• The biological target of thioacetazone has proven elusive and its mechanism of action remains unknown, although it is thought to interfere with mycolic acid synthesis. (wikipedia.org)
  • Use of thioacetazone is declining because it can cause severe (sometimes fatal) skin reactions in HIV positive patients. (wikipedia.org)
  • Thioacetazone (INN, BAN), also known as amithiozone (USAN), is an oral antibiotic which is used in the treatment of tuberculosis. (wikipedia.org)
  • Second series antituberculosis pro-drugs as thioacetazone that is useful in stopping resistance to better drugs such as for example?isoniazid, isoxyl (thiocarlide) that's effective against multi-drug resistant strains, ethionamide (ETH) and prothionamide (Fig.?1) [11C17], were utilized to inspire the buildings of our brand-new thiourea derivatives, as well as their mode of actions. (bio-cavagnou.info)
  • Cross-resistance has been reported in vitro with isoniazid or with thioacetazone. (gullerupstrandkro.dk)
  • There is no advantage to using thioacetazone if the regimen used already contains ethambutol, but many countries in sub-Saharan Africa still use thioacetazone because it is extremely cheap. (wikipedia.org)