• testes
  • PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effects in humans. (popcouncil.org)
  • One SSC is the precursor for multiple spermatozoa and therefore SSCs are much less numerous in the testes than cells undergoing spermatogenesis. (wikipedia.org)
  • Cells present in the testes express molecules that play key roles in the regulation of SSC self-renewal. (wikipedia.org)
  • This factor is thought to be expressed in the peritubular cells in human testes. (wikipedia.org)
  • Chemokine (C-X-C motif) ligand 12 (CXCL12) signaling via its receptor C-X-C chemokine receptor type 4 (CXCR4) is also involved in regulation of SSC fate decisions.CXCL12 is found in Sertoli cells in the basement membrane of the seminiferous tubules in adult mouse testes, and its receptor is expressed in undifferentiated spermatogonial cells. (wikipedia.org)
  • cultures
  • Only follitropin will stimulate an increase in cyclic AMP in these cells, yet each agent individually increased the synthesis of androgen-binding protein in short-term cultures. (biochemj.org)
  • past
  • This information is based on the routine use of this system in our laboratory to study the Sertoli cell blood-testis barrier in the past two decades, which should be helpful for investigators in the field. (popcouncil.org)
  • When they move past the basal membrane they differentiate due to cell signals. (wikipedia.org)
  • capable
  • Overexpression of a FAK phosphomimetic and constitutively active mutant p-FAK-Y407E in these cells was capable of rescuing the PFOS-induced injury through corrective cellular organization of cytoskeletal elements. (popcouncil.org)
  • The stem cells are capable of dividing into more SSCs which is vital for maintaining the stem cell pool. (wikipedia.org)
  • These cells are capable of dividing to produce more SSCs but usually do not. (wikipedia.org)
  • In mice A Single (As) spermatogonia are capable of creating 2 separate daughter SSCs when they divide or the daughter cells can join and form A Paired (Apr) spermatogonia. (wikipedia.org)