• pyoverdine
  • Like most siderophores, pyoverdine is synthesized and secreted into the environment when the microorganism that produces it detects that intracellular iron concentrations have fallen below a preset threshold. (wikipedia.org)
  • Antibiotics Actinomycin Bacitracin Calcium dependent antibiotic Daptomycin Vancomycin Teixobactin Tyrocidine Gramicidin Zwittermicin A Antibiotic precursors ACV-Tripeptide Cytostatics Epothilone Bleomycin Immunosuppressants Ciclosporin (Cyclosporine A) Siderophores Pyoverdine Enterobactin Myxochelin A Pigments Indigoidine Toxins Microcystins and Nodularins, cyanotoxins from cyanobacteria. (wikipedia.org)
  • Salmonella
  • Mice immunized with the CTB-siderophore conjugate developed anti-siderophore antibodies in the gut mucosa, and whenmice were infected with the enteric pathogen Salmonella, they exhibited reduced intestinal colonization and reduced systemic dissemination of the pathogen. (universia.net)
  • fungal
  • Combined with the absence of a sidA ortholog-and the fungal siderophore system in general-in mammals, these data demonstrate that the siderophore biosynthetic pathway represents a promising new target for the development of antifungal therapies. (rupress.org)
  • demonstrate
  • We reconstituted the reaction in vitro with the main enzyme AvbD and the putative biosynthetic precursors, and demonstrate that multispecificity of this enzyme results in the production of all three cyclic hydroxamate siderophores that were previously isolated as natural products from S. algae. (uni-konstanz.de)
  • In live cells, however, siderophore ratios are maximized toward avaroferrin production, and we demonstrate that these siderophore ratios are the result of a regulation on substrate pool level, which may allow rapid evolutionary adaptation to environmental changes. (uni-konstanz.de)
  • metabolites
  • Diffusion chamber experiments demonstrated that physical attachment or contact of soluble metabolites such as siderophores with the basaltic glass plays a pivotal role in this process. (ucsd.edu)
  • Aspergillus
  • Eisendle, M., Oberegger, H., Zadra, I. and Haas, H. (2003) The Siderophore System Is Essential for Viability of Aspergillus nidulans Functional Analysis of Two Genes Encoding L-Ornithine N5-Monooxygenase (sidA) and a Non-Ribosomal Peptide Synthetase (sidC). (scirp.org)
  • Infection
  • In Candida albicans, the siderophore transporter Arn1p/Sit1p is required for epithelial invasion and penetration but not for systemic infection ( 13 ). (rupress.org)
  • We conducted cheating assays using defined siderophore deletion mutants, in conditions designed to model infected fluids and tissue in cystic fibrosis lung infection and non-healing wounds. (nottingham.ac.uk)
  • Our results show that it is crucial to develop defined in vitro models in order to predict whether siderophores are social, cheatable and suitable for clinical exploitation in specific infection contexts. (nottingham.ac.uk)
  • The binding of NGAL to bacterial siderophores is important in the innate immune response to bacterial infection. (wikipedia.org)
  • ions
  • Siderophores usually form a stable, hexadentate, octahedral complex preferentially with Fe3+ compared to other naturally occurring abundant metal ions, although if there are fewer than six donor atoms water can also coordinate. (wikipedia.org)