• For example, telomere length is positively linked with nutritional status in human and animal studies ( see a review ), possibly through the effects of various nutrients on reducing inflammation and oxidative stress, and a study in 2013 found that lifestyle changes (a plant-based diet, moderate exercise, stress reduction and weekly group support) increased telomere length by about 10% in men with prostate cancer. (meresearch.org.uk)
  • Results suggest that WF inhalation increased telomere length without affecting telomerase in whole brain. (cdc.gov)
  • Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. (sciencedaily.com)
  • Short telomeres - the protective caps on the ends of chromosomes - have been previously linked to increased risk of death from heart disease. (scienceblog.com)
  • Telomeres specialized structures found at the ends of chromosomes are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. (cshlpress.com)
  • Telomeres are the tips at the ends of chromosomes that protect our DNA. (enzymedica.com)
  • The DNA still seemed to look normal, until the researchers focused on the caps that protect the ends of chromosomes, called telomeres. (labroots.com)
  • Telomeres are tandem nucleotide repeats that protect the ends of chromosomes from erosion during cell division. (datadryad.org)
  • Telomeres are repetitive DNA sequences located at the ends of chromosomes , playing a vital role in maintaining chromosomal integrity and stability. (bvsalud.org)
  • all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
  • A 2007 dermatology study conducted at King's College London indicates that people with more moles often have longer telomeres. (howstuffworks.com)
  • In reality, some people are born with longer telomeres than others. (howstuffworks.com)
  • The longer the telomere, the more cell divisions can take place over a lifetime - and more moles were linked to longer telomeres . (stackexchange.com)
  • There are a several different claims in the article: moles are correlated with: skin cells that divide more often, better bone density, and longer telomeres. (stackexchange.com)
  • Researchers have correlated higher vitamin D levels with longer telomeres in humans. (mindbodygreen.com)
  • It is not understood why there are variations of telomere length but if you had a choice, you would want to be born with longer telomeres. (bellenews.com)
  • Heterogeneity among studies and their publication bias were further assessed by the χ(2)-based Q statistic test and Egger's test, respectively.The results showed that shorter telomeres were significantly associated with cancer risk (OR = 1.35, 95% CI = 1.14-1.60), compared with longer telomeres. (duke.edu)
  • From each sample, relative telomere length was measured using real-time PCR. (meresearch.org.uk)
  • Telomere length was determined as relative telomere length (RTL) by comparison with an internal cell line control (1301 cells) 4 . (ersjournals.com)
  • This hypothesis awaits confirmation in a prospective study measuring changes in relative telomere length over time. (huffpost.com)
  • A series of epidemiological studies have examined the association between shortened telomeres and risk of cancers, but the findings remain conflicting.A dataset composed of 11,255 cases and 13,101 controls from 21 publications was included in a meta-analysis to evaluate the association between overall cancer risk or cancer-specific risk and the relative telomere length. (duke.edu)
  • Furthermore, the results also indicated that the association between the relative telomere length and overall cancer risk was statistically significant in studies of Caucasian subjects, Asian subjects, retrospective designs, hospital-based controls and smaller sample sizes. (duke.edu)
  • Each time a cell divides, however, the telomeres become shorter. (howstuffworks.com)
  • Even now, your telomeres may grow shorter with each cell division, burning down ever closer to the point of guttering out. (howstuffworks.com)
  • We do know, however, that telomeres are shorter than usual in patients with diseases like cancer, osteoporosis and the cardiovascular disorders, even when the effect of ageing is taken into account. (meresearch.org.uk)
  • Recently, evidence has come to light that telomeres are also shorter than normal in people with ME/CFS. (meresearch.org.uk)
  • Based on adjusted group means, telomere length was shorter by 593 and 508 base pairs in the CFS and 'fatigue' groups, respectively, compared with the controls. (meresearch.org.uk)
  • Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. (goodreads.com)
  • We examined whether adverse neighborhood conditions, alone or in conjunction with discrimination, associate with shorter leukocyte telomere length among a predominantly AA cohort. (rand.org)
  • Less walkable neighborhoods were associated with shorter telomeres. (rand.org)
  • Higher air pollution (PM 2.5 ) was associated with shorter telomeres among those experiencing greater discrimination. (rand.org)
  • Shorter telomeres on the ends of white blood cell chromosomes were discovered to be associated with an increased risk of dementia. (nepalnews.com)
  • However, whether patients with schizophrenia also have shorter telomeres remains inconclusive, because the results of previous studies investigating an association between leukocyte telomere length and schizophrenia have been largely inconsistent. (databasefootball.com)
  • Telomeres become shorter with age, oxidation and chemical insults. (huffpost.com)
  • Most Tetrahymena are immortal, Blackburn explained, and they have lots of telemorase, but the mutant had shorter and shorter telomeres over time, so its cells started to die. (lindau-nobel.org)
  • As we get older, our telomeres get shorter and can directly impact our body health and how we age. (antiaging-systems.com)
  • As we age, our telomeres naturally get shorter due to cell replication and the natural wear and tear of everyday life. (antiaging-systems.com)
  • Our telomeres get shorter with every cell division until they eventually become too small to protect the chromosomes. (antiaging-systems.com)
  • as our telomeres get shorter, we experience the effects of aging[ 1 ]. (antiaging-systems.com)
  • Telomere length can also impact overall health, as shorter telomeres can increase our risk for age-related diseases like cancer and heart disease [ 2 ] and even shorten our lifespan. (antiaging-systems.com)
  • As we get older, our telomeres naturally get shorter, increasing the risk of age-related diseases and impacting overall wellness. (antiaging-systems.com)
  • Shorter telomeres were found in older women, Latinas, particularly those who were Mexican-born, and those with higher education. (confex.com)
  • There was a dose-response relationship between higher educational attainment and shorter telomeres (p-trend = 0.006). (confex.com)
  • Women who chose an affirmative or neutral response to the statement, I would move from this neighborhood if I could , had shorter telomeres (p=0.02) than women who disagreed with this statement. (confex.com)
  • Our results also demonstrated significantly shorter telomere lengths in NSCLC patients compared to controls (p = 0.0004). (bvsalud.org)
  • Cancer cells overcome this replicative senescence in one of two ways: through activating telomerase, an enzyme that extends telomeres, or using another process called the alternative lengthening of telomeres (ALT) pathway. (massgeneral.org)
  • However, it turns out that cells lacking functional telomerase have a backup plan to restore telomere length by "alternative lengthening of telomeres" (ALT). (yeastgenome.org)
  • Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length. (sciencedaily.com)
  • Since telomeres shorten with each cell division, it pays to start out ahead. (howstuffworks.com)
  • Telomeres naturally shorten with age. (cdc.gov)
  • Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes, which shorten with age in all replicating somatic cells 3 , 4 . (ersjournals.com)
  • In somatic cells such as leukocytes, telomeres gradually shorten with each cell division because of low telomerase activity. (databasefootball.com)
  • In the next stage of their research, the Glasgow scientists will look at what causes telomeres to shorten - including inherited and environmental factors - to make it possible to predict life expectancy more accurately. (bellenews.com)
  • Telomeres have been implicated in senescence and mortality because they tend to shorten with stress, growth and age. (datadryad.org)
  • Every time a cell divides, the telomeres shorten a bit. (msdmanuals.com)
  • The researchers measured patients' leukocyte telomere length at the start of the study and again five years later, and then examined whether the difference between these measurements predicted which patients were most likely to die over the next four years. (scienceblog.com)
  • Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2000. (cdc.gov)
  • Here, we investigate the association of leukocyte telomere length with schizophrenia with the quantitative polymerase chain reaction method in independent Japanese cohorts consisting of 1,241 patients with schizophrenia and 1,042 controls, which we believe is the largest ever as an independent sample set of telomere studies in schizophrenia. (databasefootball.com)
  • Correlations between leukocyte telomere length and age in patients with schizophrenia and healthy controls. (databasefootball.com)
  • The red and blue dashed lines show non-linear relationships between leukocyte telomere length and age in patients with schizophrenia and healthy controls, respectively. (databasefootball.com)
  • Black lines represent the mean leukocyte telomere length in each group. (databasefootball.com)
  • The researchers also measured the length of their leukocyte telomeres. (huffpost.com)
  • Is leukocyte telomere length (LTL) associated with alterations in cardiovascular structure and function? (cdc.gov)
  • On one hand, Noah might have been born with rather long telomeres, while Batty drew the proverbial shortest straw. (howstuffworks.com)
  • While short telomeres do lead to health problems, long telomeres lead to health problems of their own. (cdc.gov)
  • Far from extending life, long telomeres appear to cause cancer and a blood disorder known as CHIP, a condition that increases the risk of blood cancers and heart disease. (cdc.gov)
  • Mice have long telomeres and senesce just fine. (cdc.gov)
  • At present, scientists are exploring interventions to lengthen telomeres. (meresearch.org.uk)
  • By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)
  • Studies have shown taking telomerase activation supplements can help lengthen telomeres, which can help slow down the aging process and reduce the risk of age-related diseases [ 3 ]. (antiaging-systems.com)
  • Less understood are a newly recognized group of cancer-prone syndromes that are associated with mutations that lengthen telomeres. (cdc.gov)
  • Furthermore, it was predicted that a specialized DNA polymerase (originally called a tandem-DNA-polymerase) could extend telomeres in immortal tissues such as germ line, cancer cells and stem cells. (wikipedia.org)
  • In contrast to the RNA-directed DNA synthesis by telomerase, ALT relies on recombination and replication of telomere DNA to extend telomeres. (massgeneral.org)
  • In the new study, Whooley and colleagues asked whether the rate of telomere change - rather than absolute telomere length - might be a better predictor of health span in heart disease patients. (scienceblog.com)
  • To test this hypothesis, the rate of telomere shortening was compared with age in circulating lymphocytes harvested from smokers with and without COPD. (ersjournals.com)
  • This makes telomeres a telling marker for how a body will age: After studying telomere length across multiple species, a research team out of Spain found that the rate of telomere decay over time could accurately predict the life span of that species. (mindbodygreen.com)
  • In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
  • Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
  • In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
  • Systematic analysis of telomere length and somatic alterations in 31 cancer types. (sens.org)
  • Telomere length shortens with age in all replicating somatic cells. (ersjournals.com)
  • The steady shortening of telomeres with each replication in somatic cells is linked to cellular aging, genetic instability, and tumor formation. (news-medical.net)
  • This epigenetic protection of fly telomeres has been essentially studied in somatic cells where capping proteins such as HOAP or HP1 are essential in preventing chromosome end-to-end fusions. (ens-lyon.fr)
  • While HipHop is involved in telomere capping in somatic cells, K81 hasspecialized in the protection of telomeres in post-meiotic male germ cells. (ens-lyon.fr)
  • Overall, telomere lengths were found to be significantly longer in the healthy controls than in the Fukuda 1994 CFS patients or in the group of 'fatigue' patients, and these differences remained significant after statistical adjustment for differences between groups. (meresearch.org.uk)
  • The study - which used zebra finches, one of Australia's most common bird species - is the first to measure telomere lengths at regular intervals through an entire life. (bellenews.com)
  • It cannot help in determining the cellular threshold for the number of dysfunctional telomeres that causes cells to stop dividing due to persistent DNA damage response signaling. (genengnews.com)
  • Telomerase is the enzyme that repairs shortened or dysfunctional telomeres, and various telomerase-activating drugs are under development, with some success as recent work on blood disorders has shown ( read more ). (meresearch.org.uk)
  • In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)
  • They went on to evaluate potential correlations between leucocyte telomere length and dementia risk, including Alzheimer's disease and vascular dementia, as well as total and regional brain volumes, using data from the UK Biobank. (nepalnews.com)
  • The length of leucocyte telomeres was determined by analysing blood samples collected at the time of enrollment. (nepalnews.com)
  • The data analysis found a substantial link between leucocyte telomere length and the risk of dementia. (nepalnews.com)
  • Participants with the shortest leucocyte telomeres were 14 per cent more likely to be diagnosed with dementia and 28 per cent more likely to be diagnosed with Alzheimer's disease after controlling for gender and age. (nepalnews.com)
  • Nevertheless, the researchers conclude, "We found that leucocyte telomere length acts as an aging biomarker associated with the risk of dementia. (nepalnews.com)
  • Furthermore, we also observed linear associations of leucocyte telomere length with total and regional brain structure. (nepalnews.com)
  • The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. (frontiersin.org)
  • Our GWAS confirmed 11 genetic loci previously associated with leucocyte telomere length (LTL) and two novel loci in SCNN1D and PITPNM1. (cdc.gov)
  • Recently, another study in the journal PLoS ONE showed that stress from phobic anxieties -- like being afraid of spiders, social situations, or the like -- is linked with shortened telomeres. (huffpost.com)
  • As expected, there was a correlation between telomere length and age in the total sample. (meresearch.org.uk)
  • There was no correlation between telomere length and growth in either sex, suggesting that our results are a consequence of divergent selection on life histories of males and females. (datadryad.org)
  • Telomere, a complex of guanine-rich repeat sequences and associated proteins, caps and protects every eukaryotic chromosome end against chromosomal fusion, recombination, and terminal DNA degradation ( Blackburn, 2001 ). (nature.com)
  • To prevent degradation by exonucleases or processing as damaged DNA, the telomere 3′ single-strand overhang folds back into the D-loop of duplex telomeric DNA to form a protective 'T-loop', which is reinforced with TRF2 and other telomeric DNA-binding proteins named Shelterin ( de Lange, 2005 ). (nature.com)
  • In a study published on-line on August 27 in Molecular Cell, the Wistar scientists, led by Lieberman, describe how they discovered the telomere proteins that interact with TERRA and the processes by which they do so. (news-medical.net)
  • Telomeres consist of tandem repeats of TTAGGG and DNA binding proteins that form a cap to protect chromosomal termini from the loss of genetic material. (databasefootball.com)
  • We thus propose that the maintenance of capping proteins at Drosophila sperm telomeres is crucial for the transmission of telomere identity to the diploid zygote. (ens-lyon.fr)
  • We therefore focus on elucidating the roles of the telomere binding proteins in this process. (lu.se)
  • A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. (bvsalud.org)
  • In 1975-1977, Elizabeth Blackburn, working as a postdoctoral fellow at Yale University with Joseph G. Gall, discovered the unusual nature of telomeres, with their simple repeated DNA sequences composing chromosome ends. (wikipedia.org)
  • Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
  • Telomeres are a protective nucleoprotein structure at each chromosome end. (cdc.gov)
  • Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. (goodreads.com)
  • This is because telomeres eventually 'run out' after a certain number of cell divisions, resulting in the loss of vital genetic information from the cell's chromosome with future divisions. (news-medical.net)
  • At the end of each chromosome is a telomere, which acts as a protective cap. (antiaging-systems.com)
  • A critical function of telomeres is to prevent the ligation of chromosome ends by DNA repair enzymes. (ens-lyon.fr)
  • Telomeres play a key role in the maintenance of chromosome integrity and stability, and telomere shortening is involved in initiation and progression of malignancies. (duke.edu)
  • Moreover, we observed that components of the shelterin complex, Trf1 and Trf2, play an important role in telomere end protection, and their regulation may be responsible for the increase in telomere length. (cdc.gov)
  • Given that ME Research UK-funded work has found high levels of oxidative stress and associated arterial stiffness to be a feature in ME/CFS patients ( read more ), it may be that telomere shortening is intimately linked with ongoing inflammatory processes. (meresearch.org.uk)
  • [ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)
  • A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
  • A team of cancer scientists led by Francis Rodier, PhD, a professor at the University of Montréal, has updated the current model of cellular senescence by providing evidence that the aging-related arrest of DNA replication is caused by irreversible damage to the genome rather than simply by an erosion of telomeres. (genengnews.com)
  • The study is reported in an article in the journal Nucleic Acids Research, titled, " Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence . (genengnews.com)
  • The new multistep model for entry into telomere-mediated senescence presented in the current study reconciles observations of senescence-associated genomic instability with observations that telomere breaks are largely irreparable and that cells can tolerate telomere-induced DNA damage foci (TIF) during an unstable "pre-senescent" state. (genengnews.com)
  • This updated model offers a new basis for stress- or age-associated genome damage and indicates, cells that escape telomere-mediated senescence harbor irreparable genome damage. (genengnews.com)
  • The telomere plays a key role in the continuous duplication of proliferating cells, and its erosion eventually leads to a cell's senescence. (massgeneral.org)
  • Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. (sens.org)
  • Telomeres and Cell Senescence - Size Matters Not. (sens.org)
  • Telomere length is, therefore, a marker of cell ageing and senescence 5 . (ersjournals.com)
  • Progerin induced senescence, lamin B1 loss, DNA damage, and telomere shortening are prevented by TERT in primary and HGPS fibroblasts, control experiments. (elifesciences.org)
  • Numerous factors localize at telomeres to regulate their length, structure and function, to avert replicative senescence or genome instability and cell death. (cdc.gov)
  • However, it is still unclear whether lead exposure affects telomere length. (bmj.com)
  • TA65® capsules - plant based compound to help maintain telomere length, or rebuild where necessary. (antiaging-systems.com)
  • Although most cancer cells activate telomerase to maintain telomere length, about 10% of tumors use an alternative telomere lengthening mechanism, the so-called ALT mechanism. (lu.se)
  • Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. (evmedreview.com)
  • Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)
  • As shortened telomeres are also found in a range of other chronic diseases, including cancer ( read more ), diabetes, Alzheimer's disease and Parkinson's disease, the phenomenon is most likely associated with chronic illness per se , rather than with ME/CFS in particular. (meresearch.org.uk)
  • Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. (meresearch.org.uk)
  • When telomeres are not properly controlled, the resulting chromosomal alterations can induce genomic instability and ultimately the development of human diseases, such as cancer. (nih.gov)
  • Researchers, journalists, and inquiring minds want to know more about telomeres, which seem to hold clues to human aging and age-related diseases. (cdc.gov)
  • Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging. (cshlpress.com)
  • Since this RNA also facilitates the formation of DNA at telomeres-a process that can protect aging cells and destabilize tumor cells-manipulating its expression may be useful in treating cancer and other diseases. (news-medical.net)
  • Many of the diseases of ageing, including cancers, are associated with the shortening of telomeres,' Blackburn said. (lindau-nobel.org)
  • Even the risk factors for these diseases increases with short telomeres. (lindau-nobel.org)
  • Dr. Park's book offers a clear and friendly account of the role of telomeres in causing age-related diseases and the enormous potential of telomerase to prevent and cure age-related diseases by reversing human aging at the genetic level. (rechargebiomedical.com)
  • Objectives Critically shortening of telomere length caused by various factors including environmental pollutants results in genome instability and age-associated diseases. (bmj.com)
  • Telomeres are specialized structures that evolved to protect the end of linear chromosomes from the action of the cell DNA damage machinery. (nih.gov)
  • Telomeres Increasingly Develop Aberrant Structures in Aging Humans. (sens.org)
  • Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. (ersjournals.com)
  • To explore the mechanisms of sequence-specific ssDNA recognition, we determined the crystal structures of 10 different non-cognate ssDNAs complexed with the Oxytricha nova telomere end-binding protein (OnTEBP) and evaluated their corresponding binding affinities (PDB ID codes 1PH1-1PH9 and 1PHJ). (rcsb.org)
  • Consider telomeres little helmets for your DNA: These protein structures cap off both sides of our chromosomes to protect them from damage and decay over time. (mindbodygreen.com)
  • The telomeres are the DNA-protein structures at the ends of eukaryotic chromosomes, which serve to protect and stabilize the genome. (lu.se)
  • The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
  • Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
  • Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
  • We are using the yeast model organism Saccharomyces castellii, which has telomere traits and telomerase activity that are highly similar to human cells. (lu.se)
  • Telomeres are a widespread genetic feature most commonly found in eukaryotes. (wikipedia.org)
  • Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
  • In fact, the cell division caused by telomere dysfunction is so unstable that it ends up creating genetic defects. (genengnews.com)
  • Telomeres (in white) cap the ends of human chromosomes, protecting the genetic information from damage. (howstuffworks.com)
  • While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. (goodreads.com)
  • A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. (news-medical.net)
  • Genetic from Mendel to the Era of According to his theory of telomeres are represented by tandem repeats, which create a buffer that determines the number of divisions that a certain cell clone can undergo. (slideshare.net)
  • Genetic from Mendel to the Era of Elizabeth Blackburn and her graduate student Carol Greider then went looking for the mechanism that maintains telomeres, and on Christmas day, 1984, discovered the first evidence for the enzyme telomerase. (slideshare.net)
  • Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India. (bvsalud.org)
  • Genetic variations within telomere maintenance genes may influence the risk of developing NSCLC. (bvsalud.org)
  • The present study aimed to evaluate the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India , and to investigate the relationship between telomere length and NSCLC risk . (bvsalud.org)
  • We employed the cost -effective and high-throughput MassARRAY MALDI -TOF platform to assess the genetic associations of select variants within telomere maintenance genes in a population from Jammu and Kashmir, North India . (bvsalud.org)
  • This study highlights the crucial interplay between genetic variation in telomere maintenance genes , telomere attrition, and NSCLC risk in the Jammu and Kashmir population of North India . (bvsalud.org)
  • Telomeres are used to move the cell's genetic material in preparation for cell division. (msdmanuals.com)
  • Controlling for these and other factors, the researchers found that those whose telomeres shortened over five years were 32 percent more likely to die during the next four years than those whose telomeres stayed the same, and those who experienced telomere lengthening were 56 percent less likely to die. (scienceblog.com)
  • The researchers also point out several limitations: Because telomere length was only assessed once, it was unable to determine whether changes over time increased dementia risk. (nepalnews.com)
  • The longer a person's telomeres, researchers found, the greater the risk of cancer and other disorders, challenging a popular hypothesis about the chromosomal roots of vitality. (cdc.gov)
  • An article in this week's NEJM provides some of the best evidence yet for the role of telomere length in the trade-off between slowing aging and the risk of cancer. (evmedreview.com)
  • Discuss the potential role of telomere biology in maternal and child health outcomes. (confex.com)
  • However, little is known about regulation of telomere biology during pregnancy. (confex.com)
  • Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. (nature.com)
  • Our current understanding of cellular aging rests upon the uncapping of the repetitive, non-protein-coding extremities of our linear chromosomes called telomeres. (genengnews.com)
  • Genetically, we were able to reproduce the phenomenon of cellular aging in the laboratory and ensured that all the telomeres of a population of cells became dysfunctional," said PhD student Marc-Alexandre Olivier, co-first author of the study with former colleague Sabrina Ghadaouia, PhD, currently pursuing postdoctoral studies in England. (genengnews.com)
  • It remains unknown whether telomere shortening is simply a sign of 'cellular age' or whether it contributes to the ageing process more directly. (meresearch.org.uk)
  • On top of that, the ingredients in Telomere Plus-including astragalus root, broccoli seed, rhodiola extract and vitamin D3-give us a whole range of additional benefits, from immune support to enhancing the body's stress tolerance, cellular protection and boosted enzyme activity. (enzymedica.com)
  • Sequence-specific protein recognition of single-stranded nucleic acids is critical for many fundamental cellular processes, such as DNA replication, DNA repair, transcription, translation, recombination, apoptosis and telomere maintenance. (rcsb.org)
  • The risk of these phenotypes was mediated by extended cellular longevity and by the capacity to maintain telomeres over time. (evmedreview.com)
  • The shortening of telomeres to a critical length leads to genomic instability and cellular apoptosis. (databasefootball.com)
  • It seems that vitamin D , a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase 4 , the building blocks of telomeres that protect cellular DNA from aging. (mindbodygreen.com)
  • Telomere length is a biomarker of cellular aging and predictor of chronic disease. (confex.com)
  • Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. (cdc.gov)
  • Normal cellular ageing involves the shortening of telomeres in each cell division. (lu.se)
  • He had just observed that the ends of the irradiated chromosomes, different from the other genome, did not present alterations such as deletions or inversions, thanks to the presence of a protective cap that he called "terminal gene" and afterwards "telomere", from the greek terms "telos" (end) and "meros" (part) (Müller HJ. (wikipedia.org)
  • The model also suggests that strategies targeted at repairing telomeres in pre-senescent cells could eradicate telomere-induced DNA damage foci and low-level DNA damage response while preventing further irreversible damage to the genome. (genengnews.com)
  • TERRA is a major component in helping protect the genome at a very sensitive place, the telomeres,' said senior author Paul M. Lieberman, Ph.D., a professor in Wistar's Gene Expression and Regulation Program. (news-medical.net)
  • Without telomeres, our genome would be vulnerable to damage and dysfunction. (antiaging-systems.com)
  • Telomere attrition was also accelerated in cell populations from magnesium-deficient cultures. (wellnessresources.com)
  • Title : Association of chronic fatigue syndrome with premature telomere attrition Personal Author(s) : Rajeevan, Mangalathu S.;Murray, Janna;Oakley, Lisa;Lin, Jin-Mann S.;Unger, Elizabeth R. (cdc.gov)
  • Now, research by scientists at UC San Francisco and the Veterans Affairs Medical Center in San Francisco has found that change in telomere length over time is also important: heart disease patients whose telomeres shrank over time had a worse short-term prognosis than those whose telomeres stayed stable, and those whose average telomere length grew over the course of the study had a higher chance of survival. (scienceblog.com)
  • Overall, one quarter of patients had died by the end of the study, but only 12 percent of patients whose telomeres had lengthened during the five-year observation period were among this group. (scienceblog.com)
  • In contrast, 39 percent of patients whose telomeres had shrunk in the five-year observation period died within the next four years. (scienceblog.com)
  • However, those whose telomeres shortened over the course of the study also showed higher abdominal fat, worse kidney function, and lower overall fitness. (scienceblog.com)
  • The results hold huge implications for humans, whose telomeres work in the same way. (bellenews.com)
  • The length of telomeric repeats is dynamically regulated and can be affected by changes in the telomere chromatin structure. (nih.gov)
  • Dr. Zou and his team postulated that such cancer cell lines were those without active telomerase, relying instead on the ALT pathway, which lengthens telomeres through recombination with telomeric DNA sequences from the same or other chromosomes. (massgeneral.org)
  • TERRA associates with telomeric factors, but its precise function and mechanism of localization at telomeres had been largely unknown. (news-medical.net)
  • Among the research-vetted ways to protect telomeres, the authors cite avoiding smoking, getting at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week, and maintaining a healthy, low-fat diet. (scienceblog.com)
  • The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)
  • Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob , referring to research in the Archives of Medical Science 2 and the Journal of Nutrition 3 on the association between telomere length and vitamin D levels. (mindbodygreen.com)
  • But one bird in the group with the longest telomeres survived to almost nine years old. (bellenews.com)
  • The botanicals in Telomere Plus have been shown to increase the activity of telomerase, a naturally-occurring enzyme that lengthens telomeres and protects them from shortening. (enzymedica.com)
  • The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)
  • ALT employs recombination via extrachromosomal telomere elements called C-circles. (yeastgenome.org)
  • This pairing requires the SAGA / TREX2 complex and, once paired, the recombination between C-circles and telomeres appears to be effected by Rad59 p, the paralog of Rad52 p. (yeastgenome.org)
  • They also showed the circles interact with the SAGA/TREX2 complex, which favors telomere recombination. (yeastgenome.org)
  • In older people with stable heart disease, longevity can vary widely, but a number of studies have suggested that telomere length appears to be a good predictor of a patient's likely health span - their number of healthy years of life remaining. (scienceblog.com)
  • A new study in the journal PLoS ONE shows the impact job stress has on certain sections of our DNA called telomeres, which have been linked in research with longevity. (huffpost.com)
  • When combined with a healthy diet and regular exercise , taking a vitamin D supplement can help keep telomeres in tiptop shape and promote longevity from the inside out. (mindbodygreen.com)
  • By understanding what telomeres are and how they work, we can take measures to help lengthen our telomeres and promote longevity. (antiaging-systems.com)
  • A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)
  • And abnormally short telomeres seem to make humans more susceptible to conditions such as bone marrow failure, pulmonary fibrosis, liver disease, and gastrointestinal disease over time. (mindbodygreen.com)
  • Blackburn, Carol Greider, and Jack Szostak were awarded the 2009 Nobel Prize in Physiology or Medicine for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. (wikipedia.org)
  • Telomeres are non-coding, repetitive sequences located at the termini of linear chromosomes to act as buffers for those coding sequences further behind. (wikipedia.org)
  • Telomeres don't shrink significantly in healthy humans for decades due to an enzyme called telomerase , which partially repairs and lengthens them after each shortening. (howstuffworks.com)
  • Telomeres and the natural lifespan limit in humans. (sens.org)
  • This inconsistency may be partially due to the relatively small sample sizes in each study and heterogeneity caused by various uncontrolled confounders (e.g., duration of illness or hospitalization, lifetime antipsychotic dose, and telomere length assay methods). (databasefootball.com)
  • Indeed, only one study has recruited more than 1,000 patients with schizophrenia (and a sufficient sample of controls), although this was a meta-analysis, including different telomere length assay protocols. (databasefootball.com)
  • Discovered in 1938 by gen-eticist Hermann J. Müller, telomeres (Greek for 'end part') are essentially protective caps composed of short DNA sequences on the tips of chromosomes. (howstuffworks.com)
  • Also, statins seem to have a protective role against telomere shortening, and lifestyle factors may have an important role to play. (meresearch.org.uk)
  • It also shows, rather surprisingly, that a substantial number of people had telomere lengthening, and that this appeared to be protective. (scienceblog.com)
  • Because some really villainous free radicals have the power to tear away at your telomeres (protective tips of your DNA critical for aging), they ultimately have the power to tear away at your DNA, too. (susansmithjones.com)
  • 2017). Data from: Age-related sex differences in body condition and telomere dynamics of red-sided garter snakes [Dataset]. (datadryad.org)
  • In contrast to never-smokers, telomere length significantly decreased with age in smokers. (ersjournals.com)
  • Showcasing a revolutionary new way to think about aging and health, Dr. Ed Park's entertaining and insightful new book introduces readers to Telomeres - repetitive DNA sequences that play a vital role in aging and health. (rechargebiomedical.com)
  • The birds with the shortest telomeres did tend to die first - from as early as seven months after the start of the trial. (bellenews.com)
  • Therefore, proper establishment, regulation, and maintenance of the telomere chromatin structure are required for cell homeostasis. (nih.gov)
  • Another gene implicated in DKC, TINF2 , encodes a key component of the protein shelterin, which plays a role in telomere homeostasis. (medscape.com)
  • As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
  • So far, the mechanism of telomere lengthening is unknown, the authors say. (scienceblog.com)
  • The mechanism that limits cell division involves a structure called a telomere. (msdmanuals.com)
  • In cancer cells, the telomerase enzyme elongates telomeres, providing a mechanism for a continued unlimited cell division. (lu.se)
  • According to his theory of marginotomy DNA sequences at the ends of telomeres are represented by tandem repeats, which create a buffer that determines the number of divisions that a certain cell clone can undergo. (wikipedia.org)
  • Drosophila telomeres are unusual as they lack short tandem repeats. (ens-lyon.fr)
  • A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer. (cdc.gov)
  • Genetics of human telomere biology disorders. (cdc.gov)
  • We examined the clinical and molecular features of aging and cancer in persons carrying heterozygous loss-of-function mutations in the telomere-related gene POT1 and noncarrier relatives. (evmedreview.com)
  • Results PWBTL averaged 1.76 (telomere/single-copy gene of albumin, T/S) in 144 battery plant workers. (bmj.com)
  • Our findings suggest that TERT and POT1 gene variants, along with telomere length, may serve as potential biomarkers and therapeutic targets for NSCLC in this population . (bvsalud.org)
  • Telomere length, DNA-methylation, gene expression of Trf1, Trf2, ATM, and APP, protein expression of p-Tau, a-synuclein, and presenilin 1 and 2 were assessed in whole brain tissue at 12 wk after WF exposure ended. (cdc.gov)
  • A heterozygous mutation was found on the conserved telomere maintenance component 1 gene ( CTC1 ). (medscape.com)
  • In contrast to noncarrier relatives, who had the typical telomere shortening with age, POT1 mutation carriers maintained telomere length over the course of 2 years. (evmedreview.com)
  • POT1 mutations associated with long telomere length conferred a predisposition to a familial clonal hematopoiesis syndrome that was associated with a range of benign and malignant solid neoplasms. (evmedreview.com)
  • Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride. (ens-lyon.fr)
  • Home / Teams / Epigenetics and Zygote Formation - B. Loppin / Publications / Epigenetic maintenance of telomere identity in Drosophila: buckle up for the sperm ride. (ens-lyon.fr)
  • These findings suggest a possible correlation between epigenetic modifications, telomere length alteration, and neurodegeneration because of the presence of factors in serum after WF exposure that may cause extra-pulmonary effects as well as the translocation of potentially neurotoxic metals associated with WF to the central nervous system (CNS). (cdc.gov)
  • The processes that maintain telomeres employ replication protein A (RPA), a single-stranded DNA binding protein. (massgeneral.org)
  • Dr. Zou and his team had previously investigated the role for RPA at telomeres3 and found that it associated transiently with telomeres during S phase of DNA replication. (massgeneral.org)
  • And indeed the team found that in cells that use the ALT pathway, RPA binds persistently to telomeres, not detaching after replication. (massgeneral.org)
  • ATRX-deficient neu-roprogenitors exhibited higher incidence of telomere fusions and increased sensitivity to replication stress-inducing drugs. (bepress.com)
  • A telomere, which looks like a shoelace cap, is intended to keep chromosomes from fraying or unravelling during replication. (nepalnews.com)
  • We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentro-meric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation. (bepress.com)
  • So between DNA getting attacked by free radicals (which can be produced by harmful UV exposure) and decreasing NADs unable to adequately, efficiently repair the DNA damage caused by destroyed telomeres. (susansmithjones.com)
  • Often, when telomeres reach a critically short length, the cell dies in a process called apoptosis. (huffpost.com)