• The oldest representative of the macrolide antibiotics is erythromycin , in 1954 oleandomycin was isolated from culture filtrates of Streptomyces antibioticus. (zxc.wiki)
  • RESULTS: Oviedomycin BGC was captured from the genome of Streptomyces antibioticus by a newly constructed plasmid, pCBA, and conjugated into the heterologous strain, S. coelicolor M1152. (bvsalud.org)
  • Grixazone synthase OS=Streptomyces griseus subsp. (uu.nl)
  • But this actin-o-mycete species, which was renamed Streptomyces griseus in 1943 and played an impor-tant role in the dis-cov-ery of strep-to-mycin, was not stud-ied in detail by Waksman in 1916. (t-invariant.org)
  • Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. (wikipedia.org)
  • 16S rRNA gene-based phylogeny shows that within the Streptomyces clade, the species S. antibioticus is more closely related to Streptomyces griseorubor than to any other Streptomyces species. (wikipedia.org)
  • One study showed that these two species form a late-diverging clade within the phylogenetic tree of the genus Streptomyces. (wikipedia.org)
  • Streptomyces species produce differentiated, branch-like structures known as hyphae, which collectively make up the organism's mycelium (plural mycelia). (wikipedia.org)
  • For Streptomyces antibioticus, as with other Streptomyces species, mycelia can be divided into two types: aerial and substrate. (wikipedia.org)
  • In addition to producing antibiotics, one strain of S. antibioticus has been discovered to induce a different species of Streptomyces to produce antibiotics. (wikipedia.org)
  • They do not possess the enzyme phenoxazinone synthase (PHS) which in S. antibioticus is present and most probably catalyses premature condensation of abundant 4-MHA or 3-HA with actinomycin halves. (tu-berlin.de)
  • Several independent gene clusters containing varying lengths of type I polyketide synthase genes were isolated from 'Streptomyces nanchangensis' NS3226, a producer of nanchangmycin and meilingmycin. (microbiologyresearch.org)
  • 2) pSET152, an Escherichia coli plasmid with ϕC31 attP site, and pHZ1358, a Streptomyces-Escherichia coli shuttle cosmid vector, both carrying oriT from RP4, can be mobilized from E. coli into NS3226 by conjugation. (microbiologyresearch.org)
  • Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. (microbiologyresearch.org)
  • While the ΔSCO1712 mutant showed a significant decrease (4.6 mg/L) and the ΔphoU mutant showed no significant improvement (12.1 mg/L) in aborycin production, the ΔwblA, ΔorrA and ΔgntR mutations significantly improved the aborycin titers to approximately 23.6 mg/L, 56.3 mg/L and 48.2 mg/L, respectively, which were among the highest heterologous yields for lasso peptides in both Escherichia coli systems and Streptomyces systems. (bvsalud.org)
  • Other instances of bacteria that generate laccases comprise Streptomyces antibioticus, Pseudomonas putida , Campylobacter jejuni , E. coli , Bacillus spp. (biomedcentral.com)
  • Streptomyces aureofaciens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
  • This graph shows the total number of publications written about "Streptomyces aureofaciens" by people in this website by year, and whether "Streptomyces aureofaciens" was a major or minor topic of these publications. (ouhsc.edu)
  • Below are the most recent publications written about "Streptomyces aureofaciens" by people in Profiles. (ouhsc.edu)
  • Certain Streptomyces antibioticus strains produce antibiotics that have yet to be named and thoroughly characterized, such as the one mentioned in a 1998 study from Calcutta University. (wikipedia.org)
  • pHZ1358 was shown to be generally useful for generating mutant strains by gene disruption and replacement in NS3226 as well as in several other Streptomyces strains. (microbiologyresearch.org)
  • Streptomyces antibioticus (previously known as Actinomyces antibioticus) is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. (wikipedia.org)
  • Streptomyces antibioticus was discovered by Selman Waksman and H. Boyd Woodruff, who named the bacterium Actinomyces antibioticus. (wikipedia.org)
  • Two years later, Waksman renamed the organism Streptomyces antibioticus. (wikipedia.org)
  • The NCBI's GenBank contains thousands of DNA sequences for S. antibioticus genes, partial genome sequences, and three complete genome sequences. (wikipedia.org)
  • from Osaka University studied a strain of S. antibioticus that produced a molecule with the ability to induce the organism Streptomyces virginiae to produce the antibiotic Virginiamycin. (wikipedia.org)
  • Thus, this study provides important clues for future studies on enhancing antibiotic production in Streptomyces systems. (bvsalud.org)
  • S. antibioticus has been demonstrated to grow in temperatures ranging from 28-37 °C. As an Actinomycete, this microbe is inferred to behave as a mesophile in laboratory settings, having an optimum growth temperature between 25-30 °C. As a member of the genus Streptomyces, S. antibioticus is inferred to live off of organic matter in the soil, and possess the ability to degrade large polymers such as chitin and keratin. (wikipedia.org)
  • However, it was not only a rhetor-i-cal fig-ure, but also a state-ment of a sci-en-tif-ic fact: strep-to-mycin was indeed obtained "out of the earth," and from soil microor-gan-isms - actinomycetes. (t-invariant.org)
  • Gene replacement of simReg1 from the S. antibioticus chromosome completely abolishes simocyclinone production indicating that SimReg1 is a key regulator of simocyclinone biosynthesis. (springeropen.com)
  • We found that feeding of 4-MHA or its putative biogenetic precursor 3-hydroxyanthranilic acid (3-HA) to Streptomyces antibioticus induced formation of different new compounds at the expense of actinomycins. (tu-berlin.de)
  • Analysis of the simocyclinone biosynthesis ( sim ) gene cluster of Streptomyces antibioticus Tü6040 led to the identification of a putative pathway specific regulatory gene simReg1 . (springeropen.com)
  • Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor. (wikipedia.org)
  • The aborycin biosynthetic gene cluster gul from marine sponge-associated Streptomyces sp. (bvsalud.org)
  • The biosynthetic gene cluster (BGC) for oviedomycin is primarily found in Streptomyces antibioticus. (bvsalud.org)
  • Schematic representation of the simocyclinone biosynthesis gene cluster ( sim cluster) of S. antibioticus Tü6040 . (springeropen.com)
  • Streptomyces antibioticus is known to be an aerobic microorganism that resides in soil communities. (wikipedia.org)
  • Therefore, in this study, we would be stimulated to investigate bioactive polysaccharides (EPS) produced by marine Streptomyces sp. (springeropen.com)
  • Upon its discovery, it was found that S. antibioticus produced a then novel substance named Actinomycin. (wikipedia.org)
  • The expression of the melanin operon (melC) of Streptomyces antibioticus requires the chaperone-like protein MelC1 for the incorporation of two copper ions (designated as CuαA and Cu(B)) and the secretion of the apotyrosinase (MelC2) via a transient binary complex formation between these two proteins. (nycu.edu.tw)
  • In contrast to S. antibioticus, actinomycin-producing streptomycetes such as Streptomyces chrysomallus or Streptomyces parvulus do not form hemi-structured actinomycins when fed with 3-HA or 4-MHA. (tu-berlin.de)
  • Therefore, each of six copper ligands in Streptomyces tyrosinase binuclear copper sites plays a pivotal role in the final maturation and the discharge of tyrosinase from the binary complex but has a less significant role in its secretion. (nycu.edu.tw)