- For the purpose of this review, only the more common lactotroph and somatotroph adenomas will be addressed. (cap.org)
- Somatotroph (GH) adenomas are nearly equally divided into densely and sparsely granulated types. (cap.org)
- The evaluation of ghrelin mRNA expression in human somatotroph adenomas. (nel.edu)
- We decided to determine the expression of ghrelin in somatotroph adenomas. (nel.edu)
- We therefore hypothesized that the physiological IGF-I-GH negative feedback loop may be reset in somatotroph adenomas, and we investigated the role of type 1 IGF receptor (IGF-R) and GH receptor (GHR) by quantifying mRNA expression in somatotroph tumours, and investigated the possible presence of mutations of the GHR gene.Methods: Pituitary t. (endocrine-abstracts.org)
- 1 More than 95% of cases are caused by autonomous secretion of GH from anterior pituitary tumours and result in clonal expansion of somatotrophs. (hkmj.org)
- Somatotrophs, anterior pituitary cells, synthesize and secrete HGH. (gilmorehealth.com)
- Somatotrophs are cells in the anterior pituitary that release pituitary growth hormone. (ultimapharmaceuticals.com)
- These are synthesized and produced by cells (somatotrophs) inside the anterior pituitary. (healthcareguys.com)
- Human pituitary somatotroph adenoma tissues were obtained at the time of transsphenoidal surgery from 3 acromegalic patients and studied for ghrelin mRNA expression. (nel.edu)
- Ghrelin (GHR) may also influence GH secretion by acting directly on somatotrophs or through stimulatory effects on GHRH neurons. (endotext.org)
- Sulphonylureas stimulate GH secretion and this study was undertaken to investigate the possible stimulatory effect of repaglinide and nateglinide, two novel oral glucose regulators, on critical steps of the stimulus-secretion coupling in single rat somatotrophs. (ox.ac.uk)
- Somatotrophs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- GH release was measured from perifused rat somatotrophs. (ox.ac.uk)
- Both compounds induced action potential firing in the somatotrophs irrespective of whether GH-releasing hormone was present or not. (ox.ac.uk)
- At the pituitary level, follistatin signals could be located in carp somatotrophs, gonadotrophs, and lactotrophs. (frontiersin.org)
- The model behavior resembles that seen in somatotrophs, lactotrophs, and corticotrophs. (nih.gov)
- thyroid-stimulating hormone (TSH) producing thyrotrophs, growth hormone (GH) producing somatotrophs, prolactin (PRL) producing lactotrophs, and follicle-stimulating hormone (FSH) and luteinizing hormone (LH) producing gonadotrophs. (nih.gov)
- The secretory functions of somatotrophs and lactotrophs are also negatively controlled by hypothalamic somatostatin and dopamine, respectively. (nih.gov)
- Lactotrophs, somatotrophs, thyrotrophs, corticotrophs and gonadotrophs in the anterior pituitary gland secrete the polypeptide hormones prolactin (PRL), growth hormone (GH), thyroid stimulating hormone (TSH), adrenocorticotropic hormone (ACTH) and luteinizing (LH). (endocrine-abstracts.org)
- Somatotrophs and lactotrophs are acidophils that secrete GH and PRL, respectively, whereas mammosomatotrophs secrete both GH and PRL. (oncohemakey.com)
- 3. Somatotroph hyperplasia without pituitary adenoma associated with a long standing growth hormone-releasing hormone-producing bronchial carcinoid. (nih.gov)
- 5. Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH. (nih.gov)
- Primary pituitary diffuse large B-cell lymphoma with somatotroph hyperplasia and acromegaly: case report. (harvard.edu)
- 1. A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly. (nih.gov)
- 12. Growth hormone-releasing hormone and glucocorticoids determine the balance between luteinising hormone (LH) beta- and LH beta/follicle-stimulating hormone beta-positive gonadotrophs and somatotrophs in the 14-day-old rat pituitary tissue in aggregate cell culture. (nih.gov)
- 2. Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma. (nih.gov)
- Released from the somatotroph cells within the lateral wings of the brain's anterior pituitary gland, GH, a protein-based, 191-amino acid polypeptide, controls many bodily processes - from fat loss to bone growth to muscle building. (allmaxnutrition.com)
- INTRODUCTIONGrowth Hormone (GH) and Growth Hormone Deficiency (GHD): GH is secreted from adenohypophysis present on the somatotrophs. (gerardcambon.net)
- ABSTRACT: In rat pituitary somatotrophs, cytochrome oxidase is co-packaged with growth hormone (GH) in some storage granules. (pharmalight.eu)
- Clinical, hormonal and pathomorphological markers of somatotroph pituitary neuroendocrine tumors predicting the treatment outcome in acromegaly. (nih.gov)
- ACTH co-secretion by a mammo-somatotroph pituitary tumor can be clinically significant but phenotypically unidentifiable. (nih.gov)
- Pathological markers of somatotroph pituitary neuroendocrine tumors predicting the response to medical treatment. (nih.gov)