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  • epithelial
  • Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to its short time of action, therefore longer-acting epithelial sodium channel (ENaC) inhibitors may prove more effective, e.g. benzamil. (wikipedia.org)
  • secretion
  • Studies using isolated preparations of thick ascending limb with glomerulus attached in low NaCl perfusate were unable to inhibit renin secretion when various sodium salts were added but could inhibit renin secretion with the addition of chloride salts. (wikipedia.org)
  • cells
  • The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. (wikipedia.org)
  • Na(+)/H(+) antiporters show a marked pH dependence, which is important for their physiological function in eukaryotic and prokaryotic cells. (nih.gov)
  • Cultured vascular smooth muscle cells (VSMCs) from the spontaneously hypertensive rat (SHR) exhibit increased activity of the Na + -H + antiporter as compared to normotensive Wistar-Kyoto (WKY) rats. (ahajournals.org)
  • 1 2 Increased activity of the Na + -H + antiporter in cultured VSMCs from the SHR likewise is observed in early passaged cells (passages 2 through 6) but not in cells grown in late subpassages (passages 7 through 10). (ahajournals.org)
  • rats
  • We conclude that the increase in the V max of the Na + -H + antiporter in cultured VSMCs from the SHR, compared to those from WKY rats, is due, at least in part, to increased levels of NHE-1 protein. (ahajournals.org)
  • 1 2 3 Analysis of the kinetic properties of the Na + -H + antiporter in cultured VSMCs from the SHR has revealed that the V max of the Na + -H + antiporter is increased as compared to VSMCs from WKY rats. (ahajournals.org)
  • 1 2 3 In contrast, thymic lymphocytes from the SHR display similar kinetic properties for the Na + -H + antiporter as compared to those from WKY rats. (ahajournals.org)
  • transport
  • Differential effects of mutations on the transport properties of the Na+/H+ antiporter NhaA from Escherichia coli. (nih.gov)
  • activity
  • This finding suggests that the greater level of Na + -H + antiporter activity in cultured VSMCs from the SHR is due to a posttranscriptional alteration. (ahajournals.org)
  • specific
  • In NhaA, the Escherichia coli Na(+)/H(+) antiporter, specific single site mutations modulating the pH profile of the transporter have been described in the past. (nih.gov)
  • 4 These discordant findings may reflect cell-specific differences in the properties of the Na + -H + antiporter or, more likely, differences in the phenotype expressed in cultured VSMCs as compared to freshly isolated lymphocytes. (ahajournals.org)
  • pumps
  • The metabolic apparatus that serves this function involves Ca2+ protein-based and non-proteinaceous channels, Ca2+ antiporters (Ca2+/2H+, Ca2+/Na+), and ATP-dependent Ca2+ pumps. (heavenforum.org)
  • The coupling of proton translocation and electron transport in Complex I is currently proposed as being indirect (long range conformational changes) as opposed to direct (redox intermediates in the hydrogen pumps as in heme groups of Complexes III and IV). (wikipedia.org)