• SSCs
  • Based on these findings we propose that the deregulation of somatic and germ cell genes in the cryptorchid testis, directs the SSCs towards the differentiation pathway. (fiu.edu)
  • During foetal development gonocytes develop from primordial germ cells and following this SSCs develop from gonocytes in the testis. (wikipedia.org)
  • One SSC is the precursor for multiple spermatozoa and therefore SSCs are much less numerous in the testes than cells undergoing spermatogenesis. (wikipedia.org)
  • Sertoli
  • The expression of the Sertoli cell FGF2 gene required for SSC maintenance was significantly reduced in mutant testis. (fiu.edu)
  • Chemokine (C-X-C motif) ligand 12 (CXCL12) signaling via its receptor C-X-C chemokine receptor type 4 (CXCR4) is also involved in regulation of SSC fate decisions.CXCL12 is found in Sertoli cells in the basement membrane of the seminiferous tubules in adult mouse testes, and its receptor is expressed in undifferentiated spermatogonial cells. (wikipedia.org)
  • The SSC niche is found in the seminiferous epithelium of mammalian testis, and is primarily constituted of Sertoli and peritubular myoid cells. (wikipedia.org)
  • tests
  • This study tests a new simple machine which may quickly and easily diagnose torsion, potentially decreasing unnecessary surgeries and saving torsed testes by decreasing the time to diagnosis and corrective surgery. (grantome.com)
  • cells
  • In 1974, Lawrence Einhorn, MD, IU Distinguished Professor, Livestrong Foundation Professor of Oncology, and professor of medicine, tested cisplatin with two additional drugs that were effective in killing testis cancer cells. (iu.edu)
  • The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXF" by Lydia Ferguson, Javier J. How et al. (fiu.edu)
  • The PLZF+ cells did not show a higher rate of apoptosis in cryptorchid testis. (fiu.edu)
  • Ferguson L, How JJ, Agoulnik AI (2013) The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice. (fiu.edu)
  • This factor is thought to be expressed in the peritubular cells in human testes. (wikipedia.org)