• stent
  • A sirolimus eluting coronary stent is marketed by Cordis, a division of Johnson & Johnson , under the tradename Cypher . (wikidoc.org)
  • BRIDGEWATER, N.J., June 15, 2011 /PRNewswire-FirstCall/ -- Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO™ Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. (mdtmag.com)
  • Bioengineered, Sirolimus-Eluting Stent Found 'Safe,' and 'Effective. (wikipedia.org)
  • drug
  • Treatment with sirolimus must be monitored because the range in which the drug is effective but not toxic is very narrow. (labcorp.com)
  • Because of the long time that it takes to clear the drug from the body (its long half-life), the sirolimus concentration may take some time to reach a steady state (equilibrium) in the blood. (labcorp.com)
  • Sirolimus ( INN ) is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation , and is especially useful in kidney transplants. (wikidoc.org)
  • The purpose of this study is to find out about the safety and effectiveness of the study drug, sirolimus, in patients with uveitis and to utilize the potential effectiveness of sirolimus, and yet to avoid the potential complications of systemic use of the drug. (clinicaltrials.gov)
  • The current research is being done to determine the safety and the usefulness of treatment of non-infectious uveitis using a drug called sirolimus. (clinicaltrials.gov)
  • Consuming 8 ounces of grapefruit juice increases sirolimus levels by 350%, allowing persons with cancer to take less toxic doses of the drug. (oncologynurseadvisor.com)
  • Optimal sirolimus doses for the other two groups, however, were much lower: Persons who took ketoconazole plus sirolimus needed only 16 mg per week of the latter to maintain the same blood levels of the drug. (oncologynurseadvisor.com)
  • Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Sirolimus, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
  • This made sirolimus the first drug approved to treat this disease. (wikipedia.org)
  • Doses
  • The trials employed an adaptive escalation design to find the doses of oral, weekly sirolimus alone or in combination with either the antifungal agent ketoconazole or grapefruit juice that would achieve similar blood concentrations as temsirolimus, the intravenously administered and approved prodrug of sirolimus. (oncologynurseadvisor.com)
  • medication
  • Sirolimus may also be used for purposes not listed in this medication guide. (cigna.com)
  • An anti-rejection-type medication, sirolimus, helps to limit the overgrowth of normal cells while the artery heals which reduces the chance of re-blockage in the treated area known as restenosis, and reduces the chances that another procedure is required. (wikipedia.org)
  • evaluate
  • Other tests may also be periodically ordered to evaluate organ function and blood cell counts because sirolimus may decrease a person's platelet count, increase blood lipids, and, when taken long-term with other immunosuppressants, affect kidney function. (labcorp.com)
  • warn
  • However, on 7 October 2008, the FDA approved safety labeling revisions for sirolimus to warn of the risk for decreased renal function associated with its use. (wikipedia.org)
  • infection
  • Sirolimus can lower blood cells that help fight infection, and may cause you to produce too much of a certain type of white blood cell. (cigna.com)
  • lung
  • On May 28, 2015, the FDA approved sirolimus to treat lymphangioleiomyomatosis (LAM), a rare, progressive lung disease that primarily affects women of childbearing age. (wikipedia.org)