• Structures for all sequences containing less than 1790 nucleotides in the 2600 nucleotide late region of the SV40 virus have been computed and saved on magnetic tape. (tau.ac.il)
  • Vaccine contamination with Simian vacuolating virus 40, known as SV40 occurred in the United States and other countries between 1955 and 1961. (wikipedia.org)
  • SV40 is a monkey virus that has the potential to cause cancer in animals and humans, although this is considered very unlikely and there have been no known human cases. (wikipedia.org)
  • the technique used to inactivate the polio virus in the Salk vaccine, by means of formaldehyde, did not reliably kill SV40. (wikipedia.org)
  • It is unknown how widespread the virus was among humans before the 1950s, though one study found that 12% of a sample of German medical students in 1952 - prior to the advent of the vaccines - had SV40 antibodies. (wikipedia.org)
  • From 1955 to 1963, an estimated 10-30% of polio vaccines administered in the US were contaminated with simian virus 40 (SV40). (cdc.gov)
  • Because of research done with SV40 in animal models, there has been some concern that the virus could cause cancer in humans. (cdc.gov)
  • No vaccines used today contain SV40 virus. (cdc.gov)
  • Does Simian Virus 40 (SV40) Have a Role in UK Malignant Pleural Mesothelioma? (mesothelioma-line.com)
  • Simian virus 40 (SV40)-contaminated polio vaccine was accidentally administered to about one-third of the UK population receiving polio vaccines between 1956 and 1962. (mesothelioma-line.com)
  • SV40 was subsequently demonstrated to be a carcinogenic virus in experimental and animal models. (mesothelioma-line.com)
  • But one of the study's authors told PolitiFact this is not the same as simian virus 40, or SV40, which can cause tumors in monkeys. (politifact.com)
  • Monkey DNA and the SV40 virus also are not listed among the ingredients in the COVID-19 vaccines that federal regulators have approved for use. (politifact.com)
  • Simian virus 40, or SV40, is a tumor-causing virus found in monkeys. (politifact.com)
  • African green monkeys were used in early research on the SV40 virus. (politifact.com)
  • The study tested four expired vials of the Moderna and Pfizer COVID-19 vaccines and found elements of the virus, including an "SV40 promoter" in the Pfizer vaccine vials. (politifact.com)
  • However, McKernan said they did not find the whole SV40 virus in the vaccines. (politifact.com)
  • In this case, the "SV40 promoter" is a DNA sequence that was first identified in the SV40 virus. (politifact.com)
  • In the SV40 virus, the SV40 promoter drives the expression of a cancer-causing gene, said Phillip Buckhalts, director of the Cancer Genetics Lab and professor at the University of South Carolina, who was not involved in the study. (politifact.com)
  • The part of the SV40 virus that can potentially cause cancer, known as the T-antigen, is not present in the COVID-19 vaccine, Buckhalts said. (politifact.com)
  • Simian virus 40 (SV40) a monkey virus found for years in the polio vaccine and is a potent cancer agent. (educate-yourself.org)
  • The polyomavirus simian virus 40 (SV40) is a known oncogenic DNA virus which induces primary brain and bone cancers, malignant mesothelioma, and lymphomas in laboratory animals. (educate-yourself.org)
  • Simian virus 40 (SV40), a polyomavirus of rhesus macaque origin, was discovered in 1960 as a contaminant of polio vaccines that were distributed to millions of people from 1955 through early 1963. (educate-yourself.org)
  • SV40 is a potent DNA tumor virus that induces tumors in rodents and transforms many types of cells in culture, including those of human origin. (educate-yourself.org)
  • The health regulator says Pfizer did not disclose the presence of the Simian Virus 40 (SV40) DNA sequence in its mRNA COVID-19 vaccine at the time of filing. (theepochtimes.com)
  • Health Canada has confirmed the presence of a Simian Virus 40 (SV40) DNA sequence in the Pfizer COVID-19 vaccine, which the manufacturer had not previously disclosed. (theepochtimes.com)
  • Polio vaccines used in the late 1950s and early 1960s were found to be contaminated with SV40 as the virus was present in monkey kidney cells that were used to grow the vaccine. (theepochtimes.com)
  • The email came in response to 10 questions about the inclusion of the Simian Virus 40 (SV40) DNA sequence in the Pfizer-BioNTech shot. (zerohedge.com)
  • The recognized KT3 epitope represents the amino acid sequence KPPTPPPEPET derived from the Simian Virus 40 (SV40) large T-antigen. (novusbio.com)
  • As a post-doctoral fellow with Paul Berg, I developed a subcellular system that allowed simian virus 40 (SV40) DNA to continue replication in vitro. (nih.gov)
  • My laboratory has developed new technologies and applied them towards understanding the molecular biology and enzymology of DNA replication in animal cells and viruses (SV40, polyomavirus, papillomavirus, and herpes simplex virus), and at the beginning of animal development (mouse preimplantation embryos and frog eggs). (nih.gov)
  • Variants of the initial cell line have been tested and found negative for ectromelia virus (mousepox), but most are susceptible to polyoma and simian virus 40 ( SV40 ). (fsu.edu)
  • The polyomavirus Simian Virus 40, an oncogenic DNA virus, was previously removed from polio vaccines due to concerns about a link to cancers. (theepochtimes.com)
  • The negative controls were mouse fibroblast cell lines containing a defective strain of polyoma virus . (emf-portal.org)
  • Viral antigens in permissive cells infected with JC virus, K virus and SA12 virus were reactive in immunofluorescence tests to antisera against sodium dodecyl sulfate disrupted simian virus 40 capsids and polyoma VP1. (johnshopkins.edu)
  • The major capsid polypeptides of all papovaviruses of the simian virus 40-polyoma subgroup are immunologically related. (johnshopkins.edu)
  • Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein med. (emf-portal.org)
  • Presence of nucleic acid or antigen in semen does not represent the presence of replication-competent or infection-competent virus, which can generally only be demonstration by isolation and culture of virus. (cdc.gov)
  • Stimulation of in vitro transcription from heterologous promoters by the simian virus 40 enhancer. (wikidata.org)
  • Transcription of simian virus 40. (cshlpress.com)
  • No association between simian virus 40 and diffuse malignant mesothelioma of the pleura in Iranian patients: a molecular and epidemiologic case-control study of 60 patients. (cdc.gov)
  • No detection of simian virus 40 in malignant mesothelioma in Korea. (cdc.gov)
  • Emergent human pathogen simian virus 40 and its role in cancer. (educate-yourself.org)
  • According to the first, dogs could be the source of the hitherto unknown pathogen - a virus, most likely - responsible for the recent outbreak of "severe acute hepatitis" detected among pediatric patients from UK and other European (including Italy) and non-European (including USA) Countries. (bmj.com)
  • 2005). Some oral poliovirus vaccines were contaminated with infectious simian virus 40 after 1961. (nature.com)
  • [2] However, the emergence of circulating vaccine-derived poliovirus (cVDPV), a form of the vaccine virus that has reverted to causing poliomyelitis, has led to the development of novel oral polio vaccine type 2 (nOPV2) which aims to make the vaccine safer and thus stop further outbreaks of cVDPV2. (wikipedia.org)
  • Interruption of person-to-person transmission of the virus by vaccination is important in global polio eradication , [15] since no long-term carrier state exists for poliovirus in individuals with normal immune function, polio viruses have no non-primate reservoir in nature, [16] and survival of the virus in the environment for an extended period of time appears to be remote. (wikipedia.org)
  • OPV produces excellent immunity in the intestine , the primary site of wild poliovirus entry, which helps prevent infection with wild virus in areas where the virus is endemic . (wikipedia.org)
  • 11] When the poliovirus was passaged through the monkeys or grown on the monkey kidney cells for production, extraneous viruses became part of the final poliovirus vaccine. (ronpaulforums.com)
  • An analysis presented at the Vaccine Cell Substrate Conference in 2004[medical citation needed] suggested that vaccines used in the former Soviet bloc countries, China, Japan, and Africa, could have been contaminated up to 1980, meaning that hundreds of millions more could have been exposed to the virus unknowingly. (wikipedia.org)
  • The virus came from monkey kidney cell cultures used to make polio vaccines at that time. (cdc.gov)
  • As with other live-virus vaccines, immunity initiated by OPV is probably lifelong. (wikipedia.org)
  • Another problem is the use of euphemisms like 'weakened' or 'attenuated' to describe live-virus containing vaccines, implying that they are less virulent. (greenmedinfo.com)
  • One of the basic methods used to create these 'weakened' vaccines is to serially passage the infectious agent through both and/or either animal and human biological fluids (e.g. bovine serum) and cells, giving the vaccine master seed stock an opportunity to become contaminated along the way with hidden disease vectors, including cancer-causing viruses. (greenmedinfo.com)
  • The Epoch Times article claims an April study found "massive DNA contamination" in COVID-19 vaccines, including "monkey virus DNA. (politifact.com)
  • Molecular biology experts also told PolitiFact there was no evidence of "monkey virus DNA" in the COVID-19 vaccines. (politifact.com)
  • Here again we would always be confronted with the potential danger of picking up other contaminating viruses or other microbic agents infectious for man. (ronpaulforums.com)
  • The contamination may have been in the original seed strain (coded SOM) or in the substrate-primary kidney cells from infected monkeys that were used to grow the vaccine virus during production. (wikipedia.org)
  • The Virus and the Vaccine. (wikipedia.org)
  • In 1955, some batches of polio vaccine given to the public contained live polio virus, even though they had passed required safety testing. (cdc.gov)
  • The first successful demonstration of a polio vaccine was by Hilary Koprowski in 1950, with a live attenuated virus which people drank. (wikipedia.org)
  • When the IPV (injection) is used, 90% or more of individuals develop protective antibodies to all three serotypes of polio virus after two doses of inactivated polio vaccine (IPV), and at least 99% are immune to polio virus following three doses. (wikipedia.org)
  • [22] The live virus used in the vaccine can rarely shed in the stool and can rarely spread to others within a community. (wikipedia.org)
  • Once their strains were isolated, pharmaceutical companies needed a method to propagate the viruses in order to produce the vast quantities of vaccine needed for nation-wide immunization campaigns. (ronpaulforums.com)
  • 12] As early as 1953, Dr. Herald R. Cox, a scientist working at Lederle Laboratories, one of the polio vaccine manufacturers, published an article in a peer reviewed scientific journal in which he stated, [P]oliomyelitis virus has so far been cultivated only in the tissues of certain susceptible species namely, monkey or human tissues. (ronpaulforums.com)
  • Despite efforts made over past decades, there is no vaccine or treatment available for preventing and controlling the ASF virus (ASFV) infection, and there is an urgent need to develop novel strategies. (mdpi.com)
  • In 1956, Dr. Sabin took this virus and passaged it through seven cultures of African Green Monkey kidney cells. (ronpaulforums.com)
  • 13] In fact, in 1958, a scientific journal reported that the rate of isolation of new simian viruses (from monkey kidney cells) has continued unabated. (ronpaulforums.com)
  • Absence of hepatitis C virus and detection of hepatitis G virus/GB virus C RNA sequences in the semen of infected men. (cdc.gov)
  • Women, when taken simian virus 40 reveals a new borderline intellectual functioning and parental stress: An italian case-control study. (colorectal-cancer.net)
  • This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. (mdpi.com)
  • For each type of virus, what is known about the roles of DNA methylation, histone modifications, nucleosome positioning, and regulatory RNA in epigenetic regulation of the virus infection will be discussed. (mdpi.com)
  • The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)
  • It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
  • 1. Kulcsár G, Csata S, Nász I. Investigations into virus carriership in human semen and mouse testicular cells. (cdc.gov)
  • Maximum detection time refers to time from symptom onset (only in viruses that cause acute only, not chronic, infection). (cdc.gov)
  • We used isolated nuclei from virus infected cells supplemented with cytoplasm, and discovered that viral replicating chromosomes could continue replication in the absence of a nucleus. (nih.gov)
  • Dr. Sabin s strains would be attenuated or weakened by transferring or passaging[2] the live viruses through different host cells and then fed to children orally. (ronpaulforums.com)
  • Therefore, the overall goal of our work is to discover how DNA replication is regulated both in the large chromosomes of cells and in the "mini-chromosomes" of viruses and small extrachromosomal DNA molecules. (nih.gov)
  • We demonstrated that DNA synthesis occurs discontinuously only on one arm of replication forks (the arm where the direction of synthesis is opposite to the direction of fork movement) through the repeated initiation, synthesis and joining of Okazaki fragments (transient nascent DNA chains of 40 to 300 nucleotides). (nih.gov)
  • Genome condensation and packaging are essential processes in the life cycle of viruses. (mdpi.com)
  • Monkey virus" is not the same as monkeypox , or mpox, a virus that spreads primarily through physical contact with an infected person. (politifact.com)
  • The claim comes from a June 11 Epoch Times article headlined, "Monkey virus DNA found in COVID-19 shots. (politifact.com)
  • Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. (cdc.gov)