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  • decrease
  • It is believed this decrease in AChE and MEP structural changes could be the result of over stimulation of thyroxin blocking the axoplasmic flow of trophic factors down the axon terminal especially considering thyroxine's role in nervous system growth and metabolism regulation. (wikipedia.org)
  • Research suggests thyroxine directly causes a decrease in protein kinase affinity to cAMP within muscle fibers This causes an increase in cAMP within the muscle fibers since protein kinases are not inactivating cAMP. (wikipedia.org)
  • iodide
  • This enzyme catalyses the following chemical reaction 3,3',5'-triiodo-L-thyronine + iodide + A + H+ ⇌ {\displaystyle \rightleftharpoons } L-thyroxine + AH2 The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. (wikipedia.org)
  • known
  • Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is encoded by the DIO3 gene. (wikipedia.org)
  • Research
  • Other research indicates muscle fiber fatigue, weakness, and degradation associated with TM is the direct action thyroxine has on the muscle fibers themselves. (wikipedia.org)
  • agree
  • Scientists agree thyroxine brings about the degradation of muscle fibers specifically at the motor end plates of neuromuscular junctions. (wikipedia.org)
  • almost
  • Substances with a molar mass around 1000g/mol (e.g. thyroxine) are almost vertically aligned in the mass and molar images. (wikipedia.org)
  • evidence
  • With the onset of TM due to thyroxine toxicity, there is evidence to suggest that structural changes in MEPs could lead to muscle fiber degradation, weakness, and fatigue. (wikipedia.org)