• inhibitors
  • Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to its short time of action, therefore longer-acting epithelial sodium channel (ENaC) inhibitors may prove more effective, e.g. benzamil. (wikipedia.org)
  • secretion
  • Studies using isolated preparations of thick ascending limb with glomerulus attached in low NaCl perfusate were unable to inhibit renin secretion when various sodium salts were added but could inhibit renin secretion with the addition of chloride salts. (wikipedia.org)
  • NHE1
  • B) Example of a recording set for NHE1 transport activity in a single CHO cell using different bath sodium concentrations at fixed extracellular (8.2) and intracellular pH (6.0). (nih.gov)
  • protein
  • We conclude that the increase in the V max of the Na + -H + antiporter in cultured VSMCs from the SHR, compared to those from WKY rats, is due, at least in part, to increased levels of NHE-1 protein. (ahajournals.org)
  • cells
  • Cultured vascular smooth muscle cells (VSMCs) from the spontaneously hypertensive rat (SHR) exhibit increased activity of the Na + -H + antiporter as compared to normotensive Wistar-Kyoto (WKY) rats. (ahajournals.org)
  • 1 2 Increased activity of the Na + -H + antiporter in cultured VSMCs from the SHR likewise is observed in early passaged cells (passages 2 through 6) but not in cells grown in late subpassages (passages 7 through 10). (ahajournals.org)
  • rats
  • 1 2 3 Analysis of the kinetic properties of the Na + -H + antiporter in cultured VSMCs from the SHR has revealed that the V max of the Na + -H + antiporter is increased as compared to VSMCs from WKY rats. (ahajournals.org)
  • 1 2 3 In contrast, thymic lymphocytes from the SHR display similar kinetic properties for the Na + -H + antiporter as compared to those from WKY rats. (ahajournals.org)
  • activity
  • This finding suggests that the greater level of Na + -H + antiporter activity in cultured VSMCs from the SHR is due to a posttranscriptional alteration. (ahajournals.org)
  • Cell
  • The sodium within the tubule cell may then be retained by the body rather than excreted in the urine. (wikipedia.org)
  • 4 These discordant findings may reflect cell-specific differences in the properties of the Na + -H + antiporter or, more likely, differences in the phenotype expressed in cultured VSMCs as compared to freshly isolated lymphocytes. (ahajournals.org)