• Our docking results suggest that scytoscalarol, an antibacterial and antifungal guanidine-bearing sesterterpene, can inhibit arabinosyltransferase Mtb EmbC, and the beta-carboline alkaloids 8-hydroxymanzamine A and manzamine A can bind to the oxidoreductase of Mtb INHA On this basis, these products showing high binding affinities to the two targets in silico could be rationally selected for in vitro testing against these targets and/or semisynthetic modification. (utalca.cl)
  • To reveal the role of the cyanthin diterpenoid and sesterterpene constituents on this effects, erinacine A and S were isolated and their effects on attenuating AD-related pathology in APPswe/PS1dE9 transgenic mice were investigated. (nih.gov)
  • 3. Cytotoxic scalarane-type sesterterpenes from the Saudi Red Sea sponge Hyrtios erectus. (nih.gov)
  • 5. Cytotoxic Sesterterpenes from Thai Marine Sponge Hyrtios erectus. (nih.gov)
  • 17. Three new cytotoxic sesterterpenes from the marine sponge Hyrtios cf. erectus. (nih.gov)
  • Continuation of a detailed investigation of cancer cell growth inhibitory (P388 lymphocytic leukemia) fractions (trace) from H. erecta has revealed the presence (10 -5 to 10 -7 % yield) of cytotoxic pentacyclic sesterterpenes. (elsevierpure.com)
  • Type in " Dysidea ," "Sesterterpenes," " Dysidea pharmacological activities," or " Dysidea species" were eligible materials for writing this review. (springeropen.com)
  • A group of Italian and Jordanian researchers isolated twenty-four new sesterterpenes, some of them with interesting biological activity due to their interaction with tubulin-tyrosine ligase (TTL), an enzyme involved in the tyrosination cycle of the C-terminus of tubulin, and inhibit TTL activity in cancer cells. (wikipedia.org)
  • 16. Structures and potential antitumor activity of sesterterpenes from the marine sponge Hyrtios communis. (nih.gov)
  • Anti-angiogenic activity of terpestacin, a bicyclo sesterterpene from Embellisia chlamydospora. (bioaustralis.com)