Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. (jscientia.org)
Thromboxane B2 (TxB2) levels were significantly reduced in the NCM from both human and rabbit cells exposed at 1 ppm. (cdc.gov)
Prostaglandin1
A tendency towards increased plasma 6-keto-prostaglandin F1 alpha concentration and decreased serum thromboxane B2 concentration was found during the period of regular exercise, but prostaglandin E2 concentrations remained unchanged. (nih.gov)
Leukotriene3
Leukotriene B4, thromboxane B2, and inflammatory products also have been discovered within herniated human disks after surgery. (medscape.com)
1 Another example: inflammation is increasingly linked to chronic disease, but research shows that omega-3 fats play important roles in reducing inflammation by lowering the concentration of pro-inflammatory eicosanoids such as thromboxane B2 and leukotriene B4. (nutritionaloutlook.com)
Urinary thromboxane B2 as an indicator of acute rejection in lung allotransplantation. (medigraphic.com)
Urinary thromboxane B2 excretion during acute rejection in cyclosporine treated experimental lung allotransplantation. (medigraphic.com)
As a marker of in vivo thromboxane generation, high-level urinary thromboxane metabolites (TXA-M) increase the occurance of cardiovascular events in high-risk patients. (chronicinflammationtest.com)
In stable moderate-severe COPD, elevated urinary11dTxB2, a metabolite of the platelet activation product thromboxane A2, was associated with worse respiratory symptoms, health status, and quality of life. (copdfoundation.org)
Platelets1
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). (wikipedia.org)
Aspirin1
There is a variable cardiovascular risk reduction attributable to aspirin because of individual differences in the suppression of thromboxane A 2 and its downstream metabolite 11-dehydrothromboxane B 2 (11dhTxB2). (chronicinflammationtest.com)
Former smokers with spirometry-confirmed COPD had urine 11-dehydro-thromboxane B2 (11dTxB2), plasma soluble CD40L (sCD40L), and soluble P-selectin (sP-selectin) repeatedly measured during a 6- to 9-month study period. (copdfoundation.org)
Inactive1
Thromboxane B2 is the inactive product of thromboxane . (wikidoc.org)
Coronary1
Long-term nonplatelet thromboxane generation after coronary artery bypass graft surgery is a novel risk factor for 5-year adverse outcome, including death. (chronicinflammationtest.com)
Patients1
Urinary 11-dehydro-thromboxane (TX)B 2 has been described as a potential predictive biomarker of major adverse cardiovascular events (MACEs) in high cardiac risk patients. (chronicinflammationtest.com)
Urinary 11-dehydro-thromboxane B 2 levels are associated with vascular inflammation and prognosis in atherosclerotic cardiovascular disease. (chronicinflammationtest.com)
Clinical1
In contrast, nonplatelet thromboxane generation in the early postoperative period appears to be dirven predominantly by inflammation and did not independently predict long-term clinical outcome. (chronicinflammationtest.com)
Significant1
No significant thromboxane B 2 was detected. (nyu.edu)
Inhibition5
According to study authors, inhibition of serum thromboxane B2 formation and platelet aggregation by ASA was blocked when a single daily dose of ibuprofen was given before ASA, as well as when multiple daily doses of ibuprofen were given around the clock irrespective of the timing of ASA administration. (medscape.com)
As a result of the inhibition, the production of thromboxane B2 and P-selectin expression were suppressed by 35 % (P (usda.gov)
BACKGROUND: The antithrombotic efficacy of aspirin is attributed to its inhibition of the enzyme prostaglandin G/H synthase, which is necessary for the formation of thromboxane A2 in platelets. (ox.ac.uk)
RESULTS: Steady-state inhibition of serum thromboxane B2 required two to four days and appeared slower with 75 mg of controlled-release than with the same amount of immediate-release aspirin. (ox.ac.uk)
CONCLUSIONS: Maximal inhibition of platelet thromboxane A2 production was sustained during long-term dosing with controlled-release aspirin, whereas basal prostacyclin biosynthesis fell only slightly and systemic synthesis of prostacyclin stimulated by bradykinin was preserved. (ox.ac.uk)
Prostacyclin7
Cadmium and glutathione: effect on human placental thromboxane and prostacyclin production. (nih.gov)
Cadmium toxicity, noted in rodents during late gestation, has been compared with preeclampsia, a condition associated with an imbalance between thromboxane A2 and prostacyclin. (nih.gov)
Sulfhydryl concentrations have been shown to affect thromboxane and prostacyclin production, and glutathione binds to cadmium reducing its toxicity. (nih.gov)
This study indicates that acute exposure to cadmium at high concentrations directly affects the placental production of 6-keto-PGF1 alpha, disturbing the thromboxane A2/prostacyclin ratio. (nih.gov)
We wanted to see whether controlled-release aspirin would affect the formation of thromboxane A2 but not prostacyclin by reducing the aspirin concentration that reaches the posthepatic circulation. (ox.ac.uk)
The effects of the controlled-release preparation on plasma levels of aspirin and salicylate, serum levels of thromboxane B2, and urinary dinor metabolites of prostacyclin and thromboxane B2 (measured by gas chromatography-mass spectrometry) were compared with those of conventional immediate-release aspirin in normal volunteers. (ox.ac.uk)
Urinary3
Effect of low-dose aspirin on urinary 11-dehydro-thromboxane B2 in the ASCEND (A Study of Cardiovascular Events iN Diabetes) randomized controlled trial. (bvsalud.org)
4. Urinary 11-dehydro-thromboxane B2 is associated with cardiovascular events and mortality in patients with atrial fibrillation. (nih.gov)
It was found that the group treated with curcumin experienced reduced symptoms of depression and elevation of urinary thromboxane B2 and substance P while the control group did not. (tissuerecovery.com)
Leukotriene B41
Leukotriene B4, thromboxane B2, and inflammatory products also have been discovered within herniated human disks after surgery. (medscape.com)
Serum2
The cardioprotective effects of ASA stem from its ability to inhibit serum thromboxane B2 formation and platelet aggregation, and this beneficial effect stems from ASA's irreversible blockade of an active site on the platelet COX-1 enzyme. (medscape.com)
As expected, platelet activation (measured by thromboxane B2 levels) was higher in serum than plasma or PPP and increased progressively with clotting time. (nih.gov)
Synthesis3
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). (wikipedia.org)
The authors suggested that the effects of ethanol could be due to improved transport of the dihomo-gamma-linolenic acid to the active site of the cyclooxygenase enzyme required to catalyse the synthesis of prostaglandins and thromboxanes. (rdbnutrition.com)
This article is an open access write-up distributed under the terms and conditions in the Inventive Commons Thromboxane B2 custom synthesis Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).Materials 2021, 14, 6376. (calcium-channel.com)
Excretion2
The kinetics of the macrophage invasion temporally correlates with both the decline in glomerular filtration rate and enhanced thromboxane B2 excretion. (figshare.com)
Total body irradiation of rats prior to the onset of obstruction so as to prevent the leukocyte infiltrate in the kidney, both reduces thromboxane B2 excretion and significantly improves renal haemodynamics after release of 24 hours of obstruction. (figshare.com)
Tumor1
Also, Mr. Pender falsified data from experiments with thromboxane B2 and tumor necrosis factor alpha that were published and distributed in an abstract entitled "Antisense Oligonucleotide to G Protein Inhibits Endotoxin Stimulated Thromboxane (Tx) B2 production" (Supplement to Shock 7:20, 1997). (nih.gov)
Concentration1
Thromboxane B2 concentration in coronary sinus blood plasma increased by 132-176% (P less than 0.05) at peak leukotriene effects on blood flow. (nih.gov)
Synthase1
Our data showed that the expressions of thromboxane A synthase 1 (TBXAS1), thromboxane synthase (TXS), and thromboxane B 2 (TXB 2 ) were increased in the upper quartile of platelet aggregation (LTA-AA_Q4) group compared with the lower quartile of platelet aggregation (LTA-AA_Q1) group. (nih.gov)
Calcium1
The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. (ox.ac.uk)
Production1
This implies that infiltrating leukocytes contribute to the decline in glomerular filtration rate and renal plasma flow seen after obstruction, possibly via the production of vasoactive prostanoids such as thromboxane A2. (figshare.com)