• catalyze
  • They catalyze the desaturation of saturated fatty acyl-CoA substrates at the delta-9 position, generating essential components of phospholipids, triglycerides, cholesterol esters and wax esters. (beds.ac.uk)
  • produces
  • AceCS2 produces acetyl-CoA for oxidation through the citric acid cycle in the mitochondrial matrix. (wikipedia.org)
  • Delta
  • These desaturases are classified as delta - indicating that the double bond is created at a fixed position from the carboxyl group of a fatty acid (for example, Δ9desaturase creates a double bond at the 9th position from the carboxyl end). (wikipedia.org)
  • membrane
  • For example, in insects, the desaturase is critical in the formation of ceramide, and for complex signalling molecules (pheremones), while in fungi, the function of the enzyme, and concentration of unsaturated lipids is regulated in response to function of growth temperature by controlling membrane fluidity in cells. (wikipedia.org)
  • molecular
  • A series of redox reactions, during which two electrons flow from NADH to flavoprotein cytochrome b5, then to the electron acceptor cytochrome b5 as well as molecular oxygen introduces a single double bond within a row of methylene fatty acyl-CoA substrates. (wikipedia.org)
  • iron
  • Crystallographic studies suggest that the iron groups are held in place by the desaturase using aspartate and glutamate. (wikipedia.org)
  • activation
  • The combination of KLF15 and Sp1 resulted in a synergistic activation of the acetyl-CoA synthetase 2 (AceCS2) promoter. (wikipedia.org)