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  • Histological
  • Histological abnormalities of the reduced number of hair follicles, irregularly arranged and curved hair follicles, epidermal hyperplasia and disturbed differentiation of epidermis were observed in the PLCD1-deficient mice. (biomedcentral.com)
  • In early purpura fulminans, lesion progression correlates with the histological appearance of blockage of small skin blood vessels with blood clots causing capillary dilation and congestion with red blood cells. (wikipedia.org)
  • genetic
  • In and on our body's skin, the genetic skin manifestation , Acropigmentation of Dohi is a skin dyschromatosis also known as dyschromatosis symmertica hereditaria or symmetrical dyschromatosis of the extremities , characterized by a symmetrical distribution of hyperpigmented and hypopigmented macules on the extremities, especially over the dorsa of the hands and feet, not associated with a health challenge. (wellnessadvocate.com)
  • Incontinentia pigmenti (IP) is a rare genetic disorder that affects the skin, hair, teeth, nails, and central nervous system. (wikipedia.org)
  • abnormal
  • Other features noted in association with EEC include vesicoureteral reflux, recurrent urinary tract infections, obstruction of the nasolacrimal duct, decreased pigmentation of the hair and skin, missing or abnormal teeth, enamel hypoplasia, absent punctae in the lower eyelids, photophobia, occasional cognitive impairment and kidney anomalies, and conductive hearing loss. (wikipedia.org)
  • sparse
  • Ectodermal dysplasia is characterized by absent sweat glands resulting in dry (hypohydrotic), often scale-like skin, sparse and usually coarse scalp hair that is often blonde, sparse eyebrows and eyelashes, and small brittle nails. (wikipedia.org)
  • teeth
  • In general terms, ectodermal cells generate the skin, spinal cord, and teeth (as well as the numerous derivatives mentioned above). (wikipedia.org)
  • lesions
  • The majority of affected individuals develop the characteristic skin lesions by 20 years of age. (wikipedia.org)
  • The skin lesions evolve through characteristic stages: blistering (from birth to about four months of age), a wart-like rash (for several months), swirling macular hyperpigmentation (from about six months of age into adulthood), followed by linear hypopigmentation. (wikipedia.org)
  • Haemorrhage into the necrotic skin causes purpura fulminans lesions to become painful, dark and raised, sometimes with vesicle or blister (bulla) formation. (wikipedia.org)
  • include
  • The hands and feet of people with ectrodactyly are often described as "claw-like" and may include only the thumb and one finger (usually either the little finger, ring finger, or a syndactyly of the two) with similar abnormalities of the feet. (wikipedia.org)
  • These abnormalities include a cleft lip, a cleft palate which is an opening in the roof of the mouth, widely spaced eyes (hypertelorism), sharp corners of the mouth that point upward, a broad nose that can include a flattened tip, along with several deformations of both the external and middle ear structures. (wikipedia.org)
  • tenderness
  • Massaging the cat may also allow the owner to look for abnormalities that might appear on the cat's skin and in finding areas of tenderness or swelling that could be the signs of a serious condition. (wikipedia.org)
  • nails
  • The ectodermal derivative abnormalities can affect the epidermis including mammary, pituitary and sweat glands, as well as hairs, dental enamel, nails, lens, and the internal ear. (wikipedia.org)
  • mice
  • Hairless mice have been widely applied in skin-related researches, while hairless pigs will be an ideal model for skin-related study and other biomedical researches because of the similarity of skin structure with humans. (biomedcentral.com)
  • Krt1, Krt5, Krt13, loricrin and involucrin) involved in the differentiation of hair follicle were remarkerably increased in skin tissues of PLCD1-deficient mice. (biomedcentral.com)
  • Pups died 2-3 days after birth, and these mice exhibited marked skin abnormalities, including degeneration of keratinocytes. (wikipedia.org)
  • irregular
  • In and on our body's integumentary system , Dyschromatosis is a skin abnormality characterized by the presence of both hyperpigmented and hypopigmented macules, many of which are small in size and irregular in shape on the skin . (wellnessadvocate.com)
  • neck
  • These bulging masses occur deep under the skin, typically on the neck, tongue and lips, and vary widely in size, ranging from as small as a centimeter in diameter to several centimeters wide. (wikipedia.org)
  • seen
  • Since BFS appears to cause no actual nerve damage (at least as seen on the EMG), patients will likely exhibit a completely normal EMG (or one where the only abnormality seen is fasciculations). (wikipedia.org)
  • erythema
  • Advancing areas of necrosis are often surrounded by a thin border of erythema that fades into adjacent unaffected skin. (wikipedia.org)
  • hair
  • However, because of pig skin coated with shaggy hairs, shaving hair process is inevitable before skin test or surgery. (biomedcentral.com)
  • Hence, it makes sense to generate hairless pigs to eliminate the need for hair removal procedures before experiment and surgery, and avoid the skin damage caused thereby. (biomedcentral.com)
  • dental
  • Rabson and Mendenhall described 3 sibling (2 girls, 1 boy) who initially presented with dental and skin abnormalities, abdominal distention, and phallic enlargement. (wikipedia.org)
  • bone
  • The tertiary stage manifests years later as neurosyphilis, aortitis, and gummatous changes of the skin, bone, and viscera. (hawaii.edu)
  • small
  • Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. (wikipedia.org)
  • coat
  • Massage therapy may have a positive impact on the cats' digestive system and their coat and skin. (wikipedia.org)
  • acne
  • Signs and symptoms may include high blood pressure, abdominal obesity but with thin arms and legs, reddish stretch marks, a round red face, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly. (wikipedia.org)
  • Other striking and distressing skin changes that may appear in Cushing's syndrome include facial acne, susceptibility to superficial fungus (dermatophyte and malassezia) infections, and the characteristic purplish, atrophic striae on the abdomen. (wikipedia.org)
  • known
  • Michelin tire baby syndrome (also known as "Folded skin with scarring"), is characterized by multiple, symmetric, circular skin creases, or bands, on the forearms, lower legs, and often the neck that are present at birth. (wikipedia.org)