SerotypePneumoniaHaemophilusPneumococcusAntibodyIsolatesSerotypesColonizationStrainsBacteriaInfectionsBacterialPathogenAntibodiesNasopharynxBrain abscessInfectionCoinfectionMiceInfluenzaBiofilm formationOrganismGenesProteinSpeciesProteinsVaccineClonesStrainIntracellularResistancePRSPIsolationGenomicRespiratoryEmpyemaPrevalenceSurveillancePenicillinCarriageDistinguish
Serotype5
- The engineered vaccine worked as expected, boosting protection against S. pneumoniae serotype 4, but not against S. pneumoniae serotype 2, as compared to the wild type vaccine. (asm.org)
- The serotypes of 225 S. pneumoniae strains isolated between 1997 and 2011 were identified with the Quellung reaction and serotype-specific PCR. (biomedcentral.com)
- This study is designed to fill that gap by describing the serotype distribution and AMR of S. pneumoniae in the Philippines from 2012 to 2018. (who.int)
- International links between streptococcus pneumoniae vaccine serotype " by Rebecca A. Gladstone, L Siira et al. (aku.edu)
- We employed metabolic characterization and whole genome sequencing of biofilm-derived S. pneumoniae serotype 22F pneumococcal SCVs to investigate diversification during biofilm formation. (blogspot.com)
Pneumonia22
- Streptococcus pneumoniae (pneumococcus) is a common cause of pneumonia and meningitis in the United States. (cdc.gov)
- Streptococcus pneumoniae is an important cause of community-acquired bacterial pneumonia, meningitis, acute otitis media, and other infections (1). (cdc.gov)
- As a significant human pathogenic bacterium S. pneumoniae was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity studies. (wikipedia.org)
- Streptococcus pneumoniae is the main cause of community acquired pneumonia and meningitis in children and the elderly, and of sepsis in those infected with HIV. (wikipedia.org)
- Streptococcus pneumoniae has become a leading cause of bacteremia, pneumonia, meningitis, and otitis media in the United States. (cdc.gov)
- Whether neonatal S. pneumoniae pneumonia induced asthma was associated with vitamin A levels remains unclear. (nature.com)
- The aim of this study was to investigate the effects of neonatal S. pneumoniae pneumonia on vitamin A expressions, to explore the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on adulthood asthma development. (nature.com)
- Non-lethal S. pneumoniae pneumonia was established by intranasal inoculation of neonatal (1-week-old) female BALB/c mice with D39. (nature.com)
- S. pneumoniae pneumonia mice were supplemented with or without all-trans retinoic acid 24 hours after infection. (nature.com)
- We stated that serum vitamin A levels in neonatal S. pneumoniae pneumonia mice were lower than 0.7µmol/L from day 2-7 post infection, while pulmonary vitamin A productions were significantly lower than those in the control mice from day 7-28 post infection. (nature.com)
- Vitamin A supplement after neonatal S. pneumoniae pneumonia significantly promoted Foxp3 + Treg and Th1 productions, decreased Th2 and Th17 cells expressions, alleviated airway hyperresponsiveness (AHR) and inflammatory cells infiltration during AAD. (nature.com)
- Our data suggest that neonatal S. pneumoniae pneumonia induce serum vitamin A deficiency and long-time lung vitamin A reduction, vitamin A supplement after neonatal S. pneumoniae pneumonia inhibit the progression of asthma by altering CD4 + T cell subsets. (nature.com)
- S. pneumoniae is the most common bacterial pathogen of community acquired pneumonia in childhood. (nature.com)
- The prevention and treatment of asthma induced by S. pneumoniae pneumonia is crucial, while it remains indistinctly. (nature.com)
- Whether neonatal S. pneumoniae pneumonia promoted adulthood allergic asthma was associated with vitamin A levels remains unclear. (nature.com)
- In this study, we established a neonatal non-lethal S. pneumoniae pneumonia mice model and monitored vitamin A levels in lung, serum and liver until early adulthood. (nature.com)
- We also explored the effects of vitamin A supplement after neonatal S. pneumoniae pneumonia on the development of adulthood allergic asthma. (nature.com)
- At our center, 11 patients with COVID-19 pneumonia who had confirmed infection with SARS-CoV-2 were diagnosed with Streptococcus pneumoniae infection while in hospital. (medscimonit.com)
- Since S. pneumoniae can also cause much more serious illnesses such as meningitis and pneumonia, it's important to listen up! (supertoy.ca)
- WHERE IT LIVES Streptococcus pneumoniae is a bacteria that causes pneumococcal infections, such as pneumonia and ear infections. (supertoy.ca)
- 1990: Jim Henson, the creator of the Muppets, died of pneumonia from S. pneumoniae. (supertoy.ca)
- Streptococcus pneumoniae is a Gram-positive bacterium responsible for considerable morbidity and mortality (particularly in the yoimg and aged), causing invasive diseases such as pneumonia, bacteremia and meningitis,, and diseases associated with colonisation, such as acute Otitis media. (allindianpatents.com)
Haemophilus2
- The virus-infected cells were harvested at various times after infection and analyzed for the ability to bind strains of Haemophilus influenzae and Streptococcus pneumoniae. (lu.se)
- Streptococcus pneumoniae , nontypeable Haemophilus influenzae , and Moraxella catarrhalis are the most commonly isolated middle-ear pathogens. (medscape.com)
Pneumococcus3
- Pneumococcal disease is caused by bacteria called Streptococcus pneumoniae (pneumococcus). (cdc.gov)
- Pneumococcal infections are caused by Streptococcus pneumoniae, a lancet-shaped, gram-positive, catalase-negative facultative anaerobe commonly referred to as pneumococcus. (medscape.com)
- Streptococcus pneumoniae (pneumococcus) is an asymptomatic colonizer of the nasopharynx in most individuals but can progress to a pulmonary and systemic pathogen upon influenza A virus (IAV) infection. (lu.se)
Antibody2
- Human IgG antibody Laboratories manufactures the low antibodies to streptococcus pneumoniae reagents distributed by Genprice. (herpes-pics.com)
- Description: This is Biotin conjugated rabbit polyclonal antibody against Streptococcus pneumoniae for WB, ELISA. (herpes-pics.com)
Isolates9
- All S pneumoniae isolates, regardless of the isolation site, should be tested for susceptibility to penicillin and cefotaxime or ceftriaxone. (medscape.com)
- This report summarizes the results of that analysis, which found that the percentage of IPD nonmeningitis S. pneumoniae isolates categorized as susceptible, intermediate, and resistant to penicillin changed from 74.7%, 15.0%, and 10.3% under the former breakpoints to 93.2%, 5.6%, and 1.2%, respectively, under the new breakpoints. (cdc.gov)
- S. pneumoniae infections in persons with noninvasive isolates (e.g., from sputum) were not considered IPD cases. (cdc.gov)
- National surveillance for drug-resistant S. pneumoniae (DRSP) is limited to testing invasive isolates from sentinel hospitals in 13 states. (cdc.gov)
- To determine the extent of antimicrobial susceptibility testing of S. pneumoniae and the prevalence of penicillin resistance among pneumococcal isolates from July 1992 through June 1993, in August 1993 the Connecticut Department of Public Health and Addiction Services (DPHAS) surveyed all 44 hospitals with clinical microbiology laboratories in Connecticut. (cdc.gov)
- S. pneumoniae isolates from clinical specimens were collected through the Philippine Department of Health Antimicrobial Resistance Surveillance Program from 1 January 2012 to 31 December 2018. (who.int)
- The overall AMR of invasive S. pneumoniae isolates was low. (who.int)
- With the inclusion of PCV13 in the National Immunization Program, continued monitoring of the prevailing serotypes of S. pneumoniae isolates in the Philippines is needed to guide disease and AMR control measures. (who.int)
- We studied whether clonal relationships exist among current isolates of high-level penicillin-resistant S. pneumoniae (PRSP) in the United States. (ox.ac.uk)
Serotypes6
- The research suggests that vaccination of humans with live S. mitis might offer protection from some of the many serotypes of S. pneumoniae that vaccines currently do not exist for. (asm.org)
- And current vaccines target only 13 of more than 90 serotypes of S. pneumoniae . (asm.org)
- This study identified the serotypes/subtypes and CCs/STs of group 6 S. pneumoniae present in China. (biomedcentral.com)
- We set out to identify any new serotypes (serotypes "6E", "6F", and "6G") in serogroup 6 S. pneumoniae in China and to report the population biology of this group. (biomedcentral.com)
- Data are scarce on the prevailing Streptococcus pneumoniae serotypes in the Philippines, including the relative antimicrobial resistance (AMR) of these bacteria. (who.int)
- Owing to pediatric pneumococcal vaccination, however, the prevalence of pneumococcal serotypes not covered by the vaccines (eg, Alloiococcus otitidis, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa ) are increasingly being isolated in patients with acute otitis media (AOM). (medscape.com)
Colonization3
- Colonization rates of Streptococcus pneumoniae and Staphylococcus aureus are inversely correlated in infants. (eur.nl)
- This work links mutations in the rpoE gene to SCV formation and enhanced biofilm development in S. pneumoniae , and therefore may have important implications for colonization, carriage and persistence of the organism. (blogspot.com)
- Neuraminidase A-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization. (pacb.com)
Strains7
- Editorial Note: The spread of DRSP strains may increase the public health impact of S. pneumoniae infections because of increased morbidity and reductions in the effectiveness of antimicrobial treatment for pneumococcal disease. (cdc.gov)
- Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
- Adenovirus infection did not change the adherence of cells of poorly adhering strains of S. pneumoniae or H. influenzae. (lu.se)
- Serotyping of Streptococcus pneumoniae strains by coagglutination. (bmj.com)
- The coagglutination test, which uses staphylococcal protein A, for serotyping strains of Streptococcus pneumoniae, was extended to include serotyping within serogroups. (bmj.com)
- Fifty one strains of S pneumoniae, which belonged to one of the seven serogroups included in the 14 valent vaccine formulation, were tested, and no inconsistency was found when compared with the capsule swelling reaction. (bmj.com)
- In 1967, antibiotic-resistant strains of S. pneumoniae appeared in New Guinea, and over the last 30 years they have spread all over the world. (supertoy.ca)
Bacteria5
- S. pneumoniae infection stimulates polymorphonuclear leukocytes (granulocytes) to produce an oxidative burst that is potentially lethal to the bacteria. (wikipedia.org)
- Washington, D.C. - January 25, 2019 - Vaccinating laboratory mice with Streptococcus mitis bacteria prevents their virulent sibling, Streptococcus pneumoniae from infecting the mice. (asm.org)
- Discussions with clinicians in multiple states raised concerns about a possible increase in pediatric intracranial infections, particularly those caused by Streptococcus bacteria, during the past year and the possible contributing role of SARS-CoV-2 infection. (medscape.com)
- The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type I, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae. (mpg.de)
- FACTS: Ear aches are one of the most common health ailments found in young children - and most are caused by Streptococcus pneumoniae bacteria. (supertoy.ca)
Infections7
- Clinical signs and symptoms and physical examination findings alone cannot distinguish S pneumoniae disease from infections caused by other pathogens. (medscape.com)
- In January 2008, after a reevaluation that included more recent clinical studies, the Clinical and Laboratory Standards Institute (CLSI) published new S. pneumoniae breakpoints for penicillin (the preferred antimicrobial for susceptible S. pneumoniae infections). (cdc.gov)
- Streptococci can cause a range of diseases, from the less serious but common sore throats and skin infections to life threatening conditions such as necrotising fasciitis. (novusbio.com)
- Title : Active Bacterial Core Surveillance (ABCs) Report Emerging Infections Program Network : Streptococcus pneumoniae, 2018 Corporate Authors(s) : National Center for Immunization and Respiratory Diseases (U.S.). Division of Bacterial Diseases. (cdc.gov)
- Streptococcus pneumoniae remains the leading cause of community-acquired respiratory infections, and is one of the most important human pathogens causing severe invasive infections [ 1 ]. (biomedcentral.com)
- [ 1 ] Pediatric bacterial brain abscesses, epidural empyemas, and subdural empyemas, rare complications of respiratory infections and sinusitis, are often caused by Streptococcus species but might also be polymicrobial or caused by other genera, such as Staphylococcus . (medscape.com)
- streptococcus pneumoniae causes 5% of all cases of septic arthritis and is more often responsible for polyarticular infections than other organisms. (lookfordiagnosis.com)
Bacterial2
- However, bacterial coinfection is considered relatively infrequent in hospitalized patients with COVID-19, and the co-prevalence of Streptococcus pneumoniae is low. (medscimonit.com)
- Streptococcus pneumoniae is the most common cause of invasive bacterial disease and Otitis media in infants and young children. (allindianpatents.com)
Pathogen4
- By separating carriage and disease into distinct steps and providing the opportunity to analyze the genetic variants of both the pathogen and the host, this S. pneumoniae/IAV co-infection model permits the detailed examination of the interactions of an important pathobiont with the host at different phases of disease progression. (lu.se)
- Streptococcus pneumoniae is a commensal human pathogen and the causative agent of various invasive and non-invasive diseases. (blogspot.com)
- Streptococcus pneumoniae is an important human pathogen that often carries temperate bacteriophages. (cmu.edu)
- Streptococcus pneumoniae is an opportunistic pathogen that colonizes the nasopharynx. (pacb.com)
Antibodies2
- 1984 Monoclonal antibodies against protease-sensitive pneumococcal antigens can protect mice from fatal infection with Streptococcus pneumoniae. (qedbio.com)
- The Low Antibodies To Streptococcus Pneumoniae reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (herpes-pics.com)
Nasopharynx2
- S pneumoniae can cause a wide variety of clinical symptoms owing to its ability to cause disease by either direct extension from the nasopharynx into surrounding anatomic structures or vascular invasion with hematogenous spread. (medscape.com)
- Our study showed that, in adults , the presence of S. pneumoniae in the nasopharynx is associated with a shift in the microbiota and dominance of the Streptococcus genus. (bvsalud.org)
Brain abscess2
- In May 2022, CDC learned of three children in California hospitalized concurrently for brain abscess, epidural empyema, or subdural empyema caused by Streptococcus intermedius . (medscape.com)
- Available Streptococcus specimens isolated from a brain abscess, epidural empyema, subdural empyema, blood, or cerebrospinal fluid were collected for antimicrobial susceptibility testing and whole-genome sequencing at CDC's Streptococcus reference laboratory to identify microbiological features shared among cases. (medscape.com)
Infection3
- The increase in adherence of S. pneumoniae could be inhibited by the DNA synthesis inhibitor cytosine arabinofuranoside, which is known to block the late phase of the adenovirus infection. (lu.se)
- This suggested that adenovirus infection upregulated receptors for S. pneumoniae. (lu.se)
- Our previous study showed that neonatal Streptococcus pneumoniae ( S. pneumoniae ) infection promoted asthma development. (nature.com)
Coinfection2
- We retrospectively analyzed the clinical characteristics and outcomes of patients subsequently admitted to AMITA Health Saint Francis Hospital between March 1 and June 30, 2020, with documented SARS-CoV-2 and S. pneumoniae coinfection. (medscimonit.com)
- We identified 11 patients with S. pneumoniae coinfection. (medscimonit.com)
Mice1
Influenza1
- A lethal synergism between the influenza virus and Streptococcus pneumoniae has been identified. (medscimonit.com)
Biofilm formation1
- We observed that S. pneumoniae mutants deficient in NanA and ß-galactosidase A (BgaA) failed to form biofilms in vivo despite normal biofilm-forming abilities in vitro Subsequently, we observed that glucose, sucrose, and fructose were inhibitory for biofilm formation, whereas galactose, lactose, and low concentrations of sialic acid were permissive. (pacb.com)
Organism2
- Although S. pneumoniae was once considered to be routinely susceptible to penicillin, since the mid-1980s the incidence of resistance of this organism to penicillin and other antimicrobial agents has been increasing in the United States (1-4). (cdc.gov)
- The organism was termed Diplococcus pneumoniae from 1920 because of its characteristic appearance in Gram-stained sputum. (wikipedia.org)
Genes4
- In S. pneumoniae, at least 23 genes are required for transformation. (wikipedia.org)
- S. mitis , which lacks many of the virulence genes present in S. pneumoniae , but is otherwise quite similar, commonly inhabits the oral cavity and the upper respiratory tract, living in peaceful coexistence with the host. (asm.org)
- Competence development in Streptococcus pneumoniae involves a complex network of genes regulating DNA uptake and recombination, with comC and comD proteins playing key roles. (consensus.app)
- however, genes that were homologous to known phage virulence genes, including the pblB gene of Streptococcus mitis and the vapE gene of Dichelobacter nodosus, were also identified. (cmu.edu)
Protein4
- summarized evidence that induction of competence in S. pneumoniae is associated with increased resistance to oxidative stress and increased expression of the RecA protein, a key component of the recombinational repair machinery for removing DNA damages. (wikipedia.org)
- 1990 Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular s of Streptococcus pneumoniae. (qedbio.com)
- 1991 PspA, A surface protein of Streptococcus pneumoniae, is capable of eliciting protection against Pneumococci of more than one capsular type. (qedbio.com)
- Description: Streptococcus Pneumoniae (strain Taiwan19F-14) Prolipoprotein diacylglyceryl transferase (lgt), recombinant protein. (herpes-pics.com)
Species1
- Different streptococcal species are involved in human disease, broadly categorised as pus forming or pyogenic streptococci, non pus forming or non pyogenic streptococci, and Streptococcus pneumoniae. (novusbio.com)
Proteins3
- An immunogenic composition comprising 2 S. pneumoniae recombinant proteins wherein one of the proteins is selected from the Poly Histidine Triad family (PhtX) at a dose of between 1-100 µg and optionally comprising an adjuvant. (allindianpatents.com)
- The present invention relates to a combination of 2 or more S. pneumoniae proteins, their manufacture and use in medicine as a vaccine. (allindianpatents.com)
- In yet another related aspect is a method for making the vaccine of the invention by selecting and isolating 2 different S. pneumoniae proteins and mixing both proteins with a pharmaceutically acceptable carrier. (allindianpatents.com)
Vaccine1
- Our study reveals that S. mitis a natural human colonizer that resembles S. pneumoniae but seldom causes diseases, can be the answer offered by nature for a safe vaccine against S. pneumoniae . (asm.org)
Clones2
- No salient antibiotic-resistant clones were isolated among the serogroup 6 S. pneumoniae . (biomedcentral.com)
- Genomic backgrounds of drug-resistant Streptococcus pneumoniae in Ankara, Turkey: Identification of emerging new clones. (hacettepe.edu.tr)
Strain2
- The genome of S. pneumoniae is a closed, circular DNA structure that contains between 2.0 and 2.1 million base pairs depending on the strain. (wikipedia.org)
- Immunogen Antigen for 22001 and 22002: heat-killed S. pneumoniae strain R36A. (qedbio.com)
Intracellular1
- No, Streptococcus pneumoniae is not an intracellular obligate parasite. (answers.com)
Resistance2
- In this study, we defined the population biology of serogroup 6 Streptococcus pneumoniae collected in China and their antibiotic resistance profiles. (biomedcentral.com)
- During the past 6 to 7 years, the problem of antimicrobial resistance in Streptococcus pneumoniae has grown dramatically in the United States. (ox.ac.uk)
PRSP1
- since then, in the United States, there has been increased identification of penicillin-nonsusceptible S. pneumoniae (PNSP) (defined as minimum inhibitory concentration {MIC} to penicillin greater than or equal to 0.1 ug/mL), especially penicillin-resistant S. pneumoniae (PRSP) (defined as MIC to penicillin greater than or equal to 2.0 ug/mL). (cdc.gov)
Isolation1
Genomic1
- Comparative genomic analysis of ten Streptococcus pneumoniae temperate bacteriophages. (cmu.edu)
Respiratory3
- citation needed] Streptococcus pneumoniae resides asymptomatically in healthy carriers typically colonizing the respiratory tract, sinuses, and nasal cavity. (wikipedia.org)
- Streptococci form part of the normal human flora that resides on the skin, and can also colonise the respiratory, gastrointestinal, and genitourinary tracts. (novusbio.com)
- The upper respiratory tract microbiota of healthy adults is affected by Streptococcus pneumoniae carriage, smoking habits, and contact with children. (bvsalud.org)
Empyema1
- Empyema caused by Streptococcus pneumoniae. (medscape.com)
Prevalence1
- High prevalence of penicillin-nonsusceptible Streptococcus pneumoniae at a community hospital in Oklahoma. (cdc.gov)
Surveillance1
- The surveillance case definition for PNSP included S. pneumoniae isolated from any anatomical site with a MIC to penicillin greater than or equal to 0.1 ug/mL confirmed by an approved National Committee for Clinical Laboratory Standards (NCCLS) methodology (3). (cdc.gov)
Penicillin1
- Clonal relationships among high-level penicillin-resistant Streptococcus pneumoniae in the United States. (ox.ac.uk)
Carriage1
- To address this gap, we investigated the composition of the nasopharyngeal and oropharyngeal microbiota of healthy adults , focusing on the effect of Streptococcus pneumoniae carriage, smoking habits , and contact with children . (bvsalud.org)