found in patients with normal iron levels. (medscape.com)
Gene5
  • The gene coding for transferrin in humans is located in chromosome band 3q21. (wikipedia.org)
  • In vivo, the intravenous injection of transferrin-bearing dendriplex more than doubled the gene expression in the brain compared to the unmodified dendriplex, while decreasing the non-specific gene expression in the lung. (nih.gov)
  • These results suggest that transferrin-bearing polypropylenimine dendrimer is a highly promising gene delivery system to the brain. (nih.gov)
  • 2.To comparatively study the effect of sous vide fish on non-haem iron absorption from vegetables in a group of women with either the G277S/G277S or G277S/G277G genotype (preferably homozygous) versus a control group that do not present the indicated mutation in the transferrin gene but the wild type G277G/G277G. (europa.eu)
  • Transferrin saturation also was significantly higher in men , but only in those without HFE gene mutations . (bvsalud.org)
Reversibly1
Concentrations2
  • Methods: In a longitudinal cohort of men age 51-97, the Normative Aging Study (NAS), we evaluated toenail cadmium concentrations and missense single nucleotide polymorphisms (SNPs) in the HFE and Transferrin genes. (cdc.gov)
  • Results: HFE and Transferrin genotypes were not associated with toenail cadmium concentrations in the main effect analyses, but there were significant interactions between HFE H63D and hemoglobin (pinteraction=0.021), as well as HFE H63D and vitamin C intake (pinteraction=0.048). (cdc.gov)
Total iron bin2
  • Determines the percentage of transferrin available that is bound to the total iron binding capacity in serum. (mdapp.co)
  • Kasvosve I, Delanghe J. Total Iron Binding Capacity and Transferrin Concentration in the Assessment of Iron Status . (mdapp.co)
Prealbumin1
Receptor complex1
ELISA1
Genes1
  • Drosophila melanogaster has three transferrin genes and is highly divergent from all other model clades, Ciona intestinalis one, Danio rerio has three highly divergent from each other, as do Takifugu rubripes and Xenopus tropicalis and Gallus gallus, while Monodelphis domestica has two divergent orthologs, and Mus musculus has two relatively close and one more distant ortholog. (wikipedia.org)
Vitro3
  • For the quantitative in vitro determination of Transferrin in serum. (randox.com)
  • Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin‐bound iron by a stoichiometric excess of desferrioxamine. (elsevierpure.com)
  • FOB + Transferrin Rapid Test Kit is designed for the in vitro qualitative detection and differentiation of fecal occult blood (FOB) and transferrin in human fecal samples. (vitrosens.com)
TfR11
  • These changes were associated with lower placental transferrin receptor 1 (TfR1) in syncytiotrophoblasts in both early- and late-onset PE. (lu.se)
Ferric2
  • Human Transferrin has homologous C and N-terminal domains, each of which binds one ion of ferric iron. (prospecbio.com)
  • However, low molecular weight chelating agents, capable of forming ternary complexes with transferrin and ferric iron, can promote a rapid transfer of iron from transferrin to desferrioxamine. (elsevierpure.com)
Conjugation1
  • Human transferrin fluorescein conjugation has been tested in dot blot and is designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA), fluorescent western blotting, multiplex analysis, including multicolor imaging, utilizing various commercial platforms. (rockland.com)
Glycoproteins2
  • Transferrins are glycoproteins found in vertebrates which bind and consequently mediate the transport of iron (Fe) through blood plasma. (wikipedia.org)
  • Transferrins are glycoproteins that are often found in biological fluids of vertebrates. (wikipedia.org)
Molecule2
  • One transferrin molecule can bind to two iron ions. (encyclopedia.com)
  • To help define the steps in iron release, we have determined the three-dimensional structure of the iron-free (apo) form of the recombinant N-lobe half-molecule of human serum transferrin (ApoTfN) by X-ray crystallography. (rcsb.org)
Apotransferrin1
  • When not bound to iron, transferrin is known as "apotransferrin" (see also apoprotein). (wikipedia.org)
Plasma1
  • Plasma levels of Transferrin are regulated by the availability of iron and increase when plasma iron is low. (randox.com)
Synthesis1
  • The liver is the main site of transferrin synthesis but other tissues and organs, including the brain, also produce transferrin. (wikipedia.org)
Bovine1
  • Gibco™ Insulin-Transferrin-Selenium (ITS-G) is used as a basal medium supplement in order to reduce the amount of fetal bovine serum (FBS) needed to culture cells. (thermofisher.com)
Polypeptide chain1
  • In humans, transferrin consists of a polypeptide chain containing 679 amino acids and two carbohydrate chains. (wikipedia.org)
Clinical5
  • The second objective is to assess the clinical relevance of human recombinant transferrin in medical interventions. (prospecbio.com)
  • Clinical trials and studies involving individuals with iron-related disorders, such as iron-deficiency anemia, will be conducted to evaluate the efficacy and safety of recombinant transferrin supplementation. (prospecbio.com)
  • These investigations may provide insights into the use of recombinant transferrin as a therapeutic agent in various clinical settings. (prospecbio.com)
  • By delving into the diverse functions of human recombinant transferrin, this research aims to expand our understanding of its physiological roles and clinical applications. (prospecbio.com)
  • Transferrin glycosylation patterns may normalize so repeat testing is warranted in patients with significant clinical suspicion [1] . (icnapedia.org)
Ions2
  • Transferrins are not limited to only binding to iron but also to different metal ions. (wikipedia.org)
  • The pH of the vesicle is reduced by hydrogen ion pumps (H+ ATPases) to about 5.5, causing transferrin to release its iron ions. (wikipedia.org)
Assay1
  • Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Fluorescein, anti-Human Transferrin and anti-Human Serum. (rockland.com)
Absorption2
  • Decreased transferrin saturation may be caused by an iron-poor diet, impaired iron absorption, pregnancy and lactation or chronic blood loss. (mdapp.co)
  • Increased transferrin saturation may be caused by an iron-rich diet, iron supplements, increased iron absorption or repeated blood transfusions. (mdapp.co)
Reagents1
  • Biorex Diagnostics manufactures Transferrin reagents designed for Hitachi 917, Olympus AU 600/400/2700 and CA 180/270/400/2700 Furuno/Daytona system reagents. (biorexdiagnostics.com)
Recombinant3
  • This study aims to provide a comprehensive exploration of human recombinant transferrin, shedding light on its various functions and potential applications in health and biomedicine. (prospecbio.com)
  • The third objective is to explore the broader implications of human recombinant transferrin in biomedicine and research. (prospecbio.com)
  • Understanding the multifaceted properties of recombinant transferrin may open new avenues for innovative approaches in various medical specialties and scientific research. (prospecbio.com)
Pathway2
  • To create a system for studying this pathway, we replaced the native transferrin receptor (TR) internalization motif (YTRF) with the SDYQRL TGN-targeting motif. (rupress.org)
  • Phorbol ester treatment increases the exocytic rate of the transferrin receptor recycling pathway independent of serine-24 phosphorylation. (rupress.org)
Molecular weight2
  • Transferrin has a molecular weight of around 80 kDa and contains two specific high-affinity Fe(III) binding sites. (wikipedia.org)
  • Although iron boundto transferrin is less than 0.1% (4 mg) of the total body iron, it is themost important iron pool, with the highest rate of turnover (25 mg/24 h).Transferrin has a molecular weight of around 80 kDa and contains 2 specifichigh-affinity Fe(III) binding sites. (creativebiomart.net)
Iron-bound1
  • Although iron bound to transferrin is less than 0.1% (4 mg) of total body iron, it forms the most vital iron pool with the highest rate of turnover (25 mg/24 h). (wikipedia.org)
Human3
  • Human transferrin is the most important iron pool in mammals. (rockland.com)
  • The affinity of Human transferrin for Fe(III) is extremely high but decreases progressively with decreasing pH below neutrality. (rockland.com)
  • The current work focused on stability-structure studies of human serum transferrin using Nano-Differential Scanning Fluorimetry (NanoDSF), Isothermal Chemical Denaturation (ICD), light scattering techniques, and Small Angle X-ray Scattering (SAXS). (lu.se)
C282Y1
  • Increased transferrin saturation and HFE genotype C282Y/C282Y predict total mortality in patients with late-onset type 1 diabetes, and increased transferrin saturation after diagnosis is an independent risk factor. (nih.gov)
Cells2