• Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. (sens.org)
  • Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)
  • Due to its prolonged anti-secretory effect, Omeprazole allows for once-daily dosing. (medi-vet.com)
  • Secretory IgA (sIgA) is predominant immunoglobulin in secretions of the mucosal immune system. (wku.edu)
  • These findings in postmenopausal women support that the secretion rate of salivary immunoglobulin A and saliva flow rate are reduced immediately following maximal exercise. (thieme-connect.de)
  • Survival rates, lung inflammation and immune biomarkers including cytokine and secretory immunoglobulin A (sIgA) levels were examined. (internationalprobiotics.org)
  • In consultation with the California Department of Public Health and CDC, ACPHD recommended serologic testing for Trichinella for all persons with a suspected diagnosis of trichinellosis using a commercial laboratory's enzyme-linked immunosorbent assay* to detect immunoglobulin G (IgG) directed against a Trichinella excretory-secretory antigen. (cdc.gov)
  • These showed a clear downregulation of genes related to protein translation with decreasing growth rates, thus revealing the yeast translation machinery as cellular engineering target. (boku.ac.at)
  • In vitro incubated rat islet B cells differ in their individual rates of protein synthesis. (jci.org)
  • The dataset contains over 1.92 million data points in protein isotope labeling kinetics, culminating as the in vivo turnover rates of 3,228 cardiac proteins and the expression levels of 8,064 proteins. (nature.com)
  • The present dataset was collected using a technology platform we recently developed, which overcame several technical challenges in quantifying individual protein turnover rates on a proteome scale. (nature.com)
  • In contrast to steady-state protein abundance, which may be quantified directly in mass spectrometry (MS) by spectral intensity 16 , 17 or sampling frequency 18 , 19 , protein turnover rates cannot be predicted from steady-state data 20 , requiring instead methods that can distinguish old and new protein molecules in mass spectra 11 , 21 . (nature.com)
  • The elucidation of the cell biology of the secretory machinery is of great importance, as it drives protein expression for biopharmaceutical industry, a 140 billion USD global market. (biomedcentral.com)
  • By employing our mouse RECON to the CHO-K1 genome in a comparative genomic approach, we could reconstruct the protein secretory pathway of CHO cells counting 764 CHO components. (biomedcentral.com)
  • The RECON of the secretory pathway represents a strong tool for interpretation of data related to protein secretion as illustrated with transcriptomic data of Chinese Hamster Ovary (CHO) cells, the main platform for mammalian protein production. (biomedcentral.com)
  • In humans, malfunctions in secretory components can result in Huntington's, Alzheimer's, or Parkinson's disease, and protein specific misfolding can lead to cystic fibrosis and antitrypsin deficiency [ 42 , 48 ]. (biomedcentral.com)
  • To our knowledge, so far none has built dedicated RECONs of the protein secretion pathway with a focus on the secretory components and regulators. (biomedcentral.com)
  • On days 0, 7, 14 and 28 following surgery, the changes in the post-limb mechanical claw threshold, the phospholipase A2 (PLA2), interleukin (IL)-6 and tumor necrosis factor (TNF)-α mRNA expression levels, the secretory PLA2 (sPLA2) expression, the IL-6 and TNF-α content, the nuclear factor (NF)-κBp65 protein expression level in the nucleus pulposus, and the apoptotic rate of the nucleus pulposus cells were detected. (iasp-pain.org)
  • Recent studies have demonstrated that serum levels Inhibin-B, a Sertoli cell secretory protein, are suppressed in the presence of testicular injury. (cdc.gov)
  • usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa. (bvsalud.org)
  • Here, we show that nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the NAD + salvage pathway, governs the proinflammatory SASP independent of senescence-associated growth arrest. (nature.com)
  • Also, the increased production rate of cytokines such as IL-6 or TNF-alpha has been implicated in the pathogenesis of car diovascular complications and insulin resistance. (europa.eu)
  • The glucose-sensitive subpopulation exhibited four- to fivefold higher rates of insulin synthesis during 60-min incubations at 2.5-10 mM glucose. (jci.org)
  • CHL1 expression was found to correlate positively with insulin secretory index, GLP1R but inversely with HbA 1c and BMI. (lu.se)
  • [ 16 ] Potential mechanisms through which TCF7L2 variants influence T2DM include its role in adipogenesis, myogenesis, and pancreatic islet development, as well as in beta-cell survival and insulin secretory granule function. (medscape.com)
  • Saliva secretory IgA kinetics in obese subjects submitted to a graded " by ELIAS TORRES, JOSÉ CARLOS BOCANEGRA et al. (wku.edu)
  • The conversion rates of saliva IgA and the detection of viral nucleic acids were analyzed in the first and second weeks after hospitalization. (frontiersin.org)
  • The positive rates increased when combining saliva IgA and viral nucleic acid detection. (frontiersin.org)
  • 4 Ben-Aryeh H, Miron D, Szargel R, Gutman D. Whole-saliva secretion rates in old and young healthy subjects. (thieme-connect.de)
  • Most plasma membrane proteins are sorted by the trans -Golgi network (TGN) in the conventional secretory pathway. (jneurosci.org)
  • On the basis of manual curation of the literature on the yeast, human, and mouse secretory pathway, we have compiled a comprehensive catalogue of characterized proteins with functional annotation and their interconnectivity. (biomedcentral.com)
  • The secretory pathway has two main functions: 1) performing proper folding and post-translational modifications (PTMs) of proteins e.g. glycosylation and sulfation, and 2) sorting proteins to their final cellular or extracellular destination. (biomedcentral.com)
  • To construct their model, the team studied electron microscope images of mollusk mantles to understand the neurons connecting the sensing cells in the mantle with the secretory cells that produce calcium carbonate and pigmented proteins. (scienceblog.com)
  • First, the block in secretion is not due to aberrant folding or oligomerization of secretory proteins in the endoplasmic reticulum because the hemagglutinin of influenza virus folded and oligomerized at the same rate in mutant and parental cells at the restrictive temperature. (rupress.org)
  • Second, secretory proteins accumulated in a compartment intermediate between the ER and the Golgi. (rupress.org)
  • These different genes produce pheochromocytomas with different ages of onset, secretory profiles, locations, and potential for malignancy. (medscape.com)
  • Following irradiation, SFR decreased while senescence-associated β-galactosidase-positive cells (via immunofluorescences) and senescence-related genes and secretory-phenotypes (e.g., p21 and MMP3 in qRT-PCR) increased. (lu.se)
  • SFR was unchanged following EVs treatment, but senescence-associated genes and secretory-phenotypes decreased. (lu.se)
  • 2 Akimoto T, Kumai Y, Akama T, Hayashi E, Murakami H, Soma R, Kuno S, Kono I. Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects. (thieme-connect.de)
  • Salivary gland function was evaluated 18 days after irradiation using salivary gland flow rate (SFR), gene expression (by qRT-PCR) and histopathology. (lu.se)
  • This study showed increased secretory IgA production, and lower proinflammatory cytokine production following infection. (news-medical.net)
  • In ciliated cells, including bovine and Xenopus laevis rod photoreceptors, P/rds was robustly sensitive to endoglycosidase H, which is consistent with its bypassing the medial Golgi and traversing the unconventional secretory pathway. (jneurosci.org)
  • and is thus possibly a sign of P/rds trafficking through an unconventional secretory pathway. (jneurosci.org)
  • If unconventional secretion were to mediate the cilia trafficking of P/rds, then cooperation with the conventional secretory pathway that mediates the trafficking of rhodopsin would be required to ensure proper morphogenesis of the photoreceptive disk membranes. (jneurosci.org)
  • But why do the units associated with air as the pathway represent an external concentration, and then those associated with soil and surface water as the pathways represent an internal, mass-based, dose rate? (cdc.gov)
  • This lesson is part of the anatomy and physiology of the lactating breast series and aims to understand the physiological breast changes from neonate to the end of pregnancy, focusing on breast growth during pregnancy known as secretory differentiation. (medela.ch)
  • Reappraisal of the secretory potency and disappearance rate of pure human minigastrin. (bmj.com)
  • This series aims to develop an understanding of the anatomy and physiology of the lactating breast to drive timely and effective secretory activation to establish a copious milk supply through lactation best practices. (medela.ch)
  • Cell viability, apoptosis, and proliferation rate were not affected. (lu.se)
  • Russell, J. A. / Rapid Estradiol-17β Modulation of Opioid Actions on the Electrical and Secretory Activity of Rat Oxytocin Neurons In vivo . (ed.ac.uk)
  • Here, combining the biochemical analysis of enzymatic and motile properties for purified myosin mutants with in vivo measurements of apical constriction for the same mutants, we show that in vivo constriction rate scales with myosin motor activity. (elifesciences.org)
  • Pregnancy and birth are usually normal in individuals with microvillus inclusion disease, and polyhydramnios is usually absent, in contrast to the clinical picture of patients with other causes of congenital secretory diarrhea. (medscape.com)
  • 3. These data support the hypothesis that, for bile acids that are poorly water soluble, the maximal biliary secretion rate is dependent on conjugating capacity, which is the limiting step in the overall transport from plasma into bile. (portlandpress.com)
  • It has been observed to correlate (with positive direction) to resting energy expenditure, resting heart rate, the colour Doppler ultrasound pattern and thyroid volume, and (with negative direction) to thyroid autoantibody titres, which reflect organ destruction due to autoimmunity. (wikipedia.org)
  • Not only did these interventions enhance the health of the animals, but lowered the viral load in their lungs and boosted survival rates. (news-medical.net)
  • Morphological and pharmacological studies of the parietal cells of the stomach in the dog during periods of maximal acid output and after the gastric secretory inhibitor UK-9040. (bmj.com)
  • We found reduced basal, maximal and ATP-production coupled respiration rates, and decreased proton leak in Mφ during challenge with cPE. (stanford.edu)
  • This greatly impacts production processes, which are commonly not run at the maximum growth rate, thereby resulting in suboptimal productivities. (boku.ac.at)
  • Similarly, Seahorse XF Glycolytic Rate Assay Kit was used to detect the extracellular acidification rate (ECAR) and Seahorse XF Real-Time ATP Rate Assay kit was used to detect the real-time ATP production rates from OXPHOS and glycolysis. (stanford.edu)
  • However, the metabolic role and possible consequences of adipose tissue as a secretory organ in critically ill patients has not been investigated to date. (europa.eu)
  • The increase in temperature occurs as a result of elevated progesterone levels during the luteal (secretory) phase of the menstrual cycle. (proprofs.com)
  • Thyroid's secretory capacity (GT, also referred to as thyroid's incretory capacity, maximum thyroid hormone output, T4 output or, if calculated from serum levels of thyrotropin and thyroxine, as SPINA-GT) is the maximum stimulated amount of thyroxine that the thyroid can produce in a given time-unit (e.g. one second). (wikipedia.org)
  • Then, Fig. 17 is interpreted to indicate that, even thought dose rates for internal absorption in 6-year olds could have been higher than MRL between 1953 and 1973, still no adverse health effects due to soil and water contamination occurred in the past because the exposure levels were always less than the lowest observed adverse effect level (LOAEL). (cdc.gov)
  • Proximal tubular cells respond to OTA with a dramatic reduction in the secretory capacity for organic anions. (karger.com)
  • Cells from the glucose-sensitive subpopulation were larger, and presented a threefold higher density of a pale secretory vesicle subtype, which is thought to contain unprocessed proinsulin. (jci.org)
  • It first describes common matters comparable to maturation of secretory granules within the cells, the jobs of the chaperonic granins, and cell-specific prohormone processing. (magmachina.com)
  • The team found that the excitatory and inhibitory synapses-which promote or diminish cell activity-surrounding the secretory cells and the cells' firing thresholds act as a neural network that determines how much calcium and pigment the mollusk secretes. (scienceblog.com)
  • The apoptotic rate of the nucleus pulposus cells was increased from day 7 following surgery, as compared with the sham operation group. (iasp-pain.org)
  • Estradiol-17beta did not alter basal oxytocin neuron firing rate over 30 min, but amplified naloxone-induced increases in firing rate. (ed.ac.uk)
  • OTA increases resistance in the vas efferens with a subsequent decrease in renal blood flow and glomerular filtration rate. (karger.com)
  • Specifically, overexpression of factors associated with the closedloop conformation, a structure that increases stability and rates of translation initiation before start codon scanning is initiated, showed the strongest effects. (boku.ac.at)
  • There was an indication that this may also be related to the rates exposure a cumulative effect or a cumulative effect. (cdc.gov)
  • This paper provides an updated review of the recent progress achieved in ultra-high dose rate radiobiology experiments employing laser-driven protons, including a brief discussion of the relevant methodology and dosimetry approaches. (frontiersin.org)
  • Then, for past soil and surface water contamination, an internal chemical dose rate, designated and MRL, is given in units of mg/kg/day. (cdc.gov)
  • This time the units are for an external concentration, in mg/L, instead of the internal dose rate of mg/kg/day shown in Fig. 17. (cdc.gov)
  • Newer induction immunosuppressive agent combinations [T-cell-depleting antibody (anti-CD3 antibody, alemtuzumab, or antithymocyte globulin) and a tumor necrosis factor alpha (TNF- α ) inhibitor (etanercept or infliximab)] have improved long-term diabetes reversal rates (~50% in 5 years at the most experienced centers) [ 9 ], presumably by preserving transplanted β -cell mass. (hindawi.com)
  • To understand the oxygen consumption rate (OCR), we used Seahorse XF Cell Mito Stress Test Kit with Seahorse XF96 analyzer. (stanford.edu)
  • Of the estimated 480,000 children with type 1 DM, 24% come from the South-East Asian Region, but the European Region, where the most reliable and up-to-date estimates of incidence are available, comes a close second (23%) 3 .The incidence rate of type 1 DM in India is 4.2/100,000 population per year. (bvsalud.org)
  • This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. (frontiersin.org)
  • Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. (frontiersin.org)
  • Meanwhile, Mφ showed increased basal glycolysis and proton efflux rates (PER) when exposed to cPE. (stanford.edu)
  • To test this obesity we will characterize adipose tissue as a secretory organ using interstitial fluid sampling techniques and advanced peptide analysis in critically ill patients and healthy controls. (europa.eu)
  • Renal hemodynamics and the secretory function of the proximal tubule are affected by OTA after prolonged but not by acute exposure. (karger.com)
  • Evidence based care, established from an understanding of the basic principles of lactation and mammary gland function is imperative to improve breastfeeding rates and subsequently the health and wellbeing of breastfeeding women, infants', and their families. (medela.ch)
  • Firing pattern analysis indicated that acute estradiol-17beta increased oxytocin secretion in dependent rats by increasing action potential clustering without an overall increase in firing rate. (ed.ac.uk)
  • But the acute respiratory illness they cause and the fact that they infect the most fragile at high rates suggests that anything that bolsters the mucosal and systemic immune systems should help protect against the flu. (internationalprobiotics.org)
  • By overexpressing selected differentially expressed translation factors, translation initiation was identified to be the main rate-limiting step. (boku.ac.at)
  • We have further investigated the secretory lesion and report three main findings. (rupress.org)
  • Calculating the secretory capacity with one of these equations is an inverse problem. (wikipedia.org)
  • Misoprostol provides unique mucosal protective effects in the colon and enhances the rate of repair. (medi-vet.com)
  • These histological subtypes are organized into three grades that generally reflects the rate of growth and likelihood of recurrence based on cytological features. (aans.org)
  • Cystic fibrosis or CF, is an inherited disease of the secretory glands. (selfgrowth.com)
  • The Heart rate (HR) was registered using a digital pulse meter (Polar FT1 model) before, immediately finished the exercise and after 30 min post- exercise test. (wku.edu)
  • Blood pressure and pulse rate were not affected. (bmj.com)
  • Following secretory activation, the lactating breast enters the build phase of lactation. (medela.ch)
  • Different rates of calcium carbonate secretion determine the shape of the shell, while different amounts of pigment result in a pattern unique to each species. (scienceblog.com)
  • Naloxone-induced morphine withdrawal strongly increased the firing rate of oxytocin neurons in morphine dependent rats. (ed.ac.uk)
  • In line with the results of OCR and ECAR, we found Mφ during cPE challenge showed higher glycolytic ATP (glycoATP) production rates and lower mitochondrial ATP (mitoATP) production rates which is mainly from OXPHOS. (stanford.edu)