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  • protein
  • As the purpose of this protein is to phosphorylate an unphosphorylated thymidine (dT), one of the most important abilities of TK is its ability to bind ATP as a substrate and eventally catalyze the transfer of a phosphate group from ATP to thymidine. (kenyon.edu)
  • p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. (wikipedia.org)
  • HeLa
  • Extracts from uninfected HeLa cells produced five in vitro transcripts, one of which initiated at the in vivo start site for the thymidine kinase mRNA (an early viral message). (pnas.org)
  • substrate
  • Neither compound was a substrate of recombinant human thymidine phosphorylase nor were their respective 5′-monophosphates substrates of 5′-deoxynucleotidase 1, thereby indicating potential in vivo stability. (aacrjournals.org)
  • increases
  • 5'-Aminothymidine, a non-toxic analogue of thymidine, interferes with this regulatory mechanism and thereby increases the cytotoxicity of thymidine analogues used as antineoplastic drugs. (wikipedia.org)
  • binding site
  • As the subunits are identical and it has been found that the monomers are individually active, further exploration of the active binding site of thymidine kinase will be conducted using only a single subunit for ease of visualization. (kenyon.edu)
  • Protein
  • The effect of PI3'K was mediated via 70 kDa S6 kinase and protein kinase B, which showed maximum activation in the presence of 3-6 mM glucose. (bioscientifica.com)
  • Protein kinase C was essential for HGF-induced INS-1 cell proliferation. (bioscientifica.com)
  • Additionally, DPM down-regulated the mRNA and protein expression of jejunal Na(+)/glucose cotransporter, Na(+)/K(+)-ATPase and glucose transporter 2, and enhanced the activities as well as mRNA and protein levels of hepatic glycolysis enzymes (glucokinase, phosphofructokinase, private kinase and pyruvate decarboxylas E1). (jove.com)
  • In individuals treated with the DNA polymerase inhibitors acyclovir or ganciclovir, HSV or CMV particles can develop mutant protein kinases (thymidine kinase or UL97 protein kinase, respectively) that make them resistant to these antiviral drugs. (wikipedia.org)
  • However, unlike acyclovir and ganciclovir, foscarnet is not activated by viral protein kinases, making it useful in acyclovir- or ganciclovir-resistant HSV and CMV infections. (wikipedia.org)
  • p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. (wikipedia.org)
  • cell
  • Вид документа : Однотомное издание Шифр издания : Автор(ы) : He, Qimin Заглавие : Thymidine kinase in experimenital oncology : A study of cell growth after X-irradiation, hyperthermia a. drug-treatment1 Выходные данные : Stockholm, 1990 Колич.характеристики :Разд. (worldwidescience.org)
  • The second route is used by the cell under normal conditions, and it is sufficient to supply thymidine monophosphate for DNA repair. (wikipedia.org)
  • Distribution
  • Distribution of kinase and deaminase of 1-beta-D-arabinofuranosylcytosine in tissues of man and mouse. (semanticscholar.org)
  • Uptake and distribution of 3-H-thymidine in plerocercoids of Diphyllobothrium dendriticum (Cestoda) during short-time incubations Acta Academiae Aboensis. (worldwidescience.org)
  • Вид документа : Однотомное издание Шифр издания : K Автор(ы) : Wikgren B.-J, Lindroos P, Lindell L Заглавие : Uptake and distribution of 3-H-thymidine in plerocercoids of Diphyllobothrium dendriticum (Cestoda) during short-time incubations Выходные данные : Abo, 1984 Колич.характеристики :6 с Серия: Acta Academiae Aboensis. (worldwidescience.org)