• The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. (origene.com)
  • Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. (lu.se)
  • ASMD is a lysosomal storage disease that results from reduced activity of the enzyme acid sphingomyelinase (ASM), caused by pathogenic variants in the sphingomyelin phosphodiesterase 1 ( SMPD1 ) gene. (medscape.com)
  • Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. (foodb.ca)
  • Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. (musc.edu)
  • Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. (musc.edu)
  • Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol. (cdc.gov)
  • Sphingomyelin phosphodiesterase-1 (Smpd1) deficiency results in a very specific modulation of the platelet lipidome (Peng et al. (lipidomics.at)
  • This present study assessed centrosomal protein-55 (CEP55)' serpin family E member 1 (SERPINE1) and sphingomyelin phosphodiesterase 3 (SMPD3) genes and proteins in gastric adenocarcinoma with different tumor progression features. (springeropen.com)
  • Centrosomal protein-55 (CEP55), serpin family E member 1 (SERPINE1) and sphingomyelin phosphodiesterase 3 (SMPD3) genes were identified and included in these signatures. (springeropen.com)
  • systematic name sphingomyelin cholinephosphohydrolase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. (wikipedia.org)
  • They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. (umassmed.edu)
  • It is then converted to Sphingomyelin via the enzyme sphingosine N-acyltransferase (EC 2.3.1.24). (foodb.ca)
  • [ 3 ] SPT is the rate-limiting enzyme in synthesis of sphingolipids, including ceramide and sphingomyelin. (medscape.com)
  • Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. (thermofisher.com)
  • ASM degrades sphingomyelin to ceramide and phosphocholine. (medscape.com)
  • Brefeldin A promotes hydrolysis of sphingomyelin. (musc.edu)
  • Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. (musc.edu)
  • Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. (musc.edu)
  • We found that trivalent chromium [Cr(III)] induced autophagy by activating sphingomyelin phosphodiesterase 2 (SMPD2). (nih.gov)
  • Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? (musc.edu)
  • SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. (wikipedia.org)
  • Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. (musc.edu)
  • The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. (musc.edu)
  • 3',5'-Cyclic-GMP Phosphodiesterases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • ASM deficiency causes intra-lysosomal accumulation of sphingomyelin (and cholesterol and other cell membrane lipids) in various tissues. (medscape.com)
  • Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. (musc.edu)
  • Blood, 2018) with an order of magnitude up-regulation of lyso-sphingomyelin (SPC), and subsequent modification of platelet activation and thrombus formation, which sheds light on novel mechanisms important for platelet function, and has therefore the potential to open novel diagnostic and therapeutic opportunities. (lipidomics.at)
  • SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. (wikipedia.org)
  • An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. (wakehealth.edu)
  • ASM degrades sphingomyelin to ceramide and phosphocholine. (medscape.com)
  • Overexpression of sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) blocks ceramide kinase (CERK) activity and results in decreased ceramide to ceramide-1-phosphate (C1P) production. (scientificarchives.com)
  • systematic name sphingomyelin cholinephosphohydrolase) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. (wikipedia.org)
  • ASM deficiency causes intra-lysosomal accumulation of sphingomyelin (and cholesterol and other cell membrane lipids) in various tissues. (medscape.com)
  • 7. Sphingomyelin Phosphodiesterase Acid-Like 3b is Essential for Toll-Like Receptor 3 Signaling in Human Podocytes. (nih.gov)
  • The hydrolysis of sphingomyelin (SPM) has been reported to mediate a number of responses to extracellular agents, including cytokines. (nih.gov)
  • It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. (nih.gov)
  • Mutations that lead to the production of an enzyme that retains some activity often cause Niemann-Pick disease type B. A reduction in enzyme activity within cells allows sphingomyelin to accumulate in cells. (medlineplus.gov)
  • Using the mouse model amyloid precursor protein with Swedish (NL), Arctic (G) and Iberian (F) mutations (APPNLGF) x sphingomyelin phosphodiesterase flox/flox (Smpd3fl/fl) x Reverse Orientation Splice Acceptor 26 Cre estrogen receptor T2 (R26CreERT2), several experiments could be performed. (howest.be)
  • The most critical role sphingolipids play is in the lipid raft domains, the sphingomyelin-, cholesterol- and glycosyl-phosphatidylinositol (GPI)-rich microdomains of the plasma membrane. (scientificarchives.com)
  • Sphingomyelin also binds (attaches) to a fat called cholesterol and helps to form other lipids that play roles in various cell processes. (medlineplus.gov)
  • 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). (imperial.ac.uk)
  • Sphingomyelin Phosphodiesterase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • Two recent independent reports identified variations in the sphingomyelin phosphodiesterase gene as risk factors for Parkinson's disease. (medscape.com)
  • Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors. (jyu.fi)
  • Violin plots show distribution of expression levels for Sphingomyelin phosphodiesterase 4 (SMED30017968) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Violin plots show distribution of expression levels for Sphingomyelin phosphodiesterase 4 (SMED30017968) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • Expression of Sphingomyelin phosphodiesterase 4 (SMED30017968) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • This graph shows the total number of publications written about "Sphingomyelin Phosphodiesterase" by people in this website by year, and whether "Sphingomyelin Phosphodiesterase" was a major or minor topic of these publications. (wakehealth.edu)
  • Below are the most recent publications written about "Sphingomyelin Phosphodiesterase" by people in Profiles. (wakehealth.edu)