AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Synovitis, Pigmented VillonodularSynovitisGiant Cell TumorsChondroblastomaHemosiderinMononeuropathiesKnee JointArthroscopySynovial MembraneHip JointMagnetic Resonance Imaging
PVNSArthroscopyTumorPathologyInflammatorySynovial MembraneArthroscopicAnkleSynoviumDiagnosisAnteriorTreatmentJointsFindingsPatientsBodiesCaseGenerallyTypeTenosynovial giant cell tumorTenosynovitisTendon sheathMalignantRecurrenceSynovial cellKneeInflammationProliferationLesionsMACROPHAGESMagneticGiantOccursJoint
PVNS15
  • Pigmented villonodular synovitis (PVNS), also known as diffuse tenosynovial giant cell tumor, is a benign proliferative disorder of uncertain etiology that affects synovial lined joints, bursae, and tendon sheaths (see the images below). (medscape.com)
  • To review recent developments in the molecular pathogenesis of tenosynovial giant cell tumor (TGCT) or pigmented villonodular synovitis (PVNS) and its therapeutic implications. (nih.gov)
  • In the following report, LCG was manifested as a villous synovial proliferation mimicking pigmented villonodular synovitis (PVNS). (medscape.com)
  • Pigmented villonodular synovitis (PVNS) is a rare, benign locally aggressive disorder of the synovium of joints, bursae and tendon sheaths and has three main subtypes. (orthoracle.com)
  • In this paper, we report a rare case of pigmented villonodular synovitis (PVNS) in a 37-year-old Caucasian male soccer player, with a 4-year story of ankle swelling and ROM painful limitation. (jocr.co.in)
  • Pigmented villonodular synovitis (PVNS) is a rare benign disease of the synovium of joints and tendon sheaths, which may be locally aggressive. (boneandjoint.org.uk)
  • Pigmented villonodular synovitis (PVNS) is a rare benign proliferative condition affecting synovial membranes of joints, bursae or tendons, resulting from possibly neoplastic synovial proliferation with villous and nodular projections and haemosiderin deposition. (sicot.org)
  • Pigmented villonodular synovitis (PVNS) of the knee joint: magnetic resonance imaging (MRI) using standard and dynamic paramagnetic contrast media. (sicot.org)
  • In addition to melanoma and other solid tumors to be studied in this collaborative trial, PLX3397 is being evaluated in several other clinical indications, including tenosynovial giant cell tumor (TGCT), historically called pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS), breast cancer and glioblastoma. (merck.com)
  • TGCT is also known as giant cell tumor of the tendon sheath (GCT-TS) or pigmented villonodular synovitis (PVNS). (rxwiki.com)
  • Pigmented Villonodular Synovitis (PVNS) is a medical condition that refers to the thickening of the synovial membrane. (orthotexas.com)
  • The main purpose of this study is to gather information about the investigational drug pexidartinib, which may help to treat tumors of pigmented villonodular synovitis (PVNS) or giant cell tumor of the tendon sheath (GCT-TS). (stanford.edu)
  • The financing will enable SynOx to continue the development of emactuzumab, for the treatment of diffuse tenosynovial giant cell tumours (TGCT), also known as pigmented villonodular synovitis (PVNS), and other indications. (privateequitywire.co.uk)
  • Tenosynovial giant cell tumor (also known as pigmented villonodular synovitis [PVNS]) causes the lining of the joint to become swollen and grow. (msdmanuals.com)
  • Pigmented Villonodular Synovitis (PVNS) our Co-Founder's patient experience with ultra rare disease. (fibroflutters.com)
Arthroscopy2
  • Given the limited soft tissues surrounding the ankle in conjunction with the ability of arthroscopy to easily access the entire joint, arthroscopic management of ankle pigmented villonodular synovitis allows for successful treatment while minimizing the surgical complications of an open approach. (medscape.com)
  • The diagnosis of synovitis with rice body formation was confirmed at arthroscopy. (scielo.org.za)
Tumor2
  • Types include: Pigmented villonodular synovitis Giant cell tumor of the tendon sheath Though they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin. (wikipedia.org)
  • Letter to the Editor: Does Osteoarticular Allograft Reconstruction Achieve Long-term Survivorship After En Bloc Resection of Grade 3 Giant Cell Tumor Of Bone? (ucdavis.edu)
Pathology1
  • Knee swelling is unusual in anterior knee pain and generally implies intra-articular pathology, synovitis or loose body. (biomedcentral.com)
Inflammatory2
  • Pigmented villonodular synovitis is a proliferative synovial-based inflammatory process that can lead to joint destruction and debilitating pain. (medscape.com)
  • Radiosynovectomy is a safe and repeatable treatment method of chronic synovitis with synovial overgrowth and refractory chronic or acute inflammatory joint effusion. (jultrason.pl)
Synovial Membrane1
Arthroscopic1
  • The favorable outcome in this case suggests that combined open and arthroscopic surgery may be an effective method for treating pigmented villonodular synovitis in skeletally immature patients. (tokushima-u.ac.jp)
Ankle4
  • Arthroscopically assisted synovectomy in patients with pigmented villonodular synovitis of the ankle and hindfoot is an effective treatment option, providing adequate visualization for complete excision while minimizing soft-tissue complications related to larger surgical exposures. (medscape.com)
  • Pigmented villonodular synovitis should be considered in diagnostic flow chart of anterior ankle impingement. (jocr.co.in)
  • Ankle, impingement, pigmented villonodular synovitis. (jocr.co.in)
  • Stevenson JD, Jaiswal A, Gregory JJ, Mangham DC, Cribb G, Cool P. Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. (boneandjoint.org.uk)
Synovium2
  • Ours is the first reported case presenting clinically in the synovium of the hip joint as pigmented villonodular synovitis. (medscape.com)
  • Pigmented villonodular synovitis is an uncommon disease characterized by hyperplastic synovium, large effusions and bone erosions. (radiopaedia.org)
Diagnosis2
Anterior2
  • Learn the Open anterior synovectomy for diffuse pigmented villonodular synovitis of the knee surgical technique with step by step instructions on OrthOracle. (orthoracle.com)
  • Our e-learning platform contains high resolution images and a certified CME of the Open anterior synovectomy for diffuse pigmented villonodular synovitis of the knee surgical procedure. (orthoracle.com)
Treatment3
  • Surgical excision is the "gold standard" for treatment of pigmented villonodular synovitis. (medscape.com)
  • Treatment of Diffuse Pigmented Villonodular Synovitis of the knee with combined surgical and radio synovectomy. (sicot.org)
  • He maintains a database that tracks surgical treatment in patients with pigmented villonodular synovitis. (hopkinsmedicine.org)
Joints1
  • Additionally, three patients with pigmented villonodular synovitis in the tibiotalar and subtalar joints who were successfully treated with arthroscopically assisted synovectomy are reported.Three patients with pigmented villonodular synovitis in the tibiotalar and subtalar joints underwent arthroscopically assisted synovectomy without adjuvant radiotherapy. (medscape.com)
Findings1
  • We report the case of a 5-year-old girl with left knee pain and swelling who was diagnosed with diffuse pigmented villonodular synovitis of the left knee based on MRI findings. (tokushima-u.ac.jp)
Patients2
  • Pigmented villonodular synovitis is an extremely rare disease in skeletally immature patients. (tokushima-u.ac.jp)
  • The important differential diagnoses that need to be excluded in patients with rice bodies are synovial chondromatosis and pigmented villonodular synovitis. (scielo.org.za)
Bodies1
Case1
  • We report a case of villonodular synovitis that, also less common, has to be considered in diagnostic flowchart. (jocr.co.in)
Generally1
  • The term pigmented villonodular synovitis is generally used when diffuse intraarticular involvement is present (2,3). (facmedicine.com)
Type1
Tenosynovial giant cell tumor5
  • 2. Distinct extra-articular invasion patterns of diffuse pigmented villonodular synovitis/tenosynovial giant cell tumor in the knee joints. (nih.gov)
  • 7. Giant cell tumor of tendon sheath, tenosynovial giant cell tumor, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. (nih.gov)
  • 17. Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery. (nih.gov)
  • However, 2 conditions-synovial chondromatosis and tenosynovial giant cell tumor (pigmented villonodular synovitis)-occur in the lining (synovium) of joints. (msdmanuals.com)
  • Tenosynovial giant cell tumor (previously called pigmented villonodular synovitis) is considered a benign neoplastic tumor of the synovium that can occur around as well as in a joint. (msdmanuals.com)
Tenosynovitis5
  • Histopathological examination revealed pigmented villonodular tenosynovitis which stained positive for CD 68. (scirp.org)
  • Conclusion: Pigmented villonodular tenosynovitis of temporomandibular joint is a rare entity. (scirp.org)
  • in 1941 [2] who first introduced the term pigmented villonodular tenosynovitis. (scirp.org)
  • 4. Jaffe HL, Litchtenstein L, Sutro C. Pigmented Villonodular Synovitis: bursitis and tenosynovitis. (jbstjournal.com)
  • 20. Myers B.W, Masi A.T. Pigmented villonodular synovitis and tenosynovitis: a clinical epidemiological study of 166 cases and literature review. (jbstjournal.com)
Tendon sheath2
  • Types include: Pigmented villonodular synovitis Giant cell tumor of the tendon sheath Though they have very different names, they have the same histology, and stain positive for CD68, HAM56, and vimentin. (wikipedia.org)
  • 5. Llauger J, Palmer J, Roson N. Pigmented villonodular synovitis and giant cell tumors of the tendon sheath: radiologic and pathologic features. (jbstjournal.com)
Malignant1
  • 14. Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (nih.gov)
Recurrence1
  • High recurrence and good functional results after arthroscopic resection of pigmented villonodular synovitis. (upf.edu)
Synovial cell1
  • 11. Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis. (nih.gov)
Knee6
  • A 47-year-old white woman presents with right knee villonodular synovitis. (medscape.com)
  • [ 1 ] Davidson and Bentley [ 1 ] reported a case of a nodular variant of pigmented villonodular synovitis of the knee that developed following laser treatment. (medscape.com)
  • Pigmented villonodular synovitis of the knee. (medscape.com)
  • Eighty per cent of the time pigmented villonodular synovitis affects just one joint of the body, primarily the knee joint. (eorthopod.com)
  • C). During his follow-up, the patient developed multifocal pigmented villonodular synovitis which first affected the left knee and shortly after both elbows. (nih.gov)
  • Pigmented villonodular synovitis can affect people of all ages, but it occurs most often in young adults from 20 to 50 years of age and most commonly occurs in the knee. (bicmd.com)
Inflammation2
  • Pigmented villonodular synovitis is most often painless inflammation or swelling, and overgrowth of the lining of a joint. (eorthopod.com)
  • In our body, the dis-order, Synovitis is usually painful, particularly on motion, indicative to a specific set of signs, symptoms or other health indicators, associated with an inflammation of a synovial membrane characterized by a fluctuating swelling due to effusion within a synovial sac. (wellnessadvantage.com)
Proliferation1
  • INTRODUCTION: Pigmented villonodular synovitis (PVS) is a synovial proliferation disorder of uncertain aetiology, with some controversy as regards its proper treatment. (upf.edu)
Lesions1
MACROPHAGES1
Magnetic1
Giant1
  • 6. Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. (nih.gov)
Occurs1
Joint2
  • Dynamic stereometry to assess condylar movements relative to the fossa was performed at the 5 year follow-up of a patient who underwent condylar resection of the right TMJ followed by total alloplastic joint reconstruction to treat pigmented villonodular synovitis. (uzh.ch)
  • Pigmented villonodular synovitis of the talonavicular joint: A case report and review of the literature. (jbstjournal.com)