Upon treatment of the human estrogen receptor with the cysteine modification agents p-chloromercuribenzoic acid (PCMB) and N-ethylmaleimide (NEM), the tyrosine modification agents N-acetylimidazole (NAcI), p-nitrobenzenesulfonyl fluoride (NBS), and tetranitromethane (TNM), the serine modification agents phenylmethanesulfonyl fluoride (PMSF), and diisopropyl fluorophosphate (DFP), or the histidine modification agent diethylpyrocarbonate (DFP), specific ({dollar}\sp3{dollar}H) estradiol binding to both the native, untreated receptor and trypsin-treated receptor was inhibited. (umaryland.edu)
Laboratory1
In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and Phl p 5 modified with tetranitromethane (laboratory studies), peroxynitrite (physiological processes), and ozone and nitrogen dioxide (environmental conditions). (feedspot.com)
Explosive2
Tetranitromethane can be used as a component of highly explosive liquid explosives as an oxidizing agent. (wikipedia.org)
Even small impurities make tetranitromethane an explosive that explodes on impact or friction. (wikipedia.org)