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  • human
  • Human Membrane Type-4 Matrix Metalloproteinase (MT4-MMP) is encoded by a novel major transcript: Isolation of complementary DNA clones for human and mouse nt4-mmp transcripts'FEBS Letter. (nii.ac.jp)
  • A human breast carcinoma cell line (MDA-MB-231 cells) also secreted MT-MMP-1 into culture media, which was purified in a complex form with TIMP-2 and showed gelatinolytic activity as seen using zymography. (semanticscholar.org)
  • inhibit
  • An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo. (labome.org)
  • Disclosed herein are compounds which inhibit the expression of matrix metalloproteinases in cells. (google.com)
  • Chuang, Yeh, Yeh, Lin, Wang, Wang: Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms. (antikoerper-online.de)
  • collagenase
  • The removal of the propeptide of the proMMP-2* bound to TIMP-2 was also observed by MMP-3 (stromelysin 1), but not by MMP-1 (interstitial collagenase). (ox.ac.uk)
  • 13 14 TIMP-1, -2, and -3 appear to be approximately equally effective in binding to the catalytic site and inhibiting the active forms of stromelysin, collagenase, and gelatinases. (ahajournals.org)
  • Erythroid potentiating activity (EPA) Human collagenase inhibitor (HCI) Transcription of this gene is highly inducible in response to many cytokines and hormones. (wikipedia.org)
  • tumor
  • This regulation is altered in malignancy where metalloproteinases are necessary for tumor neoangiogenesis and invasion. (google.com)
  • MMP production in many cancers may be upregulated in surrounding stromal tissue rather than simply in the tumor lesion. (wikipedia.org)
  • transcription
  • Calcium homeostasis is an important regulator of MMP-2 transcription, activation and activity. (google.com)
  • Furthermore, changes in MMP-2 activity can come from alterations in levels of transcription, MMP secretion, MMP activation, or MMP inhibition. (wikipedia.org)
  • The nuclear transcription factor activator protein, AP-1, which controls the transcription of matrix metalloproteinases (MMP), is expressed and activated. (wikipedia.org)
  • latent
  • The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. (wikipedia.org)
  • degrade
  • Proteolysis and interruption of the basement membrane requires activation of specialized matrix metalloproteinases which selectively degrade basement membrane collagens type IV and V, the type IV collagenases or gelatinases (MMPs). (google.com)
  • promotes
  • The C3G/Rap1 pathway promotes secretion of MMP-2 and MMP-9 and is involved in serous ovarian cancer metastasis. (springer.com)
  • Clustering of integrin chains promotes activation of MMP-2. (wikipedia.org)
  • turnover
  • As a result of regulating ECM turnover, PaSCs are involved in the maintenance of the modelling of normal tissue. (wikipedia.org)
  • inhibitory
  • The 'activated' proMMP-2 (proMMP-2*) formed a new complex with TIMP-2 by binding to the N-terminal inhibitory domain of the inhibitor without processing the propeptide. (ox.ac.uk)
  • metabolites
  • They can detect and measure enzymatic activities of proteases (metalloproteinases, caspases), ions, metabolites, and other biomolecules under physiological or pathological conditions in neural cells. (frontiersin.org)
  • blockage
  • These results indicate that the blockage of TIMP-2 of the complex with an active MMP is essential for the activation of proMMP-2 when it is complexed with TIMP-2. (ox.ac.uk)
  • TIMP-2 and IGFBP7
  • However, the association of urinary TIMP-2 and IGFBP7 with long-term outcomes is unknown. (nih.gov)
  • TIMP-2 and IGFBP7) to determine if a person is at increased risk for developing moderate to severe acute kidney injury (AKI) in the next 12 hours. (wikipedia.org)
  • role
  • This is in contrast to murine knockout studies that indicate that TIMP-2 does not have a major role in mouse embryogenesis. (ox.ac.uk)
  • The role of neutral metalloproteinases in the maintenance of normal body functions, such as bone remodeling and wound healing, requires tight regulation. (google.com)
  • Additionally, it plays a role in regulating the transcriptional profile of fetal and placental tissues associated with the early stages of pregnancy. (wikipedia.org)
  • basement membrane
  • More specifically, MMP-2 (along with MMP-9) is capable of degrading type IV collagen, the most abundant component of the basement membrane. (wikipedia.org)
  • As another example, cleavage of laminin-5, a component of the basement membrane, by MMP-2 has been shown to reveal a cryptic site inducing migration of breast epithelial cells. (wikipedia.org)
  • Chemically
  • The specific species of ECM of connective tissues often differ chemically, but collagen generally forms the bulk of the structure. (wikipedia.org)
  • activity
  • Thus the APMA-treated proMMP-2*-TIMP-2 complex exhibited no gelatinolytic activity. (ox.ac.uk)
  • The gelatinolytic activity detected after APMA treatment was solely derived from the activation of free proMMP-2. (ox.ac.uk)
  • In idiopathic interstitial pneumonia, MMP-2 activity was elevated in patients with the less severe disease phenotype which is more responsive and reversible with corticosteroid therapy. (wikipedia.org)
  • Increased MMP-2 activity has also been linked with a poor prognosis in multiple forms of cancer including colorectal, melanoma, breast, lung, ovarian, and prostate. (wikipedia.org)
  • mRNA
  • It has been shown previously, in our studies as well as those by others, that ST3 mRNA is highly upregulated during apoptotic tissue remodeling during Xenopus laevis metamorphosis. (semanticscholar.org)
  • showed that MMP-2 mRNA levels are strikingly similar between metastatic and non-metastatic lesions in colorectal cancer, but metastatic cases are correlated with higher levels of MMP-2 mRNA in surrounding healthy tissue. (wikipedia.org)
  • Genes
  • Shear stress of 1 dyne/cm 2 exerted an anabolic effect on COLI and COLIII genes and catabolic effects on the aggrecan gene, while 10 dyne/cm 2 had an anabolic effect on the COLI gene and a catabolic effect on COLIII and aggrecan genes. (biomedcentral.com)
  • In vertebrates, it is a member of a 4-gene family, with the other paralogous genes known as BCAR1 (p130Cas), EFS (Sin), and CASS4 (HEPL) The NEDD9 promoter has 2 transcriptional start sites. (wikipedia.org)
  • proteins
  • Other experiments show that a single miRNA species may repress the production of hundreds of proteins, but that this repression often is relatively mild (much less than 2-fold). (wikipedia.org)
  • promoter
  • Based on inspection of sequence, the NEDD9 promoter also has potential binding sites for a number of additional transcription factors, including STAT5A and NF-kappa B. In the 3'UTR of NEDD9 is a match to positions 2-8 of mature miR-145. (wikipedia.org)
  • malignant
  • Malignant pleural effusion is a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue (pleura) lining the outside of the lung and the wall of the chest cavity. (wikipedia.org)
  • diseases
  • In addition, histological studies of chronic renal diseases confirmed that renal function correlates better with tubular and interstitial changes than with glomerular changes ( 2 , 19 , 20 ). (diabetesjournals.org)
  • Clinical
  • The most advanced AXL selective inhibitor is bemcentinib (BGB324 or R428), an oral small molecule currently in multiple Phase II clinical trials for NSCLC, TNBC, AML and melanoma. (wikipedia.org)
  • fluid
  • The sac (consisting of 2 membranes, the chorion and amnion) contains amniotic fluid, which surrounds and protects the fetus in the uterus (womb). (wikipedia.org)
  • renal
  • Previous studies have shown that renal function in type 2 diabetes correlates better with tubular changes than with glomerular pathology. (diabetesjournals.org)
  • There is growing evidence that tubular injury is a major feature in the development of renal dysfunction in type 2 diabetes ( 1 - 9 ). (diabetesjournals.org)
  • Typical glomerulopathy is present in only one-third of type 2 diabetic patients with microalbuminuria, while another third demonstrates normal renal structure. (diabetesjournals.org)
  • Microscopic evaluation of biopsied renal tissue will reveal linear deposits of Immunoglobulin G by immunofluorescence. (wikipedia.org)
  • roles
  • miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. (wikipedia.org)
  • They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. (wikipedia.org)
  • domain
  • Three type II fibronectin repeats are inserted in the catalytic domain, although these domains are omitted in most crystallographic structures of MMP9 in complex with inhibitors.The active form of MMP9 also contains a C-terminal hemopexin-like domain. (wikipedia.org)
  • 2018
  • Behavioural Brain Research, 2: 35-45, 2018. (gov.pl)
  • atherosclerosis
  • 2 However, the inflammatory processes that underlie atherosclerosis are mediated by a multitude of cytokines and are unlikely to be reflected by CRP levels alone. (ahajournals.org)
  • Insulin
  • Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice. (uni-koeln.de)
  • In obesity, similar to resistance of insulin in type 2 diabetes, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores. (wikipedia.org)
  • patients
  • Urine samples from healthy control subjects ( n = 50) and type 2 diabetic patients ( n = 100) were collected and tested for excretion of CML and the presence of proximal tubular epithelial cells (pTECs). (diabetesjournals.org)
  • cells
  • hAF cells were harvested from degenerated disc tissues in routine spine surgery, staged by magnetic resonance imaging, expanded in monolayers and then seeded onto the bio-microfluidic device. (biomedcentral.com)
  • MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. (wikipedia.org)
  • Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (wikipedia.org)
  • significantly
  • The cisplatin single dose administration to rats induced nephrotoxicity associated with a significant increase in blood urea nitrogen (BUN) and serum creatinine and significantly increase Malondialdehyde (MDA) in kidney tissues by 230 ± 5.5 nmol/g compared to control group. (biomedcentral.com)
  • However
  • However, this treatment requires an inpatient stay of approximately 2-7 days, can be painful and has a significant failure rate. (wikipedia.org)
  • single
  • Rats of group 1 control group intraperitoneal (i.p.) received 2.5 ml/kg, group 2 CP group received single dose 5 mg/kg cisplatin i.p. group 3 rutin group orally received 30 mg/kg rutin group 4 (CP plus rutin) received CP and rutin as in group 2 and 3. (biomedcentral.com)
  • control group
  • The experimental groups were subjected to 1 and 10 dyne/cm 2 shear stress for 4 h, and no shear stress was applied to the control group. (biomedcentral.com)