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  • effector memory
  • Objectives Evaluate the number and distribution of circulating CD4+ T lymphocytes and their CD4+ naïve T cells (T N ), central memory (T CM ), non-terminated effector memory (T NTEM ) and terminated effector memory (T TEM ) T cells subsets in a population of recently diagnosed DMARD naive RA patients before and along the first 6 months of methotrexate (MTX) treatment. (bmj.com)
  • helper
  • In this study, we thus investigated the expression of infiltrating lymphocyte subsets (CD3, CD20, CD4, and CD8) and T helper (Th) cytokines including interferon (IFN)-γ (Th1 type), interleukin (IL)-4 (Th2 type), IL-17 (Th17 type), and IL-10 (regulatory T cell type) by immunohistochemistry in buccal mucosa specimens from 2 GS patients compared with 15 OLP patients. (nih.gov)
  • Greater numbers of helper T lymphocytes (Leu-3+) were found at the periphery than in the central portion of the same granuloma. (semanticscholar.org)
  • bone marrow
  • 2009 Changes of lymphocyte subsets in acute leukemia patients after HLA-mismatched nonmyeloablative hematopoietic stem cell transplantation 2010 "Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report", published in Biol Blood Marrow Transplant 2009 A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD" published in Biol Blood Marrow Transplant. (wikipedia.org)
  • cells
  • Although adoptive transfer experiments have shown, for the most part, that both CD4 and CD8 T cells are required for diabetes to occur (( 1 ), ( 2 )), both CD8 T cells (( 11 )) and CD4 T cells (( 12 )) are able to transfer disease when given alone to NOD.SCID animals, which lack lymphocytes. (rupress.org)
  • There was a significantly greater increase in the percentage of Thy1.2+ and, especially of, Lyt-2+ cells in stimulated splenic lymphocytes from untrained mice given an exhaustive exercise session compared with controls and with trained mice. (biomedsearch.com)
  • TfC+ patients and controls had similar numbers and proportions for the lymphocyte subsets and NK cells. (hku.hk)
  • Lymphocytes strongly contribute to the pathology of multiple sclerosis (MS). Thereby, frequently activated or reactivated autoreactive lymphocytes differentiate into effector cells that enter the central nervous system (CNS) causing tissue inflammation and damage. (biomedcentral.com)
  • While fingolimod reduced the number of almost all analyzed subsets in the circulation IFN-β specifically reduced the numbers of marginal zone and memory B cells. (biomedcentral.com)
  • In conclusion, we think that by reducing "memory" type lymphocytes in the circulation fingolimod and IFN-β impair reactivation of autoreactive cells. (biomedcentral.com)
  • The lack of B-lymphocytes in the testis is significant, since these are the antibody-producing cells of the immune system. (wikipedia.org)
  • T-lymphocytes (T-cells) are white blood cells which take part in cell-mediated immunity. (wikipedia.org)
  • If undiagnosed or left untreated, HIV usually progresses to AIDS, defined as possessing a CD4+ lymphocyte count under 200 cells/μl or HIV infection plus co-infection with an AIDS-defining opportunistic infection. (wikipedia.org)
  • citation needed] Autologous lymphocytes are isolated from patients' tumors and cultured to large numbers of cells in vitro. (wikipedia.org)
  • The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. (wikipedia.org)
  • B cells mature into B lymphocytes in the bursa equivalent, which in humans is the GALT, which is thought to be located in the Peyer's patches of the intestine, while T cells migrate to and mature in a distinct organ, called the thymus. (wikipedia.org)
  • 2010 Application of HLA-A*0201/WT1 pentamer combined with intracellular IFNgamma+ staining in detecting circulating WT1 specific T cells in leukemia 2010 "Comparison of Wilms' tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and chronic leukemia patients", published in Int J Hematol. (wikipedia.org)
  • Highly reproducible results Possible to analyze subsets of cells using physical and immunofluorescent markers. (wikipedia.org)
  • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. (wikipedia.org)
  • Subsequent studies revealed that the dye can be used to monitor lymphocyte proliferation, both in vitro and in vivo, due to the progressive halving of CFSE fluorescence within daughter cells following each cell division. (wikipedia.org)
  • However, perhaps the most important CFSE investigations have been those demonstrating that many of the effector functions of lymphocytes, such as cytokine production by T lymphocytes, and antibody class switching by B cells, are division dependent. (wikipedia.org)
  • populations
  • Detection of gene expression specific for different kind of immune cell populations can then be used to determine the degree of lymphocyte infiltration as has been shown in breast cancer. (wikipedia.org)
  • cell
  • The present study was conducted to determine whether the stress of physical work further affects the expression of splenic lymphocyte phenotypes following in vitro stimulation by the T-cell mitogen, Con A, and also by interleukin-1 (IL1). (biomedsearch.com)
  • At Flow Contact Site Laboratory, LLC we offer a variety of panels for immunophenotyping of lymphocyte subsets and other immune cell subsets for both preclinical and clinical studies. (fcslaboratory.com)
  • Significant information can be gained by identifying these cellular subsets and monitoring the impact of a given treatment on the distribution of these immune cell subsets. (fcslaboratory.com)
  • A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system. (wikipedia.org)
  • In normal situations, the coarse, dense nucleus of a lymphocyte is approximately the size of a red blood cell (about 7 μm in diameter). (wikipedia.org)
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • mice
  • It is possible that B lymphocytes play an important role in the provision of costimulation in NOD mice which is unnecessary in the NOD-RIP-B7-1 transgenic mice. (rupress.org)
  • counts
  • Treatment with high dose factor VIII concentrate (more than 25 000 U/year) was associated with low platelet counts, low lymphocyte counts, low T4:T8 ratios, and hypergammaglobulinaemia. (bmj.com)
  • whereas
  • The immunomodulatory drug fingolimod (FTY720, Gilenya) directly targets S1P receptors and inhibits lymphocyte egress, whereas the exact effector function of interferon-β (IFN-β) in MS therapy remains elusive. (biomedcentral.com)
  • significant
  • There was a significant effect of stimulation by Con A on the percentage of splenic lymphocytes positive for Thy1.2, Lyt-2, L3T4, and goat anti-mouse Ig, regardless of treatment condition. (biomedsearch.com)
  • receptor
  • Lymphocyte receptor repertoires are continually shaped throughout the lifetime of an individual in response to environmental and pathogenic exposure. (beds.ac.uk)
  • The sphingosine 1-phosphate receptor (S1PR1) is known to act by multiple mechanisms: limiting lymphocyte egress from secondary lymphoid organs, suppressing proinflammatory endothelial cell function, and acting directly on neurons and astrocytes. (pnas.org)