AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentDisciplines and OccupationsInformation Science
Striatonigral DegenerationOlivopontocerebellar AtrophiesMultiple System AtrophySubstantia NigraCorpus StriatumGlobus PallidusRetinal DegenerationMacular DegenerationReceptors, Dopamine D1Nerve DegenerationDopamine and cAMP-Regulated Phosphoprotein 32NeostriatumReceptors, Dopamine D2OxidopaminePutamenWallerian DegenerationNeural PathwaysBenzazepinesDopamine AgentsBasal GangliaNeuronsSubstance PDopamine AgonistsDopamineDynorphinsLIM-Homeodomain ProteinsIntervertebral Disc DegenerationLevodopaCaudate NucleusEnkephalinsCell Adhesion Molecules, NeuronalAutoradiographyPhysical and Rehabilitation MedicineEncyclopedias as TopicSpeech TherapyOccupational TherapySpeech DisordersShy-Drager Syndrome
Multiple systemOlivopontocerebellar atrophy or striatonigral degenerationCorticobasal degenerationSyndromeParkinsonismNeuronsSymptomsDiseasePredominantlyDementiaFrontotemporalPrognosisDeteriorationBrainAtrophyFrontotemporal lobar degeneAmyotrophic Lateral SCaudate nucleusNigrostriatalDopamineDisorderDescriptionReflect
Multiple system5
Olivopontocerebellar atrophy or striatonigral degeneration2
Corticobasal degeneration11
  • Corticobasal degeneration, otherwise termed as, Corticobasal ganglionic degeneration or CBGD, is a kind of neurodegenerative disorder concerning a certain protein, called tau. (allhealthsite.com)
  • As an added information, a group of physicians led by doctor Rebeiz in the late 1960s first observed the occurrence of corticobasal degeneration in three affected people exhibiting the hallmark characteristics of the disorder. (allhealthsite.com)
  • Corticobasal degeneration is a rather uncommon disease and usually occurs in people in their advanced age, usually in the sixth decade of life. (allhealthsite.com)
  • This multiplication in number is indicative of a more sensitive diagnosis or simply, corticobasal degeneration is more frequently occuring in the present days. (allhealthsite.com)
  • The particular gene of interest that has been the focus of research studies, associated with corticobasal degeneration is the gene in chromosome 17. (allhealthsite.com)
  • Corticobasal degeneration affects both the subcortical as well as the cortical parts of the human brain. (allhealthsite.com)
  • As mentioned above, corticobasal degeneration is characterized by an abnormality called tauopathy. (allhealthsite.com)
  • This distinction is the main factor that sets corticobasal degeneration apart from its similar diseases such as Alzheimer's disease and progressive supranuclear palsy. (allhealthsite.com)
  • Corticobasal degeneration may be categorized into two. (allhealthsite.com)
  • In addition there are four signs and symptoms (both motion and cognitive) that are major characteristics associated with corticobasal degeneration. (allhealthsite.com)
  • Alien hand syndrome is fairly common in people with corticobasal degeneration. (allhealthsite.com)
Syndrome3
  • MSA includes conditions that were previously known individually as Shy-Drager syndrome, striatonigral degeneration and sporadic olivopontocerebellar atrophy. (parkinson.ca)
  • It includes 3 disorders previously thought to be distinct: olivopontocerebellar atrophy, striatonigral degeneration, and Shy-Drager syndrome. (msdmanuals.com)
  • They consisted of 24 patients with olivopontocerebellar atrophy (OPCA), 25 with Shy-Drager syndrome (SDS) and 10 with striatonigral degeneration (SND). (go.jp)
Parkinsonism4
  • While symptoms of autonomic failure and cerebellar degeneration may be present in striatonigral degeneration, the predominant finding is parkinsonism. (medscape.com)
  • In many cases, the disease process begins with 1 of the 3 presentations predominating (ie, parkinsonism, autonomic failure, cerebellar signs) and then later converges to include a combination of all 3 plus additional degeneration of the corticospinal system, including tract and motor neuron degeneration, as well as cognitive deterioration. (medscape.com)
  • Parkinson disease (PD) , also known as idiopathic parkinsonism , is a neurodegenerative disease and movement disorder characterized by resting tremor, rigidity and hypokinesia due to progressive degeneration of dopaminergic neurons in the substantia nigra . (radiopaedia.org)
  • Features of parkinsonism often without tremor are combined with varying degrees of autonomic failure, cerebellar involvement and pyramidal tract degeneration. (naturalayurvedictreatment.com)
Neurons3
  • This is caused by progressive degeneration of neurons in several parts of the brain including the basal ganglia, inferior olivary nucleus, and cerebellum. (wikipedia.org)
  • The dopaminergic tract is predominantly affected in Parkinson disease, and histologically, it is characterized by nigrostriatal dopaminergic degeneration leading to neuronal loss in the substantia nigra pars compacta (SNpc), most conspicuous in the ventrolateral tier of neurons 11 . (radiopaedia.org)
  • Given that QT interval depends on sympathetic and parasympathetic activities, abnormalities observed in the QTc interval may reflect the degeneration of cardioselective sympathetic and parasympathetic neurons ( 12 ). (frontiersin.org)
Symptoms1
  • Clinical diagnosis of exclusion based on progressive symptoms of upper and lower motor neuron degeneration in which no other explanation can be found. (wikipedia.org)
Disease1
  • The primary cause of degeneration is still under debate- whether cell loss in MSA is secondary to disruptions in the oligo-myelin-axon complex [ 29 , 64 ], or if MSA is a primary neuron disease, with the secondary formation of GCIs following pathological accumulation of α-syn that is neuronal in origin [ 55 ]. (biomedcentral.com)
Predominantly2
  • The damage is predominantly in the striatonigral and olivopontocerebellar regions of the brain. (targetwoman.com)
  • Muscle cell degeneration predominantly occurs in the striatonigral region leading to tremors, lack of balance and postural impairment. (targetwoman.com)
Dementia1
  • 2005). In addition, PET scans have clinical utility for discerning between AD and dementia caused by frontotemporal lobar degeneration (FTLD) (Foster et al. (cd31-signal.com)
Frontotemporal1
  • There have also been occasional instances of frontotemporal lobar degeneration associated with MSA. (wikipedia.org)
Prognosis1
  • Although in OPCA, SND and SDS the pathological alterations of the central nervous system are known to be very similar, characterized as MSA, the present study suggests that the earlier and the more severe the involvement of the autonomic nervous system, and to a lesser extent the striatonigral system, the poorer the prognosis may be. (go.jp)
Deterioration1
  • This phenomenon is medically referred to as tauopathy that ultimately leads to the deterioration or the degeneration of the individual's brain. (allhealthsite.com)
Brain1
  • Machado-Joseph State (MJD-III), often referred to as spinocerebellar ataxia kind of III, try a rare, inherited, ataxia (insufficient muscle control) affecting the fresh central nervous system and you will characterized by new slow degeneration from form of areas of the brain called the hindbrain. (sch.id)
Atrophy8
  • Yoshida M, Sone M. [Mechanism of neuronal degeneration of multiple system atrophy]. (medscape.com)
  • Yoshida M. [Multiple system atrophy - synuclein and neuronal degeneration]. (medscape.com)
  • MSA was formerly known as Shy-Drager syndrome, olivopontocerebellar atrophy (OCPA), or striatonigral degeneration. (nih.gov)
  • In 1960, van de Eecken, Adams, and van Bogaert reported 3 patients with striatonigral degeneration (SND) with atrophy of the caudate nucleus and putamen. (medscape.com)
  • It includes 3 disorders previously thought to be distinct: olivopontocerebellar atrophy, striatonigral degeneration, and Shy-Drager syndrome. (msdmanuals.com)
  • Spinal muscular atrophy (SMA) is characterized by muscle weakness and atrophy resulting from progressive degeneration and irreversible loss of the anterior horn cells in the spinal cord (i.e., lower motor neurons) and the brain stem nuclei. (beds.ac.uk)
  • This condition is also known by the names like olivopontocerebellar atrophy or striatonigral degeneration. (naturalayurvedictreatment.com)
  • Thus, this result has implications for the choice of model and interpretation of studies used to investigate potential cannabinoid-based therapies for Parkinson's disease as well as striatonigral diseases such as Huntington's disease and Multiple Systems Atrophy. (thctotalhealthcare.com)
Frontotemporal lobar degene1
  • There have also been occasional instances of frontotemporal lobar degeneration associated with MSA. (wikipedia.org)
Amyotrophic Lateral S1
  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. (elsevierpure.com)
Caudate nucleus1
  • Comprises of several syndromes of bilateral symmetric spongy degeneration of the caudate nucleus, putamen and globus pallidus with characteristics of developmental regression, choreoathetosis and dystonia progressing to spastic quadriparesis. (cdc.gov)
Nigrostriatal1
  • Cardiac sympathetic impairment parallels nigrostriatal degeneration in Probable Dementia with Lewy Bodies. (medscape.com)
Dopamine1
  • The goal of this review was to examine whether chronic Mn exposure produces dopamine neuron degeneration and PD or whether it has a distinct neuropathology and clinical presentation. (nih.gov)
Disorder1
  • Glial cytoplasmic inclusions (GCIs) and neuronal multisystem degeneration are the pathologic hallmarks of this clinically variable disorder (see the image below). (medscape.com)
Description1
  • Special attention is given to the first accurate description of striatonigral degeneration by Hans Joachim Scherer, his personal and scientific trajectory being clarified. (nih.gov)
Reflect1
  • These disorders have complex clinical presentations that reflect degeneration in various neuronal systems. (medscape.com)