• Bone Marrow
  • Correlation of bone marrow abnormalities, peripheral lymphocyte subsets and clinical features in uncomplicated common variable immunodeficiency (CVID) patients. (naver.com)
  • 2009 Changes of lymphocyte subsets in acute leukemia patients after HLA-mismatched nonmyeloablative hematopoietic stem cell transplantation 2010 "Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report", published in Biol Blood Marrow Transplant 2009 A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD" published in Biol Blood Marrow Transplant. (wikipedia.org)
  • cytokines
  • In this study, we thus investigated the expression of infiltrating lymphocyte subsets (CD3, CD20, CD4, and CD8) and T helper (Th) cytokines including interferon (IFN)-γ (Th1 type), interleukin (IL)-4 (Th2 type), IL-17 (Th17 type), and IL-10 (regulatory T cell type) by immunohistochemistry in buccal mucosa specimens from 2 GS patients compared with 15 OLP patients. (nih.gov)
  • Pineal microglia/macrophages were common and represent an important candidate for mediating these lymphocyte-pineal interactions via secretion of cytokines and chemokines. (biomedcentral.com)
  • effector memory
  • Objectives Evaluate the number and distribution of circulating CD4+ T lymphocytes and their CD4+ naïve T cells (T N ), central memory (T CM ), non-terminated effector memory (T NTEM ) and terminated effector memory (T TEM ) T cells subsets in a population of recently diagnosed DMARD naive RA patients before and along the first 6 months of methotrexate (MTX) treatment. (bmj.com)
  • Humans
  • B cells mature into B lymphocytes in the bursa equivalent, which in humans is the GALT, which is thought to be located in the Peyer's patches of the intestine, while T cells migrate to and mature in a distinct organ, called the thymus. (wikipedia.org)
  • proliferation
  • Results of previous work from this laboratory demonstrated that reduced murine splenic lymphocyte proliferation in response to Concanavalin A (Con A) is associated with acute exercise stress. (biomedsearch.com)
  • Subsequent studies revealed that the dye can be used to monitor lymphocyte proliferation, both in vitro and in vivo, due to the progressive halving of CFSE fluorescence within daughter cells following each cell division. (wikipedia.org)
  • Thus CFSE represents an extremely valuable fluorescent dye for immunological studies, allowing lymphocyte proliferation, migration and positioning to be simultaneously monitored. (wikipedia.org)
  • cells
  • There was a significantly greater increase in the percentage of Thy1.2+ and, especially of, Lyt-2+ cells in stimulated splenic lymphocytes from untrained mice given an exhaustive exercise session compared with controls and with trained mice. (biomedsearch.com)
  • Lymphocytes strongly contribute to the pathology of multiple sclerosis (MS). Thereby, frequently activated or reactivated autoreactive lymphocytes differentiate into effector cells that enter the central nervous system (CNS) causing tissue inflammation and damage. (biomedcentral.com)
  • While fingolimod reduced the number of almost all analyzed subsets in the circulation IFN-β specifically reduced the numbers of marginal zone and memory B cells. (biomedcentral.com)
  • In conclusion, we think that by reducing "memory" type lymphocytes in the circulation fingolimod and IFN-β impair reactivation of autoreactive cells. (biomedcentral.com)
  • In particular, many intermediates between established subsets have been reported, for example Th1/Th17 cells expressing both IFNγ (interferon‐gamma) and IL (interleukin)‐17. (els.net)
  • This assay provides absolute (cells/mcL) and relative (%) quantitation for the main categories of T cells, B cells, and NK cells, in addition to a total lymphocyte count (CD45+). (testcatalog.org)
  • The studies on diurnal (circadian) variation in lymphocyte counts have demonstrated progressive increase in CD4 T-cell count throughout the day, while CD8 T cells and CD19+ B cells increase between 8:30 a.m. and noon with no change between noon and afternoon. (testcatalog.org)
  • Image analysis of immunocytochemically stained sections showed that the majority of lymphocytes were CD3 + (80%) with the remaining 20% comprising B-cells and monocytes (Bu-1 + ), which tended to distribute along the periphery of the PALT. (biomedcentral.com)
  • Effects of the 24-h light:dark cycle on these lymphocyte-pineal interactions were suggested by an increase in the area of PALT, a decline in the density of TCRαβ/Vβ 1 + cells, and a decline in the area density of Bu-1 + microglia at the light:dark interphase (1900 h) compared to the dark:light interphase (0700 h). (biomedcentral.com)
  • T-lymphocytes (T-cells) are white blood cells which take part in cell-mediated immunity. (wikipedia.org)
  • If undiagnosed or left untreated, HIV usually progresses to AIDS, defined as possessing a CD4+ lymphocyte count under 200 cells/μl or HIV infection plus co-infection with an AIDS-defining opportunistic infection. (wikipedia.org)
  • The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. (wikipedia.org)
  • Highly reproducible results Possible to analyze subsets of cells using physical and immunofluorescent markers. (wikipedia.org)
  • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. (wikipedia.org)
  • counts
  • Treatment with high dose factor VIII concentrate (more than 25 000 U/year) was associated with low platelet counts, low lymphocyte counts, low T4:T8 ratios, and hypergammaglobulinaemia. (bmj.com)
  • The absolute counts of lymphocyte subsets are known to be influenced by a variety of biological factors, including hormones, the environment, and temperature. (testcatalog.org)
  • circadian
  • The pineal gland of the chicken contains large accumulations of lymphocytes that suggest an important role related to homeostatic circadian neuro-immune interactions. (biomedcentral.com)
  • Migration
  • CFSE was originally developed as a fluorescent dye that could be used to stably label lymphocytes and track their migration within animals for many months. (wikipedia.org)
  • cell
  • Our instrumentation allows up to 10 parameters to be measured in a single tube and our analysis software utilizes complex gating strategies for narrowing specific lymphocyte subsets from the larger pool of cell types present in the sample. (fcslaboratory.com)
  • Initial models of highly stable T‐cell subsets were useful but underestimated diversity. (els.net)
  • In normal situations, the coarse, dense nucleus of a lymphocyte is approximately the size of a red blood cell (about 7 μm in diameter). (wikipedia.org)
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • significant
  • There was a significant effect of stimulation by Con A on the percentage of splenic lymphocytes positive for Thy1.2, Lyt-2, L3T4, and goat anti-mouse Ig, regardless of treatment condition. (biomedsearch.com)