Swainsonine. Medical search. Frequent questions

Swainsonine is an indolizidine alkaloid. (wikipedia.org)
Reduction from the β face would then yield the R configuration of swainsonine, as opposed to the S configuration of slaframine, another indolizidine alkaloid whose biosynthesis is similar to that of swainsonine during the first half of the pathway and also shown above alongside that of swainsonine. (wikipedia.org)
Locoweeds are Astragalus and Oxytropis species that contain the toxic alkaloid swainsonine, causing widespread poisoning of livestock in Inner Mongolia. (usda.gov)
Loco heads also contained the highest concentration of the toxic alkaloid, swainsonine. (arizona.edu)
This cell of salivary biomarkers could be used as a practical and non-invasive instrument for showing the activity of numerous body structure programs active in the strain reaction.Swainsonine (SW) can be an indolizidine alkaloid, as well as the principal harmful element of your toxic legume crops Astragalus and also Oxytropis sp. (methylation-inhibitors.com)

Taxa (Astragalus, Oxytropis, Sphaerophysa, and Sophora species) suspected of causing locoism and/or poisoning in Inner Mongolia were surveyed for swainsonine and Undifilum, the fungal endophyte responsible for the production of swainsonine. (usda.gov)
Mjelt, også kjent som Astragalus mongholicus, er en vanlig urt som er kjent brukt i tradisjonell kinesisk medisin. (nafkam.no)
Mjelt (Astragalus mongholicus) er en vanlig urt i tradisjonell kinesisk medisin. (nafkam.no)

Disruption of Golgi alpha-mannosidase II with swainsonine induces hybrid-type glycans. (wikipedia.org)
Structural Investigation of the Binding of 5-Substituted Swainsonine Analogues to Golgi alpha-Mannosidase II. (expasy.org)

The chemoselective reduction of 1 followed by two-carbon homologation by the Wittig reaction afforded γ,δ-aziridino-α,β-unsaturated ester 9, which on regioselective nucleophilic aziridine ring opening either by using water as a nucleophile or hydrogenation afforded δ-lactams 11/16-true synthons for the synthesis of four structurally different iminosugars, namely quinolizidine alkaloids 5b/5c, swainsonine 6b and lentiginosine 7b analogues. (ias.ac.in)
Locoweed contains toxic alkaloids, such as swainsonine and selenium, which can cause a range of symptoms in animals that ingest it, including neurological, reproductive, and digestive problems. (coloradohorseforum.com)
Hormones and related cardenolides swainsonine atractyloside, gummiferine belladonna alkaloids cyclic antidepressants postanoxic encephalopathy increased sympathetic tone (amphetamines, cocaine, phenylephrine and other vigorous methods should help to prevent furtherplications. (oaksofwellington.com)
Colchicine accumulates in the united states, all prescription and nonprescription ackee fruit borage umbrella tree black mustard cabbage cactus caladium crown ower tea, green tea renal, carcinogenic neurologic cardiac cardiac, neurologic dermatitis: Contact, allergic xenobiotic swainsonine pyrrolizidine alkaloids are a diverse group that will allow her time to ask questions without embarrassment. (revivemedicalny.com)

In most cases, synthesis implies the use of sugars, chiral aminoacids as starting compounds, or chiral catalysts to induce chirality.The swainsonine synthesis was systemazed by three common precursors: 8-oxy-hexahydroindolizines, N-protected-3-oxy-2-substituted-piperidines and 2-substituted-pyrrolidine-3,4-protected-diols. (wikipedia.org)
Dhavale, Dilip D. (2008) Efficient synthesis of (+)-1,8,8a-tri-epi-swainsonine, (+)-1,2-di-epi-lentiginosine, (+)-9a-epi-homocastanospermine and (-)-9-deoxy-9a-epi-homocastanospermine from a D-glucose-derived aziridine carboxylate, and study of their glycosidase inhibitory activities Organic and Biomolecular Chemistry, 6 (4). (ias.ac.in)
In the clone expressing Fuc-TIII and beta3Gal-T5 (CHO-FT-T5), sialyl-Lewis a synthesis is strongly inhibited by swainsonine but not by benzyl-alpha-GalNAc, and sialyl-Lewis x is absent, although it is detected in the clones expressing Fuc-TIII and beta3Gal-T1 (CHO-FT-T1) or Fuc-TIII and beta3Gal-T2 (CHO-FT-T2). (unipv.it)

Taxa suspected of causing locoism and/or poisoning in Inner Mongolia were surveyed for swainsonine and Undifilum, the fungal endophyte responsible for the production of swainsonine. (usda.gov)

Because chronic intoxication with swainsonine causes a variety of neurological disorders in livestock, these plant species are known collectively as locoweeds. (wikipedia.org)

The inhibitory effect of swainsonine on Golgi Mannosidase II (GMII) was proposed to be due to its ability to bind in the GMII binding pocket in a similar fashion as the natural GMII substrate in its transition state. (wikipedia.org)

ABSTRACT The fungus _Slafractonia leguminicola_, the causal agent of blackpatch disease of legumes produces two mycotoxins slaframine and swainsonine, causing slobbers' symptoms and locoism of grazing animals, respectively.The genetics of this important fungus is poorly understood. (sohag-univ.edu.eg)

The biosynthesis of swainsonine has been investigated in the fungus Rhizoctonia leguminicola, and it initially involves the conversion of lysine into pipecolic acid. (wikipedia.org)
Through detection of (1,8a-trans)-1-hydroxyindolizidine and (1,8a-trans-1,2-cis)-1,2-dihydroxyindolizidine-two precursors of swainsonine in the fungus pathway-in the shoots of the plant, Harris et al. (wikipedia.org)
proposed that the biosynthetic pathway of swainsonine in the locoweed is nearly identical to that of the fungus. (wikipedia.org)

they are host of endophytic fungi which produces swainsonine. (wikipedia.org)
This species is symbiotic with an ascomycete that produces swainsonine (Cook et al. (usf.edu)

The biosynthetic pathway of swainsonine has also been investigated in the Diablo locoweed. (wikipedia.org)

Later, it was shown that the binding pattern of the swainsonine molecule resembles that of the Michaelis complex of mannose and only the protonated, charge positive swainsonine molecule binds similarly to the substrate in its transition state. (wikipedia.org)