Loading...



  • Corepressor
  • In the absence of activating ligand (or with antagonist present, as shown here) helix 12 (yellow) is disordered and the corepressor (blue) binds to the surface of the receptor (left). (els.net)
  • In the absence of hormone, TR in complex with corepressor proteins bind to HREs in a transcriptionally inactive state. (wikipedia.org)
  • syndrome
  • This could explain why patients with low T3 syndrome don't benefit from substitution therapy with thyroid hormones. (wikipedia.org)
  • Thyroid hormone resistance (sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected. (wikipedia.org)
  • Thyroid hormone resistance syndrome is rare, incidence is variously quoted as 1 in 50,000 or 1 in 40,000 live births. (wikipedia.org)
  • According to newer theories, thyroid storm results from allostatic failure in a situation were thyrotoxicosis hampers the development of non-thyroidal illness syndrome, which would help to save energy in critical illness and other situations of high metabolic demand. (wikipedia.org)
  • Usually, in critical illness (e.g. sepsis, myocardial infarction and other causes of shock) thyroid function is tuned down to result in low-T3 syndrome and, occasionally, also low TSH concentrations, low-T4 syndrome and impaired plasma protein binding of thyroid hormones. (wikipedia.org)
  • This endocrine pattern is referred to as euthyroid sick syndrome (ESS), non-thyroidal illness syndrome (NTIS) or thyroid allostasis in critical illness, tumours, uraemia and starvation (TACITUS). (wikipedia.org)
  • interaction
  • It has been shown that the C-terminal region of LGR5 is crucial for both dynamic internalization and degradation to occur, although C-terminal truncation does not inhibit LRP6 interaction and internalization, but rather, heightens receptor activity. (wikipedia.org)
  • Thus, only the initial interaction with its unknown ligand and other membrane bound receptors is crucial in its role in Wnt signalling and not the internalization itself. (wikipedia.org)
  • FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor. (wikipedia.org)
  • binds
  • C) DNA-binding domain (DBD): Highly conserved domain containing two zinc fingers that binds to specific sequences of DNA called hormone response elements (HRE). (wikipedia.org)
  • CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. (wikipedia.org)
  • PPAR
  • Some of these receptors such as FXR, LXR, and PPAR bind a number of metabolic intermediates such as fatty acids, bile acids and/or sterols with relatively low affinity. (wikipedia.org)
  • The RXR receptor itself is the second major target of obesogens next to the PPAR receptors. (wikipedia.org)
  • The PPARα receptor, when complexed with RXR and activated by the binding of a lipid, promotes peroxisome proliferation leading to increased fatty acid β-oxidation. (wikipedia.org)
  • In contrast, the PPARγ receptor, when complexed with RXR and activated by the binding of fatty acids or their derivatives, promotes lipid biosynthesis and storage of lipids is favored over fatty acid oxidation. (wikipedia.org)
  • subunit
  • The gene for the FSH beta subunit is located on chromosome 11p13, and is expressed in gonadotropes of the pituitary cells, controlled by GnRH, inhibited by inhibin, and enhanced by activin. (wikipedia.org)
  • membrane
  • Carotenoid absorption is restricted to the duodenum of the small intestine and dependent on class B scavenger receptor (SR-B1) membrane protein, which are also responsible for the absorption of vitamin E (α-tocopherol). (wikipedia.org)
  • Cancer
  • The purpose of this study is to determine the effectiveness of two anticancer drugs, everolimus and pasireotide, in patients with thyroid cancer when the cancer is no longer responding to treatment with radioiodine or where it is deemed unsafe for the patient to receive additional radioiodine treatment. (clinicaltrials.gov)
  • Additionally, the FDA has raised concerns over the lack of data to determine if the long-acting once-weekly version of exenatide (but not the twice-daily form of exenatide) may increase thyroid cancer risk. (wikipedia.org)
  • This concern comes out of observing a very small but nevertheless increased risk of thyroid cancer in rodents that was observed for another drug (liraglutide) that is in the same class as exenatide. (wikipedia.org)
  • The data available for exenatide showed less of a risk towards thyroid cancer than liraglutide, but to better quantify the risk the FDA has required Amylin to conduct additional rodent studies to better identify the thyroid issue. (wikipedia.org)
  • known
  • Levothyroxine, also known as L-thyroxine, is a manufactured form of the thyroid hormone, thyroxine (T4). (wikipedia.org)
  • The exact mechanism of the condition is not fully understood, though it is known to be tied to hormone levels, as the condition usually subsides after menopause and is also related to the menstrual cycle. (wikipedia.org)
  • symptoms
  • 10 mIU/L, people with elevated thyroid peroxidase antibody titers, people with symptoms of hypothyroidism and TSH levels between 5-10 mIU/L, and women who are pregnant or want to become pregnant. (wikipedia.org)
  • Post-menopausal women placed on hormone replacement therapy (HRT) have also reported symptoms of FBC indicating hormones may play a role. (wikipedia.org)
  • vitamin
  • In nature, β-carotene is a precursor (inactive form) to vitamin A via the action of beta-carotene 15,15'-monooxygenase. (wikipedia.org)
  • genes
  • In response, these receptors work with other proteins to regulate the expression of specific genes, thereby controlling the development, homeostasis, and metabolism of the organism. (wikipedia.org)
  • secondary
  • Eventually, the FSH level becomes so high that downregulation of FSH receptors occurs and by postmenopause any remaining small secondary follicles no longer have FSH nor LH receptors. (wikipedia.org)
  • cells
  • I also get into explaining how these Biotoxins latch on the Toll Receptor sites of fat cells and inappropriately trigger them to produce inflammatory Cytokine proteins. (biotoxinjourney.com)
  • expression
  • Over time, presumably driven by aberrant growth signals, such lesions may accumulate epigenetic, genetic and karyotypic changes such as modified expression of hormone receptors and loss of heterozygosity. (wikipedia.org)
  • high
  • Rather than starting with Dr. Shoemaker's 4th step of treating those people with AGA's or high TGF-beta 1 with a gluten free diet, I'm going to start by discussing Cytokines and show how they relate to Leptin, AGAs, and a few other inflammatory markers. (biotoxinjourney.com)
  • As it is a medical emergency with a high mortality rate, it should be treated in the intensive care unit with thyroid hormone replacement and aggressive management of individual organ system complications. (wikipedia.org)
  • alpha
  • The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of about 96 amino acids, while the beta subunits vary. (wikipedia.org)