Glycoprotein hormonesConsisting of alpha and beta subunitsReceptorThyroidGenesFollicle-stimulaAlfaChorionic gonadotropinEukaryotic translationSpecificityMolecularGeneAmino acidRadioiodineAlphaProteinSecretionHeterodimersPeptideProteinsReceptorsHumanEnzymeOrganicFreeImmuneAdditionGeneralExpressionActiveSpecificComplex
Glycoprotein hormones8
- The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. (wikipedia.org)
- Glycoprotein Hormones, alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. (wakehealth.edu)
- This graph shows the total number of publications written about "Glycoprotein Hormones, alpha Subunit" by people in this website by year, and whether "Glycoprotein Hormones, alpha Subunit" was a major or minor topic of these publications. (wakehealth.edu)
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- The 3 human pituitary glycoprotein hormones: luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropin, and the placenta-derived chorionic gonadotropin, are closely related tropic hormones. (mayocliniclabs.com)
- Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. (nih.gov)
- The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. (nih.gov)
Consisting of alpha and beta subunits1
- The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. (wikipedia.org)
Receptor8
- The alpha-subunits are essential for receptor transactivation. (mayocliniclabs.com)
- By contrast, all the different beta-subunits are transcribed from separate genes, show less homology, and convey the receptor specificity of the dimeric hormones. (mayocliniclabs.com)
- Rare genetic causes result from mutations in the genes for thyrotropin-releasing hormone (TRH), the TRH receptor [ 5 ] or TSH [ 6 , 7 ]. (rroij.com)
- the phospho-receptor binds to beta-arrestin. (rochester.edu)
- siRNA screen identifies the phosphatase acting on the G protein-coupled thyrotropin-releasing hormone receptor. (rochester.edu)
- Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor. (rochester.edu)
- Manifestations of GD/GO result from a B cell-mediated autoimmune response against the thyrotropin receptor (TSHR), resulting in the plasma cell production of autoantibodies targeting the thyrotropin receptor (TRAb). (frontiersin.org)
- A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
Thyroid6
- The genes encoding the mature common glycoprotein alpha (CGA) and hormone-specific beta subunits of feline thyroid stimulating hormone (fTSH) were cloned and sequenced. (avmi.net)
- A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. (harvard.edu)
- The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. (harvard.edu)
- Effects of Thyrotropin on Peripheral Thyroid Hormone Metabolism and Serum Lipids. (harvard.edu)
- Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. (pharmacycode.com)
- 14. Querat B, Sellouk A, Salmon C. Phylogenetic analysis of the vertebrate glycoprotein hormone family including new sequences of sturgeon (Acipenser baeri) beta subunits of the two gonadotropins and the thyroid-stimulating hormone. (ac.ir)
Genes4
- This report constitutes the first cloning and sequencing of the genes encoding the subunits of feline thyrotropin. (avmi.net)
- We analysed the mitochondrial cytochrome b gene and four nuclear genes (casein kappa, spectrin beta nonerythrocytic 1, thyroglobulin, thyrotropin subunit beta) for the first phylogeographic survey of the aoudad, and uncovered a deep Mediterranean-Saharan mitochondrial split separating two highly distinct evolutionary lineages. (ulisboa.pt)
- Objective: Congenital isolated thyrotropin (TSH) deficiency is a rare condition due to autosomal recessive defects in TSHβ, TBL1X, IGSF1, TRHR genes. (eurospe.org)
- 200?kDa composed of 13 subunits encoded by both the mitochondrial and nuclear genes. (cahrr.org)
Follicle-stimula2
- Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). (wikipedia.org)
- hCG is a glycoprotein similar in structure to follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyrotropin. (medscape.com)
Alfa5
- humani horionski gonadotropin (hCG), luteinizirajući hormon (LH), folikulostimulišući hormon (FSH), i tireostimulišući hormon (TSH) su dimeri koji se sastoje od alfa i beta podjedinica, koje su nekovalentno vezane. (wikipedia.org)
- Alfa podjedinice tih hormona su skoro identične, dok su njihovi beta lanci jedinstveni i definišu biološku specifičnost. (wikipedia.org)
- Thyrotropin Alfa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
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Chorionic gonadotropin2
- The most commonly used assays are for the beta subunit of human chorionic gonadotropin (hCG). (medscape.com)
- A single-chain analogue of fTSH termed yoked fTSH (yfTSH) was developed by fusing the nucleotides encoding the C-terminus of the beta-subunit fused to the N-terminus of the alpha-subunit with DNA encoding the C-terminal peptide (CTP) of human chorionic gonadotropin beta-subunit as a linker peptide. (avmi.net)
Eukaryotic translation2
- Eukaryotic elongation factor 1 alpha (eEF1A) is one of the four subunits composing eukaryotic translation elongation factor 1. (biomedcentral.com)
- The eukaryotic translation elongation factor 1 alpha, currently termed eEF1A, is a member of the G protein family, and one of the four subunits that compose the eukaryotic elongation factor 1 [ 5 , 6 ]. (biomedcentral.com)
Specificity3
- however, their beta chains are unique and confer biological specificity. (wikipedia.org)
- The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. (nih.gov)
- The beta subunit is different and confers its biochemical specificity. (monobind.com)
Molecular2
- Molecular cloning of the human thyrotropin-beta subunit gene. (wikipedia.org)
- Cellular and molecular biology of the beta cell. (tsu.ge)
Gene1
- There is an association of polymorphisms of the calcium channel alpha1-subunit gene with thyrotoxic periodic paralysis. (medscape.com)
Amino acid3
- Linear amino acid sequence of the alpha subunit. (wikipedia.org)
- The free beta subunit of hCG differs from the others in that it has a 30-amino acid tailpiece at the COOH terminus. (medscape.com)
- The resulting 510 bp PCR product for the CGA-subunit included the full coding sequence for the 96 amino acid mature subunit preceded by a 24 amino acid signal peptide. (avmi.net)
Radioiodine1
- Long-term efficacy of modified-release recombinant human thyrotropin augmented radioiodine therapy for benign multinodular goiter: results from a multicenter, international, randomized, placebo-controlled, dose-selection study. (harvard.edu)
Alpha6
- hCG is composed of alpha and beta subunits. (medscape.com)
- The alpha subunit of hCG is similar to the alpha subunit of FSH, LH, and thyrotropin. (medscape.com)
- hCG is present in the maternal circulation as either an intact dimer, alpha or beta subunit, and degraded form, or beta core fragment. (medscape.com)
- The resulting single-chain analogue encoded from N-terminus to C-terminus: beta-CTP-alpha-FLAG. (avmi.net)
- Each is composed of an alpha- and a beta-subunit, coupled by strong noncovalent bonds. (mayocliniclabs.com)
- Under physiological conditions, alpha- and beta-chain synthesis and secretions are tightly coupled, and only small amounts of monomeric subunits are secreted. (mayocliniclabs.com)
Protein1
- In addition to the constituent protein subunits, COX contains several redox-active prosthetic groups directly involved in electron transfer. (cahrr.org)
Secretion2
- Similar strategies are being used to ask how insulin secretion by the pancreatic beta cell is controlled. (rochester.edu)
- Stimulus-secretion coupling in rat pituitary cells: role of cytosolic free [Ca++] in the stimulation of hormone secretion by thyrotropin-releasing hormone. (vdocuments.net)
Heterodimers1
- Both subunits, the non-covalently bound heterodimers, are required for full biologic activity. (wakehealth.edu)
Peptide1
- connecting the thyrotropin: can this stress with first undiagnosed peptide Professor encourage almost used from the disease support? (sheppardengineering.com)
Proteins1
- The superfamily of G proteins includes three main classes: Ras-like GTPases, G α subunits of heterotrimeric G proteins, and the translation elongation factors. (biomedcentral.com)
Receptors2
- A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). (lookformedical.com)
- The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)
Human2
- Human pituitary thyrotropin. (wikipedia.org)
- Human, LH is a gonadotropin and a glycoprotein having two subunits. (monobind.com)
Enzyme3
- The mitochondrially encoded subunits COX1, COX2 and COX3 are evolutionarily conserved and form the catalytic and structural core of the enzyme [1]. (cahrr.org)
- One example of a suitable active agent is an enzyme such as beta-lactamases. (patentsencyclopedia.com)
- 3. The drug delivery device of claim 1, wherein the active agent is an enzyme capable of inactivating beta-lactam antibiotics. (patentsencyclopedia.com)
Organic2
- β-Subunit of the Ostα-Ostβ organic solute transporter is required not only for heterodimerization and trafficking but also for function. (rochester.edu)
- 2) In items with vitreous LV research, proteolytic future quality( SVR) to a more systolic LV donor is failure organic of such project for chemical addition in Thyrotropin to CABG genetically. (hone.world)
Free4
- Free beta subunits are degraded by macrophage enzymes in the kidney to make a beta subunit core fragment, which is primarily detected in urine samples. (medscape.com)
- Intact and free beta subunit are initially the predominant forms of hCG, with the beta core fragment emerging as the predominant form in the fifth week after conception. (medscape.com)
- Additionally, intact and free beta subunit have the most day-to-day variability and are transiently undetectable even 10 days after detection of pregnancy. (medscape.com)
- [ 3 ] Optimally, tests used for early pregnancy detection should be able to recognize all forms of intact hCG, including the free beta subunit and the beta core fragment. (medscape.com)
Immune1
- Project End native syndrome: Both techniques and non-systolic findings with parent subunits science described object in the growth of immune issues, cutting TNF, IL-1beta and IL-6, well closely as directions, in the Source of rate of care. (sheppardengineering.com)
Addition2
- The movie shows the movement of GFP-beta-arrestin after TRH addition. (rochester.edu)
- association of these nucleus-encoded subunits probably precedes their addition to COX1 during the assembly process. (cahrr.org)
General1
- Determinar la frecuencia, analizar las causas, describir las características clínicas y los resultados de los traslados no programados en pacientes pediátricos hospitalizados, desde el área de internación general pediátrica (IGP) a la UCIP, y analizar las diferencias entre traslados urgentes y emergentes. (bvsalud.org)
Expression1
- 4. Ni Y, Zhou Y, Lu L, Grossmann R, Zhao R. Developmental changes of FSH-R, LH-R, ER-beta and GnRH-I expression in the ovary of prepubertal ducks (Anas platyrhynchos). (ac.ir)
Active1
- In one embodiment, the active ingredients are those that inactivate antibiotics, such as macrolides, quinolones and beta-lactam containing antibiotics. (patentsencyclopedia.com)
Specific1
- Tissue-specific isoforms of subunits COX4, COX6A, COX6B and COX7A were identified in humans [3,4]. (cahrr.org)
Complex1
- The remaining ten evolutionarily younger subunits are encoded by the nuclear genome and are associated with the surface of the complex core. (cahrr.org)