• receptor
  • Neuronal Nogo66 receptor-1 (NgR1) binds the myelin inhibitors NogoA, OMgp, and myelin-associated glycoprotein (MAG) and has been proposed to function as the ligand-binding component of a receptor complex that also includes Lingo-1, p75 NTR , or TROY. (rupress.org)
  • glycan
  • Rescreening on a more expanded glycan array reconfirmed this finding, but also identified a second closely related ligand in which the fucose is absent (NeuAcα2-3(6-O-sulfo)Galβ1-4GlcNAc, or 6′-sulfated sialyl N-acetyl-D-lactosamine. (wikipedia.org)
  • Each lectin domain is specific for the linkage that connects sialic acid to the glycan. (wikipedia.org)
  • inhibitory
  • In contrast, signals induced by ligation of inhibitory and coinhibitory receptors (e.g., the inhibitory Ig-like transcript family members) and suppressive cytokine receptors (e.g. (jimmunol.org)
  • protein
  • Sialic acid-binding Ig-like lectin 12 is a protein that in humans is encoded by the SIGLEC12 gene. (wikipedia.org)
  • Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. (githubusercontent.com)
  • So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes. (wikipedia.org)
  • Parallel studies by Ajit Varki and colleagues on the previously cloned CD22 (a B cell surface protein involved in adhesion and activation) showed direct evidence for sialic acid recognition. (wikipedia.org)
  • The name selectin comes from the words "selected" and "lectins," which are a type of carbohydrate-recognizing protein. (wikipedia.org)
  • Types include: Type II disorders involve malfunctioning trimming/processing of the protein-bound oligosaccharide chain. (wikipedia.org)
  • neutrophils
  • Neutrophils and eosinophils bind to E-selectin. (wikipedia.org)
  • Eosinophils, like neutrophils, use sialylated, protease-resistant structures to bind to E-selectin, although the eosinophil expresses much lower levels of these structures on its surface. (wikipedia.org)
  • dependent
  • Most sialic acids are bonded via the 2, 3, 6 and occasionally 8 hydroxyl groups (number dependent on the carbon to which they are attached), in an α anomeric configuration. (wikipedia.org)
  • All selectins are single-chain transmembrane glycoproteins that share similar properties to C-type lectins due to a related amino terminus and calcium-dependent binding. (wikipedia.org)
  • Antibody
  • Amino acids 42-159 of human CD33 were used as the immunogen for the antibody. (novusbio.com)
  • The drug is a recombinant, humanized anti-CD33 monoclonal antibody (IgG4 κ antibody hP67.6) covalently attached to the cytotoxic antitumor antibiotic calicheamicin (N-acetyl-γ-calicheamicin) via a bifunctional linker (4-(4-acetylphenoxy)butanoic acid). (wikipedia.org)
  • homology
  • Analysis of this homology has revealed that the lectin domain, which binds sugars, is most conserved, suggesting that the three selectins bind similar sugar structures. (wikipedia.org)
  • carbohydrate
  • As the leukocyte rolls along the blood vessel wall, the distal lectin-like domain of the selectin binds to certain carbohydrate groups presented on proteins (such as PSGL-1) on the leukocyte, which slows the cell and allows it to leave the blood vessel and enter the site of infection. (wikipedia.org)
  • cells
  • CCR7 upregulation allows DCs to migrate to local LNs where they encounter T cells ( 3 ), and depending on their activation state, they can induce a variety of immunogenic or tolerogenic responses ( 4 , 5 ). (jimmunol.org)
  • sites
  • This suggests that sialic acid-independent sites located in Ig repeats 4 or 5 of the MAG ectodomain are important for neurite outgrowth inhibition. (rupress.org)
  • different
  • Though they share common elements, their tissue distribution and binding kinetics are quite different, reflecting their divergent roles in various pathophysiological processes. (wikipedia.org)