• rats
  • We found a prominent age-dependent accumulation of quinoprotein adducts in the substantia nigra, while no significant change of lipid peroxidation was detected in any brain regions of 2- to 15-month old rats. (springer.com)
  • stimulus
  • High-frequency stimulation of the substantia nigra induced potentiation of the cortically evoked excitation and increased the prolonged AHP after the stimulus. (jneurosci.org)
  • These findings from anesthetized animals suggest that a substantia nigra-induced AHP produces stimulus-associated firing pauses in cholinergic interneurons. (jneurosci.org)
  • pathology
  • To elucidate molecular mechanisms underlying neuronal dysfunction and alpha-synuclein pathology in the premotor phase of PD, we investigated the transcriptome of the substantia nigra (SN) of well-characterized iLBD, PD donors and age-matched controls with Braak alpha-synuclein stage ranging from 0-6. (sigmaaldrich.com)
  • Patients
  • Patients with at least one substantia nigra (SN) echogenic size ≥18 mm 2 were classified as hyperechogenic, those with at least one SN echogenic size ≥25 mm 2 was defined as markedly hyperechogenic. (springer.com)
  • changes
  • We further show that rewarding substantia nigra stimulation produces lasting changes in the prolonged AHP, which could account for the pause response seen in behavioral experiments. (jneurosci.org)