Telomere shortening. Medical search. Frequent questions

Telomerase is the enzyme that repairs shortened or dysfunctional telomeres, and various telomerase-activating drugs are under development, with some success as recent work on blood disorders has shown ( read more ). (meresearch.org.uk)
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. (meresearch.org.uk)
In iPSCs from patients with heterozygous mutations in TERT, the telomerase reverse transcriptase, a 50% reduction in telomerase levels blunts the natural telomere elongation that accompanies reprogramming. (nih.gov)
In contrast, mutation of dyskerin (DKC1) in X-linked dyskeratosis congenita severely impairs telomerase activity by blocking telomerase assembly and disrupts telomere elongation during reprogramming. (nih.gov)
In iPSCs from a form of dyskeratosis congenita caused by mutations in TCAB1 (also known as WRAP53), telomerase catalytic activity is unperturbed, yet the ability of telomerase to lengthen telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iPSCs. (nih.gov)
This cell line is characterised by a lack of telomere shortening (and hence, constant telomere length) during cell division due to overexpression of telomerase 4 . (ersjournals.com)
This strategy is being pursued by the Telomeres and Telomerase Group of the Spanish National Cancer Research Centre (CNIO), which has already succeeded to cure pulmonary fibrosis and infarctions in mice by lengthening telomeres. (cnio.es)
These results show the important role short telomeres play in its development, and this finding undoubtedly opens new doors for the treatment of renal fibrosis," says the first author of the study, Sarita Saraswati , a researcher with the Telomeres and Telomerase Group at CNIO. (cnio.es)
Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. (ca.gov)
Telomerase mutations and significantly shortened chromosomal telomeres have recently been implicated in human lung pathologies. (ca.gov)
However, the impact of shortened telomeres and telomerase dysfunction on the ability of lung cells to respond to significant challenge is still largely unknown. (ca.gov)
To determine the role telomerase plays when the lung is challenged, B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres and wild-type controls were subjected to partial pneumonectomy. (ca.gov)
We conclude that functional telomerase and properly maintained telomeres play key roles in both long-term survival and the early phase of compensatory lung growth following partial pneumonectomy. (ca.gov)
An enzyme called telomerase can slow, stop or perhaps even reverse the telomere shortening that happens as we age . (answers.com.tn)
Telomerase maintains and may even lengthen telomeres. (answers.com.tn)
Telomeres and Telomerase in Eukaryot. (thelongevityrevolution.tv)
Humans and all other mammals have an enzyme known as telomerase that can lengthen the telomere ends and thus slow down the loss of telomere base pairs. (thelongevityedge.com)
But in any case, the normal activity of telomerase is not sufficient to mitigate against the inevitable loss of telomere base pairs and the resulting senescence or apoptosis (programmed death) of our cells. (thelongevityedge.com)
The search of a safe compound that activates telomerase in humans has been going on for just over a decade now, paralleling other scientific research in the new field of telomere biology. (thelongevityedge.com)
Telomeres and telomerase are at the crux of human aging and telomere centric products like IEP offer the only current opportunity to delay our own meeting with the Grim Reaper. (thelongevityedge.com)
After each cell division, the telomeres become shortened and an enzyme known as telomerase adds more DNA to keep the telomeres intact. (theprimalmind.com)
In effect, the telomere/telomerase system is one of the major mediators of health and disease throughout the lifespan. (theprimalmind.com)
Once the telomeres are shortened, the damage is done, although there have been promising attempts to stimulate telomerase activity in adults through mindfulness meditation and lifestyle factors such as a healthy diet and nurturing relationships. (theprimalmind.com)
Medical researchers have stopped a form of blood cancer in its tracks in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres. (sciencedaily.com)
Telomerase helps maintain the caps or ends of chromosomes called telomeres, which shrink each time a cell divides and eventually - when the chromosomes get too short - force the cell to essentially commit suicide. (sciencedaily.com)
The first generation pups born to these mice contained no telomerase and very long telomeres. (sciencedaily.com)
The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)
While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. (goodreads.com)
In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. (goodreads.com)
Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
With each round of cell division, the length of telomeres is shortened and the enzyme telomerase compensates by maintaining telomere length in germline and stem cells. (medscape.com)
Because telomeres function to maintain chromosomal stability, telomerase has a critical role in preventing cellular senescence and cancer progression. (medscape.com)

For example, telomere length is positively linked with nutritional status in human and animal studies ( see a review ), possibly through the effects of various nutrients on reducing inflammation and oxidative stress, and a study in 2013 found that lifestyle changes (a plant-based diet, moderate exercise, stress reduction and weekly group support) increased telomere length by about 10% in men with prostate cancer. (meresearch.org.uk)

they shorten every time a cell divides - human blood cells shorten by 30−70 base pairs per year on average. (meresearch.org.uk)
However, every time a cell divides, telomeres become a little shorter. (gowinglife.com)
The telomeres shorten each time a cell divides to make new cells, until they reach a critical short length and the cells enter an inactive state and then die. (medindia.net)
Telomeres provide a buffer that grows shorter every time a cell divides. (cdc.gov)
Every time a cell divides, the telomeres shorten a bit. (msdmanuals.com)

One group at the University of Texas Medical Branch at Galveston correlated short fetal leukocyte telomere length with preterm prelabor rupture of the membranes and characterized the phenomenon as a "placental membrane disease likely mediated by oxidative stress-induced senescence. (theprimalmind.com)
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. (theprimalmind.com)
Short fetal leukocyte telomere length and preterm prelabor rupture of the membranes. (theprimalmind.com)
Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2000. (cdc.gov)
Methods: Average leukocyte telomere length was estimated by quantitative PCR on a sample of 677 women selected for a study of biomarkers and perceived stress in the NIEHS Sister Study cohort (median age 55, range 35-75). (cdc.gov)
Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? (cdc.gov)
The objective was to assess the moderation effect of accelerometer-based physical activity (aPA) on the association between shorter leukocyte telomere length (LTL) relatively in the population sample and incident CHD. (bvsalud.org)
The objective of this study was to assess associations of leukocyte telomere length (TL) with AD/ADRD and early markers of AD/ADRD, including cognitive performance and brain magnetic resonance imaging (MRI) phenotypes. (bvsalud.org)

Telomere length is, therefore, a marker of cell ageing and senescence 5 . (ersjournals.com)
In any case, 'these results support the notion that critical telomere shortening and the consequent onset of telomeric DNA damage and cellular senescence are a general determinant of species life span. (gowinglife.com)
Here we describe how telomere length regulates gene expression long before telomeres become short enough to produce a DNA damage response (senescence). (hal.science)
Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual. (answers.com.tn)
This study uncovers a new mechanism linking oxidative stress to telomere-driven senescence. (nature.com)
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. (sens.org)
Telomeres and Cell Senescence - Size Matters Not. (sens.org)
Figure 2: Telomere-dependent senescence. (nature.com)
Telomeres are critical for cellular replicative potential and their shortening is a marker of cellular senescence and aging process. (penta-id.org)
Objectives: Telomeres are protective DNA sequences on the ends of chromosomes, which can shorten with repeated cell replication and contribute to senescence. (cdc.gov)
Numerous factors localize at telomeres to regulate their length, structure and function, to avert replicative senescence or genome instability and cell death. (cdc.gov)
My research encompasses theoretical, methodological and empirical studies related to various eco-immunological issues such as the identification and quantification of immune costs (both in terms of physiology and Darwinian fitness), direct and long-term (hidden) costs of infection (telomeres and senescence), sexual selection and honest signaling, sexually antagonistic selection (e.g. on immune gene (MHC) diversity and immunity effects of maternal programming (antibody and hormone transfer to offspring). (lu.se)
Hidden costs of infection: chronic malaria accelerates telomere degradation and senescence. (lu.se)

From each sample, relative telomere length was measured using real-time PCR. (meresearch.org.uk)
Telomere length was determined as relative telomere length (RTL) by comparison with an internal cell line control (1301 cells) 4 . (ersjournals.com)
The relative telomere length in SM-exposed individuals was found to be significantly shorter than the non-exposed individuals. (northumbria.ac.uk)
HIV-DNA copies on CD4 cells and relative telomere length and levels of T-cell receptor rearrangement excision circle (TREC, marker of thymic output) on CD4 and CD8 cells were quantified by qPCR. (penta-id.org)

the higher the cellular oxidative stress levels the greater the degree of shortening ( read more ). (meresearch.org.uk)
Given that ME Research UK-funded work has found high levels of oxidative stress and associated arterial stiffness to be a feature in ME/CFS patients ( read more ), it may be that telomere shortening is intimately linked with ongoing inflammatory processes. (meresearch.org.uk)
A common oxidative lesion at telomeres causes rapid premature cellular aging by inducing telomere fragility, rather than telomere shortening. (nature.com)
Oxidative stress, mutations in DNA repair genes and epimutaions may be among the major mechanisms of telomere attrition. (northumbria.ac.uk)
One target of oxidative stress is telomeres, nucleoprotein complexes at the end of chromosomes that shorten at each cell division. (jsce-ip.com)
Short telomeres are also sign of oxidative stress in the womb, whether caused by maternal psychological stress or other stressors. (theprimalmind.com)
Together they inflicted oxidative damage to the chromosomes' protective endcaps - called telomeres. (cmu.edu)
Telomere shortening and chronic diseases could be caused by the same cell-damaging processes, such as oxidative stress and inflammation. (cdc.gov)
[ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)

Telomere attrition was also accelerated in cell populations from magnesium-deficient cultures. (wellnessresources.com)
Previous human studies of telomere attrition were predominantly conducted on leukocytes. (columbia.edu)
In conclusion, calorie restriction-triggered nitric oxide provides antioxidative protection and alleviates telomere attrition via mitochondrial biogenesis, thereby maintaining chromosomal stability and integrity, which are the hallmarks of longevity. (peerj.com)
In addition, telomere shortening covaried with the stress response: a delayed activation of the negative feedback loop terminating the stress response was associated with greater telomere attrition. (jsce-ip.com)
Telomere attrition is one of biological aging hallmarks and may be intervened to target multiple aging-related diseases, including Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). (bvsalud.org)

Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. (sciencedaily.com)
We directly mapped the interactions adjacent to specific telomere ends using a Hi-C (chromosome capture followed by high-throughput sequencing) technique modified to enrich for specific genomic regions. (hal.science)
We demonstrate that chromosome looping brings the telomere close to genes up to 10 Mb away from the telomere when telomeres are long and that the same loci become separated when telomeres are short. (hal.science)
At least a few hundred nucleotides of telomere repeats must « cap » each chromosome end to avoid activation of DNA repair pathways. (answers.com.tn)
Telomeres are cap- like structures at chromosome ends that play an important role in ageing and in the initiation and progression of various diseases. (medindia.net)
Telomeres are short strands of DNA at the end of each chromosome that protect the chromosomes from deterioration or from fusing with other chromosomes. (theprimalmind.com)
Telomeres are a protective nucleoprotein structure at each chromosome end. (cdc.gov)
Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. (goodreads.com)
Other research themes are molecular and genomic ecology, e.g. immune gene evolution, telomere ecology and sex chromosome evolution in birds. (lu.se)

At present, scientists are exploring interventions to lengthen telomeres. (meresearch.org.uk)
Study co-author Helen Blau adds: "Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life. (answers.com.tn)
It is the first controlled trial to show that any intervention might lengthen telomeres over time. (answers.com.tn)
What would happen if we could stop telomeres from shortening or maybe even lengthen them in spite of advancing chronological age? (thelongevityedge.com)
Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. (cdc.gov)

Here, we investigated the impact of shortened telomeres in a mouse model for Barrett esophagus (L2-IL1B). (oncotarget.com)

These include dysfunctional telomeres, DNA damage, the expression of certain oncogenes, perturbations to chromatin organization and strong mitogenic signals. (nature.com)
In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)

Additionally, we confirmed by in situ analysis (3D-FISH [three-dimensional fluorescence in situ hybridization]) that chromosomal looping occurs between the loci of those genes and their respective telomere ends. (hal.science)
With the help of telomere testing at Dr. Avi Ishaaya Centers, Dr. Ishaaya can analyze any chromosomal changes that can lead to decreased health or shorter life. (aviishaaya.com)
At Dr. Avi Ishaaya Centers, we can determine how to help you strengthen your telomeres, which help combat chromosomal aging. (aviishaaya.com)
The longer a person's telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality. (cdc.gov)

Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood. (theprimalmind.com)
Results: Currently holding a full-time job and years of full-time work were significantly associated with shorter telomere length (b =20.003 per year, p = 0.002) independent of the effects of age (b =20.006 per year, p,0.0001). (cdc.gov)

There are species with very long telomeres that are short-lived and vice versa. (gowinglife.com)
While short telomeres do lead to health problems, long telomeres lead to health problems of their own. (cdc.gov)
Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease. (cdc.gov)

While global chromatin conformation studies are emerging, very little is known about the chromatin conformation of human telomeres. (hal.science)
The researchers realized that a key difference between humans and mice is the length of each species' telomeres: Human telomeres are relatively short at 5-15 kilobases, but mice have telomeres approaching 40 kilobases. (defytime-emea.com)

Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. (ersjournals.com)
Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes, which shorten with age in all replicating somatic cells 3 , 4 . (ersjournals.com)
So, what if it were possible to treat them by acting on the causes of ageing or, more specifically, by acting on the shortening of telomeres, the structures that protect chromosomes? (cnio.es)
Telomeres are structures at the ends of chromosomes that function to protect genes. (gowinglife.com)
Telomeres Increasingly Develop Aberrant Structures in Aging Humans. (sens.org)
Feb. 27, 2019 The tips of our chromosomes have structures called telomeres that prevent our genetic material from unfolding. (sciencedaily.com)
Telomeres are structures at the ends of chromosomes that contain repetitive stretches of DNA. (cdc.gov)

Overall, telomere lengths were found to be significantly longer in the healthy controls than in the Fukuda 1994 CFS patients or in the group of 'fatigue' patients, and these differences remained significant after statistical adjustment for differences between groups. (meresearch.org.uk)
But, individuals are born with different telomere lengths and the rate at which they subsequently shorten can also vary. (medindia.net)
The research team measured telomere lengths in over 48,000 individuals and looked at their DNA and identified seven genetic variants that were associated with telomere length. (medindia.net)
We had previous evidence that shorter telomere lengths are associated with increased risk of coronary artery disease but were not sure whether this association was causal or not. (medindia.net)
But cardiomyocytes divide infrequently, and their telomere lengths remain relatively stable throughout one's life. (defytime-emea.com)
In this study, lymphocytic telomere lengths and serum levels of isoprostane F2α were measured using q-PCR and enzyme immunoassay-based methods in 40 Iranian veterans who had been exposed to SM between 1983-88 and 40 non-exposed healthy volunteers. (northumbria.ac.uk)
For example, recent data suggest that the lengths of telomeres, the DNA sequences at the ends of our chromosomes that shorten with aging, might be associated with COPD. (medlineplus.gov)

Improved quality of life and reduced stress response was associated with changes in telomere length," Nelson said. (sciencedaily.com)
Very few studies have actually followed people over time to see how changes in telomere length correlated with survival. (cdc.gov)

We embarked on the first study of telomere length and chronic stress in a cancer population and the first longitudinal analysis in whether changes in quality of life and changes in the stress response would be associated with modulating the telomere length," he said. (sciencedaily.com)

Extended culture of DKC1-mutant iPSCs leads to progressive telomere shortening and eventual loss of self-renewal, indicating that a similar process occurs in tissue stem cells in dyskeratosis congenita patients. (nih.gov)

Also, statins seem to have a protective role against telomere shortening, and lifestyle factors may have an important role to play. (meresearch.org.uk)
Thus, the aim of this study was to evaluate the protective role of Se against heavy metal-induced TL shortening. (nih.gov)
Our study indicated a protective effect of Se against the TL shortening induced by heavy metal exposure, where the effect sizes were smaller after adjusting for the Se level, compared to individual metal exposure. (nih.gov)
Eat a telomere-protective diet. (answers.com.tn)
A telomere is a DNA sequence that serves as a protective cap on the ends of chromosomes. (defytime-emea.com)
Background: There is consistent evidence of the potential benefits of lithium attenuating mechanisms of neurodegeneration, including those related to the pathophysiology of Alzheimer's disease (AD), and facilitating neurotrophic and protective responses, including maintenance of telomere length. (mdpi.com)
The aim was to investigate the protective effect of the pre-treatment with lithium on amyloid-beta (Aβ)-induced toxicity and telomere length in neurons. (mdpi.com)
Nov. 13, 2019 Loops at the ends of telomeres play a vital protective role preventing damage to chromosomes, according to new research. (sciencedaily.com)
These telomeres act as protective caps, similar to the plastic nib at the end of a shoelace. (healthnews.com)

Dyskeratosis congenita is characterized by defective maintenance of blood, pulmonary tissue and epidermal tissues and is caused by mutations in genes controlling telomere homeostasis. (nih.gov)
You want these telomeres to be strong and healthy, so they can properly fight any mutations or degeneration. (aviishaaya.com)
When telomeres shorten, it tells your cells to regenerate less healthy ones and to produce mutations that can lead to cancer development. (aviishaaya.com)
Chang compared the telomere length in cardiomyocytes from 11 patients with dilated or hypertrophic cardiomyopathy due to genetic mutations with nine people who had died from causes unrelated to heart disease. (defytime-emea.com)
In a small number of individuals with dyskeratosis congenita, mutations in other genes involved with telomere maintenance have been identified. (medlineplus.gov)
In addition to the mutations that directly effect telomere length, recent studies also indicate that a DKC diagnosis should not be based solely on the length of the telomere, but also the fact that there are defects in telomere replication and protection. (medscape.com)

Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length. (sciencedaily.com)
However, it is still unclear whether lead exposure affects telomere length. (bmj.com)

Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19-77 years). (columbia.edu)

The project studied a feature of chromosomes called telomeres. (medindia.net)

Some of the biggest factors for telomere shortening are genetics and stress. (aviishaaya.com)
Normally, when telomeres get critically short, the cell commits suicide as a means of protecting the body," says Carol Greider, Ph.D., the Daniel Nathans chair of molecular biology and genetics at Johns Hopkins. (sciencedaily.com)
A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer. (cdc.gov)
Genetics of human telomere biology disorders. (cdc.gov)

A number of proteins shown to associate with the ends of telomeres are involved in modulating TERRA transcription levels within cells. (wikipedia.org)

Most studies have focused on the role of telomeres as a tumor suppressor mechanism. (hal.science)
The Role of Telomeres in Human Disease. (cdc.gov)

We may be barking up an artificial tree when we make these associations between telomeres and incidental findings such as cadmium levels, to say nothing of equating shortened telomeres to aging. (telomeretimebombs.com)
This has resulted in the formulation of a multitude of, often name-given, hypotheses related to the associations between telomeres and life-history traits or fitness-facilitating processes (and the mechanisms underlying them). (lu.se)

Relative TL was calculated as the ratio of telomere genes to single-copy genes. (nih.gov)
So we specifically looked for alterations in the expression of genes involved in the epithelial-to-mesenchymal transition in our mice with short telomeres and renal fibrosis, to see if short telomeres could be the trigger for the changes in expression of these genes," explains Blasco. (cnio.es)
In these cases, the cause of the disorder is unknown, but other unidentified genes related to telomere maintenance are likely involved. (medlineplus.gov)

However, if mice with short telomeres were exposed to low doses of a kidney toxin, they did develop kidney fibrosis. (cnio.es)
The toxin administered -folic acid- "is not sufficient to induce fibrosis in healthy mice, but it acts synergistically with short telomeres," the paper explains. (cnio.es)
In B6.Cg-Terc(tm1Rdp) mice carrying shortened telomeres, response to pneumonectomy was characterized by decreased survival, diminished compensatory lung growth, attenuated distal lung progenitor cell response, persistent DNA damage, and cell growth arrest. (ca.gov)
In the second generation (G2) of mTERC knockout L2-IL1B.mTERC −/− G2 mice exhibited telomere dysfunction with significantly shorter telomeres as measured by qFISH compared to L2-IL1B mice, correlating with stronger DNA damage in the form of phosphorylation of H2AX (γH2AX). (oncotarget.com)
When the investigators introduced a second mutation in the mice that reduced telomere length to more closely match that of humans, the animals began to display the typical symptoms of the disease, including heart failure. (defytime-emea.com)
A subsequent study in the Blau lab found that, in mice, telomere shortening triggered a DNA-damage response that compromised the function of the cells' energy generators, or mitochondria. (defytime-emea.com)
By the fifth generation, the researchers discovered that the mice had short telomeres and stopped developing lymphomas. (sciencedaily.com)

As DNA cannot be changed by lifestyle or environmental factors, an association of these genetic variants which affect telomere length with a disease also would suggest a causal link between telomere length and that disease. (medindia.net)
Hence, among-individual variation in stress response may affect telomere dynamics. (jsce-ip.com)

Of note, differentiated goblet cells retained longer telomeres than columnar lined BE epithelium. (oncotarget.com)
A small pilot study shows for the first time that changes in diet , exercise, stress management and social support may result in longer telomeres, the parts of chromosomes that affect aging. (answers.com.tn)

Telomeres are 'caps' of DNA and protein located at the end of chromosomes to protect them from deteriorating or becoming fused with other chromosomes when cells are dividing. (meresearch.org.uk)
Telomere length shortens with age in all replicating somatic cells. (ersjournals.com)
Briefly, a suspension containing a mixture of 2×10 6 lymphocytes and 2×10 6 of 1301 cells was denatured at 82°C for 10 min, with and without the fluorescein-conjugated PNA telomere probe in the hybridisation solution. (ersjournals.com)
We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. (columbia.edu)
In addition, pilot studies of human BE-, dysplasia- and EAC tissue samples confirmed that BE epithelial cells with or without dysplasia (LGD) had shorter telomeres compared to gastric cardia tissue. (oncotarget.com)
Our results suggest a potential novel mechanism for how telomere shortening could contribute to aging and disease initiation/progression in human cells long before the induction of a critical DNA damage response. (hal.science)
The finding relates to telomeres, the caps that protect the tips of chromosomes when cells divide. (answers.com.tn)
Telomeres tell board-certified physician Dr. Avi Ishaaya how the cells in your body are aging. (aviishaaya.com)
Telomeres sit on the end of our chromosomes - the strands of DNA stored in the nucleus of cells. (medindia.net)
Patients with cardiomyopathy have abnormally short telomeres in the cells responsible for heart contraction, Stanford researchers find. (defytime-emea.com)
People with a form of heart disease called cardiomyopathy have abnormally short telomeres in heart muscle cells responsible for contraction, according to a new study by researchers at the Stanford University School of Medicine. (defytime-emea.com)
The finding dovetails with a previous study showing that people with Duchenne muscular dystrophy, a genetic muscle-wasting disease, also have short telomeres in their heart muscle cells, or cardiomyocytes. (defytime-emea.com)
The shortening of telomeres in cardiomyocytes appears to be a reliable hallmark of cardiac failures that arise due to genetic defects, and it's very specific to cells that require the missing contractile proteins such as dystrophin, troponin T or myosin heavy chain, among others," said Helen Blau, PhD, professor of microbiology and immunology and member of the Stanford Cardiovascular Institute. (defytime-emea.com)
In most cells, telomeres naturally shorten each time the cell divides. (defytime-emea.com)
In contrast, the telomere length in nonbeating heart cells of the blood vessels did not vary significantly between the two groups. (defytime-emea.com)
Chang saw similar results in cardiomyocytes generated from induced pluripotent stem cells: Those generated from people with cardiomyopathies had significantly shorter telomeres than those generated from unaffected relatives. (defytime-emea.com)
Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. (elsevierpure.com)
Emotions Stress and Rate of Telomere Shortening: Are Our Cells Listening to Us? (thelongevityrevolution.tv)
Transcription occurs in the 5' to 3' direction (from the centromere to telomere) and TERRA transcripts are heterogeneous in length, ranging anywhere from 100-bases up to 9-kilobases in length for human cells. (wikipedia.org)
A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)
Analysis of alternative lengthening of telomere markers in BRCA1 defective cells. (sens.org)
Feb. 5, 2020 To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. (sciencedaily.com)
This mechanism is thought to restrict the lifespan of cells to a limited number of divisions, making telomere length a measure of aging at the cellular level. (cdc.gov)
In most cells, telomeres become progressively shorter as the cell divides. (medlineplus.gov)

Here we show that even in the undifferentiated state, iPSCs from dyskeratosis congenita patients harbour the precise biochemical defects characteristic of each form of the disease and that the magnitude of the telomere maintenance defect in iPSCs correlates with clinical severity. (nih.gov)
This study showed that it is not the initial length of telomeres, but their rate of shortening that correlates with species longevity. (gowinglife.com)
More recently, Sonja Entringer, Elissa Epel, and colleagues demonstrated that maternal psychological stress during pregnancy correlates with shorter telomeres in young adulthood. (theprimalmind.com)

Conclusions These findings suggest that PWBTL shortening is associated with long-term lead exposure and that PWBTL may be one of the targets damaged by lead toxicity. (bmj.com)
Here is an article about a study linking heavy metal toxicity with shorter telomeres. (telomeretimebombs.com)
These findings may help for a novel therapeutic strategy by telomere elongation or for validation of an exposure biomarker for SM toxicity. (northumbria.ac.uk)

Researchers have found a correlation between the average lifespan of a species and the rate at which its telomeres are shortened. (gowinglife.com)
Although it has been known for quite some time that telomeres play a role in ageing, no relationship had been found between telomere length and lifespan of each species. (gowinglife.com)
Interestingly, when considering the timepoint of the average lifespan, the length of telomeres at death appears to be about 75% of the original length. (gowinglife.com)
The relationship between the average lifespan of each species and telomere shortening rate can be fitted to a power law curve , which is also commonly used to describe other natural phenomena such as population growth, body mass, and species extinction. (gowinglife.com)
In the words of the authors, "it is plausible that in utero telomere biology represents a molecular mechanism whereby stress exposure in this critical period before birth can impact aging and subsequent disease susceptibility over the lifespan. (theprimalmind.com)
Telomeres and the natural lifespan limit in humans. (sens.org)

Telomere shortening in somatic tissues largely reflects stem cell replication. (columbia.edu)
The slowing down of cell replication occurs due to the shortening of telomeres , which are present at the end of each DNA strand. (healthnews.com)

It remains unknown whether telomere shortening is simply a sign of 'cellular age' or whether it contributes to the ageing process more directly. (meresearch.org.uk)
Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage . (answers.com.tn)
Why Telomeres are the Cellular "Foun. (thelongevityrevolution.tv)
Due to the breadth of roles in which TERRA is implicated for maintaining the genomic integrity at the ends of chromosomes, TERRA dysfunction has also been shown to be associated with a number of disease states, including a number of syndromes related to inappropriate telomere shortening and cellular aging, and the progression of cancer. (wikipedia.org)

Sleep deprivation leads to shorter telomeres, which causes more cardiovascular disease and a shorter life expectancy. (nethealthbook.com)

We propose that shortened telomeres should be evaluated further as a possible biomarker of cancer risk in BE patients. (oncotarget.com)
Is telomere length a biomarker for aging? (cdc.gov)

There was also a dose-effect relationship between the cumulative long-life exposure to tobacco smoking (pack-yrs) and telomere length. (ersjournals.com)
The results of the current study confirm that smoking exposure enhances telomere shortening in circulating lymphocytes. (ersjournals.com)
It also demonstrates a dose-effect relationship between exposure to tobacco smoking and telomere length, but failed to show that this effect is amplified in smokers who develop chronic obstructive pulmonary disease. (ersjournals.com)
This study aims to investigate the association between lead exposure and peripheral white blood cell telomere length (PWBTL) in Chinese battery manufacturing plant workers. (bmj.com)
To investigate whether the same occurs with renal fibrosis, they worked with an animal model that reproduces what, according to their hypothesis, happens in older people with pulmonary fibrosis: a mouse with short telomeres that is also exposed to low doses of a kidney toxin that mimics the exposure of people to environmental damages throughout their lives. (cnio.es)
Preliminary evidence suggests a possible association between prenatal tobacco exposure and telomere length in children. (quitsmokingboise.com)
This study was conducted to investigate whether maternal smoking during pregnancy was associated with telomere shortening in their children and whether prenatal and childhood exposure to environmental tobacco had any impact on this association. (quitsmokingboise.com)
This is a population-representative study on the association between prenatal tobacco exposure and telomere length in children. (quitsmokingboise.com)
A negative dose-response relationship was observed between the T/S ratio and tobacco exposure duration: the longer the duration of maternal smoking in pregnancy, the shorter the child's telomere length. (quitsmokingboise.com)
The association between the child's telomere length and prenatal tobacco exposure remained significant after considering the influence of family socioeconomic status and exposure to environmental tobacco smoke during pregnancy and childhood. (quitsmokingboise.com)
Prenatal tobacco exposure was associated with telomere shortening in children. (quitsmokingboise.com)
As reflected by telomere shortening, prenatal tobacco exposure in children can cause premature aging and increased health risks, which we suggest is entirely preventable. (quitsmokingboise.com)

Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. (goodreads.com)
Last week, a company in the UK announced that it would soon be offering a test of "biological age" based on telomere length to the public for approximately $700 (US). (cdc.gov)
Telomere shortening is a biological aging hallmark. (bvsalud.org)
One of the causes linked to DS is the biological age of the mother and a marked decrease in the telomere length of the woman who gives birth to a child with DS. (bvsalud.org)

When telomeres reach a critical length, the cell stops dividing altogether in order to protect chromosomes from unravelling. (gowinglife.com)
Telomeres help protect chromosomes from abnormally sticking together or breaking down (degrading). (medlineplus.gov)

For this study, we wanted to know if chronic stress was associated with accelerated telomere shortening in cancer patients, and if a psychosocial intervention that modulates the stress response could also modulate telomere length," he said. (sciencedaily.com)
When we are exposed to chronic stress, our health is affected, especially our telomere length. (aviishaaya.com)
Shorter telomere length has been associated with chronic stress , age and obesity in women, and with metabolic and cardiovascular disease outcomes. (cdc.gov)

Telomere shortening occurs because of poor lifestyle choices, such as living a sedentary life, smoking, being overweight or obese, or eating a poor diet. (aviishaaya.com)
More specifically, telomere shortening which occurs naturally with aging is accelerated in SM-exposed individuals. (northumbria.ac.uk)
1] Now they've gone one step further to show that telomere shortening occurs in the fetus when the mother is psychologically stressed. (theprimalmind.com)

We do know, however, that telomeres are shorter than usual in patients with diseases like cancer, osteoporosis and the cardiovascular disorders, even when the effect of ageing is taken into account. (meresearch.org.uk)
Now they take a first step towards doing the same with renal fibrosis by demonstrating that short telomeres are at the origin of this disease, which is also associated with ageing. (cnio.es)

After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). (medlineplus.gov)

Stress can shorten telomere length significantly. (aviishaaya.com)
Elissa Epel, UCSF department of psychiatry, explores the affects of stress and emotions on the process of telomere shortening. (thelongevityrevolution.tv)
How Stress Affects Our Telomeres Chr. (thelongevityrevolution.tv)
We studied if, in barn swallows Hirundo rustica , changes in adult erythrocyte telomere length between 2 consecutive breeding seasons are related to corticosterone (CORT) (the main avian GC) stress response induced by a standard capture-restraint protocol. (jsce-ip.com)
Maternal stress during pregnancy is associated with shorter telomeres in newborns, according to researchers at the Universities of California at Irvine and San Francisco, and the University of Pittsburgh. (theprimalmind.com)
A number of landmark studies have shown that psychological stress in adults is associated with shortening of the telomeres and accelerated aging. (theprimalmind.com)
2] By measuring telomere length in leukocytes taken from the cord blood and assessing the mother's stress during her pregnancy, they were able to correlate the length of the telomeres with the degree of stress experienced by the mothers. (theprimalmind.com)
The Maternal Stress Shortens Fetal Telomeres and Programs Aging and Disease In Utero by The Primal Mind , unless otherwise expressly stated, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 2.5 Canada License . (theprimalmind.com)
Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. (goodreads.com)
Environmental stress can accelerate telomere shortening. (cdc.gov)

In the area of Telomere Biology, the mechanisms of human aging will become clearer and the applications for disease treatment as well as life extension will become more apparent. (thelongevityedge.com)

Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)

Based on adjusted group means, telomere length was shorter by 593 and 508 base pairs in the CFS and 'fatigue' groups, respectively, compared with the controls. (meresearch.org.uk)
For example, by time a person reaches the age of 40, their telomeres could have lost up to 1,600 base pairs. (answers.com.tn)
While comparisons across studies of telomere length in base pairs are commonly done, it is not highly accurate. (cdc.gov)

In this study, the researchers observed that telomere shortening alone is not enough to cause renal fibrosis, which is to be expected because the disease does not affect 100% of elderly persons. (cnio.es)
Researchers, journalists, and inquiring minds want to know more about telomeres, which seem to hold clues to human aging and age-related diseases. (cdc.gov)

Short telomeres, a hallmark of dyskeratosis congenita, impair tissue stem cell function in mouse models, indicating that a tissue stem cell defect may underlie the pathophysiology of dyskeratosis congenita. (nih.gov)
The authors, headed by Maria A. Blasco , also offer a possible link between short telomeres and kidney fibrosis: a phenomenon called epithelial-to-mesenchymal transition (EMT), a basic process that is crucial to the functioning of the body and is involved in regeneration and repair. (cnio.es)
Short telomeres exacerbate EMT in the kidneys and thus promote pathological scarring of kidney tissue, i.e. fibrosis. (cnio.es)
This is new - it is the first time that short telomeres have been linked to epithelial-to-mesenchymal transition," says Blasco. (cnio.es)
Blasco's group at CNIO has already shown that short telomeres are at the origin of other age-related diseases, such as pulmonary fibrosis. (cnio.es)
With each cell division, the telomeres become shorter until they are so short that they can no longer protect the chromosomes. (cnio.es)
When cell divide some telomere is lost but if it becomes too short, that cell can no longer replicate and eventual dies. (thelongevityrevolution.tv)
it only takes a single short telomere to send a cell into crisis. (thelongevityedge.com)
But over time, the telomeres reach a critical short length and the cell ages and dies. (theprimalmind.com)
Over time, telomeres become so short that cell division stops and the cell dies. (cdc.gov)
In some families, inheritance of exceptionally short telomeres is linked to specific diseases, such as pulmonary fibrosis or bone marrow failure. (cdc.gov)
Eventually, the telomeres become so short that the cell can no longer divide. (msdmanuals.com)
The effect of short telomere length may be targeted by increased physical activity to reduce the risk of multiple aging-related diseases, including coronary heart disease (CHD). (bvsalud.org)

Because we found in a previous study that cardiomyocytes from boys who had died of Duchenne muscular dystrophy had telomeres that were about 50 percent shorter than those from individuals without the disease," Blau said, "we wondered whether people with other genetic heart conditions, such as cardiomyopathies, might also have cardiomyocytes with abnormally shortened telomeres. (defytime-emea.com)

Telomeres naturally shorten with age. (cdc.gov)

They shorten with each cell division, however, and when they reach a critical length the cell stops dividing or dies. (answers.com.tn)
However, the telomeres get shorter with each cell division, possibly leading to improper cell division and errors responsible for various age-related illnesses or cancer. (healthnews.com)
Telomeres also protect a chromosome's DNA sequence as it is being copied during cell division. (cdc.gov)
The mechanism that limits cell division involves a structure called a telomere. (msdmanuals.com)
Telomeres are used to move the cell's genetic material in preparation for cell division. (msdmanuals.com)

Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging. (sens.org)

Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that function to protect DNA from deterioration or fusion with neighboring chromosomes. (wikipedia.org)
TERRA interaction with other associated telomeric proteins has also been shown to help regulate telomere integrity in a length-dependent manner. (wikipedia.org)

Anatomy16

Organisms6

Diseases11

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes39

Information Science2

Health Care2

Telomerase33

Increased telomere length1

Time a cell divides5

Leukocyte telomere length8

Senescence13

Relative telomere length4

Oxidative9

Attrition5

Chromosome9

Lengthen5

Impact of shortened telomeres1

Dysfunctional telomeres2

Chromosomal4

Associated with shorter telomere length2

Long telomeres3

Human telomeres2

Structures7

Lengths7

Changes in telomere length2

Modulating the telomere length1

Progressive telomere1

Protective9

Mutations6

Affects telomere length2

Measure telomere length1

Chromosomes called telomeres1

Genetics4

Ends of telomeres1

Role of telomeres2

Associations between telomeres2

Genes3

Mice7

Affect telomere2

Longer telomeres2

Cells24

Correlates3

Toxicity3

Lifespan6

Replication2

Cellular4

Shorter life expectancy1

Biomarker2

Exposure12

Biological4

Protect chromosomes2

Chronic stress3

Occurs3

Ageing2

Apoptosis1

Stress10

Biology1

Premature1

Base pairs3

Researchers2

Short13

Blau1

Naturally1

Cell division5

Accompanies1

Telomeric2