• These highlights do not include all the information needed to use SUCCINYLCHOLINE CHLORIDE INJECTION safely and effectively. (nih.gov)
  • Reserve use of succinylcholine chloride injection in pediatric patients for emergency intubation or instances where immediate securing of the airway is necessary, or for intramuscular use when a suitable vein is inaccessible. (nih.gov)
  • Store succinylcholine chloride injection with the cap and ferrule intact and in a manner that minimizes the possibility of selecting the wrong product. (nih.gov)
  • Unintended administration of succinylcholine chloride injection may result in paralysis, respiratory arrest and death. (nih.gov)
  • Succinylcholine chloride injection may induce serious cardiac arrhythmias or cardiac arrest due to hyperkalemia. (nih.gov)
  • Dr Reddy's Laboratories announced the launch of Succinylcholine Chloride Injection USP, 200 mg/10 mL (20 mg/mL), Multiple-Dose Vials a therapeutic equivalent generic version of Quelicin® (Succinylcholine Chloride) Injection, 20 mg/mL, approved by the US Food and Drug Administration (USFDA). (nct-cbnw.com)
  • Dr Reddy's Succinylcholine Chloride Injection USP, 200 mg/10 mL (20 mg/mL), is available in multi-dose vials. (nct-cbnw.com)
  • Succinylcholine chloride injection is indicated, in addition to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. (wikipedia.org)
  • Succinylcholine is a paralytic agent used for surgeries or short procedures, such as intubation. (picmonic.com)
  • We have received a request from Anesthesia to allow them to store succinylcholine outside of the Pyxis for the purposes being prepared to treat laryngospasm citing the reason that they cannot take the time to type in the drug name to access when a patient is crashing. (medsafetyofficer.org)
  • Suxamethonium chloride, also known as suxamethonium or succinylcholine, or simply sux by medical abbreviation, is a medication used to cause short-term paralysis as part of general anesthesia. (wikipedia.org)
  • When properly administered, succinylcholine can be used to facilitate difficult intubations in the emergency department with an acceptable incidence of adverse effects or failures. (nih.gov)
  • The US FDA-approved label contraindicates succinylcholine for individuals carrying one of many genetic variants known to increase the risk of adverse side effect. (meragenome.com)
  • Indications for treatment of malignant hyperthermia (MH) with dantrolene include signs of hypermetabolism, a rapid rise in carbon dioxide in the face of an increase in the minute ventilation, tachycardia, muscle and or jaw rigidity (after succinylcholine), and fever (a late sign). (medscape.com)
  • Apart from succinylcholine containing drugs Quelicin & Anectine, the gene also is involved in metabolism of mivacurium, ester local anesthetics particularly chloroprocaine. (meragenome.com)
  • In patients with head injuries who undergo rapid sequence intubation using succinylcholine, does pretreatment with a competitive neuromuscular blocking agent improve outcome? (bmj.com)
  • A literature search was undertaken for evidence of the effect of succinylcholine (SCH) on the intracranial pressure (ICP) of patients with acute brain injury and whether pretreatment with a defasciculating dose of competitive neuromuscular blocker is beneficial in this patient group. (bmj.com)
  • Rosenberg et al (1992) described four males under 8 years who received halothane and succinylcholine with subsequent massive rhabdomyolysis and hyperkalemia leading to arrest and death. (pedemmorsels.com)
  • The mechanism of life-threatening arrhythmias and arrest was proposed by Rosenberg et al to be massive rhabdomyolysis (from depolarizing effects of succinylcholine) leading to acute hyperkalemia , which precipitates wide complex tachyarrhythmias, bradyarrhythmias, and arrest . (pedemmorsels.com)
  • In her first ECT session, succinylcholine was avoided because of the reported risk of life-threatening hyperkalemia as a result of upregulation of nicotinic cholinergic receptors secondary to long-term immobilization (as the patient was immobilized for the past 6 months). (anesth-pain-med.org)
  • In the third ECT session, it was decided to use succinylcholine instead of atracurium with complete preparation for monitoring, diagnosis, and management of hyperkalemia, in case such an event occurred. (anesth-pain-med.org)
  • Hudcova and Schumann [ 3 ] reported ventricular tachycardia and ECG changes suggestive of hyperkalemia (with a rise in serum potassium level from 4.3 mEq/L to 6.4 mEq/L) after administering succinylcholine in a patient with catatonia scheduled to undergo ECT. (anesth-pain-med.org)
  • Succinylcholine is a short-acting depolarizing neuromuscular blocking agent. (turkjemergmed.org)
  • The incidence is higher following a second dose of succinylcholine. (nih.gov)
  • Further clinical examination and laboratory investigations led the treating physicians to suspect deliberate intravenous injection of succinylcholine. (turkjemergmed.org)
  • This is the first report describing the survival of a patient with intentional intravenous (IV) succinylcholine administration. (turkjemergmed.org)
  • Succinylcholine, is a fast-acting depolarising muscle relaxant and is widely used in clinical settings. (meragenome.com)
  • Succinylcholine keeps cells in sustained depolarization and prevents muscle contraction. (picmonic.com)
  • However, due to improvement in muscle rigidity, succinylcholine was administered in the next three sessions with all preparations in place. (anesth-pain-med.org)
  • Our experience suggests that succinylcholine may be safe when muscle rigidity is improved. (anesth-pain-med.org)
  • Succinylcholine Chloride is the chloride salt form of succinylcholine, a quaternary ammonium compound and depolarizing agent with short-term muscle relaxant properties. (cartkoo.com)
  • 4 ] reported arrhythmias and asystoles after succinylcholine administration in a patient with catatonia undergoing ECT. (anesth-pain-med.org)
  • The risk of arrhythmias led us to choose a non-depolarizing NMBD over succinylcholine in the initial two settings. (anesth-pain-med.org)
  • Zisselman and Jaffe [ 5 ] also reported ventricular tachycardia with succinylcholine administration in these patients. (anesth-pain-med.org)
  • Succinylcholine is an analog of the neurotransmitter acetylcholine. (meragenome.com)
  • Succinylcholine chloride binds to nicotinic receptors at the neuromuscular junction and opening the ligand-gated channels in the same way as acetylcholine, resulting in depolarization and inhibition of neuromuscular transmission. (cartkoo.com)
  • It is often used to overcome the desensitization experience by paralyzed patients in Phase II block of succinylcholine. (picmonic.com)
  • Based on the existing literature and our experience, the use of succinylcholine or a non-depolarizing NMBD in such patients remains controversial. (anesth-pain-med.org)
  • Before you reflexively say "Sux," we should consider some risks in the pediatric population that come with succinylcholine administration. (pedemmorsels.com)
  • The US FDA-approved label warns that individuals who are carriers of the atypical variant of the plasma cholinesterase gene (BCHE) are at risk of prolonged apnea if administered succinylcholine. (meragenome.com)
  • In the emergency department at Hennepin County Medical Center, succinylcholine has been used to assist difficult intubations since March 1, 1979. (nih.gov)
  • As routine blood investigations were normal, our main concern was serum potassium (4.45 mEq/L), which was expected to rise further with succinylcholine, a commonly used neuromuscular blocking drug (NMBD) in ECT procedures [ 2 ]. (anesth-pain-med.org)
  • Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes. (cdc.gov)
  • Succinylcholine, on the other hand, is bound for much longer time. (picmonic.com)
  • we will focus on considerations in predicted difficult airways (RSI vs. awake intubation), Rocuronium vs. Succinylcholine, and the indications. (emottawablog.com)
  • Rocuronium versus succinylcholine in air medical rapid-sequence intubation. (wakehealth.edu)
  • With the decline in the use of succinylcholine and the availability of safer alternatives such as rocuronium and sugammadex, less and less is being written in textbooks about PChE deficiency. (jicajournal.in)
  • A formulation for preparing Succinylcholine Chloride 50-mg/mL Injection. (ijpc.com)
  • Succinylcholine or Suxamethonium is a muscle-relaxant agent with a peripheric depolarizing action that is used for rapid endotracheal intubation procedures, mechanical ventilation, and surgical procedures. (e-lactancia.org)
  • Suxamethonium chloride, also known as suxamethonium or succinylcholine, or simply sux by medical abbreviation, is a medication used to cause short-term paralysis as part of general anesthesia. (wikipedia.org)
  • As routine blood investigations were normal, our main concern was serum potassium (4.45 mEq/L), which was expected to rise further with succinylcholine, a commonly used neuromuscular blocking drug (NMBD) in ECT procedures [ 2 ]. (anesth-pain-med.org)
  • with prolonged duration of action of mivacurium or succinylcholine during anaesthesia. (nih.gov)
  • PChE (BuChE, EC 3.1.1.8): Also known as plasma cholinesterase, butyrylcholinesterase, or acylcholine acylhydrolase: Found primarily in the liver and is responsible for the metabolism of succinylcholine, mivacurium, and local anesthetics chloroprocaine, tetracaine, procaine, and benzocaine. (jicajournal.in)
  • PChE or butyrylcholinesterase deficiency is a rare, acquired, or inherited condition where the PChE levels are absent or lower than normal with a reduced ability to metabolize succinylcholine and mivacurium leading to prolonged muscular paralysis from standard doses. (jicajournal.in)
  • In her first ECT session, succinylcholine was avoided because of the reported risk of life-threatening hyperkalemia as a result of upregulation of nicotinic cholinergic receptors secondary to long-term immobilization (as the patient was immobilized for the past 6 months). (anesth-pain-med.org)
  • In the third ECT session, it was decided to use succinylcholine instead of atracurium with complete preparation for monitoring, diagnosis, and management of hyperkalemia, in case such an event occurred. (anesth-pain-med.org)
  • Hudcova and Schumann [ 3 ] reported ventricular tachycardia and ECG changes suggestive of hyperkalemia (with a rise in serum potassium level from 4.3 mEq/L to 6.4 mEq/L) after administering succinylcholine in a patient with catatonia scheduled to undergo ECT. (anesth-pain-med.org)
  • [2] , [3] The Food and Drug Administration issued a black box warning in 1993 for succinylcholine after a series of cardiac arrests occurred related to hyperkalemia in children with undiagnosed muscular dystrophy. (jicajournal.in)
  • Avoid succinylcholine as a paralytic in any patient with possible rhabdomyolysis to prevent the development of hyperkalemia. (medscape.com)
  • Succinylcholine is a commonly used depolarizing neuromuscular blocking agent in anesthesia for relaxation of the skeletal muscles during endotracheal intubation. (providence.org)
  • Because of multiple complications related to succinylcholine, many anesthesiologists now avoid its use for emergency and elective intubation. (jicajournal.in)
  • [6] Since the mutation is recessive, heterozygotes will present with an approximately 30% increase in the duration of action of succinylcholine. (jicajournal.in)
  • PharmGKB summary: succinylcholine pathway, pharmacokinetics/pharmacodynamics. (cdc.gov)
  • One documented side effects of succinylcholine is postoperative myalgia, which was first described in the literature in 1952. (providence.org)
  • Given recent surgery, succinylcholine-induced postoperative myalgia was considered the likely culprit. (providence.org)
  • Although succinylcholine-induced postoperative myalgia is generally mild and self-limited, certain cases can be severe. (providence.org)
  • The mechanism behind postoperative myalgias is not definitively elucidated, but is thought to be related to the fasciculations that occur soon after succinylcholine is administered. (providence.org)
  • Since the 1950s, cardiac arrest has been observed in burn patients receiving succinylcholine. (medscape.com)
  • What are the contraindications to succinylcholine administration? (brainkart.com)
  • Contraindications to succinylcholine administration follow logically from its known side-effects. (brainkart.com)
  • [1] The delayed reversal from neuromuscular blockade after administration of succinylcholine, was unlike the classic complete prolonged neuromuscular block seen in a patient with PChE deficiency. (jicajournal.in)
  • It is thus important to revisit PChE deficiency, and start a conversation on this life-threatening but relatively easy-to-manage complication following succinylcholine administration. (jicajournal.in)
  • echothiophate iodide increases levels of succinylcholine by decreasing metabolism. (medscape.com)
  • When large muscle groups are involved, a massive efflux of potassium ions from the muscle cells into the serum occurs after succinylcholine administration. (medscape.com)
  • Administration of succinylcholine to patients without neuromuscular disease results in a small, transient increase in a serum potassium concentration of about 0.55 meq/L. [ 7 ] Potassium increases greater than 5 meq/ L are extremely rare. (medscape.com)
  • Succinylcholine administration has been associated with acute onset of malignant hyperthermia. (nih.gov)
  • Uncommon neuro-muscular diseases, such as myotonia and dermatomyositis, react with sustained muscular contraction following succinylcholine administration. (brainkart.com)
  • 4 ] reported arrhythmias and asystoles after succinylcholine administration in a patient with catatonia undergoing ECT. (anesth-pain-med.org)
  • Zisselman and Jaffe [ 5 ] also reported ventricular tachycardia with succinylcholine administration in these patients. (anesth-pain-med.org)
  • Partial, weak respiratory efforts were observed initially, but complete recovery from neuromuscular block occurred 6 h after administration of succinylcholine. (jicajournal.in)
  • Following the administration of succinylcholine chloride, a one-hour waiting period is advisable before initiation of dexpanthenol therapy. (drugs.com)
  • The rapid onset and ultra-short duration of succinylcholine provide excellent intubating conditions and can theoretically facilitate an earlier reversal of NM blockade making it highly desirable in emergent situations. (jicajournal.in)
  • Structurally, succinylcholine consists of two acetylcholine molecules arranged back-to-back and mimics the pharmacologic action of acetylcholine at the acetylcholine receptor. (medscape.com)
  • amikacin increases effects of succinylcholine by pharmacodynamic synergism. (medscape.com)
  • amphotericin B deoxycholate increases effects of succinylcholine by pharmacodynamic synergism. (medscape.com)
  • 1,2] A general anesthetic regimen that included succinylcholine for cesarean section caused a delay in the time to the first breastfeeding, but the part that succinylcholine played in this difference in outcome in unknown. (nih.gov)
  • Electroconvulsive therapy in a catatonia patient: succinylcholine or no succinylcholine? (anesth-pain-med.org)