LactonesLactoneHydrocarbonsAbstractEudesmaneConstituentsBiosynthesisCompoundsFarnesolTerpenesCytotoxicCyclicChemistryFractionsSubstancesMetabolitesEvaluateIsolationHumuleneStructuralTypePresentDoubleEssentialNovel sesquiterpeneMonoterpenes and SesquiterpenesEstersFarneseneSesquiterpenoidsEnzymesCommonlyCytotoxicMolecularStronglyActivityHighEssential oilFoundFreeProductionRingsLeaves
Lactones17
- Sesquiterpene lactones are a common class of sesquiterpenoids that contain a lactone ring, hence the name. (wikipedia.org)
- We have previously shown that helenalin and other sesquiterpene lactones selectively inhibit activation of the transcription factor NF-kappaB, a central mediator of the human immune response. (greenmedinfo.com)
- It has previously been reported that sesquiterpene lactones exert their effect by inhibiting degradation of IkappaB, the inhibitory subunit of NF-kappaB. (greenmedinfo.com)
- Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity in vitro showed that total sesquiterpene lactone extracts exhibited the most cytotoxicity activities against HepG-2 cells (IC 50 = 4.2 μg/mL). (researchsquare.com)
- Carpesium abrotanoides L., is rich in sesquiterpene lactones with significant cytotoxicity effects on the HepG-2 cell line. (researchsquare.com)
- The Chemistry and Biological Activity of Sesquiterpene Lactones of Heliantheae (Compositae). (lsu.edu)
- Investigations of the antineoplastic crude extracts of Melampodium cinereum No. 2015B provided low yields of four new cis, cis-germacranolide sesquiterpene lactones which were named melcanthin D (83), E (84), F (87), and G (88). (lsu.edu)
- For structure-biological activity correlation studies (antineoplastic activity, cytotoxicity, and phosphofructokinase deactivation), acetate, isobutyrate, hexanoate, and palmitate ester derivatives were prepared of four melampolide-type sesquiterpene lactones from Melampodium: melampodin B (86), melcanthin B (99), melampodin A (100), and cinerenin (101). (lsu.edu)
- Twenty-two melampolide-type sesquiterpene lactones and their ester derivatives were tested for inhibition of the enzyme phosphofructokinase (PFK) and the apparent K(,i) values were determined. (lsu.edu)
- Saturated sesquiterpene lactones-rich species (Artemisia kopetdaghensis, Artemisia santolina, Artemisia sieberi) showed the highest suppressive activity on NO and PGE2 production via suppression of iNOS and COX-2 expression. (ac.ir)
- Fractions bearing unusual (Artemisia fragrans and Artemisia absinthium) and unsaturated sesquiterpene lactones (Artemisia ciniformis) possess less modulatory effect on PGE2 production and COX-2 expression. (ac.ir)
- Determining sesquiterpene lactones in Belgian endive roots (Cichorium intybus L. var. (ilvo.be)
- In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (univ-reunion.fr)
- Three sesquiterpene lactones were isolated, namely 8-(4'-hydroxymethacrylate) dehydromelitensin (1), onopordopicrin (2) and 8α-[4'-hydroxymethacryloyloxy]-4-epi-sonchucarpolide (3). (univ-reunion.fr)
- Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in plants of the Asteraceae family, e.g., in chicory plants, displaying a wide range of interesting biological activities. (mdpi.com)
- Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
- Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N (2010) What Made Sesquiterpene Lactones Reach Cancer Clinical Trials? (who.int)
Lactone8
- Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling. (harvard.edu)
- The anti-inflammatory sesquiterpene lactone helenalin found in Arnica inhibits the transcription factor NF-kappaB by directly targeting p65. (greenmedinfo.com)
- The sesquiterpene lactone helenalin is a potent anti-inflammatory drug whose molecular mechanism of action remains unclear despite numerous investigations. (greenmedinfo.com)
- This sesquiterpene lactone is the first anti-inflammatory agent shown to exert its effect by directly modifying NF-kappaB. (greenmedinfo.com)
- Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. (lu.se)
- Three sesquiterpene lactone compounds, 2 α ,5 α -dihydroxy-11 α H-eudesma-4(15)-en-12,8 β -olide ( 1 ), telekin ( 2 ), oxoeudesm-11(13)-eno-12,8 α -lactone ( 3 ) were obtained. (researchsquare.com)
- In conclusion, three sesquiterpene lactone compounds inhibited the proliferation of HepG-2 cells via suppressing the JAK2/STAT3 signaling pathway. (researchsquare.com)
- 11. Emami SA, Taghizadeh Rabe SZ, Iranshahi M, Ahi A, Mahmoudi M. Sesquiterpene lactone fraction from Artemisia khorassanica inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB. (ac.ir)
Hydrocarbons3
- A recent study conducted in the Cosmics Leaving Outdoor Droplets large cloud chamber at CERN, has identified sesquiterpenes - gaseous hydrocarbons that are released by plants - as potentially playing a major role in cloud formation in relatively pristine regions of the atmosphere. (wikipedia.org)
- The present study aims to evaluate sesquiterpene hydrocarbons (SHs) as markers of EVOO geographical origin and to compare the discrimination efficiency of targeted profiling and fingerprinting approaches. (unboundmedicine.com)
- Sesquiterpenes are hydrocarbons of the composition, C15H24, which occur in many essential oils. (wgtn.ac.nz)
Abstract1
- abstract = "Two new sesquiterpenes, godotol A (1) and godotol B (2), were isolated from Pluchea arabica. (elsevierpure.com)
Eudesmane6
- Sesquiterpenes, Eudesmane" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Sesquiterpenes, Eudesmane" by people in Harvard Catalyst Profiles by year, and whether "Sesquiterpenes, Eudesmane" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Sesquiterpenes, Eudesmane" by people in Profiles. (harvard.edu)
- The gas-chromatography/mass spectrometry (GC/MS) and gas-chromatography-flame ionization detector (GC/FID) analyses showed that the EOs were rich in sesquiterpenes, germacrene D (10.3-12.1%), β-bisabolene (14.4%), kessane (26.9%), germacrene B (8.2%), elemol (3.4-46.9%), β-bisabolenal (1.4-70.7%), β-bisabolenol (8.4%) and an eudesmane type sesquiterpene (1) (16.1%) with [M+218]. (iyte.edu.tr)
- Structure determination was accomplished from 1D- and 2D-NMR spectroscopic data which determined a new eudesmane type sesquiterpene, 3,7(11)-eudesmadien-2-one (1). (iyte.edu.tr)
- Members contain eudesmane and elemane SESQUITERPENES. (bvsalud.org)
Constituents3
- In the process of continuing to investigate ultraviolet b (UVB) irradiation protective constituents from Oplopanax elatus stems, nine new sesquiterpenes, named as eurylosesquiterpenosides A-D (1-4), eurylosesquiterpenols E-I (5-9), and ten known ones (10-19) were gained. (figshare.com)
- The principal constituents are bicyclic terpenes (e.g. α-pinene, β-pinene, δ-3-carene), with smaller proportions of monoterpenes, sesquiterpenes and their hydrogenated and oxygenated terpenoid derivatives. (europa.eu)
- Sesquiterpenes are constituents of a variety of essential oils that are used in flavorings, perfumes, personal care, and cleaning products. (cdc.gov)
Biosynthesis1
- The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. (wikipedia.org)
Compounds3
- The compound is widespread in nature and serves as an important biosynthetic intermediate towards many other sesquiterpene alcohols including eudesmols, guaiols and rearranged compounds. (researchgate.net)
- The compounds 11,12,13-tri-nor-sesquiterpenes are degraded sesquiterpenoids which have lost the C3 unit of isopropyl or isopropenyl at C-7 of the sesquiterpene skeleton. (researchgate.net)
- Yu, Z 2010, ' Anticancer effects and mechanisms of sesquiterpene compounds isolated from Atractylodes Macrocephala in B16 melanoma cells ', The 9th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM) = 第九屆中藥全球化聯盟國際研討會, 23/08/10 - 25/08/10 pp. (edu.hk)
Farnesol2
Terpenes1
- Sesquiterpenes are a class of terpenes that consist of three isoprene units and often have the molecular formula C15H24. (wikipedia.org)
Cytotoxic2
- Cytotoxic effect of sesquiterpenes isolated from dichloromethane (DCM) extract of Tanacetum vulgare subsp sicilum (Guss. (anadolu.edu.tr)
- Cytotoxic effect of sesquiterpenes isola. (anadolu.edu.tr)
Cyclic3
- Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. (wikipedia.org)
- Cyclic sesquiterpenes are more common than cyclic monoterpenes because of the increased chain length and additional double bond in the sesquiterpene precursors. (wikipedia.org)
- In the present study, a persistency screening assessment was conducted on 11 cyclic sesquiterpenes selected from 10 different families of sesquiterpenes characterized by their carbon skeleton. (nih.gov)
Chemistry1
- Hedycaryol is a strained 10‐membered monocyclic sesquiterpene alcohol whose chemistry is characterised by its transannular acid catalysed and thermal (Cope) reactions. (researchgate.net)
Fractions2
- The present study was designed to isolate sesquiterpene fractions from several Artemisia species and evaluate their anti-inflammatory activities on key mediators and signaling molecules involved in regulation of inflammation. (ac.ir)
- Sesquiterpene fractions were prepared from several Artemisia species using the Herz-Högenauer technique. (ac.ir)
Substances1
- RL)D (1) Acyclic 69.5 (2) Monocyclic 67.8 (3) Bicyclic 66.1 (4) Tricyclic 64.4 Of the several hundred sesquiterpenes reported in the literature, it is probable that only a small percentage are homogenous substances. (wgtn.ac.nz)
Metabolites1
- Lindenane type sesquiterpene dimers (LSDs) are characteristic metabolites of plants belonging to the genus Sarcandra (Chloranthaceae). (bvsalud.org)
Evaluate1
- Inuloxin A is a promising plant phytotoxic sesquiterpene that deserves further studies to evaluate its potential as a bioherbicide. (rsc.org)
Isolation1
- Bioassay-guided (murine P388 lymphocytic leukemia and human cancer cell lines) separation of an ethyl acetate extract prepared from the inky cap fungus Coprinus cinereus led to the isolation of three new sesquiterpenes, 7,7a-diepicoprinastatin 1 (1), 14-hydroxy-5-desoxy-2S,3S,9R-illudosin (2), and 4,5-dehydro-5-deoxyarmillol (3), together with the known armillol (4). (elsevierpure.com)
Humulene1
- Chemical investigation of the steam-volatile oil of the shrub Rubus rosifolius yielded pregeijerene (2), β-caryophyllene (3), humulene (4), dihydroagarofuran (5), an unidentified sesquiterpene ether, hedycaryol (6) and the novel epieudesmol rosifoliol for which structure (1) is proposed. (researchgate.net)
Structural2
- Current biodegradation prediction models (BioWin™, BioHCwin, and Catalogic) were found to be of limited use because most of the sesquiterpenes studied were outside the structural domain of the models. (nih.gov)
- Here, we report the genome mining discovery and structural characterization of two class II sesquiterpene cyclases (STCs) from Streptomyces. (chemrxiv.org)
Type2
- However, these effects could be dependent on the type of their sesquiterpene content. (ac.ir)
- Lindenane-Type Sesquiterpene Dimers Mitigate Lipopolysaccharide-Induced Inflammation by Inhibiting Toll-Like Receptor Signaling. (bvsalud.org)
Present2
- Given that the shape of the biodegradation curves indicates poor bioavailability and ready biodegradability tests are very stringent, it is expected that all the sesquiterpenes tested in the present study would be degraded under environmental conditions. (nih.gov)
- Therefore, the present work is focus on isolating target sesquiterpenes rapidly via the strategy of high-pressure liquid chromatography coupled with electrospray ionization-quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS/MS) combined with high-speed counter-current chromatography (HSCCC). (researchsquare.com)
Double1
- ß-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the "Trier Social Stress Test" in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study. (harvard.edu)
Essential1
- Sesquiterpenes are ubiquitous in essential oils but an assessment of their environmental behavior is still required for their use as components of natural fragrance ingredients and oral care flavors. (nih.gov)
Novel sesquiterpene1
- Five novel sesquiterpene glycosides, namely, cosmosporasides A-E (1-5), were isolated from the ethyl acetate extract of the fermented broth of Cosmospora joca. (tmu.edu.tw)
Monoterpenes and Sesquiterpenes1
- however, monoterpenes and sesquiterpenes are inside the most abundant molecules. (intechopen.com)
Esters2
- The extracts include sesquiterpene esters, pyrrolizidine alkaloids (PAs) and essential oils. (nih.gov)
- and Sesquiterpene Esters (in E Purpurea). (optimallyorganic.com)
Farnesene2
- The reaction of geranyl pyrophosphate with isopentenyl pyrophosphate results in the 15-carbon farnesyl pyrophosphate (FPP), which is an intermediate in the biosynthesis of sesquiterpenes such as farnesene. (wikipedia.org)
- Farnesene (FNS) is an acyclic sesquiterpene. (tubitak.gov.tr)
Sesquiterpenoids1
- All sesquiterpenoids feature a complex C 15 carbohydrate skeleton which is formed by the cyclization of the universal, aliphatic precursor farnesyl diphosphate (FPP), a reaction catalyzed by enzymes from the sesquiterpene synthase family. (biomedcentral.com)
Enzymes1
- Sesquiterpene synthases typically belong to the class I terpene synthase (TPS) family, commonly exhibiting a α, αβ or αβγ domain architecture for monofunctional enzymes, with the catalytic site located in their respective α-domains. (biomedcentral.com)
Commonly1
- Essential oils high in sesquiterpenes are commonly used in aromatherapy to promote relaxation and create a soothing environment. (incenseherb.com)
Cytotoxic1
- The sesquiterpene (+)-δ-cadinol was previously shown to exhibit cytotoxic activity therefore having an application as possible, new, and sustainably sourced anti-tumor agent. (biomedcentral.com)
Molecular1
- We solved the crystal structure of Copu9 in its closed conformation, for the first time providing molecular details of sesquiterpene synthase from Basidiomycota. (biomedcentral.com)
Strongly1
- Furthermore, the three sesquiterpenes strongly inhibited root and shoot growth of the weed. (bioone.org)
Activity2
- The results of this study indicated that the herbicidal activity of the isolated sesquiterpene may be attributed to inhibition of ALS. (bioone.org)
- In an endeavour to study the pheromonal activity of four himachalene sesquiterpenes as an insect pest management strategy for the control of the blueberry flea beetle Altica sylvia Malloch (a major insect pest of the blueberry plantations in North America), attempts to repeat literature synthetic routes were found to be low yielding. (unb.ca)
High8
- This study sought to show that a high sesquiterpene C. aeruginosa extract (CA-ext) retards axillary hair growth in women. (nih.gov)
- What are the benefits of essential oils high in sesquiterpenes? (incenseherb.com)
- Essential oils high in sesquiterpenes have a wide range of benefits for both the mind and body. (incenseherb.com)
- Essential oils high in sesquiterpenes have been shown to have a positive impact on emotional and mental well-being. (incenseherb.com)
- Essential oils high in sesquiterpenes have a unique ability to deepen spiritual connections and facilitate a sense of grounding and centering. (incenseherb.com)
- In addition to their emotional and spiritual benefits, essential oils high in sesquiterpenes also have numerous physical health benefits. (incenseherb.com)
- If you're looking to deepen your meditation practice or improve your focus and concentration, essential oils high in sesquiterpenes can be incredibly beneficial. (incenseherb.com)
- Incorporating essential oils high in sesquiterpenes into your daily rituals and spiritual practices can have a profound impact on your overall well-being. (incenseherb.com)
Essential oil2
- Sesquiterpenes are a type of organic compound found in many plants, including certain herbs used in essential oil production. (incenseherb.com)
- A. Yes, the sesquiterpene ketone nootkatone is found in trace amounts in Grapefruit essential oil. (youngliving.com)
Found1
- Primarily produced by the Atlantic White Cypress tree, this sesquiterpene can also be found in the downy Japanese Enokitake mushroom. (eybna.com)
Free1
- Look up sesquiterpene in Wiktionary, the free dictionary. (wikipedia.org)
Production1
- In an Escherichia coli strain, optimized for sesquiterpene production, titers of 225 mg l −1 and 395 mg l −1 , respectively, could be achieved. (biomedcentral.com)
Rings3
- Like monoterpenes, sesquiterpenes may be cyclic or contain rings, including many unique combinations. (wikipedia.org)
- SESQUITERPENES cyclized into two adjoining rings, one being 7-carbons and the other is 5-carbons. (childrensmercy.org)
- SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS. (ouhsc.edu)
Leaves2
- Two new sesquiterpenes and two new lignans from the leaves of Juniperus chinensis var. (tmu.edu.tw)
- Dive into the research topics of 'Two new sesquiterpenes and two new lignans from the leaves of Juniperus chinensis var. (tmu.edu.tw)