Stearoyl-CoA desaturase 1 (SCD1) is a membrane-embedded metalloenzyme that catalyzes the formation of a double bond on a saturated acyl-CoA. (nih.gov)
Given the importance of lipid metabolism in ferroptosis and the key role of lipids in ovarian cancer, we examined the contribution to ferroptosis of stearoyl-CoA desaturase (SCD1, SCD ), an enzyme that catalyzes the rate-limiting step in monounsaturated fatty acid synthesis in ovarian cancer cells. (aacrjournals.org)
Stearoyl CoA desaturase 1 (SCD1) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids (MUFAs). (nuthealth.org)
Sleep deprivation has been associated with obesity among adults, and accumulating data suggests that stearoyl-CoA desaturase 1 (SCD1) expression has a relevant impact on fatty acid (FA) composition of lipid pools and obesity. (nih.gov)
Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the endoplasmic reticulum (ER). (elsevierpure.com)
Physique 1 Structure and topology of mouse SCD1 Physique 2 Architecture of the acyl-CoA binding site Vigabatrin The cytosolic domain name contains a substantial nonprotein density consistent with an 18-carbon acyl-CoA molecule (Physique 2a Extended Data Physique 5a). (tam-receptor.com)
The Vigabatrin residues that form polar interactions with the CoA group in the mSCD1 structure are strongly conserved among known stearoyl-CoA desaturases including human SCD1 but not among stearoyl-lipid desaturases (Extended Data Physique 1). (tam-receptor.com)
In SCD1 Ala108 Leu109 Ala288 and Val289 line the distal end of the substrate binding channel Ala115 is near the position of double bond formation while Gln277 and Vigabatrin Ser278 are on the cytoplasmic surface opposite to the CoA binding site. (tam-receptor.com)
In addition to the bound stearoyl-CoA molecule SCD1 also contains two metal ions. (tam-receptor.com)
Polymorphisms in the SCD1 gene are associated with indices of stearoyl CoA desaturase activity and obesity: a prospective study. (cdc.gov)
The ∆9 desaturase steroyl-CoA desaturase 1 (SCD1) is important for the generation of monounsaturated fatty acids during lipogenesis. (biomedcentral.com)
Sterol regulat2
Polymorphisms in stearoyl CoA desaturase and sterol regulatory element binding protein interact with N-3 polyunsaturated fatty acid intake to modify associations with anthropometric variables and metabolic phenotypes in Yup'ik people. (ohsu.edu)
We searched for biologically plausible candidate genes in these regions and prioritized seven genes for exhaustive genetic investigation: adiponectin (3q27), AMP kinase gamma 2 subunit and nuclear respiratory factor-1 (7q36), stearoyl CoA desaturase (10q23), sterol regulatory element binding protein (17p11), insulin sensitive glucose transporter (17p13), and hepatocyte nuclear factor 4 alpha (20q12). (nih.gov)
STEARYL-COA DESATURASE1
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. (nih.gov)
Hydrogen-donor2
Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase. (wikipedia.org)
An enzyme that catalyzes the formation of oleoyl-CoA, A, and water from stearoyl-CoA, AH2, and oxygen where AH2 is an unspecified hydrogen donor. (bvsalud.org)
MRNA4
To determine if they affect the expression of stearoyl CoA desaturase (SCD)-1 and -2, their mRNA was measured in livers of normal, hyperleptinemic, troglitazone-treated, and fat-fed rats. (elsevierpure.com)
The addition of N. commune lipid extract markedly reduced mRNA abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and LDL receptor (LDLR) ( P P (unl.edu)
Interactions between CF treatment × day were detected (P ≤ 0.01) for mRNA expression of adipocyte fatty acid-binding protein, fatty acid synthase, PPAR-γ, and stearoyl-CoA desaturase, which were greater (P ≤ 0.02) in the feedlot in steers receiving CSSO during CF. No treatment differences were detected for (P ≥ 0.18) performance or carcass traits, including marbling and backfat thickness. (oregonstate.edu)
Stearoyl coenzyme A desaturase mRNA concentration also was low in all preweaning samples, but it peaked (P = .07) at 12 mo of age. (tamu.edu)
Acyl5
A series of redox reactions, during which two electrons flow from NADH to flavoprotein cytochrome b5, then to the electron acceptor cytochrome b5 as well as molecular oxygen introduces a single double bond within a row of methylene fatty acyl-CoA substrates. (wikipedia.org)
Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the first double bond into saturated fatty acyl-CoAs1-4. (tam-receptor.com)
The higher level of plasma acetylcarnitine may reflect a stimulated mitochondrial and peroxisomal β-oxidation of fatty acids, as the hepatic activities of peroxisomal acyl-CoA oxidase 1 and mitochondrial carnitine palmitoyltransferase-II were higher in the FPH-fed mice. (biomedcentral.com)
Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:15610069). (nih.gov)
FADs can also be functionally categorized as front-end and methyl-end desaturase, which introduces a double bond towards the carboxyl terminus and methyl-end of the fatty acyl chain, respectively [ 3 ]. (biomedcentral.com)
Fatty acids3
Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the formation of monounsaturated fatty acids (MUFAs), specifically oleate and palmitoleate from stearoyl-CoA and palmitoyl-CoA. (wikipedia.org)
Stearoyl-CoA desaturase (SCD), an ER resident protein and a key enzyme in the biosynthesis of monounsaturated fatty acids, is known to regulate cellular functions by controlling the ratio of saturated to monounsaturated fatty acids. (nih.gov)
Fatty acid desaturases (FADs) catalyze the sequential desaturation of fatty acids, leading to the production of MUFAs and PUFAs. (biomedcentral.com)
Inhibitor1
Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. (uc.edu)
Genes3
Moreover, genes such as DGAT1 and ELOVL2 appear to be more sensitive to genetic background than to dietary manipulation, whereas genes encoding for desaturases, such as FADS1 , appear to be modulated by dietary silage level. (biomedcentral.com)
We present the molecular characterization of four fatty acid desaturase (FAD) genes in R. toruloides . (biomedcentral.com)
Satellite cells were cultured at 2°C incremental temperatures between 33 and 43°C and compared to cells cultured at the control temperature of 38°C to ascertain temperature effects on lipid accumulation and expression of adipogenic genes: CCAAT/enhancer-binding protein-β (C/EBPβ), peroxisome proliferator-activated receptor-γ (PPARγ), and stearoyl-CoA desaturase (SCD). (umn.edu)
Receptor3
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. (nuthealth.org)
These mice have altered cellular and systemic lipid transport and composition, leading to enhanced insulin receptor signaling, enhanced muscle AMP-activated kinase (AMP-K) activity, and dramatically reduced liver stearoyl-CoA desaturase-1 (SCD-1) activity underlying their phenotype. (nih.gov)
1. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. (nih.gov)
Liver3
11. Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target. (nih.gov)
BIBN led to a moderate improvement of oGT which was accompanied by an increased expression of stearoyl-CoA desaturase in the liver. (charite.de)
The n-3/n-6 fatty acid ratio was higher in mice fed the FPH diet than in mice fed the control diet in both adipose tissue and liver, and the FPH diet affected the gene expression of ∆6 and ∆9 desaturases. (biomedcentral.com)
Protein1
The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. (nih.gov)
Metabolism1
Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. (wikipedia.org)
Stem cells1
Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention. (nih.gov)
Gene expression2
Postnatal development of stearoyl coenzyme A desaturase gene expression and adiposity in bovine subcutaneous adipose tissue. (tamu.edu)
This investigation addressed the hypothesis that stearoyl coenzyme A desaturase (SCD) gene expression would serve as a postnatal marker of adipocyte differentiation in bovine s.c. adipose tissue. (tamu.edu)
Adipose tissue1
FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue. (cdc.gov)
Activity2
Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women. (nih.gov)
This is not the first report of the potential health benefits of sterculic oil: In 2008 researchers from the University of Nottingham in England reported that sterculic acid, the major component of sterculic oil, can reduce the activity of the enzyme stearoyl CoA desaturase (SCD). (nutraingredients.com)
Biosynthesis1
In terms of its biosynthesis, stearic acid is produced from carbohydrates via the fatty acid synthesis machinery wherein acetyl-CoA contributes two-carbon building blocks, up to the 16-carbon palmitate, via the enzyme complex fatty acid synthase (FA synthase), at which point a fatty acid elongase is needed to further lengthen it. (hmdb.ca)
Reaction1
It catalyzes the chemical reaction stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ ⇌ {\displaystyle \rightleftharpoons } oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O The 4 substrates of this enzyme are stearoyl-CoA, ferrocytochrome b5, O2, and H+, whereas its 3 products are oleoyl-CoA, ferricytochrome b5, and H2O. (wikipedia.org)
Double bond1
It is responsible for forming a double bond in stearoyl-CoA. (wikipedia.org)
Data1
The stacked mutations Ile112Ala/Glu113Leu were able to convert SCD3 from exclusively a 16:0 Vigabatrin desaturase into a predominantly 18:0 desaturase (Physique 2e f and Extended Data Physique 5). (tam-receptor.com)