Transcription factor tfiib. Medical search. Frequent questions

First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various components within the Pre-Initiation Complex (PIC), which consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, Mediator itself, and pol II. (colorado.edu)
The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding RNA genes in the human genome and is over 4.0 MDa in size. (colorado.edu)
Additionally, we identified six other factors that target the histone gene array: JIL-1, hormone-like receptor 78 (Hr78), the long isoform of female sterile homeotic (1) (fs(1)h) as well as the general transcription factors TBP associated factor 1 (TAF-1), Transcription Factor IIB (TFIIB), and Transcription Factor IIF (TFIIF). (bvsalud.org)
Additionally, we identified six other transcription factors that target the histone gene array: JIL-1, Hr78, the long isoform of fs(1)h as well as the generalized transcription factors TAF-1, TFIIB, and TFIIF. (bvsalud.org)
We find that alterations to Pol II, TFIIB, or TFIIF function widely alter the initiation landscape consistent with promoter scanning operating at all yeast promoters, regardless of promoter class. (tamu.edu)

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. (nih.gov)
The core promoter provides the site of action to RNA polymerase II which is a multisubunit enzyme with the basal or general transcription factors like, TFIIA, B, D, E, F and H. These factors assemble into a transcription pre initiation complex (PIC) that catalyzes the synthesis of RNA from DNA template. (allindianpatents.com)

DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
These proteins assemble at the core promoter of a gene, which is commonly defined as the minimal region necessary to trigger transcription ( 2 - 4 ). (biorxiv.org)
Genomic sites of DNA methylation can be bound by methyl-CpG-binding domain proteins (MBDs) and specific zinc finger proteins, which can recruit co-repressor complexes to silence transcription on targeted loci. (biomedcentral.com)
Each RNA polymerase requires the assistance of several other proteins or protein complexes, called general (or basal) transcription factors, which must assemble into a complex on the promoter in order for RNA polymerase to bind and start transcription. (stemcelldaily.com)
For example the σB-mediated response to low pH also enables the AMD 070 invasion of intestinal epithelial cells which is partially but not solely facilitated by σB-dependent contributions to the transcription of invasion proteins (e.g. (biotech2012.org)
We identified novel transcription factor candidates, including the Drosophila Hox proteins Ultrabithorax (Ubx), Abdominal-A (Abd-A), and Abdominal-B (Abd-B), suggesting a new pathway for these factors in influencing body plan morphogenesis. (bvsalud.org)
This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)
As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
Of particular interest are the protein interactions that occur between Hox proteins and general transcription factors (GTF) from the RNA Pol II basal transcription machinery. (biomedcentral.com)
Here, we focused on the interplay between Antp and the basal transcription machinery and show the direct interaction of Antp with TBP through the poly-glutamine (PolyQ) regions of both proteins. (biomedcentral.com)
Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
The activation of the core promoter is done by the additional sequence of regulatory DNA sequence elements to which various proteins bind and subsequently interact with the transcription initiation complex to activate gene expression. (allindianpatents.com)

The TATA box is recognized by a transcription factor called TATA-binding protein (TBP), which is part of a larger complex called TFIID. (stemcelldaily.com)
Most promoters for RNA polymerase II also have a conserved sequence called the TATA box, which is recognized by a subunit of the transcription factor TFIID. (stemcelldaily.com)
Transcription factor TFIID (or TATA-binding. (genexplain.com)

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. (wikipedia.org)

At the core promoter, the regulatory region containing the transcription start site (TSS), all inputs regulating transcription are integrated. (biorxiv.org)
It was previously shown that transcription of a gene in eukaryotic cells is not always initiated from the same nucleotide, but that it can be initiated from a range of positions in the core promoter region, with an individual, sequence-influenced pattern for each gene ( 3 - 6 ). (biorxiv.org)
Other regulatory sequences, such as promoter-proximal elements and enhancers , also affect the frequency of transcription. (basicmedicalkey.com)
The most-extensively studied core promoter element in eukaryotes is a short DNA sequence known as a TATA box, found 25-30 base pairs upstream from the start site of transcription. (stemcelldaily.com)
Other transcription factors and RNA polymerase then assemble on the promoter to form a pre-initiation complex (PIC). (stemcelldaily.com)
Transcription factor IIB serves as a bridge between IID, thefactor which initially recognizes the promoter sequence, and RNA polymerase II. (biotech2012.org)
THE ALTERNATIVE SIGMA FACTOR σB Sigma factors are required for transcription initiation as they confer promoter specificity to the RNA polymerase holoenzyme and induce helix destabilization to expose the DNA template strand for RNA synthesis. (biotech2012.org)
These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. (umassmed.edu)
The initiation of transcription and modulation of gene expression in eukaryotic genes is directed by a variety of DNA sequence elements collectively arranged in a larger sequence called promoter. (allindianpatents.com)
The minimal promoter or core promoter is a minimal stretch of contiguous DNA sequence that is sufficient to direct accurate initiation of transcription by RNA [Pol II machinery, Smale, S. T, genes dev 15, 2503-2508 2001]. (allindianpatents.com)
These short regulatory elements are located at a varying distance from transcription start point, some regulatory elements (called proximal elements) are adjacent to core promoter while other elements can be positioned several kilobases upstream or downstream of the promoter (enhancers). (allindianpatents.com)
Both types of promoter elements modulate the level of transcription from core promoter [(Wasylyk, B. CRC, Critical Rev. Biochem, 23: 77-120 (1988), Johnson & McKnight Ann. (allindianpatents.com)
The RNA polymerase II primary promoter - the gateway to transcription. (opioid-receptors.com)

Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. (wikipedia.org)
In eukaryotes the initiation of transcription of protein encoding genes by polymerase II (Pol II) is modulated by general and specific transcription factors. (embl.de)
Transcription in eukaryotes is a complex and highly regulated process that ensures accurate and timely expression of genes. (stemcelldaily.com)
MALT-lymphomas represent a wide range of extranodal lymphomas that often recognize environmental factors driving to specific genes deregulation. (biomedcentral.com)
To illustrate bacterial exposure to an initial stress condition (e.g. acidic pH in the stomach) not only triggers the AMD 070 expression of acid resistance functions that facilitate survival in this environment but also upregulates the transcription of genes important for survival in subsequent host compartments. (biotech2012.org)
This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. (umassmed.edu)

The general transcription factors operate through common promoters elements (such as the TATA box). (embl.de)
We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
Specific sequences on DNA, called promoters , determine where the RNA polymerase binds and how frequently it initiates transcription. (basicmedicalkey.com)
These tracks show the results of the ChIP-nexus analyses of transcription factors that are associated with the core promoters. (wustl.edu)
Background The majority of eukaryotic promoters utilize multiple transcription start sites (TSSs). (tamu.edu)
transcription start site of p53-responsive promoters. (opioid-receptors.com)
Physique 2 The multi-subunit general transcription apparatus The same group has recently exhibited that p53 target promoters are structurally diverse and display pronounced differences in Poll II occupancy [9]. (opioid-receptors.com)

In S. cerevisiae, a preinitiation complex comprised of Pol II and conserved general transcription factors (GTFs) assembles and opens DNA upstream of TSSs. (tamu.edu)

All organisms-bacteria, archaea, and eukaryotes-have a transcription initiation factor that contains a structural module that binds within the RNA polymerase (RNAP) active-center cleft and interacts with template-strand single-stranded DNA (ssDNA) in the immediate vicinity of the RNAP active center. (osti.gov)
In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. (umassmed.edu)

39504) translation initiation factor 2%2C alpha subunit CP001857 CDS Arcpr_0045 complement(39546. (go.jp)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
TFIIIB-DNA complexes in yeast comprise the TATA-binding protein (TBP), the TFIIB-related factor TFIIIB70, and TFIIIB90. (elsevierpure.com)
In addition, transcription is also regulated by upstream control elements that lie 5′ to the TATA box. (stemcelldaily.com)
And while other drugs such as Flavopiridol were shown to abolish transcription during the elongation phase [7] this study reports that Hypericin Rottlerin and SP600125 inhibit modification of the TATA Binding Protein (TBP) during the initial phase of transcription. (opioid-receptors.com)

Here, we used Cap Analysis of Gene Expression (CAGE) to analyze the pattern of transcription start sites at four different environmental conditions (limited in ethanol, limited in nitrogen, limited in glucose and limited in glucose under anaerobic conditions) using the Saccharomyces cerevisiae strain CEN.PK113-7D. (biorxiv.org)

Because bacteria do not contain nuclei, ribosomes bind to mRNA as it is being transcribed, and protein synthesis occurs simultaneously with transcription. (basicmedicalkey.com)
most of these interfere with the transcription of β-globin mRNA or its processing or translation. (basicmedicalkey.com)
Transcription is the process of copying genetic information from DNA into RNA, especially mRNA, by the enzyme RNA polymerase. (stemcelldaily.com)
A cleavage and polyadenylation specificity factor (CPSF) recognizes a polyadenylation signal (AAUAAA) on the pre-mRNA and cleaves it downstream of this signal. (stemcelldaily.com)
regulation by RNA polymerase II (RNA Pol II) is a highly regulated process involving the action of multiple transcription factors that collectively regulate synthesis of messenger RNA (mRNA). (opioid-receptors.com)

Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)
Nucleic-acid-binding motif in transcriptional elongation factor TFIIS and RNA polymerases. (embl.de)
analyzed the impact of multiple kinase inhibitors on RNA transcriptional activity along three p53 target gene core regulatory elements using transcription and electrophoretic mobility shift (EMSA) assays. (opioid-receptors.com)

A gene is a segment of DNA that functions as a unit to generate an RNA product or, through the processes of transcription and translation, a polypeptide chain. (basicmedicalkey.com)
The process of gene expression involves two constitutive steps i.e., transcription and translation and leads to the formation of a protein or polypeptide or in some cases RNA with specific functions. (allindianpatents.com)

One of the fundamental processes that determine cellular fate is regulation of gene transcription. (biorxiv.org)
The process of transcription is the most important regulatory step in the process of gene expression and its regulation. (allindianpatents.com)

e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens. (lookformedical.com)

2 Genomic sequences of the transcription factors were obtained from the dm3/BDGP Release 5 genome assembly . (starklab.org)

The Taatjes lab investigates the molecular mechanisms by which the human transcription machinery functions and is regulated. (colorado.edu)
It contains the signals for RNA polymerase machinery that initiates transcription and also modulates the level of transcription. (allindianpatents.com)

In general bacteria possess at least one alternative sigma factor (e.g. σB) to mediate specialized functions such as cell differentiation biofilm formation and modulation of an appropriate response to changing environmental conditions (18). (biotech2012.org)
Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
Alter J, Bengal E. (2011) Stress-Induced C/EBP Homology Protein (CHOP) Represses MyoD Transcription to Delay Myoblast Differentiation . (technion.ac.il)
Alter, J., Rozentzweig, D., and Bengal, E. (2008) Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor . (technion.ac.il)
Zetser, A., Gredinger, E., and Bengal, E. (1999) p38 mitogen-activated protein kinase promotes skeletal muscle differentiation: participation of the MEF2C transcription factor . (technion.ac.il)
Tamir, Y., and Bengal, E. (1998) p53 protein is activated during muscle differentiation and participates with MyoD in the transcription of muscle creatine kinase gene . (technion.ac.il)

This transcription initiation-factor structural module preorganizes template-strand ssDNA to engage the RNAP active center, thereby facilitating binding of initiating nucleotides and enabling transcription initiation from initiating mononucleotides. (osti.gov)

GTF2B is one of the ubiquitous factors required for transcription initiation by RNA polymerase II.The protein localizes to the nucleus where it forms a complex (the DAB complex) withtranscription factors IID and IIA. (biotech2012.org)
PubMed] 3 Morachis J Huang R Emerson B. Id of Kinase Inhibitors the mark Transcription Initiation by RNA Polymerase II. (opioid-receptors.com)
2917366 . RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). (genexplain.com)

Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB. (umassmed.edu)

In this paper, we report four sets of crystal structures of bacterial initially transcribing complexes that demonstrate and define details of stepwise, RNA-extension-driven displacement of the "σ-finger" of the bacterial transcription initiation factor σ. (osti.gov)
Among environmental factors, some bacterial infections have been found associated to MALT lymphomas of specific anatomic districts, such as H. pylori in gastric MALT lymphoma, C. Jejuni in intestinal MALT lymphoma and Borrelia Burgdoferi in cutaneous B cell lymphoma [ 6 - 10 ]. (biomedcentral.com)
While the particular function of σB in was unknown subsequent function showed that substitute sigma factor has a key function in bacterial success under unfortunate circumstances including admittance into stationary stage (3 -6). (biotech2012.org)

Regulatory factors concentrate in a nuclear body known as the histone locus body (HLB), which forms around the locus. (bvsalud.org)
One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. (umassmed.edu)

This entry represents a zinc finger motif found in transcription factor IIs (TFIIS). (embl.de)

Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)

Figure1) 1 are kinase inhibitors that impair transcription initiation by targeting components of the Pol II pre-initiation complex. (opioid-receptors.com)

Transcription in eukaryotes is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. (stemcelldaily.com)
Transcription occurs in eukaryotes in a way that is similar to prokaryotes with reference to the basic steps involved. (stemcelldaily.com)

High levels of RNA polymerase III gene transcription are achieved by facilitated recycling of the polymerase on transcription factor IIIB (TFIIIB)-DNA complexes that are stable through multiple rounds of initiation. (elsevierpure.com)

TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). (nih.gov)

RESULTS: To expand the list of known HLB factors, we performed a candidate-based screen by mapping 30 publicly available ChIP datasets of 27 unique factors to the Drosophila histone gene array. (bvsalud.org)
CONCLUSIONS: Our foundational screen provides several candidates for future studies into factors that may influence histone biogenesis. (bvsalud.org)
A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)

A primary sigma factor σA in Gram-positive bacteria (17) is required for housekeeping functions essential for cellular growth and reproduction. (biotech2012.org)
This sigma factor is found in a subset of Gram-positive bacteria and has been identified in species as well as in other genera in the order (e.g. and (22). (biotech2012.org)

Chromatin assembly factor 1. (lookformedical.com)

We applied an assay that is loosely based upon the minichromosome maintenance screen conducted in budding yeast ( 1 ) in which we measured the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new factors required for DNA replication. (aacrjournals.org)

Eukaryotic RNA polymerases do not terminate transcription at a specific site but rather transcription can stop at varying distances downstream of the gene. (stemcelldaily.com)

Anatomy4

Organisms1

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes20

Information Science3

TFIIF6

TFIIA2

Proteins12

TFIID3

TFIIE1

Promoter14

Genes7

Promoters7

Preinitiation complex1

Interacts2

Subunit2

TATA4

Saccharomyces1

MRNA5

Transcriptional3

Polypeptide2

Regulation2

Synthesis1

Genomic1

Machinery2

Differentiation6

Enabling transcription initiation1

Polymerase II3

Regulates1

Bacterial3

Regulatory2

Zinc1

Specific transcription factors1

Complex1

Eukaryotes2

Complexes1

Widely1

Histone3

Sigma factor2

Chromatin1

Yeast1

Polymerases1