• ligands
  • Scientists from the University of York have developed a new synthetic route that delivers significant quantities of two very important sparteine-based chiral ligands that could help in future development of drug molecules. (york.ac.uk)
  • Dr James Firth, lead chemist on the project, said: "Our approach to the family of sparteine chiral ligands allows synthesis of either mirror-image form on a gram-scale for the first time. (york.ac.uk)
  • This difference can arise from the method of preparation of silyllithiums, the steric hindrance caused by the bulky alkyl substituents on silicon, and the less polarized nature of Si-Li bonds.The addition of strongly donating ligands, such as TMEDA and (-)-sparteine, can displace coordinating solvent molecules in silyllithiums. (wikipedia.org)
  • Lithium
  • We also reported on the preparation of lithium compounds 1 obtained by kinetic resolution of racemic precursors by deprotonation with n-butyllithium/( )-sparteine. (docme.ru)
  • piperine
  • The institute then discovered and scientifically validated Piperine as the world's first bioenhancer using Sparteine and Vasicine which became the world's first experimentally bioenhanced drugs. (wikipedia.org)
  • synthesis
  • Angewandte Chemie Asymmetric Synthesis Highly Enantiomerically Enriched Ketone Homoenolate Reagents Prepared by ( )-Sparteine-Mediated g-Deprotonation of Achiral 1-Alkenyl Carbamates** Michael Seppi, Rainer Kalkofen, Jens Reupohl, Roland Frhlich, and Dieter Hoppe* Dedicated to Professor Manfred T. Reetz on the occasion of his 60th birthday Enantiomerically enriched, 1-hetero-substituted 2-alkenylmetal compounds 1 (e.g. (docme.ru)