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  • glycan
  • Rescreening on a more expanded glycan array reconfirmed this finding, but also identified a second closely related ligand in which the fucose is absent (NeuAcα2-3(6-O-sulfo)Galβ1-4GlcNAc, or 6′-sulfated sialyl N-acetyl-D-lactosamine. (wikipedia.org)
  • Each lectin domain is specific for the linkage that connects sialic acid to the glycan. (wikipedia.org)
  • CD33
  • In contrast, IL-1beta and IL-3 stimulation resulted in a 10- and 100-fold increase in cell numbers with more than 90% of these cells being CD33(+).Fewer 2-week cobblestones and greater amounts of 5-week cobblestones were observed with IL-6 and IL-3.IL-1beta and IL-3 stimulated endothelium induces proliferation and differentiation of myeloid precursors, while IL-6 treatment induced a benefit of HPC survival. (nih.gov)
  • Amino acids 42-159 of human CD33 were used as the immunogen for the antibody. (novusbio.com)
  • CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. (novusbio.com)
  • The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.6) covalently attached to the cytotoxic antitumor antibiotic calicheamicin (N-acetyl-γ-calicheamicin) via a bifunctional linker (4-(4-acetylphenoxy)butanoic acid). (wikipedia.org)
  • Antigen
  • Several glycoconjugates, including stage-specific embryonic antigen (SSEA)-3, SSEA-4, and tumor-rejection antigen (TRA)-1-60, are used as molecular makers of pluripotency to control the quality of induced pluripotent stem (iPS) cells [ 2 ]. (hindawi.com)
  • homology
  • Analysis of this homology has revealed that the lectin domain, which binds sugars, is most conserved, suggesting that the three selectins bind similar sugar structures. (wikipedia.org)
  • Cells
  • Plating efficiencies and LTC initiating cells were greatest in IL-6 supernatants, whereas the highest numbers of burst-forming units were observed using IL-3. (nih.gov)
  • CCR7 upregulation allows DCs to migrate to local LNs where they encounter T cells ( 3 ), and depending on their activation state, they can induce a variety of immunogenic or tolerogenic responses ( 4 , 5 ). (jimmunol.org)
  • different
  • Though they share common elements, their tissue distribution and binding kinetics are quite different, reflecting their divergent roles in various pathophysiological processes. (wikipedia.org)
  • preferentially
  • Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N -acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. (vectorlabs.com)
  • lymphoid
  • In addition, PNA binding can be used to measure cellular maturity in lymphoid tissues, to distinguish a variety of lymphocyte subpopulations in man and experimental animals, and to measure the levels of lymphoid cell populations in many diseases. (vectorlabs.com)
  • motifs
  • Unexpectedly, MHV NTD contains a core structure that has the same β-sandwich fold as human galectins (S-lectins) and additional structural motifs that bind to the N-terminal Ig-like domain of mCEACAM1a. (nih.gov)
  • and virus-binding motifs (VBMs) are in blue. (nih.gov)
  • carbohydrate
  • As the leukocyte rolls along the blood vessel wall, the distal lectin-like domain of the selectin binds to certain carbohydrate groups presented on proteins (such as PSGL-1) on the leukocyte, which slows the cell and allows it to leave the blood vessel and enter the site of infection. (wikipedia.org)
  • Each selectin has a carbohydrate recognition domain that mediates binding to specific glycans on apposing cells. (wikipedia.org)
  • characteristic
  • The production of hypochlorous acid (HOCl) is a characteristic of granulocyte activation, a hallmark of the early phase of innate immune responses. (jimmunol.org)
  • Kinetics
  • Though they share common elements, their tissue distribution and binding kinetics are quite different, reflecting their divergent roles in various pathophysiological processes. (wikipedia.org)
  • cells
  • The two germ layers are spatially structured by an ECM in which embedded, interstitial (stem) cells give rise to nematocysts, mucous glands, and sensory or nerve cells ( 2 , 3 ). (pnas.org)
  • structural
  • There are structural differences between the ECM produced by X. elongata cell cultures and that of M. digitata , and ascorbic acid, a critical cofactor for proline hydroxylation, significantly increased the production of collagen in the ECM of the latter species. (pnas.org)
  • Structural analysis and mutagenesis localize the sugar-binding site in coronavirus NTDs to be above the β-sandwich core. (nih.gov)
  • We propose that coronavirus NTDs originated from a host galectin and retained sugar-binding functions in some contemporary coronaviruses, but evolved new structural features in MHV for mCEACAM1a binding. (nih.gov)