• Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution. (nature.com)
  • SGO2-MAD2 can functionally replace securin and sequesters most separase in securin-knockout cells. (nature.com)
  • It is enabled by SAC-activated Mad2 to bind and inhibit separase and can functionally replace securin. (uni-bayreuth.de)
  • ALBUQUERQUE, N.M. , Sept. 11, 2023 /PRNewswire-PRWeb/ -- Securin , the industry's leading tech-enabled cybersecurity solutions provider, announced today that it was named a SINET16 Innovator Award winner for 2023. (prweb.com)
  • Selected as WCRCINT India's Best Emerging and Performing CEO 2023, Ram Movva, Chairman & CoFounder, Securin Inc has grown his ventures valuing accountability, transparency and unparalleled growth strategies. (securin.io)
  • Securin is a leading provider of tech-enabled cybersecurity solutions, helping hundreds of customers worldwide gain resilience against emerging threats. (pitchwall.co)
  • Securin is a protein involved in control of the metaphase-anaphase transition and anaphase onset. (wikipedia.org)
  • Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin, produces an abrupt stimulus that induces highly synchronous chromosome separation in anaphase. (wikipedia.org)
  • However, yeast does not appear to require securin to form functional separase as anaphase occurs in yeast with a securin deletion mutation. (wikipedia.org)
  • To initiate the onset of anaphase, securin is dephosphorylated by Cdc14 and other phosphatases. (wikipedia.org)
  • Dephosphorylated securin is recognized by the Anaphase-Promoting Complex (APC) bound primarily to Cdc20 (Cdh1 is also an activating substrate of APC). (wikipedia.org)
  • It is thought that securin integrates multiple regulatory inputs to make separase activation switch-like, resulting in sudden, coordinated anaphase. (wikipedia.org)
  • Overall, securin and separase act in an anaphase-regulating network. (wikipedia.org)
  • Silencing of the SAC during metaphase activates the ubiquitin ligase APC/C (anaphase-promoting complex, also known as the cyclosome) and results in the proteasomal destruction of the separase inhibitor securin 1 . (nature.com)
  • Thus, while the canonical, securin-dependent branch of anaphase control requires proteolysis, the release of active separase from Sgo2-Mad2 does not. (uni-bayreuth.de)
  • Silencing of the spindle assembly checkpoint (SAC) in metaphase enables the ubiquitin ligase APC/C to mediate the proteasomal destruction of securin (and cyclin B1), thereby activating separase. (uni-bayreuth.de)
  • Acute loss of securin and SGO2, but not of either protein individually, resulted in separase deregulation associated with premature cohesin cleavage and cytotoxicity. (nature.com)
  • The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. (nih.gov)
  • Securin is beyond grateful and proud to be recognized as a winner of the SINET16 Innovator Award," said Ram Movva, CEO, Securin. (prweb.com)
  • Securin announces that Chairman Ram Movva is to be named the CEO and Chairman and GTM Veteran Rahul Kannan as President and COO. (securin.io)
  • NAME OF STARTUP: Securin FOUNDED IN (Year): 2020 FOUNDER'S NAME: Ram Movva THE IDEA: What is the problem being solved by your startup / business? (startupanz.com)
  • Thomas C, Wetherall B, Levasseur MD, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes . (ncl.ac.uk)
  • Securin will continue to protect organizations from cybersecurity threats and vulnerabilities with our intuitive, flexible, and scalable platform. (prweb.com)
  • To learn more about Securin and its one-of-a-kind suite of cybersecurity solutions, go to Securin.io today. (prweb.com)
  • Security software company Securin scanned 8 million addressable IPs among US state government systems, and discovered 119,000 instances of high-risk services that could be easily exploited, according to a report released yesterday, dubbed "The State of Cybersecurity in America. (securin.io)
  • The APCCdc20 complex ubiquitinates securin and targets it for degradation by 26S proteasome. (wikipedia.org)
  • One proposed signaling pathway generating switch-like behavior contains a positive feedback loop for activation of Cdc14 by separase, leading to dephosphorylation and degradation of securin (Figure 3). (wikipedia.org)
  • This suggests that it might assist the proper folding of this giant protease and offers a first mechanistic explanation for the genetic evidence that securin is not only an inhibitor but also an activator of separase. (uni-bayreuth.de)
  • The latter mechanism facilitates a considerable degree of sister chromatid separation in securin-knockout cells that lack APC/C activity. (nature.com)
  • Fig. 2: Co-depletion of securin and SGO2 is cytotoxic and results in premature sister chromatid separation and cohesin cleavage. (nature.com)
  • This securin-separase complex is maintained when securin is phosphorylated by Cdk1, inhibiting ubiquitination. (wikipedia.org)
  • APC/C triggers ubiquitination of Securin and Cyclin B, which leads to loss of sister chromatid cohesion and inactivation of Cyclin B/Cdk1, respectively. (warwick.ac.uk)
  • Securin is initially present in the cytoplasm and binds to separase, a protease that degrades the cohesin rings that link the two sister chromatids. (wikipedia.org)
  • Acute depletion of Sgo2 and securin (but not the individual knock-downs) result in separase deregulation and premature loss of cohesion. (uni-bayreuth.de)
  • 2) APC/C prefers phosphorylated securin over un-phosphorylated securin as a substrate. (uni-bayreuth.de)
  • Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). (biomedcentral.com)
  • RAN-mediated pRb-inactivation induced securin upregulation, a putative E2F1 target, by inducing misregulation in chromatin remodeling in its promoter region, which led to transcriptional activation and subsequent development of chromosomal instability. (biomedcentral.com)
  • Therefore, present results have led to the hypothesis that RAN-induced changes in the epigenetic landscape, securin overexpression and subsequent elevation of chromosomal instability is probably byproducts of inactivation of the pRb pathway. (biomedcentral.com)
  • Thus, our results identify an unexpected function of SGO2 in mitotically dividing cells and a mechanism of separase regulation that is independent of securin but still supervised by the SAC. (nature.com)
  • Since the molecular mechanism underlying securin upregulation remains unclear, this study intended to investigate the association of securin upregulation with the Rb-E2F1 circuit and epigenetic histone (H3) modification patterns both globally and in the promoter region of the securin gene. (biomedcentral.com)
  • Note that separase cannot function without initially forming the securin-separase complex. (wikipedia.org)
  • Separase can alternatively be inhibited by association with Cdk1-cyclin B1 but the corresponding complex is scarce in early mitosis and cannot explain why vertebrate securin is dispensable. (uni-bayreuth.de)
  • Until then, this essential protease is kept inactive by association with securin. (uni-bayreuth.de)
  • This is because securin helps properly fold separase into the functional conformation. (wikipedia.org)
  • Securin helps customers gain resilience against evolving threats. (prweb.com)
  • Securin helps leaders continuously improve their security posture. (securin.io)
  • For more information, visit http://www.securin.io or follow us on LinkedIn or Twitter . (prweb.com)
  • Security vulnerabilities in medical devices and the software applications that support them continue to pose a significant threat to healthcare, the Health Information Sharing and Analysis Center (Health-ISAC) underscored in a new report issued alongside Finite State and Securin. (securin.io)
  • Securin released a report detailing their findings after conducting passive scans of the 50 United States' domains and State departments. (securin.io)
  • Securin media coverage including news from when we were Cyber Security Works (CSW) Inc. (securin.io)
  • While free securin is phosphorylated in mitosis, separase-bound securin is kept in an unphosphorylated state by associated PP2A. (uni-bayreuth.de)
  • A joint research project conducted by Health Information Sharing and Analysis Center (Health-ISAC), Finite State, and Securin exploitable vulnerabilities in software and firmware, which can be used by hackers to breach connected devices, software applications and healthcare systems. (securin.io)
  • David Morgan's group found that segregation time of chromosomes 4 and 5 is significantly elongated in budding-yeast strains with mutations in the 2 N-terminal securin phosphorylation sites and securin deletion strains. (wikipedia.org)
  • 4) Pin1 catalyzed trans-to-cis isomerization of separase is essential for Cdk1-cyclin B1-dependent inhibition and explains why the kinase and securin bind separase in a mutually exclusive manner. (uni-bayreuth.de)
  • An association of Securin/PTTG1 upregulation and gastric cancer in human was also demonstrated earlier. (biomedcentral.com)
  • This effecuates supernumerous securin to be degraded first and largely gone by the time separase-associated securin is targeted for proteolysis. (uni-bayreuth.de)