Somatomedins are a group of proteins produced predominantly by the liver when growth hormones act on target tissue. (wikipedia.org)
The liver is thought to be the predominant source of circulating somatomedins. (wikipedia.org)
The anabolic effects, meanwhile, are mediated by somatomedin C (insulin-like growth factor I), which is secreted by the liver in response to growth hormone stimulation. (petmd.com)
GH stimulates growth indirectly by promoting the liver?s production of somatomedins in response to stimulation, which act directly on bone and soft tissue to cause growth. (biogenex.com)
Growth14
Somatomedins inhibit the release of growth hormones by acting directly on anterior pituitary and by stimulating the secretion of somatostatin from the hypothalamus. (wikipedia.org)
Somatomedins are a group of proteins that promote cell growth and division in response to stimulation by growth hormone (GH), also known as somatotropin (STH). (wikipedia.org)
In addition to their actions that stimulate growth, somatomedins also stimulate production of somatostatin, which suppresses growth hormone release. (wikipedia.org)
Thus, levels of somatomedins are controlled via negative feedback through the intermediates of somatostatin and growth hormone. (wikipedia.org)
During short-term administration of human growth hormone (HGH) his response with regard to fasting blood-glucose and free fatty acids, plasma-somatomedin, urinary excretion of calcium, nitrogen, and hydroxyproline was minimal or absent. (bmj.com)
These findings suggest that somatomedin-C participates in the growth hormone negative feedback loop with an immediate effect on hypothalamic somatostatin and a delayed effect on the anterior pituitary. (nih.gov)
The growth hormone (GH)-releasing hormone (GHRH)-GH-somatomedin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II. (nih.gov)
7. Relationship between somatomedin-C and growth hormone levels in acromegaly: basal and dynamic evaluation. (nih.gov)
9. Value of growth hormone dynamics and somatomedin C (insulin-like growth factor I) levels in predicting the long-term benefit after transsphenoidal surgery for acromegaly. (nih.gov)
The excessive levels of somatomedin C, however, promote protein synthesis and growth in a variety of tissues such as the bone cartilage, soft tissues, especially in the head and neck region. (petmd.com)
Laron type d. d. associated with an absent or very low levels of somatomedin C (insulinlike growth factor I) or abnormalities in receptor activity. (theodora.com)
Z300059Insulin-like growth factor I, also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. (topsan.org)
To identify the possible causes of his growth failure, we performed other laboratory tests, including those for hepatic and renal function, thyroid hormones, human growth hormone (hGH), somatomedin C and celiac disease. (biomedcentral.com)
There was no significant change in their muscle function, but there was a significant reduction in weight gain and in levels of growth hormone, somatomedin C, hair zinc, serum zinc, and serum LDH. (bmj.com)
Somatostatin1
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus. (nih.gov)
Insulin1
Insulin secretion had not increased and plasma somatomedin levels remained extremely low. (bmj.com)
Serum1
In particular the role of serum somatomedin and cartilage responsiveness to somatomedin have been examined. (wits.ac.za)
Levels4
somatomedin C) levels in patients with acromegaly. (nih.gov)
Plasma somatomedin levels are also reduced. (medscape.com)
A radioimmunoassay for plasma somatomedin C is available at Michigan State University -- which can confirm the elevated plasma levels associated with acromegaly -- but this is often impractical. (petmd.com)
The cat slowly regained normal plasma somatomedin C levels and the diabetes mellitus resolved after two months. (petmd.com)
Acromegaly2
4. Evaluation of selective transsphenoidal adenomectomy by endocrinological testing and somatomedin-C measurement in acromegaly. (nih.gov)
13. Somatomedin-C in active and successfully treated acromegaly. (nih.gov)
Normal1
Laboratory tests showed a high level of immunoglobulin E, hypereosinophilia with a normal white blood cell count and a low level of somatomedin C. The patient had had atopic dermatitis resistant to treatment since the age of 6 months. (biomedcentral.com)
Thought1
This includes a lack of generation of somatomedin, which is thought to be the cause of his short stature. (bmj.com)
Effects1
Somatomedins have similar biological effects to somatotropin. (wikipedia.org)