• gene
  • In search for the mechanisms behind fish oil induced fat loss, it has been found that fish oil exerts favorable metabolic effects by modulating gene expression (which is the process by which the information encoded in a gene is converted into protein)2 13-26. (anabolicminds.com)
  • Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. (wikipedia.org)
  • This human gene encodes for a transmembrane protein of 277 amino acids with probably 6 transmembrane domains. (wikipedia.org)
  • Importantly, the protein encoded by this gene plays a critical role in regulating cholesterol concentrations in cells. (wikipedia.org)
  • Membrane-bound transcription factor site-1 protease, or site-1 protease (S1P) for short, also known as subtilisin/kexin-isozyme 1 (SKI-1), is an enzyme (EC 3.4.21.112) that in humans is encoded by the MBTPS1 gene. (wikipedia.org)
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. (wikipedia.org)
  • DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene. (wikipedia.org)
  • The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. (wikipedia.org)
  • This extra exon in the VLDLR gene accounts for the extra cysteine-binding repeat not found in LDLR. (wikipedia.org)
  • Together, the exons making up the VLDLR gene encode a protein that is 873 amino acid residues long. (wikipedia.org)
  • 2002
  • The MEROPS online database for peptidases and their inhibitors: AEBSF A Link to the ABRF group usegroup archive with an informative discussion of covalent modifications to proteins resulting from use of AEBSF: [1][permanent dead link] Powers JC, Asgian JL, Ekici OD, James KE (2002). (wikipedia.org)
  • site-1 protea
  • Membrane-bound transcription factor site-1 protease Brown MS, Goldstein JL (1999). (wikipedia.org)
  • site-1 protease at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • These cleavages are carried out by two distinct proteases, called site-1 protease (S1P) and site-2 protease (S2P). (wikipedia.org)
  • enzyme
  • Allosteric control triggers the binding of an activating/de-activating substrate to a key enzyme. (mdpi.com)
  • Two Mg2+ are coordinated by the phosphate groups on the ATP, and are required for ATP binding to the enzyme. (wikipedia.org)
  • Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. (wikipedia.org)
  • It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. (wikipedia.org)
  • mice
  • Increased PKA activity in response to adrenergic stimulation results in a lean phenotype and improved insulin sensitivity in mice in which the PKA-regulatory type II β-subunit is ablated ( 12 , 34 ). (physiology.org)
  • transmembrane
  • All members of this family share five highly conserved structural domains: an extracellular N-terminal ligand-binding domain with cysteine-rich repeats (also called ligand-binding repeats), an epidermal growth factor (EGF), an O-linked glycosylation sugar domain, a single transmembrane sequence, and a cytoplasmic domain which contains an NPxY sequence. (wikipedia.org)
  • cysteine
  • The conventional model for organization of FAS (see the 'head-to-tail' model on the right) is largely based on the observations that the bifunctional reagent 1,3-dibromopropanone (DBP) is able to crosslink the active site cysteine thiol of the KS domain in one FAS monomer with the phosphopantetheine prosthetic group of the ACP domain in the other monomer. (wikipedia.org)
  • Mimicking this general structure, VLDLR has eight, 40 amino acid long cysteine-rich repeats in its extracellular N-terminal ligand-binding domain. (wikipedia.org)
  • The modular structures of these two proteins are almost superimposable, with the only difference being the additional cysteine-rich repeat in VLDLR. (wikipedia.org)
  • These ligands attach to the cysteine binding repeats in the N-terminus end. (wikipedia.org)
  • glucose
  • AMPK stimulates glucose uptake in skeletal muscle by phosphorylating Rab-GTPase-activating protein TBC1D1, which ultimately induces fusion of GLUT4 vesicles with the plasma membrane. (wikipedia.org)
  • covalently
  • The growing fatty acid chain is carried between these active sites while attached covalently to the phosphopantetheine prosthetic group of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid). (wikipedia.org)
  • levels
  • The results are summarized in Figure 3, which shows mean relative expression levels for a number of classes of proteins through pregnancy and lactation to involution. (nih.gov)