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  • patients
  • To address this question we measured, by positron emission tomography imaging, levels of the brain serotonin transporter (SERT), a marker for serotonin neurones, as inferred from binding of [ 11 C]-3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB), a second generation SERT radioligand, in subcortical and cerebral cortical brain areas of clinically advanced non-depressed (confirmed by structured psychiatric interview) patients with PD. (wiley.com)
  • known
  • Since serotonin is known to act as a growth factor, the synthesized compounds were tested for activity against several human cancer cell lines. (tdl.org)
  • side
  • One of these side effects is sexual dysfunction, which has been associated with the serotonin receptor 2A (5-HT2A). (tdl.org)
  • uptake
  • The serotonin is secreted luminally and basolaterally , which leads to increased serotonin uptake by circulating platelets and activation after stimulation, which gives increased stimulation of myenteric neurons and gastrointestinal motility . (wikipedia.org)
  • The word ` selective ' has special pharmacological meaning, and, in context, refers to the ability of a drug to inhibit the neural / glial uptake of serotonin , over, say, noradrenaline . (everything2.com)
  • The mechanism of action of sertraline is presume d to be linked to its inhibition of CNS neuron al uptake of serotonin ( 5HT ). (everything2.com)
  • Studies at clinically relevant dose s in human s have demonstrate d that sertraline blocks the uptake of serotonin into human platelets . (everything2.com)
  • A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma. (wikipedia.org)
  • increase serotonin
  • I took some a couple weeks ago but felt a little groggy in the morning so I discontinued it, and started taking samE instead, although at the dosage I'm taking it doesn't increase serotonin anywhere near as well. (diabetesdaily.com)
  • The reason drugs like Zoloft work is that they increase serotonin levels by blocking its reuptake by neurotransmitters. (psyweb.com)
  • fenfluramine
  • A closely related type of drug is a serotonin releasing agent (SRA), an example of which is fenfluramine. (wikipedia.org)
  • A closely related type of drug is a serotonin-norepinephrine releasing agent (SNRA), for instance the withdrawn appetite suppressant fenfluramine/phentermine (Fen-Phen). (wikipedia.org)
  • Fenfluramine/phentermine (Fen-Phen), a combination formulation of fenfluramine, a serotonin releasing agent, and phentermine, a norepinephrine releasing agent, is a functional SNRA that was formerly used as an appetite suppressant for the treatment of obesity. (wikipedia.org)
  • regulates intestinal
  • Since serotonin regulates intestinal activity, its presence in the fruits of plants may serve as a way of ensuring seeds are passed through and expelled by the digestive tract quickly, in much the same way as some fruit-based laxatives do. (news-medical.net)
  • Approximately 90% of the human body 's total serotonin is located in the enterochromaffin cells in the GI tract, where it regulates intestinal movements. (wikipedia.org)
  • regulate
  • Approximately 90% of the human body's total serotonin is located in the enterochromaffin cells in the GI tract, where it is used to regulate intestinal movements. (wikipedia.org)
  • Clinical
  • Medical studies have shown that changes in serotonin transporter metabolism appear to be associated with many different phenomena, including alcoholism, clinical depression, obsessive-compulsive disorder (OCD), romantic love, hypertension and generalized social phobia. (wikipedia.org)