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  • Human Genome
  • Birney is one of the founders of the Ensembl genome browser and other databases, and has played a key role in many large-scale genomics projects, notably the sequencing of the Human Genome in 2000 and the analysis of genome function in the ENCODE project. (wikipedia.org)
  • Following this he played an important role in data collection for and interpretation of the human genome sequence. (wikipedia.org)
  • matrices
  • T his page presents several data matrices and DNA sequence alignments published or presented by staff and collaborators of the Lewis B. and Dorothy Cullman Program for Molecular Systematics Studies at The New York Botanical Garden. (nybg.org)
  • Different PAM matrices correspond to different lengths of time in the evolution of the protein sequence. (wikipedia.org)
  • substitution
  • The absence of substitutions, or the presence of only very conservative substitutions (that is, the substitution of amino acids whose side chains have similar biochemical properties) in a particular region of the sequence, suggest that this region has structural or functional importance. (wikipedia.org)
  • The scores in the substitution matrix may be either all positive or a mix of positive and negative in the case of a global alignment, but must be both positive and negative, in the case of a local alignment. (wikipedia.org)
  • inference
  • We take profit from some results on Grammatical Inference that allow us to build iteratively an abstract machine that considers in each inference step an increasing amount of sequences. (springer.com)
  • Unlike most phylogeny inference software, input sequences need not be aligned beforehand. (wikipedia.org)
  • 1984
  • The most widely used approach to multiple sequence alignments uses a heuristic search known as progressive technique (also known as the hierarchical or tree method) developed by Paulien Hogeweg and Ben Hesper in 1984. (wikipedia.org)
  • gene
  • Expressed Sequence Tag mapping of TMEM229B gene expression indicates that it is ubiquitously expressed throughout the body. (wikipedia.org)
  • common ancestor
  • If two sequences in an alignment share a common ancestor, mismatches can be interpreted as point mutations and gaps as indels (that is, insertion or deletion mutations) introduced in one or both lineages in the time since they diverged from one another. (wikipedia.org)
  • genes
  • We sequenced mating type (MAT) genes and nuclear DNA fragments in sexual and putatively asexual species. (scribd.com)