• Thymidine kinase is a cellular enzyme involved in the salvage pathway of DNA-synthesis. (slu.se)
  • Thymidine kinase 1 (TK1) is regulated by the cell cycle and is located in the cytoplasm. (slu.se)
  • Thymidine kinase 1 activity is present in the early S-phase of cell division in normal cells. (slu.se)
  • Acyclovir is becomes acyclovir monophosphate due to the action of viral thymidine kinase. (nicaweb.com)
  • The cancer cells will uptake and immediately phosphorylated by thymidine-kinase to active monophosphate. (ijpsr.com)
  • To investigate the in vitro effects of suicide gene therapy system of herpes simplex virus thymidine kinase gene (HSV-TK) in combination with the treatment of nucleotide analog-ganciclovir (GCV) on human pancreatic cancer, and to provide a novel clinical therapeutic method for human pancreatic cancer. (wjgnet.com)
  • Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. (medicscientist.com)
  • Thymidine monophosphate (TMP), also known as thymidylic acid (conjugate base thymidylate), deoxythymidine monophosphate (dTMP), or deoxythymidylic acid (conjugate base deoxythymidylate), is a nucleotide that is used as a monomer in DNA. (wikipedia.org)
  • Thymidylate synthase is vital for de novo DNA synthesis, by catalyzing the transformation of deoxy-uridine monophosphate (dUMP) to deoxy-thymidine monophosphate (dTMP). (careersfromscience.org)
  • To become active and inhibit viral DNA synthesis acyclovir must be phosphorylated to acyclovir monophosphate by specific HSV-1 thymidine kinases (tk) and then phosphorylated to acyclovir triphosphate, the active form of acyclovir able to inhibit viral DNA-polymerases, by host cell kinases. (biomedcentral.com)
  • The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase and reverse transcriptase, consequently blocking the viral replication. (prosci-inc.com)
  • MTX blocks conversion of uridine to thymidine, one of the building blocks of DNA. (medscape.com)
  • Folinic acid provides a methyl group to uridine monophosphate, thus forming thymidine monophosphate, overcoming effects of MTX on tetrahydrofolic acid reductase. (medscape.com)
  • Explanation: Uridine monophosphate is present in RNA. (sanfoundry.com)
  • Inhibition of TS with the 5-FU metabolite fluorodeoxyuridine monophosphate continues to be identified as the primary system of 5-FU actions[9]. (careersfromscience.org)
  • Subsequently, TFD-triphosphate was formed by phosphorylation and it directly merges into the DNA of cancer cells in thymidine place leads to inhibition of DNA functioning, DNA production, and proliferation of cancer cells. (ijpsr.com)
  • Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. (prosci-inc.com)
  • It is an ester of phosphoric acid with the nucleoside thymidine. (wikipedia.org)
  • 4-Nitrophenyl thymidine-5′- monophosphate, ammonium salt Thymidine-5′-monophosphate-4-nitrophenyl ester ammonium salt MOLECULAR BIOLOGY GRADE Off white to light yellow crystalline powder Chromogenic substrate for Phosphodiesterase l, a marker enzyme for plasma. (gbiosciences.com)
  • Two other potential substrates, NADP+ and thymidine 5'-monophosphate p-nitrophenyl ester were only weakly inhibitory as was 1-hydroxyethylidene 1,1-bisphosphonate. (ox.ac.uk)
  • Dorland's Illustrated Medical Dictionary provides an explanation of the nomenclature variation at its entry for thymidine. (wikipedia.org)
  • Explanation: Thymidine monophosphate is present in DNA. (sanfoundry.com)
  • Together with other substrates and cofactors it is involved in the synthesis of the purine ring, 247-780-0 manufacture conversion of 2-deoxyuridine monophosphate to thymidine monophosphate, via nm) is usually selected to give the maximum absorption using the appropriate monochromator slit width. (bio2009.org)
  • Thymine, thymidine and thymidine 5'-monophosphate studied by femtosecond fluorescence upconversion spectroscopy T . Gustavsson, A. Sharonov, D. Markovitsi, Chem. (cea.fr)
  • It is an ester of phosphoric acid with the nucleoside thymidine. (wikipedia.org)
  • Herpesvirus TK (but not host cell TK) uses acyclovir as a purine nucleoside, converting it into acyclovir monophosphate, a nucleotide analogue. (medscape.com)
  • The major function of the pyrimidine nucleoside kinases is to maintain a cellular balance between the level of pyrimidine nucleosides and pyrimidine nucleoside monophosphates. (golifescience.com)
  • This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. (drugs.com)
  • The essential process of making one of these subunits, thymidine monophosphate (TMP), was thought to be similar for most living things, but scientists recently discovered that some bacteria and viruses use a different type of enzyme to perform this reaction. (stanford.edu)
  • The research group led by Prof. Amnon Kohen of the University of Iowa analyzed the reactions of the enzyme called flavin-dependent thymidylate synthase (FDTS), used by some pathogenic bacteria, to turn dexoyuridine monophosphate (dUMP) into TMP. (stanford.edu)
  • When ATP is absent from the enzyme, the enzyme appears as a dimer with low affinity for thymidine and when ATP is present the enzyme appears as a tetramer with high affinity for thymidine. (ruc.dk)
  • K, for thymidine for recombinant TKI and TKI-l93 incubated with ATP is 0.5 *O.l (mean +s.d., n = 3) pM, while enzyme incubated without ATP has a K, of 14.08 20.68 (n = 3) pM for TKI and 12.8 k0.65 (n = 3) ,uM for TKI-193. (ruc.dk)
  • Methotrexate: This drug inhibits the enzyme dihydrofolate reductase, which is involved in the synthesis of thymidine, one of the building blocks of DNA. (microbiologynote.com)
  • Azathioprine: This drug inhibits the enzyme inosine monophosphate dehydrogenase, which is involved in the synthesis of guanosine, another building block of DNA. (microbiologynote.com)
  • Its monophosphate form, guanosine monophosphate (GMP), when salted out, acts as a flavoring agent that imparts an umami taste. (biologywise.com)
  • An unchanged affinity for the natural substrate, thymidine, combined with a lower V,,, value suggest that the last 40 amino acids have a structural role or that the ATP binding is disturbed. (ruc.dk)
  • Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. (nih.gov)
  • Phosphate esters of THYMIDINE in N-glycosidic linkage with ribose or deoxyribose, as occurs in nucleic acids. (bvsalud.org)
  • In presence of UV light, this base forms dimers between two adjacent thymidine molecules along the DNA strand. (biologywise.com)
  • Dorland's Illustrated Medical Dictionary provides an explanation of the nomenclature variation at its entry for thymidine. (wikipedia.org)
  • Fluorouracil is inactive as such in mammalian cells but is converted into the active 5-fluorodeoxyuridine monophosphate (FdUMP) by a variety of different metabolic pathways. (medeasy.health)
  • We chose to concentrate on by far the most potent of these, clemastine, an low-cost, extensively available, over-the-counter antihistamine.Clemastine is a host-directed compound that needs host Thymidine-5′-monophosphate (disodium) salt Autophagy macrophages to lower bacterial growthWe found that clemastine consistently reduced mycobacterial development in vivo more than the course of a 5day infectio. (idhinhibitor.com)